Towards personalized, tumour-specific, therapeutic vaccines for cancer
Open accessAbstract
Cancer vaccines, which are designed to amplify tumour-specific T cell responses through active immunization, have long been envisioned as a key tool of effective cancer immunotherapy. Despite a clear rationale for such vaccines, extensive past efforts were unsuccessful in mediating clinically relevant antitumour activity in humans. Recently, however, next-generation sequencing and novel bioinformatics tools have enabled the systematic discovery of tumour neoantigens, which are highly desirable immunogens because they arise from somatic mutations of the tumour and are therefore tumour specific. As a result of the diversity of tumour neoepitopes between individuals, the development of personalized cancer vaccines is warranted. Here, we review the emerging field of personalized cancer vaccination and discuss recent developments and future directions for this promising treatment strategy.
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- Authors
- Hu, Z., Ott, P. A., & Wu, C. J.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Corresponding author
- Wu, Catherine J.
- Venue
- Nature Reviews Immunology
- Published
- 2017-12-11
- Volume
- 18
- Issue
- 3
- Pages
- 168-182
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC6508552
- OpenAlex
- W2774113098
- Cited by
- 1,067
- References
- 17
- Citations by year
- 2026: 83 · 2025: 134 · 2024: 128 · 2023: 137 · 2022: 146 · 2021: 165 · 2020: 141 · 2019: 89 · 2018: 44
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Leukemia and Lymphoma Society
- Melanoma Research Alliance
- Ludwig Institute for Cancer Research
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL103532)
- National Cancer Institute (T32CA207021, 1RO1CA155010-02, R01CA155010)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- cancer vaccines, personalized cancer vaccines, neoantigens, active immunotherapy, somatic mutations, cancer immunotherapy, vaccine design
- MeSH terms
- Humans, Neoplasms, T-Lymphocytes, Vaccination, Immunotherapy, Adoptive, Cancer Vaccines, Precision Medicine
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