Muotri, Alysson R.

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell

Genetics and Neurodevelopmental DisordersPluripotent Stem Cells Research

Cited by 1,329

The Brazilian Zika virus strain causes birth defects in experimental models

Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature

Mosquito-borne diseases and controlVirology and Viral Diseases

Cited by 1,326

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

Trujillo, C. A., Gao, R., Negraes, P. D., Gu, J., Buchanan, J., Preissl, S., Wang, A., Wu, W., Haddad, G. G., Chaim, I. A., et al. (2019) · Cell Stem Cell

Neural dynamics and brain functionNeurogenesis and neuroplasticity mechanisms

Cited by 974

Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

Muotri, A. R., Chu, V. T., Marchetto, M. C. N., Deng, W., Moran, J. V., & Gage, F. H. (2005) · Nature

Chromosomal and Genetic VariationsNeurogenesis and neuroplasticity mechanisms

Cited by 942

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D. C., Moore, L., Nakashima, K., Asashima, M., & Gage, F. H. (2009) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsWnt/β-catenin signaling in development and cancer

Cited by 648

L1 retrotransposition in neurons is modulated by MeCP2

Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K., & Gage, F. H. (2010) · Nature

Genetics and Neurodevelopmental DisordersChromosomal and Genetic Variations

Cited by 626

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., & Gage, F. H. (2008) · Cell Stem Cell

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 475

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

Marchetto, M. C., Belinson, H., Tian, Y., Freitas, B. C., Fu, C., Vadodaria, K. C., Beltrao-Braga, P. C., Trujillo, C. A., Mendes, A. P. D., Padmanabhan, K., et al. (2017) · Molecular Psychiatry

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 466

Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation

Thomas, C. A., Tejwani, L., Trujillo, C. A., Negraes, P. D., Herai, R. H., Mesci, P., Macia, A., Crow, Y. J., & Muotri, A. R. (2017) · Cell Stem Cell

interferon and immune responsesSystemic Lupus Erythematosus Research

Cited by 330

Efficient generation of human iPSCs by a synthetic self-replicative RNA

Yoshioka, N., Gros, E., Li, H.-R., Kumar, S., Deacon, D. C., Maron, C., Muotri, A. R., Chi, N. C., Fu, X.-D., Yu, B. D., et al. (2013) · Cell stem cell

Pluripotent Stem Cells ResearchRNA Interference and Gene Delivery

Cited by 312

Getting to the cores of autism

Iakoucheva, L. M., Muotri, A. R., & Sebat, J. (2019) · Cell

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 260

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 236

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Marchetto, M. C. N., Muotri, A. R., Mu, Y., Carson, C. T., Macia, A., Moran, J. V., & Gage, F. H. (2011) · Proceedings of the National Academy of Sciences

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 229

Paternally inherited cis-regulatory structural variants are associated with autism

Brandler, W. M., Antaki, D., Gujral, M., Kleiber, M. L., Whitney, J., Maile, M. S., Hong, O., Chapman, T. R., Tan, S., Tandon, P., et al. (2018) · Science

Autism Spectrum Disorder ResearchGenomic variations and chromosomal abnormalities

Cited by 209

A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex

Antaki, D., Guevara, J., Maihofer, A. X., Klein, M., Gujral, M., Grove, J., Carey, C. E., Hong, O., Arranz, M. J., Hervas, A., et al. (2022) · Nature Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 206

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 201

L1-associated genomic regions are deleted in somatic cells of the healthy human brain

Erwin, J. A., Paquola, A. C. M., Singer, T., Gallina, I., Novotny, M., Quayle, C., Bedrosian, T. A., Alves, F. I. A., Butcher, C. R., Herdy, J. R., et al. (2016) · Nature Neuroscience

Genomic variations and chromosomal abnormalitiesChromosomal and Genetic Variations

Cited by 195

A human neurodevelopmental model for Williams syndrome

Chailangkarn, T., Trujillo, C. A., Freitas, B. C., Hrvoj-Mihic, B., Herai, R. H., Yu, D. X., Brown, T. T., Marchetto, M. C., Bardy, C., McHenry, L., et al. (2016) · Nature

Williams Syndrome ResearchGenetics and Neurodevelopmental Disorders

Cited by 195

Transposable Elements, Inflammation, and Neurological Disease

Saleh, A., Macia, A., & Muotri, A. R. (2019) · Frontiers in Neurology

Chromosomal and Genetic VariationsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 149

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

Marchetto, M. C., Hrvoj-Mihic, B., Kerman, B. E., Yu, D. X., Vadodaria, K. C., Linker, S. B., Narvaiza, I., Santos, R., Denli, A. M., Mendes, A. P., et al. (2019) · eLife

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 132

Altered neuronal network and rescue in a human MECP2 duplication model

Nageshappa, S., Carromeu, C., Trujillo, C. A., Mesci, P., Espuny-Camacho, I., Pasciuto, E., Vanderhaeghen, P., Verfaillie, C. M., Raitano, S., Kumar, A., et al. (2016) · Molecular Psychiatry

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 117

Frequency and complexity of de novo structural mutation in autism

Brandler, W. M., Antaki, D., Gujral, M., Noor, A., Rosanio, G., Chapman, T. R., Barrera, D. J., Lin, G. N., Malhotra, D., Watts, A. C., et al. (2016) · The American Journal of Human Genetics

Genomic variations and chromosomal abnormalitiesAutism Spectrum Disorder Research

Cited by 104

Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids

Trujillo, C. A., Adams, J. W., Negraes, P. D., Carromeu, C., Tejwani, L., Acab, A., Tsuda, B., Thomas, C. A., Sodhi, N., Fichter, K. M., et al. (2021) · EMBO Molecular Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 101

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

Maimon, R., Chillon-Marinas, C., Snethlage, C. E., Singhal, S. M., McAlonis-Downes, M., Ling, K., Rigo, F., Bennett, C. F., Da Cruz, S., Hnasko, T. S., et al. (2021) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 62