The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity
Open accessAbstract
The brain has an extraordinary capacity for memory storage, but how it stores new information without disrupting previously acquired memories remains unknown. Here we show that different motor learning tasks induce dendritic Ca2+ spikes on different apical tuft branches of individual layer V pyramidal neurons in the mouse motor cortex. These task-related, branch-specific Ca2+ spikes cause long-lasting potentiation of postsynaptic dendritic spines active at the time of spike generation. When somatostatin-expressing interneurons are inactivated, different motor tasks frequently induce Ca2+ spikes on the same branches. On those branches, spines potentiated during one task are depotentiated when they are active seconds before Ca2+ spikes induced by another task. Concomitantly, increased neuronal activity and performance improvement after learning one task are disrupted when another task is learned. These findings indicate that dendritic-branch-specific generation of Ca2+ spikes is crucial for establishing long-lasting synaptic plasticity, thereby facilitating information storage associated with different learning experiences.
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A disinhibitory circuit mediates motor integration in the somatosensory cortex
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Metadata
- Authors
- Cichon, J., & Gan, W.-B.
- Venue
- Nature
- Published
- 2015-03-30
- Volume
- 520
- Issue
- 7546
- Pages
- 180-185
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2067840211
- Cited by
- 500
- References
- 14
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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