Cited by 130Paleontology and Stratigraphy of FossilsProtist diversity and phylogenyOrigins and Evolution of Life

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Paleoproterozoic sterol biosynthesis and the rise of oxygen

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Gold, David A., Caron, Abigail, Fournier, Gregory P., Summons, Roger E.·2017·Nature

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Abstract

Natural products preserved in the geological record can function as 'molecular fossils', providing insight into organisms and physiologies that existed in the deep past. One important group of molecular fossils is the steroidal hydrocarbons (steranes), which are the diagenetic remains of sterol lipids. Complex sterols with modified side chains are unique to eukaryotes, although simpler sterols can also be synthesized by a few bacteria. Sterol biosynthesis is an oxygen-intensive process; thus, the presence of complex steranes in ancient rocks not only signals the presence of eukaryotes, but also aerobic metabolic processes. In 1999, steranes were reported in 2.7 billion year (Gyr)-old rocks from the Pilbara Craton in Australia, suggesting a long delay between photosynthetic oxygen production and its accumulation in the atmosphere (also known as the Great Oxidation Event) 2.45-2.32 Gyr ago. However, the recent reappraisal and rejection of these steranes as contaminants pushes the oldest reported steranes forward to around 1.64 Gyr ago (ref. 6). Here we use a molecular clock approach to improve constraints on the evolution of sterol biosynthesis. We infer that stem eukaryotes shared functionally modern sterol biosynthesis genes with bacteria via horizontal gene transfer. Comparing multiple molecular clock analyses, we find that the maximum marginal probability for the divergence time of bacterial and eukaryal sterol biosynthesis genes is around 2.31 Gyr ago, concurrent with the most recent geochemical evidence for the Great Oxidation Event. Our results therefore indicate that simple sterol biosynthesis existed well before the diversification of living eukaryotes, substantially predating the oldest detected sterane biomarkers (approximately 1.64 Gyr ago), and furthermore, that the evolutionary history of sterol biosynthesis is tied to the first widespread availability of molecular oxygen in the ocean-atmosphere system.

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Authors: Gold, D. A., Caron, A., Fournier, G. P., & Summons, R. E.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Summons, Roger E.
ORCID: Gold, David A.
Caron, Abigail
Fournier, Gregory P.
Summons, Roger E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2017-03
Volume: 543
Issue: 7645
Pages: 420-423
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature21412
OpenAlex: W2594412381
Cited by: 129
References: 34
Citations by year: 2026: 11 · 2025: 10 · 2024: 8 · 2023: 19 · 2022: 11 · 2021: 15 · 2020: 18 · 2019: 13 · 2018: 18 · 2017: 6
FWCI: 10.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
Funders: National Science Foundation (1338810)
Simons Foundation
Agouron Institute (1338810)
Topics: Physical Sciences › Earth and Planetary Sciences › Paleontology › Paleontology and Stratigraphy of Fossils
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Keywords: steranes, sterol biosynthesis, Great Oxidation Event, atmospheric oxygenation, horizontal gene transfer, molecular fossils, molecular clock, divergence time estimation, Pilbara Craton, early eukaryotes, Precambrian geochemistry
MeSH terms: Atmosphere, Bacteria, Oceans and Seas, Oxygen, Phylogeny, Seawater, Sterols, Gene Transfer, Horizontal, Synteny, History, Ancient, Eukaryota

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Paleoproterozoic sterol biosynthesis and the rise of oxygen

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