An epigenome-wide association study of total serum immunoglobulin E concentration

METAL: fast and efficient meta-analysis of genomewide association scans

Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618

DNA methylation arrays as surrogate measures of cell mixture distribution

Houseman, E. A., Accomando, W. P., Koestler, D. C., Christensen, B. C., Marsit, C. J., Nelson, H. H., Wiencke, J. K., & Kelsey, K. T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-86 · Cited by 3,175

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

Pavord, I. D., Korn, S., Howarth, P. H., Bleecker, E. R., Buhl, R., Keene, O. N., Ortega, H. G., & Chanez, P. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60988-x · Cited by 2,238

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Moffatt, M. F., Gut, I. G., Démenais, F., Strachan, D. P., Bouzigon, E., Heath, S. C., von Mutius, E., Farrall, M., Lathrop, M. G., & Cookson, W. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906312 · Cited by 2,043

lumi : a pipeline for processing Illumina microarray

Du, P., Kibbe, W. A., & Lin, S. M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn224 · Cited by 2,028

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

Howie, B., Fuchsberger, C., Stephens, M., Marchini, J., & Abecasis, G. R. (2012) · Nature Genetics · doi:10.1038/ng.2354 · Cited by 1,737

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D. P., Heath, S. C., Depner, M., Berg, A. V., Bufe, A., Rietschel, E., et al. (2007) · Nature · doi:10.1038/nature06014 · Cited by 1,590

DNA methylation profiling of human chromosomes 6, 20 and 22

Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J. H., Cox, T. V., Davies, R., Down, T. A., et al. (2006) · Nature Genetics · doi:10.1038/ng1909 · Cited by 1,378

Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

Reinius, L. E., Acevedo, N., Joerink, M., Pershagen, G., Dahlén, S., Greco, D., Söderhäll, C., Scheynius, A., & Kere, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041361 · Cited by 1,037

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

Feinberg, A. P. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1402513 · Cited by 638

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 584

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Démenais, F., Margaritte‐Jeannin, P., Barnes, K. C., Cookson, W., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J. P., et al. (2017) · Nature Genetics · doi:10.1038/s41588-017-0014-7 · Cited by 547

Clinical epigenetics: seizing opportunities for translation

Berdasco, M., & Esteller, M. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0074-2 · Cited by 516

Integrative Analysis of Multi-omics Data for Discovery and Functional Studies of Complex Human Diseases

Sun, Y. V., & Hu, Y.-J. (2016) · Advances in Genetics · doi:10.1016/bs.adgen.2015.11.004 · Cited by 459

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

Montaner, J., Ramiro, L., Simats, A., Tiedt, S., Makris, K., Jickling, G. C., Debette, S., Sanchez, J., & Bustamante, A. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0350-6 · Cited by 338

Mitochondria in lung disease

Cloonan, S. M., & Choi, A. M. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81113 · Cited by 322

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Persson, E. K., Verstraete, K., Heyndrickx, I., Gevaert, E., Aegerter, H., Percier, J.-M., Deswarte, K., Verschueren, K. H. G., Dansercoer, A., Gras, D., et al. (2019) · Science · doi:10.1126/science.aaw4295 · Cited by 319

Mendelian randomization: where are we now and where are we going?

Burgess, S., Timpson, N. J., Ebrahim, S. B. J., & Smith, G. D. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv108 · Cited by 313

Statistical and integrative system-level analysis of DNA methylation data

Teschendorff, A. E., & Relton, C. L. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.86 · Cited by 297

A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

Stadhouders, R., Lubberts, E., & Hendriks, R. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.007 · Cited by 298

Epigenetics and Allergy: from Basic Mechanisms to Clinical Applications

Potaczek, D. P., Harb, H., Michel, S., Alhamwe, B. A., Renz, H. E., & Tost, J. (2017) · Epigenomics · doi:10.2217/epi-2016-0162 · Cited by 286

Cellular and molecular mechanisms of allergic asthma

Komlósi, Z. I., van de Veen, W., Kovács, N., Szűcs, G., Sokołowska, M., O’Mahony, L., Akdiş, M., & Akdiş, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100995 · Cited by 271

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Xu, C., Söderhäll, C., Bustamante, M., Baïz, N., Gruzieva, O., Gehring, U., Mason, D., Chatzi, L., Basterrechea, M., Llop, S., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30052-3 · Cited by 236

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

Zhu, Z., Lee, P. H., Chaffin, M. D., Chung, W., Loh, P., Lu, Q., Christiani, D. C., & Liang, L. (2018) · Nature Genetics · doi:10.1038/s41588-018-0121-0 · Cited by 239

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)

Koestler, D. C., Jones, M. J., Usset, J. L., Christensen, B. C., Butler, R. A., Kobor, M. S., Wiencke, J. K., & Kelsey, K. T. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-0943-7 · Cited by 207

The nasal methylome as a biomarker of asthma and airway inflammation in children

Cárdenas, A., Sordillo, J. E., Rifas‐Shiman, S. L., Chung, W., Liang, L., Coull, B. A., Hivert, M., Lai, P. S., Forno, E., Celedon, J. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11058-3 · Cited by 192

DNA methylation in lung cells is associated with asthma endotypes and genetic risk

Nicodemus-Johnson, J., Myers, R. A., Sakabe, N. J., Sobreira, D. R., Hogarth, D. K., Naureckas, E. T., Sperling, A. I., Solway, J., White, S. R., Nobrega, M. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90151 · Cited by 180

The environment, epigenome, and asthma

Yang, I. V., Lozupone, C., & Schwartz, D. A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.011 · Cited by 177

The nasal methylome and childhood atopic asthma

Yang, I. V., Pedersen, B. S., Liu, A. H., O’Connor, G. T., Pillai, D. K., Kattan, M., Misiak, R. T., Gruchalla, R. S., Szefler, S. J., Hershey, G. K. K., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.036 · Cited by 163

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway

Kiryluk, K., Li, Y., Moldoveanu, Z., Suzuki, H., Reily, C., Hou, P., Xie, J., Mladkova, N., Prakash, S., Fischman, C. J., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006609 · Cited by 138

Challenges and novel approaches for investigating molecular mediation

Richmond, R. C., Hemani, G., Tilling, K. M., Smith, G. D., & Relton, C. L. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw197 · Cited by 133

Epidemiology and risk factors for asthma

Kuruvilla, M. E., Vanijcharoenkarn, K., Shih, J. A., & Lee, F. E.-H. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2019.01.014 · Cited by 131

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

Valentine, W. J., Yanagida, K., Kawana, H., Kono, N., Noda, N. N., Aoki, J., & Shindou, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101470 · Cited by 127

New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease

O’Donnell, V. B. (2022) · Biochemical Society Transactions · doi:10.1042/bst20210579 · Cited by 125

Using omics approaches to understand pulmonary diseases

Kan, M., Shumyatcher, M., & Himes, B. E. (2017) · Respiratory Research · doi:10.1186/s12931-017-0631-9 · Cited by 129

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The M e DALL hypothesis

Bousquet, J. J., Anto, J. M., Wickman, M. C., Keil, T. O. P., Valenta, R., Haahtela, T., Carlsen, K.-H., van Hage, M., Akdiş, C. A., Bachert, C., et al. (2015) · Allergy · doi:10.1111/all.12637 · Cited by 125

Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging

Li, J., Zhu, X., Yu, K., Jiang, H., Zhang, Y., Wang, B., Liu, X., Deng, S., Hu, J., Deng, Q., et al. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2773 · Cited by 111

Leveraging gene-environment interactions and endotypes for asthma gene discovery

Bønnelykke, K., & Ober, C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.01.006 · Cited by 113

Recent findings in the genetics and epigenetics of asthma and allergy

Kabesch, M., & Tost, J. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-019-00777-w · Cited by 107

Leveraging -omics for asthma endotyping

Tyler, S. R., & Bunyavanich, S. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.05.015 · Cited by 106

Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome

Li, J., Zhu, X., Yu, K., Jiang, H., Zhang, Y., Deng, S., Cheng, L., Liu, X., Zhong, J., Zhang, X., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.310324 · Cited by 101

Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification

Johansson, Å., Andreassen, O. A., Brunak, S., Franks, P. W., Hedman, H., Loos, R. J. F., Meder, B., Melén, E., Wheelock, C. E., & Jacobsson, B. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13640 · Cited by 102

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals

Zhang, X., Justice, A. C., Hu, Y., Wang, Z., Zhao, H., Wang, G., Johnson, E. O., Emu, B., Sutton, R. E., Krystal, J. H., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1221569 · Cited by 98

DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework

Richmond, R. C., Sharp, G. C., Ward, M. E., Fraser, A., Lyttleton, O., McArdle, W. L., Ring, S. M., Gaunt, T. R., Lawlor, D. A., Smith, G. D., et al. (2016) · Diabetes · doi:10.2337/db15-0996 · Cited by 97

Regulation of IL-4 Expression in Immunity and Diseases

Ho, I., & Miaw, S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-0921-5_3 · Cited by 97

Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation

Resource, T. M. T. H. E., Busche, S., Shao, X., Caron, M., Kwan, T., Allum, F., Cheung, W., Ge, B., Westfall, S., Simon, M.-M., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0856-1 · Cited by 95

Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction

Rask‐Andersen, M., Martinsson, D., Ahsan, M., Enroth, S., Ek, W. E., Gyllensten, U. B., & Johansson, Å. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw302 · Cited by 94

Transgenerational and intergenerational epigenetic inheritance in allergic diseases

Knudsen, T. M., Rezwan, F. I., Jiang, Y., Karmaus, W., Svanes, C., & Holloway, J. W. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.007 · Cited by 94

Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA

Chen, J., Behnam, E., Huang, J., Moffatt, M. F., Schaid, D. J., Liang, L., & Lin, X. (2017) · BMC Genomics · doi:10.1186/s12864-017-3808-1 · Cited by 92

Nasal DNA methylation profiling of asthma and rhinitis

Qi, C., Jiang, Y., Yang, I. V., Forno, E., Wang, T., Vonk, J. M., Gehring, U., Smit, H. A., Milanzi, E. B., Carpaij, O. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.12.911 · Cited by 89

Systemic lupus erythematosus: still a challenge for physicians

Bengtsson, A., & Rönnblom, L. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12529 · Cited by 90

Urban air pollution and climate change: “The Decalogue: Allergy Safe Tree” for allergic and respiratory diseases care

Patella, V., Florio, G., Magliacane, D., Giuliano, A., Crivellaro, M., Bartolomeo, D. D., Genovese, A., Palmieri, M., Postiglione, A., Ridolo, E., et al. (2018) · Clinical and Molecular Allergy · doi:10.1186/s12948-018-0098-3 · Cited by 86

Epigenetics of Sepsis

Binnie, A., Tsang, J. L. Y., Hu, P., Carrasqueiro, G., Castelo‐Branco, P., & dos Santos, C. C. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004247 · Cited by 84

Epigenetics and pulmonary diseases in the horizon of precision medicine: a review

Benincasa, G., DeMeo, D. L., Glass, K., Silverman, E. K., & Claudio Napoli, A. (2020) · European Respiratory Journal · doi:10.1183/13993003.03406-2020 · Cited by 85

Epigenetic Mechanisms in Asthma

DeVries, A., & Vercelli, D. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201507-420mg · Cited by 81

The immune factors driving DNA methylation variation in human blood

Bergstedt, J., Azzou, S. A. K., Tsuo, K., Jaquaniello, A., Urrutia, A., Rotival, M., Lin, D. T. S., MacIsaac, J. L., Kobor, M. S., Albert, M. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33511-6 · Cited by 82

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

Everson, T. M., Lyons, G., Zhang, H., Soto-Ramírez, N., Lockett, G. A., Patil, V. K., Merid, S. K., Sӧderhӓll, C., Melén, E., Holloway, J. W., et al. (2015) · Genome Medicine · doi:10.1186/s13073-015-0213-8 · Cited by 78

Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva

Peng, C., Cárdenas, A., Rifas‐Shiman, S. L., Hivert, M., Gold, D. R., Platts‐Mills, T. A. E., Lin, X., Oken, E., Ávila, L., Celedon, J. C., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.01.034 · Cited by 77

Epigenome-wide association study of asthma and wheeze in childhood and adolescence

Arathimos, R., Suderman, M. J., Sharp, G. C., Burrows, K., Granell, R., Tilling, K. M., Gaunt, T. R., Henderson, J., Ring, S. M., Richmond, R. C., et al. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0414-7 · Cited by 75

The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases

Ahsan, M., Ek, W. E., Rask‐Andersen, M., Karlsson, T., Lind-Thomsen, A., Enroth, S., Gyllensten, U., & Johansson, Å. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007005 · Cited by 75

Air pollution, epigenetics, and asthma

Ji, H., Myers, J. M. B., Brandt, E. B., Brokamp, C., Ryan, P., & Hershey, G. K. K. (2016) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-016-0159-4 · Cited by 74

The Genetics and Genomics of Asthma

Willis‐Owen, S. A. G., Cookson, W., & Moffatt, M. F. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021651 · Cited by 81

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk

Richardson, T. G., Zheng, J., Smith, G. D., Timpson, N. J., Gaunt, T. R., Relton, C. L., & Hemani, G. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.09.003 · Cited by 71

Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies

Hachiya, T., Furukawa, R., Shiwa, Y., Ohmomo, H., Ono, K., Katsuoka, F., Nagasaki, M., Yasuda, J., Fuse, N., Kinoshita, K., et al. (2017) · npj Genomic Medicine · doi:10.1038/s41525-017-0016-5 · Cited by 70

Mendelian Randomization: Applications and Limitations in Epigenetic Studies

Relton, C. L., & Smith, G. D. (2015) · Epigenomics · doi:10.2217/epi.15.88 · Cited by 67

Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*

Binnie, A., Walsh, C. J., Hu, P., Dwivedi, D. J., Fox‐Robichaud, A., Liaw, P. C., Tsang, J. L. Y., Batt, J. A. E., Carrasqueiro, G., Gupta, S., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000004097 · Cited by 65

Epigenome-Modifying Tools in Asthma

Brook, P., Perry, M. M., Adcock, I. M., & Durham, A. L. (2015) · Epigenomics · doi:10.2217/epi.15.53 · Cited by 65

Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

Ringh, M. V., Hagemann-Jensen, M., Needhamsen, M., Kular, L., Breeze, C. E., Sjöholm, L. K., Slavec, L., Kullberg, S., Wahlström, J., Grünewald, J., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.006 · Cited by 64

Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood

Huang, Y., Chu, S. H., Loucks, E. B., Lin, C., Eaton, C. B., Buka, S. L., & Kelsey, K. T. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146853 · Cited by 66

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy

Hong, X., Ladd‐Acosta, C., Hao, K., Sherwood, B., Ji, H., Keet, C. A., Kumar, R., Caruso, D., Liu, X., Wang, G., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.01.056 · Cited by 65

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity

Solano, M. E., Holmes, M. C., Mittelstadt, P. R., Chapman, K. E., & Tolosa, E. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0575-z · Cited by 63

Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

Hillary, R. F., Baños, D. T., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., Patxot, M., Ojavee, S. E., Zhang, Q., Liewald, D. C. M., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00754-1 · Cited by 65

Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study

Hoang, T. T., Sikdar, S., Xu, C., Lee, M. K., Cardwell, J., Forno, E., Imboden, M., Jeong, A., Madore, A., Qi, C., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00217-2020 · Cited by 61

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility

Stadhouders, R., Li, B. W. S., de Bruijn, M. J. W., Gómez, A., Rao, T. N., Fehling, H. J., van IJcken, W. F. J., Lim, A. I., Santo, J. P. D., Graf, T., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.12.1006 · Cited by 60

An epigenome-wide association study of total serum IgE in Hispanic children

Chen, W., Wang, T., Pino-Yanes, M. D. M., Forno, E., Liang, L., Yan, Q., Hu, D., Weeks, D. E., Baccarelli, A., Acosta‐Pérez, E., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.030 · Cited by 59

Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samples

Hong, X., Sherwood, B., Ladd‐Acosta, C., Peng, S., Ji, H., Hao, K., Burd, I. D., Bartell, T. R., Wang, G., Tsai, H., et al. (2017) · Epigenetics · doi:10.1080/15592294.2017.1287654 · Cited by 58

A translational perspective on epigenetics in allergic diseases

Tost, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.009 · Cited by 57

Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization

Peng, C., van Meel, E. R., Cárdenas, A., Rifas‐Shiman, S. L., Sonawane, A. R., Glass, K., Gold, D. R., Platts‐Mills, T. A. E., Lin, X., Oken, E., et al. (2019) · Epigenetics · doi:10.1080/15592294.2019.1590085 · Cited by 56

Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care

Latvala, A., & Ollikainen, M. (2016) · Genome biology · doi:10.1186/s13059-016-1018-9 · Cited by 55

The role of epigenetics in the development of childhood asthma

Qi, C., Xu, C., & Koppelman, G. H. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1686977 · Cited by 54

Cell-Specific DNA Methylation Signatures in Asthma

Thibeault, A.-A. H., & Laprise, C. (2019) · Genes · doi:10.3390/genes10110932 · Cited by 50

The Nasal Methylome: A Key to Understanding Allergic Asthma

Yang, I. V., Richards, A., Davidson, E., Stevens, A. D., Kolakowski, C. A., Martin, R. J., & Schwartz, D. A. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201608-1558le · Cited by 49

Nasal DNA Methylation is Associated with Childhood Asthma

Zhang, X., Myers, J. M. B., Burleson, J., Ulm, A., Bryan, K. S., Chen, X., Weirauch, M. T., Baker, T. A., Kovacic, M. B., & Ji, H. (2018) · Epigenomics · doi:10.2217/epi-2017-0127 · Cited by 49

Epigenetic regulation of immune function in asthma

Sharma, S., Yang, I. V., & Schwartz, D. A. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.06.002 · Cited by 49

Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

Peng, C., Cárdenas, A., Rifas‐Shiman, S. L., Hivert, M., Gold, D. R., Platts‐Mills, T. A. E., Lin, X., Oken, E., Baccarelli, A., Litonjua, A. A., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0488-x · Cited by 46

Epigenetics in allergic diseases

DeVries, A., & Vercelli, D. (2015) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000285 · Cited by 45

Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

Soliai, M. M., Kato, A., Helling, B. A., Stanhope, C. T., Norton, J. E., Naughton, K. A., Klinger, A. I., Thompson, E. E., Clay, S. M., Kim, S., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00967-y · Cited by 44

DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty

Zhang, X., Hu, Y., Justice, A. C., Li, B., Wang, Z., Zhao, H., Krystal, J. H., & Xu, K. (2017) · Nature Communications · doi:10.1038/s41467-017-02326-1 · Cited by 44

Leukemia Inhibitory Factor Signaling Enhances Production of Galactose-Deficient IgA1 in IgA Nephropathy

Yamada, K., Huang, Z. Q., Raška, M., Reily, C., Anderson, J. C., Suzuki, H., Kiryluk, K., Gharavi, A. G., Julian, B. A., Willey, C. D., et al. (2020) · Kidney Diseases · doi:10.1159/000505748 · Cited by 44

Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management

Verstegen, R. E. M., Kostadinova, A. I., Merenciana, Z., Garssen, J., Folkerts, G., Hendriks, R. W., & Willemsen, L. E. M. (2021) · Nutrients · doi:10.3390/nu13114153 · Cited by 42

Shared DNA methylation signatures in childhood allergy: The MeDALL study

Xu, C., Gruzieva, O., Qi, C., Esplugues, A., Gehring, U., Bergström, A., Mason, D., Chatzi, L., Porta, D., Carlsen, K. C. L., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.11.044 · Cited by 41

The Effects of Environmental Exposure on Epigenetic Modifications in Allergic Diseases

Mijač, S., Banić, I., Genc, A.-M., Lipej, M., & Turkalj, M. (2024) · Medicina · doi:10.3390/medicina60010110 · Cited by 40

Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches

Baye, T. M., Afanador, Y., Johansson, E., Proper, S. P., Bernstein, J. A., Rothenberg, M. E., & Hershey, G. K. K. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08787-5 · Cited by 40

Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins

Murphy, T. M., Wong, C. C. Y., Arseneault, L., Burrage, J., Macdonald, R., Hannon, E. J., Fisher, H. L., Ambler, A. P., Moffitt, T. E., Caspi, A., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0163-4 · Cited by 39

An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States

Celedon, J. C., Burchard, E. G., Schraufnagel, D. E., Castillo‐Salgado, C., Schenker, M. B., Balmes, J. R., Neptune, E., Cummings, K. J., Holguín, F., Riekert, K. A., et al. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201702-167ws · Cited by 39

From Genotype to Phenotype: Through Chromatin

Romanowska, J., & Joshi, A. (2019) · Genes · doi:10.3390/genes10020076 · Cited by 39

Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis

Long, A. J., Bunning, B., Sampath, V., DeKruyff, R. H., & Nadeau, K. C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3449-2_6 · Cited by 39

Understanding asthma and allergies by the lens of biodiversity and epigenetic changes

Fiuza, B. S. D., Fonseca, H. F., Meirelles, P. M., Marques, C. R., da Silva, T. M., & Figueiredo, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623737 · Cited by 38

Opportunities and challenges of big data for the social sciences: The case of genomic data

Liu, H., & Guo, G. (2016) · Social Science Research · doi:10.1016/j.ssresearch.2016.04.016 · Cited by 39

From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive

Relton, C. L., Hartwig, F. P., & Smith, G. D. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv198 · Cited by 39

A Summary of the Biological Processes, Disease-Associated Changes, and Clinical Applications of DNA Methylation

Andersen, G. B., & Tost, J. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7481-8_1 · Cited by 36

Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges

Tang, H. H. F., Sly, P. D., Holt, P. G., Holt, K. E., & Inouye, M. (2019) · European Respiratory Journal · doi:10.1183/13993003.00844-2019 · Cited by 36

Role of epigenetics in the development of childhood asthma

Davidson, E., & Yang, I. V. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000429 · Cited by 36

Cell-type-specific disturbance of DNA methylation pattern: a chance to get more benefit from and to minimize cohorts for epigenome-wide association studies

Bauer, M. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy029 · Cited by 36

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis

Sarnowski, C., Laprise, C., Malerba, G., Moffatt, M. F., Dizier, M.-H., Morin, A., Vincent, Q. B., Rohde, K., Esparza-Gordillo, J., Margaritte-Jeannin, P., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1341 · Cited by 35

A Multiomics Approach to Identify Genes Associated with Childhood Asthma Risk and Morbidity

Forno, E., Wang, T., Yan, Q., Brehm, J. M., Acosta‐Pérez, E., Colón‐Semidey, A., Alvarez, M., Boutaoui, N., Cloutier, M. M., Alcorn, J. F., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0002oc · Cited by 37

DNA methylation modules in airway smooth muscle are associated with asthma severity

Perry, M. M., Lavender, P., Kuo, C.-H. S., Galea, F., Michaeloudes, C., Flanagan, J. M., Chung, K. F., & Adcock, I. M. (2018) · European Respiratory Journal · doi:10.1183/13993003.01068-2017 · Cited by 33

Local Immunoglobulin E in nasal polyps: Role and modulation

Shen, Y., Zhang, N., Yang, Y., Hong, S., & Bachert, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961503 · Cited by 33

News Beyond Our Pages

Rothenberg, M. E., & Bousquet, J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.017

Epigenome-Wide DNA Methylation Study of IgE Concentration in Relation to Self-Reported Allergies

Ek, W. E., Ahsan, M., Rask‐Andersen, M., Liang, L., Moffatt, M. F., Gyllensten, U. B., & Johansson, Å. (2017) · Epigenomics · doi:10.2217/epi-2016-0158 · Cited by 19

DNA methylation and serum total immunoglobulin E (IgE) levels: a methylome-wide association study in adults with asthma

Chanoine, S., Malpertuis, A., Beaumier, L., Aïssi, D., Bouzigon, E., Boulier, E. L., Shao, X. J., Lathrop, M. G., Grundgerg, E., Pin, I., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.congress-2018.pa1263

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

Recto, K., Kachroo, P., Huan, T., Berg, D. V. D., Lee, G. Y., Bui, H., Lee, D. H., Gereige, J., Yao, C., Hwang, S., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104758 · Cited by 20

An epigenome-wide association study of total serum IgE in Hispanic children

Chen, W., Wang, T., Pino-Yanes, M. D. M., Forno, E., Liang, L., Yan, Q., Hu, D., Weeks, D. E., Baccarelli, A., Acosta‐Pérez, E., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.030 · Cited by 59