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Cited by 652Ion channel regulation and functionIon Channels and ReceptorsErythrocyte Function and Pathophysiology

Mechanically Activated Ion Channels

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Ranade, Sanjeev S., Syeda, Ruhma, Patapoutian, Ardem·2015·Neuron
DOI 10.1016/j.neuron.2015.08.032PMC PMC4582600
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Abstract

Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical force is transduced has remained elusive. A number of recent studies on previously known ion channels along with the identification of novel MA ion channels have greatly transformed our understanding of touch and hearing in both vertebrates and invertebrates. Here, we present an updated review of eukaryotic ion channel families that have been implicated in mechanotransduction processes and evaluate the qualifications of the candidate genes according to specified criteria. We then discuss the proposed gating models for MA ion channels and highlight recent structural studies of mechanosensitive potassium channels.

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Crossref · 10.1016/j.neuron.2015.08.032

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  • Piezo1 is a mechanosensitive ion channel highly expressed in vascular endothelial cells.

    “Piezo1 - a mechanosensitive ion channel highly expressed in vascular endothelial cells”

    From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [19]

    The Piezo Ion Channels section identifies Piezo1 as a mechanically activated ion channel, and the Conclusions/Future Directions section says it is required for mechanotransduction in endothelial cells. The copy does not say that Piezo1 is highly expressed in vascular endothelial cells; that expression-level qualifier is unsupported. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Mechanical stress from altered blood flow activates Piezo1, a mechanosensitive ion channel highly expressed in vascular endothelial cells.

    “Particularly, the mechanical stress from altered blood flow activates Piezo1 - a mechanosensitive ion channel highly expressed in vascular endothelial cells (VECs)[19].”

    From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [19]

    The Piezo Ion Channels section says Piezo1 is a mechanically activated ion channel required for endothelial cells to transduce hemodynamic shear stress, supporting the blood-flow mechanism. The Conclusions/Future Directions section likewise links Piezo1 to endothelial shear-stress responses. Neither passage establishes that Piezo1 is highly expressed in vascular endothelial cells. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Portal hemodynamic changes influence liver regeneration through endothelial-hepatocyte communication.

    “It is shown, that portal hemodynamic changes influence LR through endothelial-hepatocyte communication.”

    From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [19]

    The TRP Ion Channels section discusses fluid shear stress in kidney epithelial cells and endothelial cells, but not liver regeneration or endothelial–hepatocyte communication. Searches for portal hemodynamic changes and liver regeneration found no passage addressing the claim; page numbers were not available in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Ranade, S. S., Syeda, R., & Patapoutian, A.
Affiliations
Scripps Research Institute (US)
Corresponding author
Patapoutian, Ardem
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2015-09
Volume
87
Issue
6
Pages
1162-1179
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2015.08.032
PMC
PMC4582600
OpenAlex
W4211168555
Cited by
652
References
2
Citations by year
2026: 61 · 2025: 59 · 2024: 57 · 2023: 67 · 2022: 78 · 2021: 84 · 2020: 61 · 2019: 49 · 2018: 56 · 2017: 44 · 2016: 31 · 2015: 4 · 2014: 1
FWCI
4.36
Type
journal article
Language
en
Update notices
erratum (2015-10-21)
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Dental and Craniofacial Research (R01DE022358)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords
mechanosensitive ion channels, mechanotransduction, tactile perception, hearing
MeSH terms
Animals, Humans, Ion Channels, Sensation, Touch, Ion Channel Gating, Ion Transport, Mechanotransduction, Cellular

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