The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Progesterone receptor modulates ERα action in breast cancer
Open accessAbstract
Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its behaviour. In the presence of agonist ligands, PR associates with ERα to direct ERα chromatin binding events within breast cancer cells, resulting in a unique gene expression programme that is associated with good clinical outcome. Progesterone inhibited oestrogen-mediated growth of ERα+ cell line xenografts and primary ERα+ breast tumour explants, and had increased anti-proliferative effects when coupled with an ERα antagonist. Copy number loss of PGR, the gene coding for PR, is a common feature in ERα+ breast cancers, explaining lower PR levels in a subset of cases. Our findings indicate that PR functions as a molecular rheostat to control ERα chromatin binding and transcriptional activity, which has important implications for prognosis and therapeutic interventions.
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Differential expression analysis for sequence count data
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TopHat: discovering splice junctions with RNA-Seq
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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
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Self-citationSupervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
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Self-citationHistone modifications at human enhancers reflect global cell-type-specific gene expression
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Wang, T., Shao, W., Huang, Z., Tang, H., Zhang, J., Ding, Z., & Huang, K. (2021) · Nature Communications · doi:10.1038/s41467-021-23774-w · Cited by 671
3D scaffolds in breast cancer research
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Estrogen receptor alpha controls gene expression via translational offsetting
Lorent, J., Rebello, R. J., Hoef, V. V., Lawrence, M. G., Szkop, K. J., Kusnadi, E., Samreen, B., Balanathan, P., Scharmann, K., Takizawa, I., et al. (2018) · doi:10.1101/507574 · Cited by 46
Metadata
- Authors
- Mohammed, H., Russell, I. A., Stark, R., Rueda, O. M., Hickey, T. E., Tarulli, G. A., Serandour, A. A., Birrell, S. N., Bruna, A., Saadi, A., Menon, S., Hadfield, J., Pugh, M., Raj, G. V., Brown, G. D., D’Santos, C., Robinson, J. L. L., Silva, G., Launchbury, R., Perou, C. M., Stingl, J., Caldas, C., Tilley, W. D., & Carroll, J. S.
- Venue
- Nature
- Published
- 2015-07-08
- Volume
- 523
- Issue
- 7560
- Pages
- 313-317
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2531506996
- Cited by
- 659
- References
- 42
- FWCI
- 41.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Mohammed, H., Russell, I. A., Stark, R., Rueda, O. M., Hickey, T. E., Tarulli, G. A., Serandour, A. A., Birrell, S. N., Bruna, A., Saadi, A., Menon, S., Hadfield, J., Pugh, M., Raj, G. V., Brown, G. D., D’Santos, C., Robinson, J. L. L., Silva, G., Launchbury, R., . . . Carroll, J. S. (2015). Progesterone receptor modulates ERα action in breast cancer. Nature. https://doi.org/10.1038/nature14583
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
