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A heterochromatin-dependent transcription machinery drives piRNA expression
Open accessAbstract
Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the small RNAs themselves. How small RNA source loci are efficiently transcribed while transposon promoters are potently silenced is not understood. Here we show that, in Drosophila, transcription of PIWI-interacting RNA (piRNA) clusters-small RNA source loci in animal gonads-is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin. This is accomplished through Moonshiner, a paralogue of a basal transcription factor IIA (TFIIA) subunit, which is recruited to piRNA clusters via the heterochromatin protein-1 variant Rhino. Moonshiner triggers transcription initiation within piRNA clusters by recruiting the TATA-box binding protein (TBP)-related factor TRF2, an animal TFIID core variant. Thus, transcription of heterochromatic small RNA source loci relies on direct recruitment of the core transcriptional machinery to DNA via histone marks rather than sequence motifs, a concept that we argue is a recurring theme in evolution.
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“Based on current understanding, cells have two layers of defense against potentially deleterious transposable element activation: 1) Transposable element transcription is limited by heterochromatin-mediated silencing, and 2) Transposable element transcripts are cleared from the cell by piRNA-mediated degradation”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [39]
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Metadata
- Authors
- Andersen, P. R., Tirian, L., Vunjak, M., & Brennecke, J.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Corresponding author
- Andersen, Peter Refsing
- Brennecke, Julius
- Venue
- Nature
- Published
- 2017-08-23
- Volume
- 549
- Issue
- 7670
- Pages
- 54-59
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5590728
- OpenAlex
- W2748864067
- Cited by
- 280
- References
- 78
- Citations by year
- 2026: 20 · 2025: 32 · 2024: 39 · 2023: 37 · 2022: 21 · 2021: 35 · 2020: 25 · 2019: 37 · 2018: 27 · 2017: 6
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Novo Nordisk Fonden (NNF14OC0009189)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- piRNA, heterochromatin, rhinoceros, HP1, TRF2, TFIID, transposon silencing, germline, Drosophila, histone modifications, genome stability
- MeSH terms
- Animals, Chromosomal Proteins, Non-Histone, DNA Transposable Elements, Drosophila melanogaster, Female, Multigene Family, Heterochromatin, Promoter Regions, Genetic, RNA Polymerase II, Transcription, Genetic, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, Telomeric Repeat Binding Protein 2, Transcription Factor TFIIA, Transcription Initiation, Genetic
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