The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
Decoding ALS: from genes to mechanism
Open accessAbstract
Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative disease. A plethora of genetic factors have been identified that drive the degeneration of motor neurons in ALS, increase susceptibility to the disease or influence the rate of its progression. Emerging themes include dysfunction in RNA metabolism and protein homeostasis, with specific defects in nucleocytoplasmic trafficking, the induction of stress at the endoplasmic reticulum and impaired dynamics of ribonucleoprotein bodies such as RNA granules that assemble through liquid–liquid phase separation. Extraordinary progress in understanding the biology of ALS provides new reasons for optimism that meaningful therapies will be identified.
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Self-citationUbiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
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Tau protein liquid–liquid phase separation can initiate tau aggregation
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Self-citationMizushima, N., & Levine, B. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2022774 · Cited by 1,140
A framework for understanding the functions of biomolecular condensates across scales
Lyon, A. S., Peeples, W. B., & Rosen, M. K. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00303-z · Cited by 895
RNA phase transitions in repeat expansion disorders
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Metadata
- Authors
- Taylor, J. P., Brown, R. H., & Cleveland, D. W.
- Venue
- Nature
- Published
- 2016-11-09
- Volume
- 539
- Issue
- 7628
- Pages
- 197-206
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2556818673
- Cited by
- 2,066
- References
- 154
- FWCI
- 121.00
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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