The DOI matches its Crossref record; 48 of the 50 references it cites were found in a registry or an index.
A cannabinoid link between mitochondria and memory
Abstract
Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate ATP. Acute cannabinoid intoxication induces amnesia in humans and animals, and the activation of type-1 cannabinoid receptors present at brain mitochondria membranes (mtCB 1) can directly alter mitochondrial energetic activity. Although the pathological impact of chronic mitochondrial dysfunctions in the brain is well established, the involvement of acute modulation of mitochondrial activity in high brain functions, including learning and memory, is unknown. Here, we show that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB 1 receptors. Genetic exclusion of CB 1 receptors from hippocampal mitochondria prevents cannabinoid-induced reduction of mitochondrial mobility, synaptic transmission and memory formation. mtCB 1 receptors signal through intra-mitochondrial Gα i protein activation and consequent inhibition of soluble-adenylyl cyclase (sAC). The resulting inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system eventually leads to decreased cellular respiration. Hippocampal inhibition of sAC activity or manipulation of intra-mitochondrial PKA signalling or phosphorylation of the Complex I subunit NDUFS2 inhibit bioenergetic and amnesic effects of cannabinoids. Thus, the G protein-coupled mtCB 1 receptors regulate memory processes via modulation of mitochondrial energy metabolism. By directly linking mitochondrial activity to memory formation, these data reveal that bioenergetic processes are primary acute regulators of cognitive functions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Importantly, CB1 receptors have been shown to be expressed in the mitochondrial membrane, where they act on the regulation of energy metabolism and mitochondrial functions25–27.”
In the citing paper
“Recently, CB1 receptors were shown to be expressed in mitochondria where they regulate energy metabolism and mitochondrial functions25–27.”
In the citing paper
“recent evidence for glial (Han et al., 2012) and mitochondrial CB1R (Hebert-Chatelain et al., 2016) in eCB-mediated mnemonic processes, together with a known role for astrocytes (Oliveira et al., 2015) and mitochondria (Manji et al., 2012) in stress- and anxiety-related processes.”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Hebert-Chatelain et al., 2016
Citations
Cites
Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Semi-supervised learning for peptide identification from shotgun proteomics datasets
Käll, L., Canterbury, J. D., Weston, J., Noble, W. S., & MacCoss, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1113 · Cited by 2,424
Nakai, K., & Horton, P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01336-x · Cited by 2,181
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Self-citationEndocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
Mitochondria in neuroplasticity and neurological disorders
Mattson, M. P., Gleichmann, M., & Cheng, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.010 · Cited by 1,081
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 940
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–300 of 434
Reece, A., & Hulse, G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912759 · Cited by 12
Singlár, Z., Ganbat, N., Szentesi, P., Osgonsandag, N., Szabó, L. Z., Telek, A., Fodor, J., Dienes, B., Gönczi, M., Csernoch, L. J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415653 · Cited by 16
Cinquina, V., Keimpema, E., Pollak, D. D., & Harkany, T. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13320 · Cited by 16
Ginsenoside Rg5 Improves Sleep by Regulating Energy Metabolism in Sleep-Deprived Rats
Chen, J., Li, M., Huo, X., Gong, T.-J., Han, X., Liu, J., Liu, S., & Sun, Y. (2023) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x23500817 · Cited by 16
Cannabinoids Regulate an Insula Circuit Controlling Water Intake
Zhao, Z., Covelo, A., Couderc, Y., Mitra, A., Varilh, M., Wu, Y., Jacky, D., Fayad, R., Cannich, A., Bellocchio, L., et al. (2022) · Current Biology · doi:10.1016/j.cub.2024.03.053 · Cited by 16
Atkinson, D. L., & Abbott, J. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804791-0.00003-3 · Cited by 16
Δ9-tetrahydrocannabinol modulates the proteasome system in the brain
Salgado-Mendialdúa, V., Aguirre‐Plans, J., Güney, E., Reig‐Viader, R., Maldonado, R. J., Bayés, À., Oliva, B., & Ozaita, A. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.026 · Cited by 14
Huguet, J. E., Río, I. B., Gómez‐Urquijo, S., Mimenza, A., Saumell-Esnaola, M., Roman, L. B., del Caño, G. G., Sallés, J., Puente, N., Gerrikagoitia, I., et al. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.645940 · Cited by 16
Achicallende, S., Río, I. B., Serrano, M., Mimenza, A., Lekunberri, L., Lusar, I. A., Puente, N., Gerrikagoitia, I., & Grandes, P. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02139-4 · Cited by 16
Reece, A. S., Bennett, K., & Hulse, G. K. (2023) · Journal of Xenobiotics · doi:10.3390/jox13030024 · Cited by 15
Cannabinoid-Induced Immunomodulation during Viral Infections: A Focus on Mitochondria
Beji, C., Loucif, H., Telittchenko, R., Olagnier, D. P., Dagenais-Lussier, X., & van Grevenynghe, J. (2020) · Viruses · doi:10.3390/v12080875 · Cited by 15
A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
Licitra, R., Marchese, M., Naef, V., Ogi, A., Martinelli, M., Kiferle, C., Fronte, B., & Santorelli, F. M. (2022) · Biomedicines · doi:10.3390/biomedicines10081820 · Cited by 17
Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
Yin, X., Zhang, Z., Zhou, R., Zuo, P., Sang, D., Zhou, S., Shi, B., Chen, L., Wu, C., Guo, Y., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2418317122 · Cited by 15
Pozdniakova, S., Guitart‐Mampel, M., Garrabou, G., Benedetto, G. D., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14455 · Cited by 15
Swinton, M. K., Sundermann, E. E., Pedersen, L., Nguyen, J. D., Grelotti, D. J., Taffe, M. A., Iudicello, J. E., & Fields, J. A. (2021) · Viruses · doi:10.3390/v13091742 · Cited by 15
Zhou, H., Peng, X., Hou, T., Zhao, N., Qiu, M., Zhang, X., & Liang, X. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112218 · Cited by 16
Chesney, E., Oliver, D., Sarma, A., Lamper, A. D., Slimani, I., Lloyd, M., Dickens, A. M., Welds, M., Kråkström, M., Gasparini-Andre, I., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02175-3 · Cited by 14
Zottola, A. C. P., Martín-Jiménez, R., Lavanco, G., Hamel-Côté, G., Ramon‐Duaso, C., Rodrigues, R. S., Mariani, Y., Khan, M., Drago, F., Jean, S., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02032-y · Cited by 15
Circadian regulation of memory under stress: Endocannabinoids matter
Morena, M., Santori, A., & Campolongo, P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104712 · Cited by 15
Reece, A. S., & Hulse, G. K. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043360 · Cited by 14
Steiger, L. J., Tsintsadze, T. S., Mattheisen, G. B., & Smith, S. M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112247 · Cited by 14
Research progress in the management of vascular disease with cannabidiol: a review
Guo, Y., Ren, W., Deng, J., & Guo, W. (2024) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-023-02476-y · Cited by 14
Kim, C., Potluri, P., Khalil, A., Gaut, D. L., McManus, M. J., Compton, S. L., Wallace, D. C., & Yadava, N. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.05.003 · Cited by 14
Ishii, M., Beeson, G. C., Beeson, C. C., & Rohrer, B. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.04.012 · Cited by 14
Messina, F., Cecconi, F., & Rodolfo, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00271 · Cited by 14
Amyloid-β (25–35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice
Zhu, L., Lu, F., Jia, X., Yan, Q., Zhang, X., & Mu, P. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101945 · Cited by 16
Song, C., Kang, X., Yang, F., Du, W., Zhang, J., Liu, L., Kang, J., Jia, N., Yue, H., Fan, L., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0134 · Cited by 15
Kamnate, A., Sirisin, J., Watanabe, M., Kondo, H., Hipkaeo, W., & Chomphoo, S. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211063516 · Cited by 14
Lam, T., Mastos, C., Sloan, E. K., & Halls, M. L. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108331 · Cited by 14
Energy sensors in drug addiction: A potential therapeutic target
López-Gambero, A. J., de Fonseca, F. R., & Suárez, J. (2020) · Addiction Biology · doi:10.1111/adb.12936 · Cited by 14
Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective
Perin, P., Tagne, A. M., Enrico, P., Marino, F., Cosentino, M., Pizzala, R., & Boselli, C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.505995 · Cited by 15
Li, Y., & Cui, Z. J. (2020) · Biomolecules · doi:10.3390/biom10101423 · Cited by 13
Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT7 Receptor
Tempio, A., Niso, M., Laera, L., Trisolini, L., Favia, M., Ciranna, L., Marzulli, D., Petrosillo, G., Pierri, C. L., Lacivita, E., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249629 · Cited by 13
New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling
Riquelme-Sandoval, A., de Sá-Ferreira, C. O., Miyakoshi, L. M., & Hedin‐Pereira, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.596572 · Cited by 14
Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study
Reece, A. S., & Hulse, G. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19137726 · Cited by 13
Protective role of soluble adenylyl cyclase against reperfusion-induced injury of cardiac cells
Rinaldi, L., Pozdniakova, S., Jayarajan, V., Troidl, C., Abdallah, Y., Aslam, M., & Ladilov, Y. V. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.021 · Cited by 13
Li, R., Fukumori, R., Takeda, T., Song, Y., Morimoto, S., Kikura‐Hanajiri, R., Yamaguchi, T., Watanabe, K., Aritake, K., Tanaka, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45969-4 · Cited by 13
Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment
Vallés, A. S., & Barrantes, F. J. (2021) · Biomolecules · doi:10.3390/biom11111697 · Cited by 14
The endocannabinoid system as a therapeutic target for schizophrenia: Failures and potentials
Seillier, A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136064 · Cited by 12
Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Dempster, E. L., Wong, C. C. Y., Burrage, J., Hannon, E. J., Quattrone, D., Trotta, G., Rodríguez, V., Alameda, L., Spinazzola, E., Tripoli, G., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02689-0 · Cited by 12
Chagtoo, M., George, N., Pathak, N., Tiwari, S., Godbole, M. M., & Ladilov, Y. V. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0473-y · Cited by 12
Margvelani, G., Meparishvili, M., Tevdoradze, E., McCabe, B., & Solomonia, R. (2017) · NeuroReport · doi:10.1097/wnr.0000000000000936 · Cited by 9
Sabbir, M. G., Swanson, M., & Albensi, B. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1158604 · Cited by 11
Cosentino, L., Urbinati, C., Lanzillotta, C., Rasmo, D. D., Valenti, D., Pellas, M., Quattrini, M. C., Piscitelli, F., Kostrzewa, M., Domenico, F. D., et al. (2024) · Molecular Autism · doi:10.1186/s13229-024-00617-1 · Cited by 11
Brzeźniakiewicz‐Janus, K., Jarczak, J., Konopko, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10847-2 · Cited by 11
Zeng, Q. L., Xiong, Q., Lin, K., Zheng, L., Zhou, M., Tian, X., Xu, C., & Ru, Q. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.04.002 · Cited by 11
Human iPSC-Derived Cortical Neurons Display Homeostatic Plasticity
Cordella, F., Ferrucci, L., D’Antoni, C., Ghirga, S., Brighi, C., Soloperto, A., Gigante, Y., Ragozzino, D., Bezzi, P., & Angelantonio, S. D. (2022) · Life · doi:10.3390/life12111884 · Cited by 11
Podinić, T., Werstuck, G. H., & Raha, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311003 · Cited by 11
Elexpe, A., Nieto, N., Fernández-Cuétara, C., Domínguez-Fernández, C., Morera‐Herreras, T., Torrecilla, M., Miguélez, C., Laso, A., Ochoa, E., Bailén, M., et al. (2021) · Membranes · doi:10.3390/membranes11120943 · Cited by 10
Region-specific dysregulation of endocannabinoid system in learned helplessness model of depression
Huang, W., Ke, Y., & Chen, R. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001601 · Cited by 11
Reece, A. S., & Hulse, G. K. (2022) · Genes · doi:10.3390/genes14010032 · Cited by 10
Silva, P. D. S., Kra, G., Butenko, Y., Daddam, J. R., Levin, Y., & Zachut, M. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01033-4 · Cited by 10
Bastola, T., Perkins, G. A., Huu, V. A. N., Ju, S., Kim, K.-Y., Shen, Z., Skowronska‐Krawczyk, D., Weinreb, R. N., & Ju, W. (2024) · Antioxidants · doi:10.3390/antiox13060743 · Cited by 14
Gargano, A., Beins, E. C., Zimmer, A., & Bilkei‐Gorzó, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010005 · Cited by 10
Extended Signaling by Melatonin
Hardeland, R. (2018) · Cell & Cellular Life Sciences Journal · doi:10.23880/cclsj-16000123 · Cited by 10
Sánchez‐Magraner, L., de la Fuente, M., Evans, C., Miles, J., Elexpe, A., Rodriguez-Astigarraga, M., Astigarraga, E., & Barreda‐Gómez, G. (2021) · Analytica—A Journal of Analytical Chemistry and Chemical Analysis · doi:10.3390/analytica2040015 · Cited by 10
Reece, A. S., & Hulse, G. K. (2022) · Spatial and Spatio-temporal Epidemiology · doi:10.1016/j.sste.2022.100480 · Cited by 10
Safety of cannabis- and hemp-derived constituents in reproduction and development
Akingbasote, J. A., Szlapinski, S. K., Charrette, A., Hilmas, C. J., & Guthrie, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00024-2 · Cited by 10
Cross‐talk between neurosteroid and endocannabinoid systems in cannabis addiction
Raux, P., & Vallée, M. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13191 · Cited by 10
Navarri, X., Robertson, D. N., Charfi, I., Wünnemann, F., do Nascimento, A. S. F., Trottier, G., Leclerc, S., Andelfinger, G., Cristo, G. D., Richer, L., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2256-23.2024 · Cited by 10
Su, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00761 · Cited by 9
Insight into the Interactome of Intramitochondrial PKA Using Biotinylation-Proximity Labeling
Amer, Y. O., & Hébert-Chatelain, É. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218283 · Cited by 9
Early Consumption of Cannabinoids: From Adult Neurogenesis to Behavior
Netzahualcoyotzi, C., Rodríguez–Serrano, L. M., Chávez–Hernández, M. E., & Buenrostro-Jáuregui, M. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147450 · Cited by 9
Li, W., Yang, T., Wang, N., Li, B., Meng, C., Yu, K., Zhou, X., Cao, R., & Cui, S. (2025) · Advanced Science · doi:10.1002/advs.202414547 · Cited by 9
Astrocytic EphB3 receptors regulate d-serine-gated synaptic plasticity and memory
Langlais, V. C., Mountadem, S., Benazzouz, I., Amadio, A., Matos, M., Jourdes, A., Cannich, A., Julio‐Kalajzić, F., Belluomo, I., Matias, I., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102747 · Cited by 9
Reece, A. S., & Hulse, G. K. (2022) · Current Zoology · doi:10.1093/eep/dvac012 · Cited by 8
Xu, H., Li, T., Gong, Q., Xu, H., Hu, Y., Lü, W., Yang, X., Li, J., Xu, W., & Kuang, W. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1153509 · Cited by 9
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
Durydivka, O., Mackie, K., & Blahoš, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1213094 · Cited by 9
Reece, A. S., & Hulse, G. K. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01446-0 · Cited by 8
Learning-induced modulation of the effect of endocannabinoids on inhibitory synaptic transmission
Ghosh, S., Reuveni, I., Zidan, S., Lamprecht, R., & Barkai, E. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00623.2017 · Cited by 10
Embracing complexity of (brain) aging
Polidori, M. C. (2024) · FEBS Letters · doi:10.1002/1873-3468.14941 · Cited by 8
Manterola, A., Chara, J. C., Aguado, T., Palazuelos, J., Matute, C., & Mato, S. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.1030060 · Cited by 7
The effects of cannabinoids on the kidney
Didik, S., Palygin, O., Chandy, M., & Staruschenko, A. (2024) · Acta Physiologica · doi:10.1111/apha.14247 · Cited by 7
Salazar, I. B., Elezgarai, I., Rico‐Barrio, I., Gerrikagoitia, I., Puente, N., & Grandes, P. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24808 · Cited by 7
Franco, N. D., Drutel, G., Roullot, V., Julio‐Kalajzić, F., Lalanne, V., Grel, A., Lesté-Lasserre, T., Matias, I., Cannich, A., Gonzales, D., et al. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103705 · Cited by 9
Sánchez-Sánchez, L., García, J., Fernández, R., Noskova, E., Egiguren-Ortiz, J., Gulak, M., Ochoa, E., Laso, A., Oiarbide, M., Santos, J. I., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043837 · Cited by 7
Hébert-Chatelain, É., Marsicano, G., & Desprez, T. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_8 · Cited by 8
Bastola, T., Perkins, G. A., Huu, V. A. N., Ju, S., Keun-young Kim, A., Shen, Z., Skowronska‐Krawczyk, D., Weinreb, R. N., & Ju, W. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.04.583371 · Cited by 7
Bilkei‐Gorzó, A., Schürmann, B., Schneider, M., Krämer, M., Nidadavolu, P., Beins, E. C., Müller, C. E., Dvir‐Ginzberg, M., & Zimmer, A. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00002 · Cited by 6
CB1 receptor signaling: Linking neuroplasticity, neuronal types, and mental health outcomes
Gao, Q., & Asim, M. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105938 · Cited by 6
Martínez-Torres, A. M., Cerdán-Centeno, K. T., Ramirez-Celis, C., Peniche-Zamudio, S., Durán-González, T. D. J., Roa-Gutierrez, C., Navarro‐Mabarak, C., & Morán, J. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0086 · Cited by 6
Martín-Llorente, A., Serrano, M., Río, I. B., Lekunberri, L., Ocerin, G., Puente, N., Ramos, A., Rico‐Barrio, I., Gerrikagoitia, I., & Grandes, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417316 · Cited by 7
Explaining Contemporary Patterns of Cannabis Teratology
Reece, A. S., & Hulse, G. K. (2019) · UWA Profiles and Research Repository (University of Western Australia) · doi:10.4172/2572-0775.1000146 · Cited by 6
Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca
da Cruz, J. F. O., Ioannidou, C., Zottola, A. C. P., Muguruza, C., Gómez-Sotres, P., Fernández‐Monreal, M., Callado, L. F., Marsicano, G., & Busquets-García, A. (2020) · Addiction Biology · doi:10.1111/adb.12940 · Cited by 6
García-Fernández, M. D., Larrea, A., Fernández, R., Rodríguez‐Puertas, R., Astigarraga, E., Manuel, I., & Barreda‐Gómez, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065470 · Cited by 6
Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization
Durydivka, O., Gazdarica, M., Večerková, K., Radenkovic, S., & Blahoš, J. (2023) · Gene · doi:10.1016/j.gene.2023.147851 · Cited by 6
FATTY ACIDS AS CELL SIGNALS IN INGESTIVE BEHAVIORS
Figlewicz, D. P., & Witkamp, R. F. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112985 · Cited by 6
Xiao, J., Zhou, Y., Sun, L., & Wang, H. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1152167 · Cited by 6
Chemical tools to modulate 2‐arachidonoylglycerol biosynthesis
Deng, H., & van der Stelt, M. (2017) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1568 · Cited by 6
A new mutant mouse model lacking mitochondrial-associated CB 1 receptorPreprint
Zottola, A. C. P., Gómez, E. S., Río, I. B., Muguruza, C., Terral, G., Robin, L. M., da Cruz, J. F. O., Redon, B., Lesté-Lasserre, T., Tolentino-Cortes, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.009472 · Cited by 7
Cannabinoid Receptor Signaling is Dependent on Sub-Cellular LocationPreprint
Thomas, A., Lobingier, B. T., Schultz, C., & Laguerre, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.21.586146 · Cited by 6
Yang, L.-K., Wang, W., Guo, D.-Y., & Dong, B. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108788 · Cited by 5
Maya-López, M., Monsalvo-Maraver, L. Á., Delgado-Arzate, A. L., Olivera-Pérez, C. I., El‐Hafidi, M., Silva‐Palacios, A., Medina‐Campos, O. N., Pedraza‐Chaverrí, J., Aschner, M., Tinkov, A. A., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03967-2 · Cited by 5
Izquierdo, I., Mirra, S., Manso, Y., Parcerisas, A., Rubio, J. A., del Valle, J., Gil-Bea, F. J., Ulloa, F., Herrero‐Lorenzo, M., Verdaguer, E., et al. (2024) · Science Signaling · doi:10.1126/scisignal.abq1007 · Cited by 6
Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS
Kouchaeknejad, A., van der Walt, G., de Donato, M. H., & Puighermanal, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115829 · Cited by 6
Reis, M. H., Antunes, D., Santos, L. H., Guimarães, A. C. R., & Caffarena, E. R. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00547 · Cited by 5
Maya-López, M., Zazueta, C., Retana‐Márquez, S., Ali, S. F., Karasu, Ç., Onaivi, E. S., Aschner, M., & Santamarı́a, A. (2021) · Springer eBooks · doi:10.1007/978-3-319-56015-1_461-1 · Cited by 6
Noskova, E., Fernández, R., García, J., Ochoa, E., Domínguez-Fernández, C., Adell, A., Laso, A., Andrés, M. F., González‐Coloma, A., Astigarraga, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021315 · Cited by 5
O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_2 · Cited by 4
Powlowski, P., Matheson, J., Foll, B. L., Andreazza, A. C., & Ross, R. A. (2024) · Cannabis and Cannabinoid Research · doi:10.1089/can.2023.0282 · Cited by 4
Metadata
- Authors
- Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., Varilh, M., Robin, L. M., Terral, G., García-Fernández, M. D., Colavita, M., Mazier, W., Drago, F., Puente, N., Reguero, L., Elezgarai, I., Dupuy, J.-W., Cota, D., Lopez-Rodriguez, M.-L., Barreda-Gómez, G., Massa, F., Grandes, P., Bénard, G., & Marsicano, G.
- Affiliations
- Université de Bordeaux (FR)
- Universidad Complutense de Madrid (ES)
- University of the Basque Country (ES)
- University of Catania (IT)
- Corresponding author
- Marsicano, Giovanni
- ORCID
- Venue
- Nature
- Published
- 2016-11
- Volume
- 539
- Issue
- 7630
- Pages
- 555-559
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2551139658
- Cited by
- 434
- References
- 50
- Citations by year
- 2026: 18 · 2025: 41 · 2024: 37 · 2023: 47 · 2022: 61 · 2021: 61 · 2020: 51 · 2019: 36 · 2018: 44 · 2017: 35 · 2016: 2
- FWCI
- 31.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-13-BSV4-0006, ANR-10-LABX-0043)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cannabinoids, CB1 receptor, memory impairment, amnesia, hippocampus, mitochondrial bioenergetics, synaptic transmission, Gi protein, soluble adenylyl cyclase, protein kinase A, NDUFS2, mitochondrial electron transport chain, cellular respiration, cognitive function
- MeSH terms
- Adenylyl Cyclases, Animals, Cannabinoids, Electron Transport, Energy Metabolism, Female, Hippocampus, Male, Memory, Memory Disorders, Mitochondria, NADH Dehydrogenase, Synaptic Transmission, Oxidative Phosphorylation, Signal Transduction, Cyclic AMP-Dependent Protein Kinases, Cell Respiration, GTP-Binding Protein alpha Subunits, Gi-Go, Receptor, Cannabinoid, CB1, Mitochondrial Membranes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
