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Cited by 531

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Open access
Mitchell, Duane A., Batich, Kristen A., Gunn, Michael D., Huang, Min-Nung, Sanchez-Perez, Luis, Nair, Smita K., Congdon, Kendra L., Reap, Elizabeth A., Archer, Gary E., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon II, James E., Coan, April, McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., Sampson, John H.·2015·Nature
DOI 10.1038/nature14320
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Abstract

After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy. While DC vaccines have shown limited promise in the treatment of patients with advanced cancers including glioblastoma, the factors dictating DC vaccine efficacy remain poorly understood. Here we show that pre-conditioning the vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumour-antigen-specific DCs. To assess the effect of vaccine site pre-conditioning in humans, we randomized patients with glioblastoma to pre-conditioning with either mature DCs or Td unilaterally before bilateral vaccination with DCs pulsed with Cytomegalovirus phosphoprotein 65 (pp65) RNA. We and other laboratories have shown that pp65 is expressed in more than 90% of glioblastoma specimens but not in surrounding normal brain, providing an unparalleled opportunity to subvert this viral protein as a tumour-specific target. Patients given Td had enhanced DC migration bilaterally and significantly improved survival. In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumour growth in a manner dependent on the chemokine CCL3. Our clinical studies and corroborating investigations in mice suggest that pre-conditioning with a potent recall antigen may represent a viable strategy to improve anti-tumour immunotherapy.

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Metadata

Authors
Mitchell, D. A., Batich, K. A., Gunn, M. D., Huang, M.-N., Sanchez-Perez, L., Nair, S. K., Congdon, K. L., Reap, E. A., Archer, G. E., Desjardins, A., Friedman, A. H., Friedman, H. S., Herndon II, J. E., Coan, A., McLendon, R. E., Reardon, D. A., Vredenburgh, J. J., Bigner, D. D., & Sampson, J. H.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2015-03
Volume
519
Issue
7543
Pages
366-369
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature14320
OpenAlex
W2013637325
Cited by
531
References
30
FWCI
28.17
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. https://app.cochat.ai/papers/10.1038/nature14320
The paper
Mitchell, D. A., Batich, K. A., Gunn, M. D., Huang, M.-N., Sanchez-Perez, L., Nair, S. K., Congdon, K. L., Reap, E. A., Archer, G. E., Desjardins, A., Friedman, A. H., Friedman, H. S., Herndon II, J. E., Coan, A., McLendon, R. E., Reardon, D. A., Vredenburgh, J. J., Bigner, D. D., & Sampson, J. H. (2015). Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature. https://doi.org/10.1038/nature14320

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.