Deshaies, Raymond J.

RING Domain E3 Ubiquitin Ligases

Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 2,679

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Sakamoto, K. M., Kim, K. B., Kumagai, A., Mercurio, F., Crews, C. M., & Deshaies, R. J. (2001) · Proceedings of the National Academy of Sciences

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 2,609

Function and regulation of cullin–RING ubiquitin ligases

Petroski, M. D., & Deshaies, R. J. (2005) · Nature Reviews Molecular Cell Biology

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 2,148

How Proteolysis Drives the Cell Cycle

King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 1,273

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Skrott, Z., Mistrik, M., Andersen, K. K., Friis, S., Majera, D., Gursky, J., Ozdian, T., Bartkova, J., Turi, Z., Moudry, P., et al. (2017) · Nature

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 807

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

Radhakrishnan, S. K., Lee, C. S., Young, P., Beskow, A., Chan, J. Y., & Deshaies, R. J. (2010) · Molecular Cell

Ubiquitin and proteasome pathwaysGenomics, phytochemicals, and oxidative stress

Cited by 526

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

Sakamoto, K. M., Kim, K. B., Verma, R., Ransick, A., Stein, B., Crews, C. M., & Deshaies, R. J. (2003) · Molecular & Cellular Proteomics

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 425

COP9 Signalosome

Cope, G. A., & Deshaies, R. J. (2003) · Cell

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 409

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

Pierce, N. W., Lee, J. E., Liu, X., Sweredoski, M. J., Graham, R. L. J., Larimore, E. A., Rome, M., Zheng, N., Clurman, B. E., Hess, S., et al. (2013) · Cell

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 262

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

Machida, K., Tsukamoto, H., Mkrtchyan, H., Duan, L., Dynnyk, A., Liu, H. M., Asahina, K., Govindarajan, S., Ray, R., Ou, J.-H. J., et al. (2009) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyAlcohol Consumption and Health Effects

Cited by 223

Cdc48/p97 mediates UV-dependent turnover of RNA Pol II

Verma, R., Oania, R., Fang, R., Smith, G. T., & Deshaies, R. J. (2011) · Molecular Cell

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 196

Harnessing the Power of Proteolysis for Targeted Protein Inactivation

Verma, R., Mohl, D., & Deshaies, R. J. (2020) · Molecular Cell

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 185

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

Van Nguyen, T., Lee, J. E., Sweredoski, M. J., Yang, S.-J., Jeon, S.-J., Harrison, J. S., Yim, J.-H., Lee, S. G., Handa, H., Kuhlman, B., et al. (2016) · Molecular Cell

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 177

Prime time for PROTACs

Deshaies, R. J. (2015) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 162

Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression

Liu, X., Reitsma, J. M., Mamrosh, J. L., Zhang, Y., Straube, R., & Deshaies, R. J. (2018) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 108

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Mosadeghi, R., Reichermeier, K. M., Winkler, M., Schreiber, A., Reitsma, J. M., Zhang, Y., Stengel, F., Cao, J., Kim, M., Sweredoski, M. J., et al. (2016) · eLife

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 95

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

Nguyen, T. V., Li, J., Lu, C.-C. (., Mamrosh, J. L., Lu, G., Cathers, B. E., & Deshaies, R. J. (2017) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 85

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

Reichermeier, K. M., Straube, R., Reitsma, J. M., Sweredoski, M. J., Rose, C. M., Moradian, A., den Besten, W., Hinkle, T., Verschueren, E., Petzold, G., et al. (2020) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 78