Cited by 1,326Mosquito-borne diseases and controlVirology and Viral DiseasesInfectious Encephalopathies and Encephalitis

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

The Brazilian Zika virus strain causes birth defects in experimental models

Open access

Cugola, Fernanda R., Fernandes, Isabella R., Russo, Fabiele B., Freitas, Beatriz C., Dias, João L. M., Guimarães, Katia P., Benazzato, Cecília, Almeida, Nathalia, Pignatari, Graciela C., Romero, Sarah, Polonio, Carolina M., Cunha, Isabela, Freitas, Carla L., Brandão, Wesley N., Rossato, Cristiano, Andrade, David G., Faria, Daniele de P., Garcez, Alexandre T., Buchpigel, Carlos A., Braconi, Carla T., Mendes, Erica, Sall, Amadou A., Zanotto, Paolo M. de A., Peron, Jean Pierre S., Muotri, Alysson R., Beltrão-Braga, Patricia C. B.·2016·Nature

DOI 10.1038/nature18296PMC PMC4902174

Open this paper in CoChat — free account Open PDF

Abstract

Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. However, in 2007, vectored by Aedes aegypti mosquitoes, ZIKV caused the first noteworthy epidemic on the Yap Island in Micronesia. Patients experienced fever, skin rash, arthralgia and conjunctivitis. From 2013 to 2015, the Asian lineage of the virus caused further massive outbreaks in New Caledonia and French Polynesia. In 2013, ZIKV reached Brazil, later spreading to other countries in South and Central America. In Brazil, the virus has been linked to congenital malformations, including microcephaly and other severe neurological diseases, such as Guillain-Barré syndrome. Despite clinical evidence, direct experimental proof showing that the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent. Here we demonstrate that ZIKV(BR) infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death. We also report that the infection of human brain organoids results in a reduction of proliferative zones and disrupted cortical layers. These results indicate that ZIKV(BR) crosses the placenta and causes microcephaly by targeting cortical progenitor cells, inducing cell death by apoptosis and autophagy, and impairing neurodevelopment. Our data reinforce the growing body of evidence linking the ZIKV(BR) outbreak to the alarming number of cases of congenital brain malformations. Our model can be used to determine the efficiency of therapeutic approaches to counteracting the harmful impact of ZIKV(BR) in human neurodevelopment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature18296

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cerebral organoids model human brain development and microcephaly
Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372
Neutralizing Antibodies Against Certain Recently Isolated Viruses in the Sera of Human Beings Residing in East Africa
Smithburn, K. C. (1952) · The Journal of Immunology · doi:10.4049/jimmunol.69.2.223 · Cited by 3,553
Organogenesis in a dish: Modeling development and disease using organoid technologies
Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
Zika Virus (I). Isolations and serological specificity
Dick, G. W. A., Kitchen, S. F., & Haddow, A. J. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90042-4 · Cited by 2,698
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Cao‐Lormeau, V., Blake, A., Mons, S., Lastère, S., Roche, C., Vanhomwegen, J., Dub, T., Baudouin, L., Teissier, A., Larre, P., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00562-6 · Cited by 2,196
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Brasil, P., Pereira, J. P., Moreira, M. E. L., Nogueira, R. M. R., Damasceno, L. S., Wakimoto, M. D., Rabello, R. S., Gaw, S. L., Halai, U., Salles, T. R. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602412 · Cited by 2,192
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007
Lanciotti, R. S., Kosoy, O. L., Laven, J. J., Velez, J. O., Lambert, A. J., Johnson, A. J., Stanfield, S. M., & Duffy, M. R. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080287 · Cited by 2,173
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127
Zika Virus and Birth Defects — Reviewing the Evidence for Causality
Rasmussen, S. A., Jamieson, D. J., Honein, M. A., & Petersen, L. R. (2016) · New England Journal of Medicine · doi:10.1056/nejmsr1604338 · Cited by 1,989

Flagged first, then by citations

Show all 37 references

Sorted by citations

Items 701–800 of 998

Modeling Williams syndrome with induced pluripotent stem cells
Chailangkarn, T., & Muotri, A. R. (2017) · Neurogenesis · doi:10.1080/23262133.2017.1283187 · Cited by 18
Self-citation
A bacterium‐like particle vaccine displaying Zika virus prM‐E induces systemic immune responses in mice
Jin, H., Bai, Y., Wang, J., Jiao, C., Liu, D., Zhang, M., Li, E., Huang, P., Gong, Z., Song, Y., et al. (2022) · Transboundary and Emerging Diseases · doi:10.1111/tbed.14594 · Cited by 16
Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes
Sankhala, R. S., Dussupt, V., Donofrio, G. C., Gromowski, G. D., Barrera, R. A. D. L., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W. I., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112942 · Cited by 16
Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants
Kreutz, A., Oyetade, O. B., Chang, X., Hsieh, J., Behl, M., Allen, D., Kleinstreuer, N., & Högberg, H. T. (2024) · Toxics · doi:10.3390/toxics12060437 · Cited by 19
Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and maternal decidua
Alippe, Y., Wang, L., Coskun, R., Muraro, S. P., Zhao, F. R., Elam-Noll, M., White, J. M., Vota, D., Hauk, V. C., Gordon, J. I., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240694 · Cited by 16
Zika Virus and Patient Blood Management
Goodnough, L. T., & Marques, M. B. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001770 · Cited by 16
DETECTION OF HUMAN ANTI-ZIKA VIRUS IgG BY ELISA USING AN ANTIGEN FROM in vitro INFECTED VERO CELLS: PRELIMINARY RESULTS
Sumita, L. M., Rodrigues, J. P., Ferreira, N. E., Félix, A. C., Souza, N. C. S., Machado, C. M., & de Andrade, H. F. (2016) · Revista do Instituto de Medicina Tropical de São Paulo · doi:10.1590/s1678-9946201658089 · Cited by 16
Molecular and cellular insights into Zika virus-related neuropathies
Zhou, K., Wang, L., Yu, D., Huang, H., Ji, H. L., & Mo, X. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0514-3 · Cited by 16
Using immunocompromised mice to identify mechanisms of Zika virus transmission and pathogenesis
Winkler, C. W., & Peterson, K. E. (2017) · Immunology · doi:10.1111/imm.12883 · Cited by 15
Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection
Alves, M. P., Vielle, N. J., Thiel, V., & Pfaender, S. (2018) · Viruses · doi:10.3390/v10110593 · Cited by 16
Zika virus‐induced brain malformations in chicken embryos
Wachholz, G. E., Varela, A. P. M., Teixeira, T. F., de Matos, S. M. S., Soster, P. R. D. L., Vianna, F. S. L., Souza, D. O., Roehe, P. M., Schüler‐Faccini, L., & Fraga, L. R. (2020) · Birth Defects Research · doi:10.1002/bdr2.1813 · Cited by 16
Functional Mapping of AGO-Associated Zika Virus-Derived Small Interfering RNAs in Neural Stem Cells
Zeng, J., Luo, Z., Dong, S., Xie, X., Liang, X., Yan, Y., Liang, Q., & Zhao, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.628887 · Cited by 16
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids
Trevisan, M., Riccetti, S., Sinigaglia, A., & Barzon, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052356 · Cited by 16
Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection
Marim, F. M., Teixeira, D. C., Queiroz‐Junior, C. M., Valiate, B. V. S., Alves-Filho, J. C., Cunha, T. M., Dantzer, R., Teixeira, M. M., Teixeira, A. L., & Costa, V. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702048 · Cited by 16
Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference
Sze, A., Olagnier, D. P., Hadj, S. B., Han, X., Tian, X., Xu, H., Yang, L., Shi, Q., Wang, P., Wainberg, M. A., et al. (2017) · Viruses · doi:10.3390/v9100287 · Cited by 16
Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: the ZIKAlliance consortium
Avelino‐Silva, V. I., Mayaud, P., Tami, A., Miranda, M. C., Rosenberger, K. D., Alexander, N. D. E., Nacul, L., Segurado, A. A. C., Pohl, M., Bethencourt, S. E., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4685-9 · Cited by 16
Effect of Serial Systemic and Intratumoral Injections of Oncolytic ZIKVBR in Mice Bearing Embryonal CNS Tumors
Ferreira, R. O., Granha, I. F. D. O., Ferreira, R. S., Bueno, H. M. D. S., Okamoto, O. K., Kaid, C., & Zatz, M. (2021) · Viruses · doi:10.3390/v13102103 · Cited by 16
Modeling neurodevelopmental and psychiatric diseases with human iPSCs
Wen, Z. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24031 · Cited by 15
Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses
Setoh, Y. X., Peng, N. Y. G., Nakayama, E., Amarilla, A. A., Prow, N. A., Suhrbier, A., & Khromykh, A. A. (2018) · Viruses · doi:10.3390/v10100541 · Cited by 15
Emerging and Reemerging Human Viral Diseases
Kumar, J. D., Liu, J., Rong, H., & Zhu, H. (2018) · Annals of Microbiology and Research · doi:10.36959/958/567 · Cited by 15
The impact of antidepressants on human neurodevelopment: Brain organoids as experimental tools
Marinho, L. S. R., Chiarantin, G. M. D., Ikebara, J. M., Cardoso, D. S., de Lima-Vasconcellos, T. H., Higa, G. S. V., Ferraz, M. S. A., Pasquale, R. D., Takada, S. H., Papes, F., et al. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.007 · Cited by 35
Self-citation
Salivary Detection of Zika Virus Infection Using ATR-FTIR Spectroscopy Coupled with Machine Learning Algorithms and Univariate Analysis: A Proof-of-Concept Animal Study
Oliveira, S. W., Cardoso-Sousa, L., Georjutti, R. P., Shimizu, J. F., Silva, S., Caixeta, D. C., Guevara-Vega, M. F., Cunha, T. M., Carneiro, M. G., Goulart, L. R., et al. (2023) · Diagnostics · doi:10.3390/diagnostics13081443 · Cited by 15
Human brain organoid: trends, evolution, and remaining challenges
Li, M., Yuan, Y., Hou, Z., Hao, S., Jin, L., & Wang, B. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390972 · Cited by 16
Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids
Schöbel, A., dos Reis, V. P., Burkhard, R., Hehner, J., Schneider, L., Schauflinger, M., Vièyres, G., & Herker, E. (2024) · Communications Biology · doi:10.1038/s42003-024-06776-4 · Cited by 15
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Abdelbasset, M., Saron, W. A. A., Ma, D., Rathore, A. P. S., Kozaki, T., Zhong, C., Mantri, C. K., Tan, Y., Tung, C.-C., Tey, H. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.028 · Cited by 16
Studying the effects of emerging infections on the fetus: Experience with West Nile and Zika viruses
Rasmussen, S. A., Meaney‐Delman, D. M., Petersen, L. R., & Jamieson, D. J. (2017) · Birth Defects Research · doi:10.1002/bdr2.1006 · Cited by 15
MALDI imaging detects endogenous digoxin in glioblastoma cells infected by Zika virus—Would it be the oncolytic key?
Lima, E. D. O., Guerreiro, T. M., Melo, C. F. O. R., de Oliveira, D. N., Machado, D., Lancelloti, M., & Catharino, R. R. (2017) · Journal of Mass Spectrometry · doi:10.1002/jms.4058 · Cited by 17
Zika virus and pregnancy in Brazil: What happened?
Pereira, A. M., Monteiro, D. L. M., Werner, H., Daltro, P. A. N., Fazecas, T. M., Guedes, B., Tonni, G., Peixoto, A. B., & Júnior, E. A. (2018) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.2017.0072 · Cited by 15
Zika Virus and Neurologic Disease
Reid, S., Rimmer, K., & Thakur, K. T. (2018) · Neurologic Clinics · doi:10.1016/j.ncl.2018.06.003 · Cited by 15
Early stimulation in the development of children with microcephaly: maternal perception
de Oliveira, B. S. B., Melo, F. M. D. S., de Oliveira, R. K. L., Neta, J. F. D. F., Monteiro, F. P. M., & Joventino, E. S. (2019) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2018-0272 · Cited by 15
Basic insights into Zika virus infection of neuroglial and brain endothelial cells
Mutso, M., John, J. A. S., Ling, Z. L., Burt, F. J., Poo, Y. S., Liu, X., Žusinaite, E., Grau, G. E., Hueston, L., Merits, A., et al. (2020) · Journal of General Virology · doi:10.1099/jgv.0.001416 · Cited by 14
Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains
Lingel, A., Lin, H., Gavriel, Y., Weaver, E. A., Polepole, P., Lopez, V., Lei, Y., Petro, T. M., Solomon, B., Zhang, C., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015165 · Cited by 16
Clinical and Preclinical Evidence for Adverse Neurodevelopment after Postnatal Zika Virus Infection
Raper, J., & Chahroudi, A. (2021) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed6010010 · Cited by 16
Engineered NS1 for Sensitive, Specific Zika Virus Diagnosis from Patient Serology
Yap, T. L., Hong, S. Y., Soh, J. H., Ravichandraprabhu, L., Lim, V. W., Chan, H., Ong, T., Chua, Y. P., Koh, S. E., Wang, H., et al. (2021) · Emerging infectious diseases · doi:10.3201/eid2705.190121 · Cited by 15
Focus on organoids: cooperation and interconnection with extracellular vesicles – Is this the future of in vitro modeling?
Jurj, A. M., Paşca, S., Braicu, C., Rusu, I., Korban, S. S., & Berindan‐Neagoe, I. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.12.002 · Cited by 15
Molecular tweezers – a new class of potent broad-spectrum antivirals against enveloped viruses
Le, M., Kaptouom, E. S. T., & Schrader, T. H. (2022) · Chemical Communications · doi:10.1039/d1cc06737k · Cited by 15
Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells
Zhou, J., Guan, M.-Y., Li, R.-T., Qi, Y., Yang, G., Deng, Y., Li, X., Li, L., Yang, X. Y., Liu, J., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104457 · Cited by 16
Zika in the Brain: New Models Shed Light on Viral Infection
Hickman, H. D., & Pierson, T. C. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.004 · Cited by 15
Does adaptation to vertebrate codon usage relate to flavivirus emergence potential?
Paola, N. D., Freire, C. C. D. M., & Zanotto, P. M. D. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191652 · Cited by 15
Self-citation
Exploring the Lead Compounds for Zika Virus NS2B-NS3 Protein: an e-Pharmacophore-Based Approach
Rohini, K., Agarwal, P., Preethi, B., Veerappapillai, S., & Ramanathan, K. (2018) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2814-3 · Cited by 15
A zebrafish-based in vivo model of Zika virus infection unveils alterations of the glutamatergic neuronal development and NS4A as a key viral determinant of neuropathogenesis
Sow, A. A., Jamadagni, P., Scaturro, P., Patten, S. A., & Chatel‐Chaix, L. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012756 · Cited by 14
DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1
Li, S., Zhu, A., Ren, K., Li, S., & Chen, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118564 · Cited by 14
Human Embryos, Induced Pluripotent Stem Cells, and Organoids: Models to Assess the Effects of Environmental Plastic Pollution
Miloradović, D., Pavlović, D., Gazdic, M., Nikolić, S., Papić, M., Milivojević, N. N., Stojković, M., & Ljujić, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.709183 · Cited by 15
Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis
Xie, X., & Zeng, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.662447 · Cited by 14
Breakthroughs in microbiology made possible with organoids
Ramírez‐Flores, C. J., & Knoll, L. J. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010080 · Cited by 14
Overexpression of estrogen receptor GPER1 and G1 treatment reduces SARS-CoV-2 infection in BEAS-2B bronchial cells
Costa, A. J., Lemes, R. M. R., Bartolomeo, C. S., Nunes, T. A., Pereira, G. C., Oliveira, R. B., Gomes, A. L., Smaili, S. S., Maciel, R. M. B., Newson, L. R., et al. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111775 · Cited by 14
Tracing the steps of Zika virus
Hofer, U. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.80 · Cited by 14
Cortical organoids: why all this hype?
Marsoner, F., Koch, P., & Ladewig, J. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.04.008 · Cited by 14
Assessing the utility of antivirals for preventing maternal-fetal transmission of zika virus in pregnant mice
Watanabe, S., Tan, N. W. W., Chan, K. W. K., & Vasudevan, S. G. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.04.013 · Cited by 14
Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology.
Tsunoda, I., Omura, S., Sato, F., Kusunoki, S., Fujita, M., Park, A.-M., Hasanovic, F., Yanagihara, R. T., & Nagata, S. (2016) · PubMed · Cited by 14
Central nervous system infections in a tropical area: influence of emerging and rare infections
Chaumont, H., Roze, E. F., Tressières, B., Lazarini, F., & Lannuzel, A. (2020) · European Journal of Neurology · doi:10.1111/ene.14422 · Cited by 15
Harnessing pluripotent stem cells as models to decipher human evolution
Dannemann, M., & Romero, I. G. (2021) · FEBS Journal · doi:10.1111/febs.15885 · Cited by 14
Anthropometric Parameters of Children with Congenital Zika Virus Exposure in the First Three Years of Life
de Aguiar, E. B., Pone, S. M., Gomes, S. C., Soares, F. V. M., Zin, A., de Vasconcelos, Z. F. M., Ribeiro, C. T. M., Pereira, J. P., Moreira, M. E. L., Nielsen‐Saines, K., et al. (2022) · Viruses · doi:10.3390/v14050876 · Cited by 14
3D engineered tissue models for studying human-specific infectious viral diseases
Hwang, K. S., Seo, E. U., Choi, N., Kim, J., & Kim, H. N. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.010 · Cited by 13
Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches
Ramos, P. R. P. S., Mottin, M., Lima, C. S., de Assis, L. R., de Oliveira, K. I. Z., Mesquita, N. C. D. M. R., Cassani, N. M., Santos, I. A., Borba, J. V. V. B., Costa, V. A. F., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15121493 · Cited by 15
Zika virus research models
Kublin, J. L., & Whitney, J. B. (2017) · Virus Research · doi:10.1016/j.virusres.2017.07.025 · Cited by 14
Zika Virus Infection in Children
Hendrixson, D. T., & Newland, J. G. (2018) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.10.003 · Cited by 14
Direct Generation of Human Cortical Organoids from Primary Cells
Schukking, M., Miranda, H. C., Trujillo, C. A., Negraes, P. D., & Muotri, A. R. (2018) · Stem Cells and Development · doi:10.1089/scd.2018.0112 · Cited by 16
Self-citation
Responding to the Zika Epidemic: Preparation of a Neurodevelopmental Testing Protocol to Evaluate Young Children in Rural Guatemala
Connery, A. K., Berrios-Siervo, G. M., Arroyave, P., Bauer, D., Hernandez, S., Paniagua-Ávila, A., Bolaños, G. A., Bunge-Montes, S., Sahly, H. M. E., Calvimontes, M., et al. (2018) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.18-0713 · Cited by 14
Assessing drug response in engineered brain microenvironments
Tate, K. M., & Munson, J. M. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.04.027 · Cited by 14
Zika virus: Molecular responses and tissue tropism in the mammalian host
Shaily, S., & Upadhya, A. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2050 · Cited by 14
Generation of Zika virus–specific T cells from seropositive and virus-naïve donors for potential use as an autologous or “off-the-shelf” immunotherapeutic
Hanajiri, R., Sani, G. M., Hanley, P. J., Silveira, C. G. T., Kallas, E. G., Keller, M. D., & Bollard, C. M. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.06.008 · Cited by 14
Cross-sectional study of the anthropometric characteristics of children with congenital Zika syndrome up to 12 months of life
Carvalho-Sauer, R., Costa, M. D. C. N., Paixão, E. S., Silva, N. D. J., Barreto, F. R., & Teixeira, M. G. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-02365-6 · Cited by 14
Flavivirus vaccines: Virus-like particles and single-round infectious particles as promising alternatives
Cuevas‐Juárez, E., Pando‐Robles, V., & Palomares, L. A. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.10.049 · Cited by 14
Organoid as a culture system for viral vaccine strains
Hong, K., & Seo, S. H. (2018) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2018.7.2.145 · Cited by 13
Contact-Dependent Transmission of Langat and Tick-Borne Encephalitis Virus in Type I Interferon Receptor 1-Deficient Mice
Schreier, S., Cebulski, K., & Kröger, A. (2021) · Journal of Virology · doi:10.1128/jvi.02039-20 · Cited by 13
An Overview of Zika Virus and Zika Virus Induced Neuropathies
Wahaab, A., Mustafa, B. E., Hameed, M., Batool, H., Minh, H. T. N., Tawaab, A., Shoaib, A., Wei, J., & Rasgon, J. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010047 · Cited by 15
Preventing Zika Virus Infection during Pregnancy Using a Seasonal Window of Opportunity for Conception
Martinez, M. E. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002520 · Cited by 13
Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?
Singh, M. V., Weber, E. A., Singh, V. B., Stirpe, N. E., & Maggirwar, S. B. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0513-4 · Cited by 13
O Corpo Marcado: a construção do discurso midiático sobre Zika Vírus e Microcefalia
Porto, R. M., & Costa, P. R. S. M. (2017) · Cadernos de Gênero e Diversidade · doi:10.9771/cgd.v3i2.22125 · Cited by 13
Zika Virus Potentiates the Development of Neurological Defects and Microcephaly: Challenges and Control Strategies
Siddique, R., Liu, Y., Nabi, G., Sajjad, W., Xue, M., & Khan, S. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00319 · Cited by 13
Different Gene Networks are Disturbed by Zika Virus Infection in a Mouse Microcephaly Model
Chang, Y., Jiang, Y., Li, C., Wang, Q., Zhang, F., Qin, C., Wu, Q., Li, J., & Xu, Z. (2020) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.06.004 · Cited by 13
Diagnostic Testing for Zika: Observing Rapid Translation During a Public Health Emergency
Kurani, S. S., Theel, E. S., & Greenberg, A. J. (2017) · Clinical and Translational Science · doi:10.1111/cts.12529 · Cited by 13
Unilateral Phrenic Nerve Palsy in Infants with Congenital Zika Syndrome
Rajapakse, N., Ellsworth, K. R., Liesman, R. M., Ho, M. L., Henry, N. K., Theel, E. S., Wallace, A. D., Alvino, A. C. I., de Mello, L. M., & Meneses, J. (2018) · Emerging infectious diseases · doi:10.3201/eid2408.180057 · Cited by 13
In silico approaches to Zika virus drug discovery
Sinigaglia, A., Riccetti, S., Trevisan, M., & Barzon, L. (2018) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1515909 · Cited by 13
Host Immune Response to ZIKV in an Immunocompetent Embryonic Mouse Model of Intravaginal Infection
Khaiboullina, S. F., Lopes, P., Carvalho, T. G., Real, A. L. C. V., Souza, D. G., Costa, V. V., Teixeira, M. M., Bloise, E., Verma, S. C., & Ribeiro, F. M. (2019) · Viruses · doi:10.3390/v11060558 · Cited by 13
Identification of potential Zika virus NS2B-NS3 protease inhibitors via docking, molecular dynamics and consensus scoring-based virtual screening
Bowen, L., Li, D. J., Nola, D. T., Anderson, M. O., Heying, M., Groves, A. T., & Eagon, S. (2019) · Journal of Molecular Modeling · doi:10.1007/s00894-019-4076-6 · Cited by 13
Modulation in phase and frequency of neural oscillations during epileptiform activity induced by neonatal Zika virus infection in mice
Pinheiro, D. J. L. L., Oliveira, L. F., Souza, I. N. D. O., Brogin, J. A. F., Bueno, D., Assunção‐Miranda, I., Poian, A. T. D., Ferreira, S. T., Figueiredo, C. P., Clarke, J. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63685-2 · Cited by 13
A Primer on Human Brain Organoids for the Neurosurgeon
Blue, R., Miranda, S. P., Gu, B. J., & Chen, H. I. (2020) · Neurosurgery · doi:10.1093/neuros/nyaa171 · Cited by 13
An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens
Jin, H., Jiao, C., Cao, Z., Huang, P., Chi, H., Bai, Y., Liu, D., Wang, J., Feng, N., Li, N., et al. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009484 · Cited by 13
Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain
Faravelli, I., Antón-Bolaños, N., Brown, J. R., & Arlotta, P. (2025) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111522-014009 · Cited by 14
Zika purified inactivated virus (ZPIV) vaccine reduced vertical transmission in pregnant immunocompetent mice
Kim, I.-J., Tighe, M. P., Lanthier, P. A., Clark, M. J., Barrera, R. A. D. L., Dussupt, V., Mendez-Rivera, L., Krebs, S. J., Travis, K. L., Low-Beer, T. C., et al. (2024) · npj Vaccines · doi:10.1038/s41541-024-00823-1 · Cited by 12
Automated detection of Zika and dengue in Aedes aegypti using neural spiking analysis: A machine learning approach
Sharifrazi, D., Javed, N., Alizadehsani, R., Paradkar, P. N., Acharya, U. R., & Bhatti, A. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106594 · Cited by 11
Zika virus vertical transmission induces neuroinflammation and synapse impairment in brain cells derived from children born with Congenital Zika Syndrome
Benazzato, C., Lojudice, F. H., Pöehlchen, F., Leite, P. E. C., Manucci, A. C., van der Linden, V., Jungmann, P., Sogayar, M. C., Bruni‐Cardoso, A., Russo, F. B., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65392-8 · Cited by 14
Self-citation
Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity
Darmuzey, M., Touret, F., Slowikowski, E., Gladwyn-Ng, I. E., Ahuja, K., Sánchez-Felipe, L., de Lamballerie, X. N., Verfaillie, C. M., Marques, P. E., Neyts, J. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-55155-4 · Cited by 11
Emerging trends of Zika apprehension in an epidemic setting
Fritzell, C., Raude, J., Kazanji, M., & Flamand, C. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006167 · Cited by 12
Generation of human midbrain organoids from induced pluripotent stem cells
Mohamed, N., Mathur, M., da Silva, R. V., Thomas, R. A., Lépine, P., Durcan, T. M., Fon, E. A., & Durcan, T. M. (2019) · MNI Open Research · doi:10.12688/mniopenres.12816.1 · Cited by 26
Animal Models of Human Viral Diseases
Ruiz, S. I., Zumbrun, E. E., & Nalça, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00033-4 · Cited by 14
Congenital Zika virus infection
Alsufayanp, P. (2019) · Pediatrics & Therapeutics · Cited by 12
Standardization and Evaluation of an Anti-ZIKV IgM ELISA Assay for the Serological Diagnosis of Zika Virus Infection
Sirikajornpan, K., Suntarattiwong, P., Suwanpakdee, D., Tabprasit, S., Buddhari, D., Thaisomboonsuk, B., Klungthong, C., Poolpanichupatam, Y., Buathong, R., Srikiatkhachorn, A., et al. (2021) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.21-0163 · Cited by 12
3D Bioprinted Neural‐Like Tissue as a Platform to Study Neurotropism of Mouse‐Adapted SARS‐CoV‐2
de Melo, B. A. G., Mundim, M. V., Lemes, R. M. R., Cruz, E. M., Ribeiro, T. N., Santiago, C. F., da Fonsêca, J. H. L., Benincasa, J. C., Stilhano, R. S., Mantovani, N., et al. (2022) · Advanced Biology · doi:10.1002/adbi.202200002 · Cited by 14
Safety Assessment of Transgenic Organisms in the Environment, Volume 8
OECD (2018) · Harmonisation of regulatory oversight in biotechnology · doi:10.1787/9789264302235-en · Cited by 15
Adaptation to host cell environment during experimental evolution of Zika virus
Grass, V., Hardy, E., Kobert, K., Talemi, S. R., Décembre, É., Guy, C., Markov, P. V., Kohl, A., Paris, M., Böckmann, A., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03902-y · Cited by 12
The effect of Zika virus infection in the ferret
Hutchinson, E. B., Chatterjee, M., Reyes, L. D., Djankpa, F. T., Valiant, W. G., Dardzinski, B. J., Mattapallil, J. J., Pierpaoli, C. M., & Juliano, S. L. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24640 · Cited by 12
Detecting Vertical Zika Transmission: Emerging Diagnostic Approaches for an Emerged Flavivirus
Collins, M. H., & Waggoner, J. J. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00003 · Cited by 12
Experimental Models for SARS-CoV-2 Infection
Kim, T., Lee, J. S., & Ju, Y. S. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0094 · Cited by 13
The latest advancements in Zika virus vaccine development
Du, L., Zhou, Y., & Jiang, S. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1363648 · Cited by 12
Organoids: physiologically relevant ex vivo models for viral disease research
Wang, Y., Peng, D., Li, M., Meng, Y., Li, T., Li, S., Qiu, H., & Li, L. (2025) · Journal of Virology · doi:10.1128/jvi.01132-25 · Cited by 11
From Mosquito Bites to Sexual Transmission: Evaluating Mouse Models of Zika Virus Infection
Balint, E., Montemarano, A., Feng, E., & Ashkar, A. A. (2021) · Viruses · doi:10.3390/v13112244 · Cited by 11
Copper regulation disturbance linked to oxidative stress and cell death during Zika virus infection in human astrocytes
Puig‐Pijuan, T., Souza, L. R. Q., Pedrosa, C. D. S. G., Higa, L. M., Monteiro, F. L. L., Tanuri, A., Valverde, R. H. F., Einicker‐Lamas, M., & Rehen, S. K. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30323 · Cited by 13

Authors: Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., Polonio, C. M., Cunha, I., Freitas, C. L., Brandão, W. N., Rossato, C., Andrade, D. G., Faria, D. D. P., Garcez, A. T., Buchpigel, C. A., Braconi, C. T., Mendes, E., Sall, A. A., Zanotto, P. M. D. A., Peron, J. P. S., Muotri, A. R., & Beltrão-Braga, P. C. B.
Affiliations: Universidade de São Paulo (BR)
University of California San Diego (US)
Institut Pasteur de Dakar (SN)
ORCID: Cugola, Fernanda R.
Fernandes, Isabella R.
Russo, Fabiele B.
Freitas, Beatriz C.
Benazzato, Cecília
Almeida, Nathalia
Polonio, Carolina M.
Freitas, Carla L.
Brandão, Wesley N.
Rossato, Cristiano
Faria, Daniele de P.
Garcez, Alexandre T.
Braconi, Carla T.
Sall, Amadou A.
Zanotto, Paolo M. de A.
Peron, Jean Pierre S.
Muotri, Alysson R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-05-11
Volume: 534
Issue: 7606
Pages: 267-271
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature18296
PMC: PMC4902174
OpenAlex: W2356757232
Cited by: 1,326
References: 37
Citations by year: 2026: 31 · 2025: 57 · 2024: 70 · 2023: 73 · 2022: 102 · 2021: 147 · 2020: 132 · 2019: 147 · 2018: 196 · 2017: 246 · 2016: 124
FWCI: 235.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Fundação de Amparo à Pesquisa do Estado de São Paulo (11/18703-2, 2014/, 14/17766-9)
National Institutes of Health
National Institute of Mental Health (U19MH107367, R01MH094753)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords: Zika virus, microcephaly, congenital brain malformation, fetal growth restriction, placental infection, cortical progenitor cells, apoptosis, autophagy, brain organoids, brain development, fetal infection, Guillain-Barré syndrome
MeSH terms: Zika Virus Infection, Zika Virus, Animals, Autophagy, Brain, Brazil, Disease Models, Animal, Female, Fetal Growth Retardation, Fetus, Microcephaly, Organoids, Placenta, Pregnancy, Apoptosis, Cell Proliferation, Mice, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Brazilian Zika virus strain causes birth defects in experimental models

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks