Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

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Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity

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Disulfiram Suppressed Peritendinous Fibrosis Through Inhibiting Macrophage Accumulation and Its Pro-inflammatory Properties in Tendon Bone Healing

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One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy

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Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy

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Cuproptosis nanoprodrug-initiated self-promoted cascade reactions for postoperative tumor therapy

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Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy

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Transition‐Metal‐Free Synthesis of Unsymmetrical Disulfides via Three‐Component Reaction of Thiosulfonates, Thiourea and Alkyl halides

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Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model

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Boosting the anti-tumor performance of disulfiram against glioblastoma by using ultrasmall nanoparticles and HIF-1α inhibitor

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Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram

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Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

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Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy

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Impact of proteostasis workload on sensitivity to proteasome inhibitors in multiple myeloma

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Direct targeted therapy for MLL‐fusion‐driven high‐risk acute leukaemias

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Recent research of BTK inhibitors: Methods of structural design, pharmacological activities, manmade derivatives and structure–activity relationship

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Copper Coordination‐Based Nanomedicine for Tumor Theranostics

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Augmenting MEK inhibitor efficacy in BRAF wild-type melanoma: synergistic effects of disulfiram combination therapy

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Revealing the adsorption nature of disulfiram on metal clusters (Au, Pt, Ag, Pd, Cu, and Ni): DFT analysis, SERS enhancement and sensor properties

Al-Otaibi, J. S., Mary, Y. S., Mary, Y. S., & Al‐Saadi, A. A. (2024) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2024.114543 · Cited by 15

Activation of NF-κB signaling regulates ovariectomy-induced bone loss and weight gain

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Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition

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A Drug Repurposing Method Based on Drug-Drug Interaction Networks and Using Energy Model Layouts

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Overview of Antabuse® (Disulfiram) in Radiation and Cancer Biology

Jia, Y., & Huang, T. (2021) · Cancer Management and Research · doi:10.2147/cmar.s308168 · Cited by 15

Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice

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Disulfiram protects against abdominal aortic aneurysm by ameliorating vascular smooth muscle cells pyroptosis

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A Noval Established Cuproptosis-Associated LncRNA Signature for Prognosis Prediction in Primary Hepatic Carcinoma

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Identification of cuproptosis-related patterns and construction of a scoring system for predicting prognosis, tumor microenvironment-infiltration characteristics, and immunotherapy efficacy in breast cancer

Li, W., Zhang, X., Chen, Y., & Pang, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.966511 · Cited by 15

Antifibrotic effect of disulfiram on bleomycin-induced lung fibrosis in mice and its impact on macrophage infiltration

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PD‐1 + CD8 + T Cell‐Mediated Hepatocyte Pyroptosis Promotes Progression of Murine Autoimmune Liver Disease

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From cell death to neurological disease: Unraveling the role of copper

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Aptamer Functionalized Upconversion Nanotheranostic Agent With Nuclear Targeting as the Highly Localized Drug-Delivery System of Doxorubicin

Song, X., Yan, T., Tian, F., Li, F., Ren, L., Li, Q., & Zhang, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.639487 · Cited by 14

Advances in the Application of Nanomaterials to the Treatment of Melanoma

Wang, Z., Yu, Y., Wang, C., Li, J., & Pang, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102090 · Cited by 14

Green electrosynthesis of drug metabolites

Asra, R., & Jones, A. M. (2023) · Toxicology Research · doi:10.1093/toxres/tfad009 · Cited by 16

NIR-II light triggered burst-release cascade nanoreactor for precise cancer chemotherapy

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Copper-based fluorinated MOFs for activatable multicolor 19F MRI and regulated cell death-promoting therapy of tumor

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Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)

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A metabolic perspective on cuproptosis

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Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation

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Isoquinoline thiosemicarbazone displays potent anticancer activity with in vivo efficacy against aggressive leukemias

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Disulfiram/cytarabine eradicates a subset of acute myeloid leukemia stem cells with high aldehyde dehydrogenase expression

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Dual Action of Acidic Microenvironment on the Enrichment of the Active Metabolite of Disulfiram in Tumor Tissues

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Antibacterial Effects of Disulfiram in Helicobacter pylori

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ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

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Design, synthesis and bioactive properties of a class of macrocycles with tunable functional groups and ring size

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The p97‐Nploc4 ATPase complex plays a role in muscle atrophy during cancer and amyotrophic lateral sclerosis

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GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy

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Design, synthesis and biological evaluation of novel dithiocarbamate-substituted diphenylaminopyrimidine derivatives as BTK inhibitors

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A disulfiram-loaded electrospun poly(vinylidene fluoride) nanofibrous scaffold for cancer treatment

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Functional duality of ethanol on cancer

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Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

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Structure and Function of the AAA+ ATPase p97, a Key Player in Protein Homeostasis

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A siramesine-loaded metal organic framework nanoplatform for overcoming multidrug resistance with efficient cancer cell targeting

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The Evolving Role of Disulfiram in Radiobiology and the Treatment of Breast Cancer

Wang, R., Shen, J., Yan, H., Gao, X., Dong, T., Wang, P., & Zhou, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s271532 · Cited by 13

Effect of Sepatronium Bromide (YM-155) on DNA Double-Strand Breaks Repair in Cancer Cells

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Sonoprinting nanoparticles on cellular spheroids via surface acoustic waves for enhanced nanotherapeutics delivery

Rasouli, R., Paun, R. A., & Tabrizian, M. (2023) · Lab on a Chip · doi:10.1039/d2lc00854h · Cited by 14

Ultrasound-Visualized Cuproptosis in Glioblastoma via Endogenous Copper Sequestration and Nitric Oxide-Gas Controlled Release Using a Programmable Nanoliposomal Platform

Liu, Y., Wang, X., Xu, H., Wu, H. C., Ju, Y., Cui, L., Zhao, Y., Chen, Y., Cui, M., & Yang, F. (2025) · ACS Nano · doi:10.1021/acsnano.5c13110 · Cited by 12

AΙ-Driven Drug Repurposing: Applications and Challenges

Keramida, P., Syrigos, N. K., Kouvela, M., Poulakou, G., Charpidou, A. G., & Fiste, O. (2025) · Medicines · doi:10.3390/medicines12040028 · Cited by 12

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Liu, M., Li, Z., Ren, Q., Lu, Z., Zhang, Y., Guo, Y., Li, R., Hu, D., & Zhang, L. (2026) · Advanced Science · doi:10.1002/advs.202517028 · Cited by 13

High‐throughput tandem‐microwell assay for ammonia repositions FDA‐Approved drugs to inhibit Helicobacter pylori urease

Liu, F., Yu, J., Zhang, Y., Li, F., Liu, Q., Zhou, Y., Huang, S., Fang, H., Xiao, Z., Liao, L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100465rr · Cited by 12

A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy

Li, T., Rong, M., Wang, Y., Sun, W., & Lu, L. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02879h · Cited by 12

ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer

Song, L., Nguyen, V., Xie, J., Jia, S., Chang, C. J., Uchio, E., & Zi, X. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0876 · Cited by 13

Polydopamine-Modified Copper Coordination Mesoporous Silica Nanoparticles Loaded with Disulfiram for Synergistic Chemo-Photothermal Therapy

Ling, J., Cai, Y., Feng, H., Liu, Z., & Ouyang, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040512 · Cited by 12

Regenerating Chemotherapeutics through Copper‐Based Nanomedicine: Disrupting Protein Homeostasis for Enhanced Tumor Therapy

Wu, X., Wu, Q., Hou, M., Jiang, Y., Li, M., Jia, G., Yang, H., & Zhang, C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401954 · Cited by 12

N ‐(Acyldithio)Saccharin: Design, Synthesis and Applications in Catalytic Enantioselective Disulfuration/Amination of Alkenes

Huo, Y., Cao, R., Huang, J., Li, Z., Wei, Z., Zhu, D., & Chen, Z. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202503815 · Cited by 12

Intranasal delivery of temozolomide and disulfiram in situ gel combined with copper for enhanced glioblastoma therapy

Qu, Y., Zhao, J., Ma, L., Wang, X., Sun, F., Li, Y., Wu, Y., Zhao, G., Liu, S., Ma, W., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114898 · Cited by 12

Phenylboronic acid-catalyzed tandem construction of S–S and C–S bonds: a new method for the synthesis of benzyl disulfanylsulfone derivatives from S -benzyl thiosulfonates

Reddy, R. J., Waheed, M., & Krishna, G. R. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob00442a · Cited by 12

Inclusion Complexes of Gold(I)‐Dithiocarbamates with β‐Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery

Morgen, M., Fabrowski, P., Amtmann, E., Gunkel, N., & Miller, A. K. (2021) · Chemistry - A European Journal · doi:10.1002/chem.202101366 · Cited by 12

Tetraethylthiuram disulphide alleviates pulmonary fibrosis through modulating transforming growth factor-β signalling

Jiang, H., Zhao, Y., Tang, H., Duan, S., Li, M., Yang, X., Liu, J., Lou, X., Cai, Y., Zhao, W., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105923 · Cited by 12

Diethyl phosphite-mediated switchable synthesis of bis(imidazoheterocycles) derived disulfanes and sulfanes using imidazoheterocycles and octasulfur

Reddy, R. J., Shankar, A., Kumar, J. J., Sharadha, N., & Krishna, G. R. (2022) · New Journal of Chemistry · doi:10.1039/d1nj05226h · Cited by 12

Prognostic and Immunological Significance of the Molecular Subtypes and Risk Signatures Based on Cuproptosis in Hepatocellular Carcinoma

Tang, X., Ren, X., Huang, T., Miao, Y., Ha, W., Li, Z., Yang, L., & Mi, D. (2023) · Mediators of Inflammation · doi:10.1155/2023/3951940 · Cited by 13

Preparation and anticancer actions of CuET-nanoparticles dispersed by bovine serum albumin

He, Y., Yang, M., Yang, L., Hao, M., Wang, F., Li, X., Taylor, E. W., Zhang, X., & Zhang, J. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113329 · Cited by 12

CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane remodeling in endometrial carcinoma

Yang, Y., Chen, H.-L., Wu, F. S., & Bao, W. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130497 · Cited by 13

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

Xu, N., Yang, Y., Chen, L., & Lin, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c00293 · Cited by 12

Cannabidiol‐induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET

Buchtova, T., Skrott, Z., Chroma, K., Rehulka, J., Dzubak, P., Hajduch, M., Lukac, D., Arampatzis, S., Bartek, J., & Mistrik, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13114 · Cited by 11

Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communication

Sorokin, O., Hause, F., Wedler, A., Alakhras, T., Bauchspiess, T., Dietrich, A., Günther, W. F., Guha, C., Obika, K. B., Kraft, J., et al. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02161-6 · Cited by 14

Identification and validation of a novel cuproptosis-related gene signature in multiple myeloma

Zhang, B., Wang, Q., Zhang, T., Zheng, Z., Lin, Z., Zhou, S., Zheng, D., Chen, Z., Zheng, S., Zhang, Y., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1159355 · Cited by 12

Disulfiram combined with chemoimmunotherapy potentiates pancreatic cancer treatment efficacy through the activation of cGAS-STING signaling pathway via suppressing PARP1 expression.

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Co-delivery of a tumor microenvironment-responsive disulfiram prodrug and CuO 2 nanoparticles for efficient cancer treatment

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