Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, Prasenjit, Baddour, Joelle, Muller, Florian, Wu, Chia Chin, Wang, Huamin, Liao, Wen-Ting, Lan, Zangdao, Chen, Alina, Gutschner, Tony, Kang, Yaan, Fleming, Jason, Satani, Nikunj, Zhao, Di, Achreja, Abhinav, Yang, Lifeng, Lee, Jiyoon, Chang, Edward, Genovese, Giannicola, Viale, Andrea, Ying, Haoqiang, Draetta, Giulio, Maitra, Anirban, Wang, Y. Alan, Nagrath, Deepak, DePinho, Ronald A.·2017·Nature
DOI 10.1038/nature21052

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  65. FAIRsharing record for: Metabolic Atlas
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