The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identity and dynamics of mammary stem cells during branching morphogenesis
Open accessAbstract
During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis, are unknown. Here we show that morphogenesis is driven by proliferative terminal end buds that terminate or bifurcate with near equal probability, in a stochastic and time-invariant manner, leading to a heterogeneous epithelial network. We show that the majority of terminal end bud cells function as highly proliferative, lineage-committed MaSCs that are heterogeneous in their expression profile and short-term contribution to ductal extension. Yet, through cell rearrangements during terminal end bud bifurcation, each MaSC is able to contribute actively to long-term growth. Our study shows that the behaviour of MaSCs is not directly linked to a single expression profile. Instead, morphogenesis relies upon lineage-restricted heterogeneous MaSC populations that function as single equipotent pools in the long term.
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Cites
Generation of a functional mammary gland from a single stem cell
Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005
Distinct stem cells contribute to mammary gland development and maintenance
Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C. (2011) · Nature · doi:10.1038/nature10573 · Cited by 854
De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
Grün, D., Muraro, M. J., Boisset, J.-C., Wiebrands, K., Lyubimova, A., Dharmadhikari, G., van den Born, M., van Es, J., Jansen, E., Clevers, H., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.05.010 · Cited by 586
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Cited by
Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping
Gehart, H., van Es, J. H., Hamer, K., Beumer, J., Kretzschmar, K., Dekkers, J. F., Rios, A., & Clevers, H. (2019) · Cell · doi:10.1016/j.cell.2018.12.029 · Cited by 346
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2018 · Cited by 267
Incidence of breast cancer in the life span study of atomic bomb survivors: 1958-2009
Brenner, A. V., Preston, D. L., Sakata, R., Sugiyama, H., de Gonzalez, A. B., French, B., Utada, M., Cahoon, E. K., Sadakane, A., Ozasa, K., et al. (2018) · Radiation Research · doi:10.1667/rr15015.1 · Cited by 113
Metadata
- Authors
- Scheele, C. L. G. J., Hannezo, E., Muraro, M. J., Zomer, A., Langedijk, N. S. M., van Oudenaarden, A., Simons, B. D., & van Rheenen, J.
- Venue
- Nature
- Published
- 2017-01-30
- Volume
- 542
- Issue
- 7641
- Pages
- 313-317
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2581006281
- Cited by
- 195
- References
- 3
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Scheele, C. L. G. J., Hannezo, E., Muraro, M. J., Zomer, A., Langedijk, N. S. M., van Oudenaarden, A., Simons, B. D., & van Rheenen, J. (2017). Identity and dynamics of mammary stem cells during branching morphogenesis. Nature. https://doi.org/10.1038/nature21046
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