eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues
Abstract
Nitric oxide production in response to flow-dependent shear forces applied on the surface of endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral resistance, and tissue perfusion. This implicates the concerted action of multiple upstream "mechanosensing" molecules reversibly assembled in signalosomes recruiting endothelial nitric oxide synthase (eNOS) in specific subcellular locales, e.g., plasmalemmal caveolae. Subsequent short- and long-term increases in activity and expression of eNOS translate this mechanical stimulus into enhanced NO production and bioactivity through a complex transcriptional and posttranslational regulation of the enzyme, including by shear-stress responsive transcription factors, oxidant stress-dependent regulation of transcript stability, eNOS regulatory phosphorylations, and protein-protein interactions. Notably, eNOS expressed in cardiac myocytes is amenable to a similar regulation in response to stretching of cardiac muscle cells and in part mediates the length-dependent increase in cardiac contraction force. In addition to short-term regulation of contractile tone, eNOS mediates key aspects of cardiac and vascular remodeling, e.g., by orchestrating the mobilization, recruitment, migration, and differentiation of cardiac and vascular progenitor cells, in part by regulating the stabilization and transcriptional activity of hypoxia inducible factor in normoxia and hypoxia. The continuum of the influence of eNOS in…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Regulation of eNOS is intimately related to physical forces important in vascular function such as shear stress induced by blood flow.
“Regulation of eNOS is also intimately related to the physical forces important in vascular function such as shear stress induced by blood flow (27, 31).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [31]
For inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism.
“At the extreme of this spectrum, it is known that for inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism (28, 31, 32, 46).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [31]
NOS3 produces relatively low quantities of NO, and its activity is controlled by calcium/calmodulin, post-translational modifications, and physical forces such as shear stress.
“It produces relatively low quantities of NO, and its activity is controlled by Ca2+ and calmodulin, post-translational modifications [72, 73], and physical forces such as shear stress [74, 75].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [74]
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110 · see citing works
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., Cooper, C. E., & Knowles, R. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570593 · Cited by 4,106 · see citing works
Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Glagov, S., Weisenberg, E. S., Zarins, C. K., Stankunavicius, R., & Kolettis, G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705283162204 · Cited by 3,614 · see citing works
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591 · see citing works
The Protective Effects of Estrogen on the Cardiovascular System
Mendelsohn, M. E., & Karas, R. H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402306 · Cited by 3,108 · see citing works
Nitric oxide synthases: Roles, tolls, and controls
Nathan, C., & Xie, Q. W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,920 · see citing works
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802 · see citing works
Postmenopausal Estrogen Therapy and Cardiovascular Disease
Stampfer, M. J., Colditz, G. A., Willett, W. C., Manson, J. E., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109123251102 · Cited by 2,000 · see citing works
Asahara, T., Takahashi, T., Masuda, H., Kalka, C., Chen, D., Iwaguro, H., Inai, Y., Silver, M., & Isner, J. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3964 · Cited by 1,856 · see citing works
Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D. C., Moore, M. A. S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00754-7 · Cited by 1,751 · see citing works
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D., Engelhardt, B., Cao, G., DeLisser, H. M., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,738 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660 · see citing works
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652 · see citing works
Hypoxia-Inducible Factor-1 (HIF-1)
Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,638 · see citing works
Maniotis, A. J., Chen, C. S., & Ingber, D. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.849 · Cited by 1,606 · see citing works
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555 · see citing works
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Simoncini, T., Hafezi‐Moghadam, A., Brazil, D. P., Ley, K. F., Chin, W. W., & Liao, J. K. (2000) · Nature · doi:10.1038/35035131 · Cited by 1,437 · see citing works
Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340 · see citing works
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C. H., Technau‐Ihling, K., Zeiher, A. M., & Dimmeler, S. (2003) · Nature Medicine · doi:10.1038/nm948 · Cited by 1,297 · see citing works
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,192 · see citing works
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
Razani, B., Engelman, J. A., Wang, X., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105408200 · Cited by 1,163 · see citing works
Langille, B. L., & O'Donnell, F. E. (1986) · Science · doi:10.1126/science.3941904 · Cited by 1,124 · see citing works
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040 · see citing works
Dynamic activation of endothelial nitric oxide synthase by Hsp90
García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029 · see citing works
Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.
Glagov, S., Zarins, C. K., Giddens, D. P., & Ku, D. N. (1988) · PubMed · Cited by 1,029 · see citing works
Nitric oxide synthases: which, where, how, and why?
Michel, T. M., & Féron, O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119750 · Cited by 1,018 · see citing works
Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cheng, C., Tempel, D., van Haperen, R., van der Baan, A., Grosveld, F. G., Daemen, M. J. A. P., Krams, R., & de Crom, R. (2006) · Circulation · doi:10.1161/circulationaha.105.590018 · Cited by 1,002 · see citing works
Haemodynamic shear stress activates a K+ current in vascular endothelial cells
Olesen, S., Clapham, D. E., & Davies, P. F. (1988) · Nature · doi:10.1038/331168a0 · Cited by 1,002 · see citing works
Modulation of Akt kinase activity by binding to Hsp90
Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967 · see citing works
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science · doi:10.1126/science.1073634 · Cited by 950 · see citing works
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 941 · see citing works
Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M. E., & Shaul, P. W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5347 · Cited by 924 · see citing works
Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H. T., Donnini, S., Granger, H. J., & Bicknell, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119451 · Cited by 914 · see citing works
Du, X. L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., & Brownlee, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11235 · Cited by 907 · see citing works
Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., & Irani, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704329104 · Cited by 881 · see citing works
Nobuyoshi, M., Kimura, T., Nosaka, H., Mioka, S., Ueno, K., 横井, 博., Hamasaki, N., Horiuchi, H., & Ohishi, H. (1988) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(88)80046-9 · Cited by 875 · see citing works
Ion Channels and Their Functional Role in Vascular Endothelium
Nilius, B., & Droogmans, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1415 · Cited by 868 · see citing works
Nitric oxide synthase: Aspects concerning structure and catalysis
Marletta, M. A. (1994) · Cell · doi:10.1016/0092-8674(94)90268-2 · Cited by 862 · see citing works
Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858 · see citing works
AMP‐activated protein kinase phosphorylation of endothelial NO synthase
Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
Rudic, R. D., Shesely, E. G., Maeda, N., Smithies, O., Segal, S. S., & Sessa, W. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1699 · Cited by 821 · see citing works
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works
Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770 · see citing works
Kojda, G. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00169-8 · Cited by 769 · see citing works
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Barouch, L. A., Harrison, R. W., Skaf, M. W., Rosas, G. O., Cappola, T. P., Kobeissi, Z. A., Hobai, I. A., Lemmon, C. A., Burnett, A. L. “., O'Rourke, B. P., et al. (2002) · Nature · doi:10.1038/416337a · Cited by 760 · see citing works
Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738 · see citing works
Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735 · see citing works
Antioxidants and Oxidative Stress in Exercise
Ji, L. L. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-145.x · Cited by 734 · see citing works
KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 724 · see citing works
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works
Postmenopausal Estrogen Therapy and Cardiovascular Disease
MacLean, D. B., & Bostom, A. G. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203053261012 · Cited by 703 · see citing works
Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women
Lieberman, E. H., Gerhard, M. D., Uehata, A., Walsh, B. W., Selwyn, A. P., Ganz, P., Yeung, A. C., & Creager, M. A. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00005 · Cited by 701 · see citing works
Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells
Suárez, Y., Fernandez-Hernando, C. F., Pober, J. S., & Sessa, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000265065.26744.17 · Cited by 698 · see citing works
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697 · see citing works
Dekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 694 · see citing works
Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction
Lee, S. H., Wolf, P. L., Escudero, R., Deutsch, R., Jamieson, S. W., & Thistlethwaite, P. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420904 · Cited by 693 · see citing works
Hambrecht, R. (2000) · JAMA · doi:10.1001/jama.283.23.3095 · Cited by 689 · see citing works
Peroxynitrite reductase activity of bacterial peroxiredoxins
Bryk, R., Griffin, P. R., & Nathan, C. (2000) · Nature · doi:10.1038/35025109 · Cited by 679 · see citing works
Endothelial Nitric Oxide Synthase Targeting to Caveolae
Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 676 · see citing works
Nitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673 · see citing works
The enigma of Mayer waves: facts and models.
JULIEN, C. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.008 · Cited by 670 · see citing works
Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.
Balligand, J., Kelly, R. A., Marsden, P. A., Smith, T. W., & Michel, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.347 · Cited by 659 · see citing works
Self-citationSex Differences in Coronary Heart Disease
Barrett-Connor, E. L. (1997) · Circulation · doi:10.1161/01.cir.95.1.252 · Cited by 648 · see citing works
Kuhlencordt, P. J., Gyurko, R., Han, F., Scherrer‐Crosbie, M., Aretz, T. H., Hajjar, R. J., Picard, M. H., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc2901.091399 · Cited by 631 · see citing works
Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase
Raman, C. S., Li, H., Pavel Martasek, E., Král, V., Masters, B. S. S., & Poulos, T. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81718-3 · Cited by 621 · see citing works
Nieuwdorp, M., van Haeften, T. W., Gouverneur, M., Mooij, H. L., van Lieshout, M. H. P., Levi, M. M., Meijers, J. C. M., Holleman, F., Hoekstra, J. B. L., Vink, H., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1103 · Cited by 621 · see citing works
Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells
Florian, J. A., Kosky, J. R., Ainslie, K. M., Pang, Z., Dull, R. O., & Tarbell, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000101744.47866.d5 · Cited by 619 · see citing works
Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin
Li, S. C., Okamoto, T., Chun, M., Sargiacomo, M., Casanova, J. E., Hansen, S. H., Nishimoto, I., & Lisanti, M. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15693 · Cited by 608 · see citing works
Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State
Keulenaer, G. W. D., Chappell, D. C., Ishizaka, N., Nerem, R. M., Alexander, R. W., & Griendling, K. K. (1998) · Circulation Research · doi:10.1161/01.res.82.10.1094 · Cited by 605 · see citing works
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602 · see citing works
Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 597 · see citing works
Hafezi‐Moghadam, A., Simoncini, T., Yang, Z., Limbourg, F. P., Plumier, J.-C., Rebsamen, M. C., Hsieh, C.-M., Chui, D.-S., Thomas, K. L., Prorock, A. J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-473 · Cited by 595 · see citing works
Bucci, M., Gratton, J., Rudic, R. D., Acevedo, L. M., Roviezzo, F., Cirino, G., & Sessa, W. C. (2000) · Nature Medicine · doi:10.1038/82176 · Cited by 573 · see citing works
Estrogen Modulation of Endothelial Nitric Oxide Synthase
Chambliss, K. L., & Shaul, P. W. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0045 · Cited by 572 · see citing works
Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress
Uematsu, M., Ohara, Y., Navas, J. P., Nishida, K., Murphy, T. J., Alexander, R. W., Nerem, R. M., & Harrison, D. G. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.6.c1371 · Cited by 571 · see citing works
Nitric Oxide and Cardiac Function
Massion, P. B., Féron, O., Dessy, C., & Balligand, J. (2003) · Circulation Research · doi:10.1161/01.res.0000088351.58510.21 · Cited by 566 · see citing works
Self-citationMichell, B. J., Chen, Z., Tiganis, T., Stapleton, D., Katsis, F., Power, D. A., Sim, A. T. R., & Kemp, B. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100122200 · Cited by 560 · see citing works
The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Kopp, H., Avecilla, S. T., Hooper, A. T., & Rafii, S. (2005) · Physiology · doi:10.1152/physiol.00025.2005 · Cited by 554 · see citing works
Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553 · see citing works
S-nitrosylation in health and disease
Foster, M. W., McMahon, T., & Stamler, J. S. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00028-5 · Cited by 552 · see citing works
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training
Fukai, T., Siegfried, M. R., Ushio‐Fukai, M., Cheng, Y. C., Kojda, G., & Harrison, D. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9551 · Cited by 552 · see citing works
Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium
Chappell, D. C., Varner, S. E., Nerem, R. M., Medford, R. M., & Alexander, R. W. (1998) · Circulation Research · doi:10.1161/01.res.82.5.532 · Cited by 548 · see citing works
Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location
Shaul, P. W. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155952 · Cited by 541 · see citing works
Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression
Torella, D., Rota, M., Nurzyńska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E. A., Walsh, K., Rosenzweig, A., Sussman, M. A., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000117306.10142.50 · Cited by 538 · see citing works
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
Potente, M., Urbich, C., Sasaki, K., Hofmann, W. K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R. A., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23126 · Cited by 531 · see citing works
Reís, S. E., Gloth, S. T., Blumenthal, R. S., Resar, J. R., Zacur, H. A., Gerstenblith, G., & Brinker, J. A. (1994) · Circulation · doi:10.1161/01.cir.89.1.52 · Cited by 530 · see citing works
Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells
Kuchan, M. J., & Frangos, J. A. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.3.c628 · Cited by 521 · see citing works
Fulton, D. J., Gratton, J., & Sessa, W. C. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29198-9 · Cited by 495 · see citing works
Nitric oxide synthase in cardiac sarcoplasmic reticulum
Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S., & Becker, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.657 · Cited by 480 · see citing works
Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion
Gao, F., Gao, E., Yue, T.-L., Ohlstein, E. H., Lopez, B. L., Christopher, T. A., & Ma, X. (2002) · Circulation · doi:10.1161/01.cir.0000012529.00367.0f · Cited by 469 · see citing works
Nitric oxide and atherosclerosis: An update
Claudio Napoli, A., de Nigris, F., Williams‐Ignarro, S., Pignalosa, O., Sica, V., & Ignarro, L. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.03.011 · Cited by 463 · see citing works
Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
Kawashima, S., & Yokoyama, M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125114.88079.96 · Cited by 455 · see citing works
Boo, Y. C., Sorescu, G. P., Boyd, N. L., Shiojima, I., Walsh, K., Du, J., & Jo, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108789200 · Cited by 447 · see citing works
Fundamentals of Reperfusion Injury for the Clinical Cardiologist
Verma, S., Fedak, P. W. M., Weisel, R. D., BUTANY, J. W., Rao, V., Maitland, A. M., Li, R., Dhillon, B., & Yau, T. M. (2002) · Circulation · doi:10.1161/01.cir.0000016602.96363.36 · Cited by 447 · see citing works
Takimoto, E., Champion, H. C., Li, M., Ren, S. V., Rodríguez, E. R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K. L., Wang, Y., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci21968 · Cited by 446 · see citing works
Regulation of HIF-1α Stability through S-Nitrosylation
Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujašković, Ž., Dewhirst, M. W., & Li, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.024 · Cited by 439 · see citing works
Mechanotransduction and the glycocalyx
Tarbell, J. M., & Pahakis, M. Y. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01620.x · Cited by 437 · see citing works
Stone, P. H., Coskun, A. U., Kinlay, S., Clark, M. E., Milan Sonka, A., Wahle, A., Ilegbusi, O. J., Yeghiazarians, Y., Popma, J. J., Orav, E. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000080882.35274.ad · Cited by 435 · see citing works
Drummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430 · see citing works
Landmesser, U., Engberding, N., Bahlmann, F. H., Schaefer, A., Wiencke, A., Heineke, A., Spiekermann, S., Hilfiker‐Kleiner, D., Templin, C., Kotlarz, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143232.67642.7a · Cited by 423 · see citing works
Cosentino, F., Eto, M., Paolis, P. D., van der Loo, B., Bachschmid, M. M., Ullrich, V., Kouroedov, A., Gatti, C., Joch, H., Volpe, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000051367.92927.07 · Cited by 419 · see citing works
Jalali, S., del Pozo, M. Á., Chen, K., Miao, H., Li, Y.-S. J., Schwartz, M. A., Shyy, J. Y.-J., & Chien, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1042 · Cited by 417 · see citing works
Chambliss, K. L., Yuhanna, I. S., Mineo, C., Liu, P., German, Z., Sherman, T. S., Mendelsohn, M. E., Anderson, R. G. W., & Shaul, P. W. (2000) · Circulation Research · doi:10.1161/01.res.87.11.e44 · Cited by 416 · see citing works
Fluid Shear Stress Activation of Focal Adhesion Kinase
Li, S., Kim, M. S., Hu, Y., Jalali, S., Schlaepfer, D. D., Hunter, T. R., Chien, S., & Shyy, J. Y.-J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30455 · Cited by 414 · see citing works
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., & Brüne, B. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0791 · Cited by 414 · see citing works
Disruption of methylarginine metabolism impairs vascular homeostasis
LEIPER, J. M., Nandi, M., Torondel, B., Murray‐Rust, J., Malaki, M., O'Hara, B. P., Rossiter, S., Anthony, S., Madhani, M., Selwood, D. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1543 · Cited by 403 · see citing works
Bryan, N. S., Rassaf, T., Maloney, R. E., Rodriguez, C. M., Saijo, F., Rodriguez, J. R., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306706101 · Cited by 400 · see citing works
Life history of eNOS: partners and pathways
DUDZINSKI, D., & MICHEL, T. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.023 · Cited by 400 · see citing works
van der Zee, R., Murohara, T., Luo, Z., Zollmann, F. S., Passeri, J. J., Lekutat, C., & Isner, J. M. (1997) · Circulation · doi:10.1161/01.cir.95.4.1030 · Cited by 399 · see citing works
The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress
Pahakis, M. Y., Kosky, J. R., Dull, R. O., & Tarbell, J. M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.137 · Cited by 391 · see citing works
Jin, Z., Ueba, H., Tanimoto, T., Lungu, A. O., Frame, M. D. S., & Berk, B. C. (2003) · Circulation Research · doi:10.1161/01.res.0000089257.94002.96 · Cited by 388 · see citing works
McCabe, T. J., Fulton, D., Roman, L. J., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6123 · Cited by 387 · cited 14× · see citing works
“Other kinases, e.g., protein kinase A (278), protein kinase G (61), AMP-activated kinase (76), and calcium/CaM-dependent protein kinase II also phosphorylate eNOS on serine-1177.”
BackgroundInfluentialHormonal Treatment of Postmenopausal Women
Wood, A. J. J., & Belchetz, P. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301508 · Cited by 386 · see citing works
Endothelial cellular response to altered shear stress
Fisher, A. B., Chien, S., Barakat, A. I., & Nerem, R. M. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.3.l529 · Cited by 384 · see citing works
Yu, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27100 · Cited by 384 · see citing works
8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
Shah, A. M., Spurgeon, H. A., Sollott, S. J., Talo, A., & Lakatta, E. G. (1994) · Circulation Research · doi:10.1161/01.res.74.5.970 · Cited by 377 · see citing works
Kojda, G., & Hambrecht, R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.032 · Cited by 370 · see citing works
Paulus, W. J., Vantrimpont, P. J. M. J., & Shah, A. M. (1994) · Circulation · doi:10.1161/01.cir.89.5.2070 · Cited by 367 · see citing works
Adams, V., Lenk, K., Linke, A., Lenz, D., Erbs, S., Sandri, M., Tarnok, A., Gielen, S., Emmrich, F., Schuler, G., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000124104.23702.a0 · Cited by 367 · see citing works
The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle
Féron, O., Saldaña, F., Michel, J. B., & Michel, T. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3125 · Cited by 361 · see citing works
Mitochondria as signaling organelles in the vascular endothelium
Quintero, M., Colombo, S. L., Godfrey, A. R., & Moncada, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601026103 · Cited by 360 · see citing works
Ohno, M., Cooke, J. P., Dzau, V. J., & Gibbons, G. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117787 · Cited by 359 · see citing works
Dekker, R. J., van Thienen, J. V., Rohlena, J., de Jager, S. C. A., Elderkamp, Y. W., Seppen, J., de Vries, C. J. M., Biessen, E. A. L., van Berkel, T. J. C., Pannekoek, H., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63002-7 · Cited by 355 · see citing works
Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation
Parton, R. G., Way, M., Zorzi, N., & Stang, E. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.1.137 · Cited by 354 · see citing works
Köhler, R., Heyken, W., Heinau, P., Schubert, R., Si, H., Kacik, M., Busch, C., Grgic, I., Maier, T., & Hoyer, J. D. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000225698.36212.6a · Cited by 346 · see citing works
Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells
Shen, J., Luscinskas, F. W., Connolly, A. J., Dewey, C. F., & Gimbrone, M. A. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.2.c384 · Cited by 346 · see citing works
Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells
Hishikawa, K., Nakaki, T., Marumo, T., Suzuki, H., Kato, R., & Saruta, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00124-r · Cited by 344 · see citing works
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis
Dayoub, H., Achan, V., Adimoolam, S., Jacobi, J., Stuehlinger, M. C., Wang, B., Tsao, P. S., Kimoto, M., Vallance, P. J., Patterson, A. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000101924.04515.2e · Cited by 340 · see citing works
Fontana, J. T., Fulton, D. J., Chen, Y., Fairchild, T. A., McCabe, T. J. D., Fujita, N., Tsuruo, T., & Sessa, W. C. (2002) · Circulation Research · doi:10.1161/01.res.0000016837.26733.be · Cited by 340 · see citing works
VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., & Resnick, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142224299 · Cited by 339 · see citing works
Pritchard, K. A., Ackerman, A. W., Gross, E. R., Stepp, D. W., Shi, Y., Fontana, J. T., Baker, J. E., & Sessa, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100084200 · Cited by 338 · see citing works
Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release
Mochizuki, S., Vink, H., Hiramatsu, O., Kajita, T., Shigeto, F., Spaan, J. A. E., & Kajiya, F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00691.2002 · Cited by 332 · see citing works
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
Petroff, M. V., Kim, S. H., Pepe, S., Dessy, C., Marbán, E., Balligand, J., & Sollott, S. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-867 · Cited by 329 · see citing works
Self-citationFleming, I., Fißlthaler, B., Dixit, M., & Busse, R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02541 · Cited by 328 · see citing works
Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells.
Awolesi, M. A., Sessa, W. C., & Sumpio, B. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118181 · Cited by 328 · see citing works
Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells
Ido, Y., Carling, D., & Ruderman, N. B. (2002) · Diabetes · doi:10.2337/diabetes.51.1.159 · Cited by 323 · see citing works
Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 321 · see citing works
Davis, M. E., Cai, H. “., Drummond, G. R., & Harrison, D. G. (2001) · Circulation Research · doi:10.1161/hh2301.100806 · Cited by 310 · see citing works
Hiasa, K., Ishibashi, M., Ohtani, K., Inoue, S., Zhao, Q. D., Kitamoto, S., Sata, M., Ichiki, T., Takeshita, A., & Egashira, K. (2004) · Circulation · doi:10.1161/01.cir.0000128213.96779.61 · Cited by 308 · see citing works
Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress
Fisslthaler, Dimmeler, S., Hermann, Busse, & Fleming (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00627.x · Cited by 308 · see citing works
Osawa, M., Masuda, M., Kusano, K.-I., & Fujiwara, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205049 · Cited by 307 · see citing works
Rizzo, V., McIntosh, D. P., Oh, P., & Schnitzer, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34724 · Cited by 306 · see citing works
Rivard, A., Berthou-Soulié, L., Principe, N., Kearney, M., Curry, C., Branellec, D., Semenza, G. L., & Isner, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001029200 · Cited by 305 · see citing works
Wang, J., Wolin, M. S., & Hintze, T. H. (1993) · Circulation Research · doi:10.1161/01.res.73.5.829 · Cited by 304 · see citing works
Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia
Stuehlinger, M., Oka, R. K., Graf, E. E., Schmoelzer, I., Upson, B. M., Kapoor, O., Szuba, A., Malinow, M. R., Wascher, T. C., Pachinger, O. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000085067.55901.89 · Cited by 303 · see citing works
Hemodynamics and atherosclerosis1
Stehbens, W. E. (1982) · Biorheology · doi:10.3233/bir-1982-191-210 · Cited by 303 · see citing works
Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., Acetis, M. D., Vecchione, C., Marino, G., Altruda, F., et al. (2002) · Nature Medicine · doi:10.1038/nm805 · Cited by 295 · see citing works
Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress
Ranjan, V., Xiao, Z., & Diamond, S. L. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.2.h550 · Cited by 294 · see citing works
Krzysztof Reiss, F., Cheng, W. N., Ferbér, A., Kajstura, J., Li, P., Li, B., Olivetti, G., Homcy, C. J., Baserga, R., & Anversa, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8630 · Cited by 292 · see citing works
Protection from Experimental Asthma by an Endogenous Bronchodilator
Que, L. G., Liu, L., Yan, Y., Whitehead, G. S., Gavett, S. H., Schwartz, D. A., & Stamler, J. S. (2005) · Science · doi:10.1126/science.1108228 · Cited by 290 · see citing works
LEIPER, J. M., Murray‐Rust, J., McDonald, N. Q., & Vallance, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212269799 · Cited by 288 · see citing works
Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response
Tzima, E. (2006) · Circulation Research · doi:10.1161/01.res.0000200162.94463.d7 · Cited by 286 · see citing works
Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase
Garcin, E. D., Bruns, C. M., Lloyd, S. J., Hosfield, D. J., Tiso, M., Gachhui, R., Stuehr, D. J., Tainer, J. A., & Getzoff, E. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406204200 · Cited by 285 · see citing works
Butt, E., Bernhardt, M., Smolenski, A., Kotsonis, P., Fröhlich, L. G., Sickmann, A., Meyer, H. E., Lohmann, S. M., & Schmidt, H. H. H. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5179 · Cited by 284 · see citing works
The subendothelial extracellular matrix modulates NF-κB activation by flow
Orr, A. W., Sanders, J. M., Bevard, M. H., Coleman, E. J., Sarembock, I. J., & Schwartz, M. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410073 · Cited by 284 · see citing works
Myocardial Contractile Response to Nitric Oxide and cGMP
Mohan, P., Brutsaert, D. L., Paulus, W. J., & Sys, S. U. (1996) · Circulation · doi:10.1161/01.cir.93.6.1223 · Cited by 281 · see citing works
Fiedler, B., Lohmann, S. M., Smolenski, A., Linnemüller, S., Pieske, B. M., Schröder, F., Molkentin, J. D., Drexler, H., & Wollert, K. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162100799 · Cited by 276 · see citing works
Schwarz, P., Diem, R., Dun, N. J., & Förstermann, U. (1995) · Circulation Research · doi:10.1161/01.res.77.4.841 · Cited by 275 · see citing works
Cheng, C., van Haperen, R., de Waard, M., van Damme, L. C. A., Tempel, D., Hanemaaijer, L., van Cappellen, G. W. A., Bos, J., Slager, C. J., Duncker, D. J., et al. (2005) · Blood · doi:10.1182/blood-2005-06-2326 · Cited by 274 · see citing works
Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., & Schuler, G. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00602-6 · Cited by 272 · see citing works
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells
Li, S., Butler, P. J., Wang, Y., Hu, Y., Han, D. C., Usami, S., Guan, J., & Chien, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052018099 · Cited by 272 · see citing works
Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins
Brouet, A., Sonveaux, P., Dessy, C., Moniotte, S., Balligand, J., & Féron, O. (2001) · Circulation Research · doi:10.1161/hh2201.100319 · Cited by 269 · see citing works
Self-citationLu, Q. R., Pallas, D. C., Surks, H. K., Baur, W. E., Mendelsohn, M. E., & Karas, R. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407492101 · Cited by 266 · see citing works
Rosselli, M., Imthurn, B., Keller, P. J., Jackson, E. K., & Dubey, R. K. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.848 · Cited by 264 · see citing works
Nitric Oxide Synthases and Cardiac Muscle
Balligand, J., & Cannon, P. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.1846 · Cited by 263 · see citing works
Self-citationAccumulation of HIF-1α under the influence of nitric oxide
Sandau, K. B., Fandrey, J., & Brüne, B. (2001) · Blood · doi:10.1182/blood.v97.4.1009 · Cited by 263 · see citing works
Ravi, K., Brennan, L., Levic, S., Ross, P. A., & Black, S. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300464101 · Cited by 263 · see citing works
Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
Ohno, M., Gibbons, G. H., Dzau, V. J., & Cooke, J. P. (1993) · Circulation · doi:10.1161/01.cir.88.1.193 · Cited by 261 · see citing works
Brutsaert, D. L., Meulemans, A., Sipido, K. R., & Sys, S. U. (1988) · Circulation Research · doi:10.1161/01.res.62.2.358 · Cited by 260 · see citing works
Lamontagne, D., Pohl, U., & Busse, R. (1992) · Circulation Research · doi:10.1161/01.res.70.1.123 · Cited by 252 · see citing works
Barile, L., Messina, E., Giacomello, A., & Marbán, E. (2007) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.03.005 · Cited by 251 · see citing works
Toporsian, M., Gros, R., Kabir, M. G., Vera, S., Govindaraju, K., Eidelman, D. H., Husain, M., & Letarte, M. (2005) · Circulation Research · doi:10.1161/01.res.0000159936.38601.22 · Cited by 249 · see citing works
Increased neuronal nitric oxide synthase-derived NO production in the failing human heart
Damy, T., Ratajczak, P., Shah, A. M., Camors, E. M., Marty, I., Hasenfuss, G. P., Marotte, F., Samuel, J., & Heymes, C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16048-0 · Cited by 247 · see citing works
Shear stress stimulates phosphorylation of eNOS at Ser635by a protein kinase A-dependent mechanism
Boo, Y. C., Hwang, J., Sykes, M. C., Michell, B. J., Kemp, B. E., Lum, H., & Jo, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2002 · Cited by 240 · see citing works
Tsuruta, D., & Jones, J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00823 · Cited by 239 · see citing works
Estrogens Increase Transcription of the Human Endothelial NO Synthase Gene
Kleinert, H., Wallerath, T., Euchenhofer, C., Ihrig‐Biedert, I., Li, H., & Förstermann, U. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.582 · Cited by 239 · see citing works
Wung, B., Cheng, J., Hsieh, H. J., Shyy, Y.-J., & Wang, D. L. (1997) · Circulation Research · doi:10.1161/01.res.81.1.1 · Cited by 237 · see citing works
Lin, M. I., Fulton, D. J., Babbitt, R. W., Fleming, I., Busse, R., Pritchard, K. A., & Sessa, W. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302836200 · Cited by 236 · see citing works
EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries
Pohl, U., Herlan, K., Huang, A., & Bassenge, E. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.6.h2016 · Cited by 234 · see citing works
Mechanical Transduction of Nitric Oxide Synthesis in the Beating Heart
Pinsky, D. J., Patton, S. R., Mesároš, Š., Brovkovych, V. M., Kubaszewski, E., Grunfeld, S., & Maliñski, T. (1997) · Circulation Research · doi:10.1161/01.res.81.3.372 · Cited by 233 · see citing works
IDENTIFICATION OF BLOOD PRESSURE CONTROL MECHANISMS BY POWER SPECTRAL ANALYSIS
Stauss, H. M. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04588.x · Cited by 231 · see citing works
Thum, T., Tsikas, D., Stein, S., Schultheiß, M., Eigenthaler, M., Anker, S. D., Poole-Wilson, P. A., Ertl, G., & Bauersachs, J. K. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.066 · Cited by 231 · see citing works
Janssens, S. P., Pokreisz, P., Schoonjans, L., Pellens, M., Vermeersch, P., Tjwa, M., Jans, P., Scherrer‐Crosbie, M., Picard, M. H., Szelid, Z., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000126497.38281.23 · Cited by 231 · see citing works
The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression
Li, Y.-S. J., Shyy, J. Y.-J., Li, S., Lee, J., Su, B., Karin, M., & Chien, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.5947 · Cited by 230 · see citing works
Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta
Delp, M. D., McAllister, R. M., & Laughlin, M. H. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1354 · Cited by 227 · see citing works
Layland, J., Li, J., & Shah, A. M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.014126 · Cited by 223 · see citing works
Hauser, W., Knobeloch, K., Eigenthaler, M., Gambaryan, S. P., Krenn, V., Geiger, J., Glazova, M. V., Rohde, E., Horak, I. D., Walter, U., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8120 · Cited by 222 · see citing works
Angiogenesis and Vasculogenesis Are Impaired in the Precocious-Aging klotho Mouse
Shimada, T., Takeshita, Y., Murohara, T., Sasaki, K., Egami, K., Shintani, S., Katsuda, Y., Ikeda, H., Nabeshima, Y., & Imaizumi, T. (2004) · Circulation · doi:10.1161/01.cir.0000139854.74847.99 · Cited by 221 · see citing works
Sonveaux, P., Martinive, P., DeWever, J., Batova, Z., Daneau, G., Pelat, M., Ghisdal, P., Grégoire, V., Dessy, C., Balligand, J., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000136344.27825.72 · Cited by 220 · see citing works
Self-citationRegulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells
Csiszár, A., Smith, K. E., Koller, Á., Kaley, G., Edwards, J. G., & Ungvari, Z. I. (2005) · Circulation · doi:10.1161/01.cir.0000164201.40634.1d · Cited by 218 · see citing works
Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro
Rizzo, V., Morton, C. A., DePaola, N., Schnitzer, J. E., & Davies, P. F. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00344.2002 · Cited by 218 · see citing works
Murray‐Rust, J., LEIPER, J. M., McAlister, M. S. B., Phelan, J. P., Tilley, S. J., MARIA, J. S., Vallance, P. J., & McDonald, N. Q. (2001) · Nature Structural Biology · doi:10.1038/90387 · Cited by 217 · see citing works
Laurindo, F. R. M., Pedro, M. D. A., Barbeiro, H. V., Pileggi, F., de Carvalho, M. H. C., Augusto, O., & da Luz, P. L. (1994) · Circulation Research · doi:10.1161/01.res.74.4.700 · Cited by 215 · see citing works
Darblade, B., Pendaries, C., Krust, A., Dupont, S., Fouque, M.-J., RAMI, J., Chambon, P., Bayard, F., & Arnal, J. (2002) · Circulation Research · doi:10.1161/hh0402.105096 · Cited by 214 · see citing works
Brouet, A., Sonveaux, P., Dessy, C., Balligand, J., & Féron, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101371200 · Cited by 213 · see citing works
Self-citationDavis, M. E., Grumbach, I. M., Fukai, T., Cutchins, A. C., & Harrison, D. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307528200 · Cited by 213 · see citing works
Michell, B. J., Harris, M. B., Chen, Z.-P., Ju, H., Venema, V. J., Blackstone, M. A., Huang, W., Venema, R. C., & Kemp, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205144200 · Cited by 212 · see citing works
Zhang, Y., Lee, T.-S., Kolb, E. M., Sun, K., Lu, X., Sladek, F. M., Kassab, G. S., Garland, T., & Shyy, J. Y.-J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000221230.08596.98 · Cited by 212 · cited 1× · see citing works
“Moreover, the interpretation of the protective effects of AMPK and HIF through the NO-driven modulation of the mitochondrial respiratory chain are further complicated by the recently described AMPK-dependent activation of eNOS (243, 367, 449).”
BackgroundIwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.553925 · Cited by 211 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280 · see citing works
Incalza, M. A., D’Oria, R., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.005 · Cited by 1,375 · see citing works
Piezo1 integration of vascular architecture with physiological force
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A. F., Ludlow, M. J., Sedó, A., Hyman, A. J., McKeown, L., Young, R. S., et al. (2014) · Nature · doi:10.1038/nature13701 · Cited by 1,210 · see citing works
Nitric oxide signalling in cardiovascular health and disease
Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779 · see citing works
Self-citationEndothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
Wang, S., Chennupati, R., Kaur, H., Iring, A., Wettschureck, N., & Offermanns, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87343 · Cited by 616 · see citing works
Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications
Andrabi, S. M., Sharma, N. S., Karan, A., Shahriar, S. M. S., Cordon, B., Ma, B., & Xie, J. (2023) · Advanced Science · doi:10.1002/advs.202303259 · Cited by 639 · see citing works
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 591 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Molecular mechanisms underlying the activation of eNOS
Fleming, I. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0767-7 · Cited by 437 · see citing works
Arnal, J., Lenfant, F., Métivier, R., Flouriot, G., Henrion, D., Adlanmérini, M., Fontaine, C., Gourdy, P., Chambon, P., Katzenellenbogen, B. S., et al. (2017) · Physiological Reviews · doi:10.1152/physrev.00024.2016 · Cited by 428 · see citing works
Mechanosensitive mechanisms in transcriptional regulation
Mammoto, A., Mammoto, T., & Ingber, D. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.093005 · Cited by 393 · see citing works
Mitochondria as a Therapeutic Target in Heart Failure
Bayeva, M., Gheorghiade, M., & Ardehali, H. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.1021 · Cited by 336 · see citing works
Sun, H., Zeng, D.-Y., Li, R.-T., Pang, R., Yang, H., Hu, Y., Zhang, Q., Jiang, Y., Huang, L., Tang, Y., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.197301 · Cited by 319 · see citing works
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
Kvietys, P. R., & Granger, D. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.002 · Cited by 313 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Cellular signaling and NO production
Michel, T. M., & Vanhoutte, P. M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0765-9 · Cited by 287 · see citing works
Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssière, C., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101861 · Cited by 309 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“It produces relatively low quantities of NO, and its activity is controlled by Ca2þ and calmodulin, posttranslational modifications [72,73], and physical forces such as shear stress [74,75].”
BackgroundEllison, G. M., Waring, C. D., Vicinanza, C., & Torella, D. (2011) · Heart · doi:10.1136/heartjnl-2011-300639 · Cited by 272 · see citing works
The critical role of hemodynamics in the development of cerebral vascular disease
Nixon, A. M., Günel, M., & Sumpio, B. E. (2009) · Journal of neurosurgery · doi:10.3171/2009.10.jns09759 · Cited by 251 · see citing works
Laughlin, M. H., Davis, M. J., Secher, N. H., LIESHOUT, J. J. V., Arce‐Esquivel, A. A., Simmons, G. H., Bender, S. B., Padilla, J., Bache, R. J., Merkus, D., et al. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100048 · Cited by 264 · see citing works
Mechanical stretch: physiological and pathological implications for human vascular endothelial cells
Jufri, N. F., Mohamedali, A., Avolio, A. P., & Baker, M. S. (2015) · Vascular Cell · doi:10.1186/s13221-015-0033-z · Cited by 246 · see citing works
Polet, F., & Féron, O. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12016 · Cited by 232 · see citing works
Villanueva, C., & Giulivi, C. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.004 · Cited by 225 · see citing works
The mechanism and therapy of aortic aneurysms
Gao, J., Cao, H., Hu, G., Wu, Y., Xu, Y., Cui, H., Lu, H. S., & Zheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01325-7 · Cited by 231 · see citing works
Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
Iring, A., Jin, Y., Albarrán-Juárez, J., Siragusa, M., Wang, S., Dancs, P. T., Nakayama, A., Tonack, S., Chen, M., Künne, C., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123825 · Cited by 219 · see citing works
Central Role of eNOS in the Maintenance of Endothelial Homeostasis
Heiß, C., Rodriguez‐Mateos, A., & Kelm, M. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6158 · Cited by 206 · see citing works
P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
Wang, S., Iring, A., Strilić, B., Albarrán-Juárez, J., Kaur, H., Troidl, K., Tonack, S., Burbiel, J. C., Müller, C. E., Fleming, I., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81067 · Cited by 202 · see citing works
Félétou, M. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00031ed1v01y201105isp019 · Cited by 202 · see citing works
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
Piacenza, L., Zeida, A., Trujillo, M., & Radí, R. (2022) · Physiological Reviews · doi:10.1152/physrev.00005.2022 · Cited by 204 · see citing works
Caveolae – mechanosensitive membrane invaginations linked to actin filaments
Echarri, A., & del Pozo, M. Á. (2015) · Journal of Cell Science · doi:10.1242/jcs.153940 · Cited by 194 · see citing works
Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
Janaszak‐Jasiecka, A., Siekierzycka, A., Płoska, A., Dobrucki, I. T., & Kalinowski, L. (2021) · Biomolecules · doi:10.3390/biom11070982 · Cited by 189 · see citing works
Chen, H., Chen, C., Spanos, M., Li, G., Lü, R., Bei, Y., & Xiao, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01153-1 · Cited by 183 · see citing works
Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure
Gogiraju, R., Bochenek, M. L., & Schäfer, K. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00020 · Cited by 186 · see citing works
Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists
Fitridge, R., & Thompson, M. M. (2011) · Cited by 168 · see citing works
Nitric oxide: Orchestrator of endothelium-dependent responses
Félétou, M., Köhler, R., & Vanhoutte, P. M. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.585658 · Cited by 163 · see citing works
Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway
He, H., Wang, L., Yang, Q., Zhou, Q., Li, H., Chen, S., Yin, D., Huang, Q., & He, M. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01531 · Cited by 162 · see citing works
Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., Patterson, N. L., & McMullen, J. R. (2017) · Physiological Reviews · doi:10.1152/physrev.00043.2016 · Cited by 168 · see citing works
Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO
Segers, V. F. M., Brutsaert, D. L., & Keulenaer, G. W. D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00382 · Cited by 154 · see citing works
Shear-Induced Nitric Oxide Production by Endothelial Cells
Sriram, K., Laughlin, J. G., Rangamani, P., & Tartakovsky, D. M. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.05.034 · Cited by 147 · see citing works
Kulandavelu, S., Whiteley, K. J., Qu, D., Mu, J., Bainbridge, S. A., & Adamson, S. L. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187559 · Cited by 145 · see citing works
Dai, X., & Faber, J. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.212746 · Cited by 141 · see citing works
Gao, Y. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0773-9 · Cited by 138 · see citing works
Cerebral consequences of environmental noise exposure
Hahad, O., Jiménez, M. T. B., Kuntić, M., Frenis, K., Steven, S., Daiber, A., & Münzel, T. F. (2022) · Environment International · doi:10.1016/j.envint.2022.107306 · Cited by 137 · see citing works
Vettor, R., Valerio, A., Ragni, M., Trevellin, E., Granzotto, M., Olivieri, M., Tedesco, L., Ruocco, C., Fossati, A., Fabris, R., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00617.2013 · Cited by 132 · see citing works
Craenenbroeck, E. M. V., Hoymans, V. Y., Beckers, P. J., Possemiers, N. M., Wuyts, K., Paelinck, B. P., Vrints, C. J., & Conraads, V. M. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0105-4 · Cited by 131 · see citing works
The Fluid Mechanics of Cancer and Its Therapy
Koumoutsakos, P., Pivkin, I., & Milde, F. (2013) · Annual Review of Fluid Mechanics · doi:10.1146/annurev-fluid-120710-101102 · Cited by 129 · see citing works
The Key Role of Nitric Oxide in Hypoxia: Hypoxic Vasodilation and Energy Supply–Demand Matching
Umbrello, M., Dyson, A., Feelisch, M., & Singer, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4979 · Cited by 131 · see citing works
Modulation of cardiac ryanodine receptor activity by ROS and RNS
Donoso, P. (2010) · Frontiers in bioscience · doi:10.2741/3705 · Cited by 127 · see citing works
Roy, R., Wilcox, J., Webb, A. J., & O’Gallagher, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015200 · Cited by 128 · see citing works
Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse
Osmanagic‐Myers, S., Kiss, A., Manakanatas, C., Hamza, O., Sedlmayer, F., Szabó, P. L., Fischer, I., Fichtinger, P., Podesser, B. K., Eriksson, M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121297 · Cited by 121 · see citing works
Wood, K. C., Cortese-Krott, M. M., Kovacic, J. C., Noguchi, A. C., Liu, V. B., Wang, X., Raghavachari, N., Boehm, M., Kato, G. J., Kelm, M., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301068 · Cited by 123 · see citing works
Engineering of arteries in vitro
Huang, A., & Niklason, L. E. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1546-3 · Cited by 115 · see citing works
The vital role for nitric oxide in intraocular pressure homeostasis
Reina‐Torres, E., Ieso, M. L. D., Pasquale, L. R., Madekurozwa, M., Sherwood, J. M., Overby, D. R., & Stamer, W. D. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100922 · Cited by 108 · see citing works
Erkens, R., Kramer, C. M., Lückstädt, W., Panknin, C., Krause, L., Weidenbach, M., Dirzka, J., Krenz, T., Mergia, E., Suvorava, T., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.409 · Cited by 108 · see citing works
Stretchable Electrochemical Sensors for Cell and Tissue Detection
Liu, Y., & Huang, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202007754 · Cited by 105 · see citing works
Van Craenenbroeck, A. H., Van Craenenbroeck, E. M., Van Ackeren, K., Vrints, C. J., Conraads, V. M., Verpooten, G. A., Kouidi, E., & Couttenye, M. M. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2015.03.015 · Cited by 115 · see citing works
Harvey, R. D., & Calaghan, S. C. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.07.007 · Cited by 97 · see citing works
Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: From contractility to remodeling
Hammond, J., & Balligand, J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.07.029 · Cited by 98 · see citing works
Self-citationBeta3-Adrenergic Receptors in Cardiac and Vascular Tissues
Dessy, C., & Balligand, J. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)59005-7 · Cited by 97 · see citing works
Self-citationThe Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side
Togliatto, G., Lombardo, G., & Brizzi, M. F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091988 · Cited by 98 · see citing works
Krause, B. J., Carrasco‐Wong, I., Caniuguir, A., Jorge Carvajal, C., Farías, M., & Casanello, P. C. (2012) · Placenta · doi:10.1016/j.placenta.2012.09.015 · Cited by 96 · see citing works
The acute angiogenic signalling response to low‐load resistance exercise with blood flow restriction
Ferguson, R. A., Hunt, J. E. A., Lewis, M. P., Martin, N. R. W., Player, D. J., Stangier, C., Taylor, C. W., & Turner, M. C. (2018) · European Journal of Sport Science · doi:10.1080/17461391.2017.1422281 · Cited by 94 · see citing works
Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels
Jung, Y., Ji, H., Chen, Z., Chan, H. F., Atchison, L., Klitzman, B. M., Truskey, G. A., & Leong, K. W. (2015) · Scientific Reports · doi:10.1038/srep15116 · Cited by 93 · see citing works
AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling
Horman, S., Beauloye, C., Vanoverschelde, J., & Bertrand, L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0102-z · Cited by 93 · see citing works
Cohen, B. E. (2010) · The Journal of Membrane Biology · doi:10.1007/s00232-010-9313-y · Cited by 92 · see citing works
Vascular endothelial ageing, heartbeat after heartbeat
Thorin, É., & Thorin‐Trescases, N. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp236 · Cited by 91 · see citing works
Wang, J., Zeng, L., Zhang, Y., Qi, W., Wang, Z., Tian, L., Zhao, D., Wu, Q., Li, X., & Wang, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.975784 · Cited by 90 · see citing works
Liu, Y., Qin, Y., Jin, Z., Hu, X., Chen, M., Liu, R., Amatore, C., & Huang, W. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705215 · Cited by 89 · see citing works
Lee, R. S., Ayala, J. E., Hunley, C. F., James, F. D., Bracy, D. P., Kang, L., & Wasserman, D. H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00004.2010 · Cited by 87 · see citing works
Boulanger, C. M. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.306940 · Cited by 88 · see citing works
Mechanical regulation of epigenetics in vascular biology and pathobiology
Chen, L., Wei, S., & Chiu, J. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12031 · Cited by 86 · see citing works
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis
Sartoretto, J. L., Kalwa, H., Pluth, M. D., Lippard, S. J., & Michel, T. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111331108 · Cited by 84 · see citing works
Impact of exercise training on cardiovascular disease and risk
Adams, V., & Linke, A. H.-P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.019 · Cited by 85 · see citing works
Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function
Zandstra, T. E., Notenboom, R. G. E., Wink, J., Kiès, P., Vliegen, H. W., Egorova, A. D., Schalij, M. J., de Ruiter, M. C., & Jongbloed, M. R. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.665298 · Cited by 83 · see citing works
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
Jaba, I. M., Zhuang, Z. W., Li, N., Jiang, Y., Martin, K. A., Sinusas, A. J., Papademetris, X., Simons, M., Sessa, W. C., Young, L. H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65112 · Cited by 80 · see citing works
Roy, B. (2025) · Medical Sciences · doi:10.3390/medsci13030087 · Cited by 89 · see citing works
Dietary inorganic nitrate mobilizes circulating angiogenic cells
Heiß, C., Meyer, C. G., Totzeck, M., Hendgen-Cotta, U. B., Heinen, Y., Luedike, P., Keymel, S., Ayoub, N., Lundberg, J. O., Weitzberg, E., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.051 · Cited by 78 · see citing works
Brown, M. B., Neto‐Neves, E. M., Long, G., Graber, J., Gladish, B., Wiseman, A., Owens, M., Fisher, A. J., Presson, R. G., Petrache, I., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00358.2016 · Cited by 78 · see citing works
González, A., Richards, M., de Boer, R. A., Thum, T., Arfsten, H., Hülsmann, M., Falcão‐Pires, I., Dı́ez, J., Foo, R., Chan, M. Y., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2493 · Cited by 80 · see citing works
The Gastrointestinal Circulation: Physiology and Pathophysiology
Granger, D. N., Holm, L. P., & Kvietys, P. R. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150007 · Cited by 94 · see citing works
The Role of Oxidative Stress in Acute Ischemic Stroke‐Related Thrombosis
Li, Z., Bi, R., Sun, S., Chen, S., Chen, J., Hu, B., & Jin, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8418820 · Cited by 76 · see citing works
Isometric Exercise Training and Arterial Hypertension: An Updated Review
Edwards, J. J., Coleman, D. A., Ritti‐Dias, R. M., Farah, B. Q., Stensel, D. J., Lucas, S. J. E., Millar, P. J., Gordon, B. D., Cornelissen, V., Smart, N. A., et al. (2024) · Sports Medicine · doi:10.1007/s40279-024-02036-x · Cited by 76 · see citing works
Exercise-induced cardioprotection: a role for eNOS uncoupling and NO metabolites
Farah, C., Kleindienst, A., Boléa, G., Meyer, G., Gayrard, S., Gény, B., Obert, P., Cazorla, O., Tanguy, S., & Reboul, C. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0389-2 · Cited by 75 · see citing works
Role of heme oxygenase in preserving vascular bioactive NO
Pae, H., Son, Y. H., Kim, N., Jeong, H. J., Chang, K. C., & Chung, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.08.002 · Cited by 76 · see citing works
The relationship of stress and blood pressure effectors.
Ayada, C., Toru, Ü., & Korkut, Y. (2015) · Europe PMC (PubMed Central) · Cited by 75 · see citing works
Vanhoutte, P. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.190215 · Cited by 75 · see citing works
Nitric oxide release follows endothelial nanomechanics and not vice versa
Fels, J., Callies, C., Kusche‐Vihrog, K., & Oberleithner, H. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0871-8 · Cited by 75 · see citing works
Alkemade, F. E., Vliet, P. P. V., Henneman, P., van Dijk, K. W., Hierck, B. P., van Munsteren, J. C., Scheerman, J. A., Goeman, J. J., Havekes, L. M., Groot, A. C. G., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090031 · Cited by 73 · see citing works
Microvascular Responsiveness to Pulsatile and Nonpulsatile Flow During Cardiopulmonary Bypass
O’Neil, M. P., Alie, R., Guo, L.-R. R., Myers, M. L., Murkin, J. M., & Ellis, C. G. (2018) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2018.01.007 · Cited by 73 · see citing works
Neri, M., Riezzo, I., Pomara, C., Schiavone, S., & Turillazzi, E. (2016) · Mediators of Inflammation · doi:10.1155/2016/3423450 · Cited by 70 · see citing works
Koju, N., Taleb, A., Zhou, J., Ge, L., Yang, J., Cao, X., Lei, H., & Ding, Q. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.128 · Cited by 71 · see citing works
Herránz, B., Marquez, S. B., Guijarro, B., Aracil, E., Aicart-Ramos, C., Rodríguez‐Crespo, I., Serrano, I., Rodrı́guez-Puyol, M., Zaragoza, C., & Saura, M. (2011) · Circulation Research · doi:10.1161/circresaha.111.253948 · Cited by 68 · see citing works
Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation
Jin, Y., Chennupati, R., Li, R., Liang, G., Wang, S., Iring, A., Graumann, J., Wettschureck, N., & Offermanns, S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145734 · Cited by 67 · see citing works
The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches
Simmons, R. D., Kumar, S., & Jo, H. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.005 · Cited by 67 · see citing works
Joris, V., Gomez, E. L., Menchi, L., Lobysheva, I. I., Mauro, V. D., Esfahani, H., Condorelli, G., Balligand, J., Catalucci, D., & Dessy, C. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311145 · Cited by 67 · see citing works
Self-citationBrugaletta, S., Gogas, B. D., García‐García, H. M., Farooq, V., Girasis, C., Heo, J. H., van Geuns, R., Bruyne, B. D., Dudek, D., Koolen, J., et al. (2012) · Circulation Journal · doi:10.1253/circj.cj-11-1416 · Cited by 66 · see citing works
Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.
Ayub, H., Khan, M. I., Micheal, S., Akhtar, F., Ajmal, M., Shafique, S., Ali, S. H. B., den Hollander, A. I., Ahmed, A., & Qamar, R. (2010) · PubMed Central · Cited by 66 · see citing works
Bretón-Romero, R., González de Orduña, C., Romero, N., Sánchez-Gómez, F. J., de Álvaro, C., Porras, A., Rodríguez-Pascual, F., Laranjinha, J., Radi, R., & Lamas, S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.026 · Cited by 66 · see citing works
- Authors
- Balligand, J.-L., Feron, O., & Dessy, C.
- Affiliations
- UCLouvain (BE)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2009-04
- Volume
- 89
- Issue
- 2
- Pages
- 481-534
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2142274635
- Cited by
- 477
- References
- 466
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 14 · 2023: 19 · 2022: 27 · 2021: 22 · 2020: 20 · 2019: 18 · 2018: 30 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 37 · 2013: 37 · 2012: 38
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- endothelial nitric oxide synthase, mechanotransduction, shear stress, nitric oxide production, endothelial cells, caveolae, signalosome, eNOS phosphorylation, cardiomyocytes, cardiac remodeling, vascular remodeling, progenitor cell mobilization, hypoxia-inducible factor, blood pressure regulation, hemodynamic overload
- MeSH terms
- Animals, Cardiovascular Physiological Phenomena, Endothelium, Vascular, Humans, Myocardial Contraction, Myocardium, Vasoconstriction, Mechanotransduction, Cellular, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review