The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.
A cannabinoid link between mitochondria and memory
Abstract
Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate ATP. Acute cannabinoid intoxication induces amnesia in humans and animals, and the activation of type-1 cannabinoid receptors present at brain mitochondria membranes (mtCB 1) can directly alter mitochondrial energetic activity. Although the pathological impact of chronic mitochondrial dysfunctions in the brain is well established, the involvement of acute modulation of mitochondrial activity in high brain functions, including learning and memory, is unknown. Here, we show that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB 1 receptors. Genetic exclusion of CB 1 receptors from hippocampal mitochondria prevents cannabinoid-induced reduction of mitochondrial mobility, synaptic transmission and memory formation. mtCB 1 receptors signal through intra-mitochondrial Gα i protein activation and consequent inhibition of soluble-adenylyl cyclase (sAC). The resulting inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system eventually leads to decreased cellular respiration. Hippocampal inhibition of sAC activity or manipulation of intra-mitochondrial PKA signalling or phosphorylation of the Complex I subunit NDUFS2 inhibit bioenergetic and amnesic effects of cannabinoids. Thus, the G protein-coupled mtCB 1 receptors regulate memory processes via modulation of mitochondrial energy metabolism. By directly linking mitochondrial activity to memory formation, these data reveal that bioenergetic processes are primary acute regulators of cognitive functions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Importantly, CB1 receptors have been shown to be expressed in the mitochondrial membrane, where they act on the regulation of energy metabolism and mitochondrial functions25–27.”
In the citing paper
“Recently, CB1 receptors were shown to be expressed in mitochondria where they regulate energy metabolism and mitochondrial functions25–27.”
In the citing paper
“recent evidence for glial (Han et al., 2012) and mitochondrial CB1R (Hebert-Chatelain et al., 2016) in eCB-mediated mnemonic processes, together with a known role for astrocytes (Oliveira et al., 2015) and mitochondria (Manji et al., 2012) in stress- and anxiety-related processes.”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hebert-Chatelain et al., 2016
Citations
Cites
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Semi-supervised learning for peptide identification from shotgun proteomics datasets
Käll, L., Canterbury, J. D., Weston, J., Noble, W. S., & MacCoss, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1113 · Cited by 2,424
Nakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Self-citationEndocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
Mitochondria in neuroplasticity and neurological disorders
Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 940
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 434
Pecze, L., Randi, E. B., & Szabó, C. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00225-8 · Cited by 43
Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice
Jacobs, R. A., Aboouf, M. A., Köster-Hegmann, C., Muttathukunnel, P., Laouafa, S., Arias‐Reyes, C., Thiersch, M., Soliz, J., Gassmann, M., & Gasser, E. M. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02465-8 · Cited by 42
Yan, W., Li, L., Ge, L., Zhang, F., Fan, Z., & Hu, L. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02702-9 · Cited by 41
Allosteric Modulation of Cannabinoid Receptor 1—Current Challenges and Future Opportunities
Hryhorowicz, S., Kaczmarek-Ryś, M., Andrzejewska-Romanowska, A., Staszak, K., Hryhorowicz, M., Korcz, A., & Słomski, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235874 · Cited by 43
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
da Cruz, J. F. O., Busquets-García, A., Zhao, Z., Varilh, M., Lavanco, G., Bellocchio, L., Robin, L. M., Cannich, A., Julio‐Kalajzić, F., Lesté-Lasserre, T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.108046 · Cited by 42
Russo, S., & de Azevedo, W. F. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180417165247 · Cited by 39
Hu, X., Hoffmann, D. S., Wang, M., Schuhmacher, L., Stroe, M. C., Schreckenberger, B., Elstner, M., & Fischer, R. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01731-9 · Cited by 44
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity
Harkany, T., & Horváth, T. L. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.020 · Cited by 39
Kataoka, K., Bilkei‐Gorzó, A., Nozaki, C., Togo, A., Nakamura, K., Ohta, K., Zimmer, A., & Asahi, T. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.03.014 · Cited by 37
Metabolic Messengers: endocannabinoids
Busquets-García, A., Bolaños, J. P., & Marsicano, G. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00600-1 · Cited by 43
Papilloud, A., Guillot de Suduiraut, I., Zanoletti, O., Grosse, J., & Sandi, C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0215-6 · Cited by 38
Carbon dioxide and MAPK signalling: towards therapy for inflammation
Gałgańska, H., Jarmuszkiewicz, W., & Gałgański, Ł. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01306-x · Cited by 46
Dinu, A. R., Rogobete, A. F., Bratu, T., Popovici, S. E., Bedreag, O. H., Păpurică, M., Bratu, T., & Săndesc, D. (2020) · Cells · doi:10.3390/cells9020307 · Cited by 38
Novel approaches and current challenges with targeting the endocannabinoid system
Morales, P., & Jagerovic, N. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1752178 · Cited by 38
Monday, H. R., Bourdenx, M., Jordan, B. A., & Castillo, P. E. (2020) · eLife · doi:10.7554/elife.54812 · Cited by 39
Cannabinoid control of hippocampal functions: the where matters
Robledo, A., Vella, M., Grandes, P., & Gómez, E. S. (2021) · FEBS Journal · doi:10.1111/febs.15907 · Cited by 38
An Alternative Maze to Assess Novel Object Recognition in Mice
da Cruz, J. F. O., Gomis‐González, M., Maldonado, R. J., Marsicano, G., Ozaita, A., & Busquets-García, A. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3651 · Cited by 37
Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells
Barchi, M., Innocenzi, E., Giannattasio, T., Dolci, S., Rossi, P., & Grimaldi, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010025 · Cited by 31
Scheyer, A. F., Yasmin, F., Naskar, S., & Patel, S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01438-7 · Cited by 37
Musaus, M., Navabpour, S., & Jarome, T. J. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107286 · Cited by 39
The extensive and functionally uncharacterized mitochondrial phosphoproteome
Niemi, N. M., & Pagliarini, D. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100880 · Cited by 35
The Basic Science of Cannabinoids
Sideris, A., Lauzadis, J., & Kaczocha, M. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006472 · Cited by 38
Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain
Melser, S., Zottola, A. C. P., Serrat, R., Puente, N., Grandes, P., Marsicano, G., & Hébert-Chatelain, É. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.06.023 · Cited by 34
Didier, S., Sauvé, F., Domise, M., Buée, L., Marinangeli, C., & Vingtdeux, V. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123716 · Cited by 34
Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity
Drummond‐Main, C. D., Ahn, Y., Kesler, M., Gavrilovici, C., Kim, D. Y., Kiroski, I., Baglot, S. L., Chen, A., Sharkey, K. A., Hill, M. N., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0011 · Cited by 34
Mitochondrial control of sleep
Hartmann, C., & Kempf, A. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102733 · Cited by 35
Endomembrane GPCR signaling: 15 years on, the quest continues
Calebiro, D., Miljuš, T., & O’Brien, S. L. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.10.006 · Cited by 33
Delivery Systems for Mitochondrial Gene Therapy: A Review
Faria, R., Boisguérin, P., Sousa, Â., & Costa, D. R. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020572 · Cited by 33
Endocannabinoid-serotonin systems interaction in health and disease
Colangeli, R., Teskey, G. C., & Giovanni, G. D. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.003 · Cited by 31
Reece, A. S., & Hulse, G. K. (2021) · BMC Cancer · doi:10.1186/s12885-021-07924-3 · Cited by 31
de la Fuente, M., Rodríguez-Agirretxe, I., Vecino, E., Astigarraga, E., Acera, A., & Barreda‐Gómez, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105639 · Cited by 31
Baghel, M. S., & Thakur, M. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1164-z · Cited by 31
Neurobiological mechanisms underlying cannabis-induced memory impairment
Prini, P., Zamberletti, E., Manenti, C., Gabaglio, M., Parolaro, D., & Rubino, T. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.02.002 · Cited by 32
Ceccarini, J., Casteels, C., Ahmad, R. U., Crabbé, M., de Vliet, L. V., Vanhaute, H., Vandenbulcke, M., Vandenberghe, W., & Laere, K. V. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04445-x · Cited by 31
Photorelease of 2-Arachidonoylglycerol in Live Cells
Laguerre, A., Hauke, S., Qiu, J., Kelly, M. J., & Schultz, C. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b05978 · Cited by 30
Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments
Pozdniakova, S., & Ladilov, Y. V. (2018) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd5020029 · Cited by 29
Río, I. B., Puente, N., Peñasco, S., Rico, I., Gutiérrez‐Rodrίguez, A., Elezgarai, I., Ramos, A., Reguero, L., Gerrikagoitia, I., Christie, B. R., et al. (2017) · Addiction Biology · doi:10.1111/adb.12585 · Cited by 30
Reece, A. S., & Hulse, G. K. (2022) · Current Zoology · doi:10.1093/eep/dvab015 · Cited by 30
Liu, B., Tian, Y., Li, Y., Wu, P., Zhang, Y., Zheng, J., & Shi, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1024279 · Cited by 29
Mitochondrial phosphoproteomes are functionally specialized across tissues
Hansen, F. M., Kremer, L. S., Karayel, O., Bludau, I., Larsson, N.-G., Kühl, I., & Mann, M. (2024) · Life Science Alliance · doi:10.26508/lsa.202302147 · Cited by 29
Reece, A. S., & Hulse, G. K. (2021) · BMC Cancer · doi:10.1186/s12885-021-08598-7 · Cited by 28
Receptor mechanisms underlying the CNS effects of cannabinoids: CB1 receptor and beyond
Hempel, B. J., & Xi, Z. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2021.10.006 · Cited by 29
Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes
Zottola, A. C. P., Severi, I., Cannich, A., Ciofi, P., Cota, D., Marsicano, G., Giordano, A., & Bellocchio, L. (2022) · Cells · doi:10.3390/cells11162582 · Cited by 28
Computational Analysis of Dipyrone Metabolite 4-Aminoantipyrine As A Cannabinoid Receptor 1 Agonist
Russo, S., & de Azevedo, W. F. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190906155339 · Cited by 27
Hemopressin as a breakthrough for the cannabinoid field
Heimann, A. S., Dale, C. S., Guimarães, F. S., Reis, R. A. D. M., Navon, A., Shmuelov, M. A., Rioli, V., Gomes, I., Devi, L. L., & Ferro, E. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108406 · Cited by 27
Rienda, B., Elexpe, A., Tolentino‐Cortez, T., Gulak, M., Bruzos-Cidón, C., Torrecilla, M., Astigarraga, E., & Barreda‐Gómez, G. (2021) · Analytica—A Journal of Analytical Chemistry and Chemical Analysis · doi:10.3390/analytica2010003 · Cited by 27
de Ceglia, M., Decara, J. M., Gaetani, S., & de Fonseca, F. R. (2021) · Pharmaceuticals · doi:10.3390/ph14101002 · Cited by 32
Fletcher-Jones, A., Hildick, K. L., Evans, A. J., Nakamura, Y., Wilkinson, K. A., & Henley, J. M. (2019) · eLife · doi:10.7554/elife.44252 · Cited by 25
Wang, T., Niu, K., Fan, A., Bi, N., Tao, H., Chen, X.-T., & Wang, H.-L. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112545 · Cited by 24
Gambino, G., Rizzo, V., Giglia, G., Ferraro, G., & Sardo, P. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00963-7 · Cited by 26
Raux, P., Drutel, G., Revest, J., & Vallée, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13034 · Cited by 24
Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease
Gu, C., Chen, Y., Chen, Y., Liu, C., Zhu, Z., & Wang, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.768156 · Cited by 26
Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
Skupio, U., Welte, J., Serrat, R., Eraso‐Pichot, A., Julio‐Kalajzić, F., Gisquet, D., Cannich, A., Delcasso, S., Matias, I., Fundazuri, U. B., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.001 · Cited by 29
Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
Fernández‐Moncada, I., Rodrigues, R. S., Fundazuri, U. B., Bellocchio, L., & Marsicano, G. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15922 · Cited by 26
Location bias: A “Hidden Variable” in GPCR pharmacology
Eiger, D. S., Hicks, C., Gardner, J., Pham, U., & Rajagopal, S. (2023) · BioEssays · doi:10.1002/bies.202300123 · Cited by 29
Lee, H.-J., Choi, T., Kim, Y., Lee, S., Han, B., Bak, I. S., Moon, S. A., Yu, D., Shin, K. S., Kwon, Y. K., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00893-2 · Cited by 25
Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R. A., Szodorai, E., Lübec, G., Shirran, S. L., Botting, C. H., Kasper, S. F., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135418 · Cited by 27
Puente, N., Río, I. B., Achicallende, S., Nahirney, P. C., & Grandes, P. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3145 · Cited by 26
Microarray and Mass Spectrometry-Based Methodology for Lipid Profiling of Tissues and Cell Cultures
Fernández, R., Garate, J., Tolentino‐Cortez, T., Herraiz, A., Lombardero, L., Ducrocq, F., Rodríguez‐Puertas, R., Trifilieff, P., Astigarraga, E., Barreda‐Gómez, G., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04529 · Cited by 25
Reece, A. S., & Hulse, G. K. (2022) · Archives of Public Health · doi:10.1186/s13690-022-00812-7 · Cited by 24
Benitez-del-Castillo, J., Soria, J. M., Acera, A., Muñoz, A. M., Rodríguez, S., & Suárez, T. (2021) · PubMed Central · Cited by 23
Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option?
Zieglgänsberger, W., Brenneisen, R., Berthele, A., Wotjak, C. T., Bandelow, B., Tölle, T. R., & Lutz, B. (2022) · Medical Cannabis and Cannabinoids · doi:10.1159/000522432 · Cited by 25
García, S., Giménez, V. M. M., Marón, F. J. M., Reiter, R. J., & Manucha, W. A. (2020) · PubMed · doi:10.14670/hh-18-212 · Cited by 25
Masuoka, T., Uwada, J., Kudo, M., Yoshiki, H., Yamashita, Y. I., Taniguchi, T., Nishio, M., Ishibashi, T., & Muramatsu, I. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.042 · Cited by 22
Oláh, A., Alam, M. A., Chéret, J., Kis, G. N., Hegyi, Z., Szöllősi, A. G., Vidali, S., Bı́ró, T., & Paus, R. (2020) · Experimental Dermatology · doi:10.1111/exd.14110 · Cited by 22
Gibuła‐Tarłowska, E., Wydra, K., & Kotlinska, J. H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070654 · Cited by 23
Río, I. B., Puente, N., Mimenza, A., Ramos, A., Serrano, M., Lekunberri, L., Gerrikagoitia, I., Christie, B. R., Nahirney, P. C., & Grandes, P. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25098 · Cited by 22
Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA
Liang, J., Kruijssen, D. L. H., Verschuuren, A. C. J., Voesenek, B. J. B., Benavides, F. F. W., González, M. S., Ruiter, M., & Wierenga, C. J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0851-21.2021 · Cited by 22
Cai, M., Yang, Q., Li, G., Sun, S., Chen, Y., Tian, L., & Dong, H. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex267 · Cited by 22
Weinrich, T. W., Hogg, C. R., & Jeffery, G. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.06.010 · Cited by 19
Computational roles of plastic probabilistic synapses
Montero, M. L., Sacramento, J., & Costa, R. P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.09.002 · Cited by 23
Pinkhasova, D. V., Jameson, L. E., Conrow, K. D., Simeone, M. P., Davis, A. P., Wiegers, T. C., Mattingly, C. J., & Leung, M. C. K. (2021) · Current Research in Toxicology · doi:10.1016/j.crtox.2021.02.007 · Cited by 22
Rabino, M., Mallia, S., Castiglioni, E., Rovina, D., Pompilio, G., & Gowran, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090936 · Cited by 24
Reardon, S. D., & Mishanina, T. V. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101815 · Cited by 21
de Ceglia, M., Bonaventura, M. V. M. D., Romano, A., Friuli, M., Bonaventura, E. M. D., Gavito, A., Botticelli, L., Gaetani, S., de Fonseca, F. R., & Cifani, C. (2023) · International Journal of Eating Disorders · doi:10.1002/eat.23917 · Cited by 21
Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
Gómez-Sotres, P., Skupio, U., Tor, T. D., Julio‐Kalajzić, F., Cannich, A., Gisquet, D., Río, I. B., Drago, F., Puente, N., Grandes, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51416-4 · Cited by 21
A Novel Cortical Mechanism for Top-Down Control of Water Intake
Zhao, Z., Gómez, E. S., Varilh, M., Covelo, A., Julio‐Kalajzić, F., Cannich, A., Castiglione, A., Vanhoutte, L., Duveau, A., Zizzari, P., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.09.011 · Cited by 24
Advances in the Treatment of Chronic Pain by Targeting GPCRs
Che, T. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00644 · Cited by 21
He, K., Zhang, J., Zhang, W., Wang, S., Li, D., Ma, X., Wu, X., Chai, X., & Liu, Q. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.772066 · Cited by 20
Endocannabinoid signaling in oligodendroglia
Molina‐Holgado, E., Esteban, P. F., Arévalo‐Martín, Á., Moreno‐Luna, R., Molina‐Holgado, F., & García‐Ovejero, D. (2022) · Glia · doi:10.1002/glia.24180 · Cited by 20
An enquiry to the role of CB1 receptors in neurodegeneration
Fernández‐Moncada, I., Eraso‐Pichot, A., Tor, T. D., Fortunato-Marsol, B., & Marsicano, G. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106235 · Cited by 23
The basics of mitochondrial cAMP signalling: Where, when, why
Benedetto, G. D., Lefkimmiatis, K., & Pozzan, T. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102320 · Cited by 20
Ravindran, S., & Kurian, G. A. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00990-4 · Cited by 19
Willingham, T. B., Zhang, Y., Andreoni, A., Knutson, J. R., Lee, D., & Glancy, B. C. (2019) · The Journal of Physiology · doi:10.1113/jp278611 · Cited by 19
Lee, C., Wu, C., Chou, W., Lee, M., Chou, M., Lee, S.-Y., & Wang, L. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.07.007 · Cited by 18
Huang, H. M., Zhang, Y., Yao, C., He, Q., Chen, F., Yu, H. Y., Lu, G., Jiang, N., & Liu, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.890330 · Cited by 18
Mitochondrial DNA as a marker for treatment-response in post-traumatic stress disorder
Hummel, E. M., Piovesan, K., Berg, F., Herpertz, S., Kessler, H., Kumsta, R., & Moser, D. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105993 · Cited by 20
Reece, A. S., & Hulse, G. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192416721 · Cited by 19
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
Fernández‐Moncada, I., & Marsicano, G. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220089 · Cited by 18
Less-invasive non-embedded cell cutting by nanomanipulation and vibrating nanoknife
Shang, W., Li, D., Lu, H., Fukuda, T., & Shen, Y. (2017) · Applied Physics Letters · doi:10.1063/1.4975004 · Cited by 18
Giorgi, P. D., Liautard, V., Pucheault, M., & Antoniotti, S. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201800064 · Cited by 18
Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival
Tang, X., Liu, Z., Li, X., Wang, J., & Li, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136886 · Cited by 18
Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses
Balezina, O. P., Tarasova, E. O., & Gaydukov, A. E. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921070038 · Cited by 18
Regulation of Mitochondrial Homeostasis by sAC-Derived cAMP Pool: Basic and Translational Aspects
Aslam, M., & Ladilov, Y. V. (2021) · Cells · doi:10.3390/cells10020473 · Cited by 16
Nouh, R. A., Kamal, A., & Abdelnaser, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041151 · Cited by 18
Local glycolysis fuels actomyosin contraction during axonal retraction
Santos, R., Lokmane, L., Ozdemir, D., Traoré, C., Agesilas, A., Hakibilen, C., Lenkei, Z., & Zala, D. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202206133 · Cited by 18
Dolcini, J., Kioumourtzoglou, M., Çayır, A., Sánchez-Guerra, M., Brennan, K. J. M., Dereix, A. E., Coull, B. A., Spiro, A., Vokonas, P., Schwartz, J. D., et al. (2020) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000108 · Cited by 17
Impairment of Synaptic Plasticity by Cannabis, Δ9-THC, and Synthetic CannabinoidsPreprint
Hoffman, A. F., Hwang, E.-K., & Lupica, C. R. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039743 · Cited by 21
GPCRs identified on mitochondrial membranes: New therapeutic targets for diseases
Pan, Y., Ji, N., Jiang, L., Zhou, Y., Feng, X., Li, J., Zeng, X., Wang, J., Shen, Y., & Chen, Q. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101178 · Cited by 16
Synthesis of Cannabinoids: “In Water” and “On Water” Approaches: Influence of SDS Micelles
del Moral, J. F. Q., Ruiz‐Martínez, C., del Pulgar, H. P., González, J. E. M., Fernández, I., López‐Pérez, J. L., Fernández‐Arteaga, A., & Barrero, A. F. (2021) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c02698 · Cited by 16
Metadata
- Authors
- Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., Varilh, M., Robin, L. M., Terral, G., García-Fernández, M. D., Colavita, M., Mazier, W., Drago, F., Puente, N., Reguero, L., Elezgarai, I., Dupuy, J.-W., Cota, D., Lopez-Rodriguez, M.-L., Barreda-Gómez, G., Massa, F., Grandes, P., Bénard, G., & Marsicano, G.
- Affiliations
- Université de Bordeaux (FR)
- Universidad Complutense de Madrid (ES)
- University of the Basque Country (ES)
- University of Catania (IT)
- Corresponding author
- Marsicano, Giovanni
- ORCID
- Venue
- Nature
- Published
- 2016-11
- Volume
- 539
- Issue
- 7630
- Pages
- 555-559
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2551139658
- Cited by
- 434
- References
- 50
- Citations by year
- 2026: 18 · 2025: 41 · 2024: 37 · 2023: 47 · 2022: 61 · 2021: 61 · 2020: 51 · 2019: 36 · 2018: 44 · 2017: 35 · 2016: 2
- FWCI
- 31.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-13-BSV4-0006, ANR-10-LABX-0043)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cannabinoids, CB1 receptor, memory impairment, amnesia, hippocampus, mitochondrial bioenergetics, synaptic transmission, Gi protein, soluble adenylyl cyclase, protein kinase A, NDUFS2, mitochondrial electron transport chain, cellular respiration, cognitive function
- MeSH terms
- Adenylyl Cyclases, Animals, Cannabinoids, Electron Transport, Energy Metabolism, Female, Hippocampus, Male, Memory, Memory Disorders, Mitochondria, NADH Dehydrogenase, Synaptic Transmission, Oxidative Phosphorylation, Signal Transduction, Cyclic AMP-Dependent Protein Kinases, Cell Respiration, GTP-Binding Protein alpha Subunits, Gi-Go, Receptor, Cannabinoid, CB1, Mitochondrial Membranes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
