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Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma

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A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest

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GhRCD1 regulates cotton somatic embryogenesis by modulating the GhMYC3–GhMYB44–GhLBD18 transcriptional cascade

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Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis

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Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia

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The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia

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GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia

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Etiology of super-enhancer reprogramming and activation in cancer

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Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential

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Enhancer and super-enhancer landscape in polycystic kidney disease

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Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage

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Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis

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A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia

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EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors

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The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells

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The Incidence and Treatment Response of Double Expression of MYC and BCL2 in Patients with Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis

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An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long‐range loop formation

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Targeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions

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Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies

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Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc

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A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation

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Enhancer-mediated FOXO3 expression promotes MSC adipogenic differentiation by activating autophagy

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Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8

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Differential regulation of myc homologs by Wnt/β‐Catenin signaling in the early metazoan Hydra

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Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

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The Causes and Consequences of Spatial Organization of the Genome in Regulation of Gene Expression

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α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia

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Chromatin occupancy and target genes of the haematopoietic master transcription factor MYB

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PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

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Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation in leukemia stem cells

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Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy

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Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis

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In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target

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Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties

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Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function

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The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

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Controlling gene activation by enhancers through a drug-inducible topological insulator

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Three-dimensional regulatory hubs support oncogenic programs in glioblastoma

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Single-Cell Sequencing Reveals that DBI is the Key Gene and Potential Therapeutic Target in Quiescent Bladder Cancer Stem Cells

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An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions

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Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

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Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule

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The Genetic Architecture of Gliomagenesis–Genetic Risk Variants Linked to Specific Molecular Subtypes

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Cisinteractions in theIrf8locus regulate stage-dependent enhancer activationPreprint

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Single-cell response to Wnt signaling activation reveals uncoupling of Wnt target gene expression

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Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns

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The Interplay of Transcription and Genome Topology Programs T Cell Development and Differentiation

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Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation

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Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression

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Repurposing of Anticancer Stem Cell Drugs in Brain Tumors

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Building a Mammalian Retina: An Eye on Chromatin Structure

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Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis

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Deregulation of enhancer structure, function, and dynamics in acute lymphoblastic leukemia

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Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia

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Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

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Upregulation of SOX9 promotes the self‐renewal and tumorigenicity of cervical cancer through activating the Wnt/β‐catenin signaling pathway

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Deregulation of Transcriptional Enhancers in Cancer

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Genome-wide association study on 13 167 individuals identifies regulators of blood CD34+cell levels

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Knockdown of Histone Methyltransferase WHSC1 Induces Apoptosis and Inhibits Cell Proliferation and Tumorigenesis in Salivary Adenoid Cystic Carcinoma

Liu, C., Jiang, Y., Zhao, Z., Wu, H., Zhang, L., Yang, Z., Hoffman, R. M., & Zheng, J. (2019) · Anticancer Research · doi:10.21873/anticanres.13399 · Cited by 11

Transcriptional regulation of MYC through G-quadruplex structures

Balaratnam, S., & Schneekloth, J. S. (2020) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2020.05.002 · Cited by 12

Regulation of N6-Methyladenosine in the Differentiation of Cancer Stem Cells and Their Fate

Xu, Y. J., Liu, J., Chen, W.-J., Ye, Q., Chen, W., Li, C., & Wu, H.-T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.561703 · Cited by 11

Enhancer rewiring in tumors: an opportunity for therapeutic intervention

Richart, L., Bidard, F., & Margueron, R. (2021) · Oncogene · doi:10.1038/s41388-021-01793-7 · Cited by 12

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia

Pingul, B. Y., Huang, H., Chen, Q., Alikarami‬, F., Zhang, Z., Qi, J., Bernt, K. M., Berger, S. L., Cao, Z., & Shi, J. (2022) · iScience · doi:10.1016/j.isci.2022.105139 · Cited by 10

Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia

Wang, H., Sun, H., Liang, B., Zhang, F., Yang, F., Cui, B., Ding, L., Wang, X., Wang, R., Cai, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42565-z · Cited by 9

Oncogenic Enhancers in Leukemia

Mulet‐Lazaro, R., & Delwel, R. (2024) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0211 · Cited by 11

Targeting pivotal amino acids metabolism for treatment of leukemia

Hong, J., Liu, W., Xiao, X., Gajendran, B., & Ben‐David, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40492 · Cited by 10

Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Yashar, W. M., Curtiss, B. M., Coleman, D. J., VanCampen, J., Kong, G., Macaraeg, J., Estabrook, J., Demir, E., Long, N., Bottomly, D., et al. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-22-0745 · Cited by 10

The evolution of leukaemia from pre‐leukaemic and leukaemic stem cells

Shlush, L. I., & Feldman, T. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13236 · Cited by 10

Jiyuan oridonin A induces differentiation of acute myeloid leukemia cells including leukemic stem-like cells

Li, F., Gao, C., Li, X., Wang, J., Zhao, Y., Ke, Y., Liu, Y., Liu, H., Hu, Z., Wei, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1001552 · Cited by 10

Regulatory Landscapes of Nppa and Nppb

Sobreira, D. R., & Nóbrega, M. A. (2021) · Circulation Research · doi:10.1161/circresaha.120.318495 · Cited by 10

Functional genomic assays to annotate enhancer–promoter interactions genome wide

Leung, A. K.-Y., Li, Y., & Yu, H. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac204 · Cited by 9

Three‐Dimensional Chromosomal Landscape Revealing miR ‐146a Dysfunctional Enhancer in Lupus and Establishing a CRISPR‐Mediated Approach to Inhibit the Interferon Pathway

Zhu, X., Zhang, Y., Yin, Z., Ye, Z., Qin, Y., Cheng, Z., Shen, Y., Yin, Z., Ma, J., Tang, Y., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42703 · Cited by 10

From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis

Mulet‐Lazaro, R., & Delwel, R. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000969 · Cited by 11

Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers

Caragine, C. M., Le, V. T., Mustafa, M., Diaz, B. J., Morris, J. A., Müller, S., Méndez‐Mancilla, A., Geller, E. T., Liscovitch‐Brauer, N., & Sanjana, N. E. (2025) · Nature Communications · doi:10.1038/s41467-025-56568-5 · Cited by 9

Mammalian genome writing: Unlocking new length scales for genome engineering

Pinglay, S., Atwater, J. T., Brosh, R., Shendure, J., Maurano, M. T., & Boeke, J. D. (2026) · Cell · doi:10.1016/j.cell.2025.12.034 · Cited by 11

Super-Enhancers Dysregulations in Hematological Malignancies

Belloucif, Y., & Lobry, C. (2022) · Cells · doi:10.3390/cells11020196 · Cited by 10

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma

Wang, H., Liu, Z., Wang, J., Hu, F., Zhou, Q., Wei, L., Bao, Q., Liang, J., Liang, J., Liu, Z., et al. (2022) · Frontiers of Medicine · doi:10.1007/s11684-022-0919-0 · Cited by 9

Esearch3D: propagating gene expression in chromatin networks to illuminate active enhancers

Heer, M., Giudice, L., Mengoni, C., Giugno, R., & Rico, D. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad229 · Cited by 8

Immune-epigenetic crosstalk in haematological malignancies

Wong, H., & Sugimura, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1233383 · Cited by 8

Characteristics and Clinical Value of MYC, BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL

Zeng, Y.-P., Wei, R., Bao, L., Xue, T., Qin, Y., Ren, M., Bai, Q., Yao, Q., Yu, C., Chen, C., et al. (2024) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000002258 · Cited by 8

Selective Enhancer Dependencies in MYC -Intact and MYC -Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma

Iyer, A. R., Gurumurthy, A., Chu, A., Kodgule, R., Aguilar, A. R., Saari, T. W., Ramzan, A., Rosa, J., Gupta, J., Emmanuel, A., et al. (2025) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-24-0126 · Cited by 9

Transcriptional condensates encode a “golden mean” to optimize enhancer–promoter communication across genomic distances

Zhu, T., Li, C., & Chu, X. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2513371122 · Cited by 10

A super-enhancer maintains homeostatic expression of Regnase-1

Yang, R., Wu, Y., Ming, Y., Xu, Y., Wang, S., Shen, J., Wang, C., Chen, X., Wang, Y., Mao, R., et al. (2018) · Gene · doi:10.1016/j.gene.2018.05.052 · Cited by 8

A cluster of enhancer modules directs differential MYC expression along the normal and leukemic haematopoietic stem cell hierarchies

Bahr, C., von Palekse, L., Uslu, V. V., Remeseiro, S., Takayama, N., Ng, S. W. K., Murison, A., Langenfeld, K., Petretich, M., Scognamiglio, R., et al. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.06.329 · Cited by 1

A Novel Enhancer Region 1.7Mb Downstream of the C-Myc Gene Drives Its Expression in Hematopoietic Stem and Progenitor Cells

von Paleske, L., Uslu, V. V., Petretich, M., Spitz, F., & Trumpp, A. (2014) · Blood · doi:10.1182/blood.v124.21.766.766 · Cited by 3

Identification of a novel enhancer region 1.7 Mb downstream of the c-myc gene controlling its expression in hematopoietic stem and progenitor cells

von Paleske, L. (2015) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00018112

Super-Enhancers Dysregulations in Hematological Malignancies

Belloucif, Y., & Lobry, C. (2022) · Cells · doi:10.3390/cells11020196 · Cited by 10

Enhancers and MYC interplay in hematopoiesis

Benetatos, L., Benetatou, A., & Vartholomatos, G. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01891-1 · Cited by 8