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MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

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Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

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Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

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Super-enhancers in cancer

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Unraveling Hematopoiesis through the Lens of Genomics

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The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer

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Acute depletion of CTCF directly affects MYC regulation through loss of enhancer–promoter looping

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BET inhibition disrupts transcription but retains enhancer-promoter contact

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A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer

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HACER: an atlas of human active enhancers to interpret regulatory variants

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Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

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Nested epistasis enhancer networks for robust genome regulation

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Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

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Transcriptional Regulation by (Super)Enhancers: From Discovery to Mechanisms

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Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

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Structural variations in cancer and the 3D genome

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High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology

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Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

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Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets

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MYC function and regulation in physiological perspective

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CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

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Whole-genome sequencing of multiple myeloma reveals oncogenic pathways are targeted somatically through multiple mechanisms

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Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

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The role of 3D chromatin domains in gene regulation: a multi-facetted view on genome organization

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Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance

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Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases

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Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

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CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

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Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling

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The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

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A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2

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MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sitesPreprint

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ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

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Shaping faces: genetic and epigenetic control of craniofacial morphogenesis

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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

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Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism

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Implications of Enhancer Transcription and eRNAs in Cancer

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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

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Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

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Super-enhancers in transcriptional regulation and genome organization

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Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

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Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression

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Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

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Distinctive regulatory architectures of germline-active and somatic genes in C. elegansPreprint

Serizay, J., Dong, Y., Jänes, J., Chesney, M. A., Cerrato, C., & Ahringer, J. (2020) · Genome Research · doi:10.1101/gr.265934.120 · Cited by 56

A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing Tumors

Xu, Y., Yu, Q., Wang, P., Wu, Z., Zhang, L., Wu, S., Li, M., Wu, B., Li, H., Zhuang, H., et al. (2022) · Advanced Science · doi:10.1002/advs.202104344 · Cited by 55

HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes

Zhong, X., Prinz, A., Steger, J., García-Cuéllar, M.-P., Radsak, M. P., Bentaher, A., & Slany, R. K. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018025866 · Cited by 52

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Zhou, Y., Yan, X., Feng, X., Bu, J., Dong, Y., Lin, P., Hayashi, Y., Huang, R., Olsson, A., Andreassen, P. R., et al. (2018) · Haematologica · doi:10.3324/haematol.2018.187708 · Cited by 50

A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice

Mills, T., Kain, B. N., Burchill, M. A., Danis, E. P., Lucas, E. D., Culp‐Hill, R., Cowan, C. M., Schleicher, W. E., Patel, S. B., Tran, B. T., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.010 · Cited by 52

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects

Gambacorta, V., Gnani, D., Vago, L., & Micco, R. D. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00207 · Cited by 49

SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia

Chambers, C., Čermáková, K., Chan, Y. S., Kurtz, K. J., Wohlan, K., Lewis, A. H., Wang, C., Pham, A., Dejmek, M., Šála, M., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2129 · Cited by 52

KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer

Wu, Y., Chen, S., Shao, Y. W., Su, Y., Li, Q., Wu, J., Zhu, J., Wen, H., Huang, Y., Zheng, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202304638 · Cited by 52

Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response

Ishikawa, Y., Kitaoka, S., Kawano, Y., Ishii, S., Suzuki, T., Wakahashi, K., KATO, T., Katayama, Y., & Furuyashiki, T. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15203 · Cited by 50

Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell–like Properties in Osteosarcoma

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A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells

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Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

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CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

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EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene.

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Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus

Taylor, T., Sikorska, N., Shchuka, V. M., Chahar, S., Ji, C., Macpherson, N. N., Moorthy, S. D., de Kort, M. A. C., Mullany, S., Khader, N., et al. (2022) · Genes & Development · doi:10.1101/gad.349489.122 · Cited by 45

IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven Tumors

Andersson, M. K., Åman, P., & Stenman, G. (2019) · Cells · doi:10.3390/cells8080913 · Cited by 45

An Epigenetic Perspective on Intra-Tumour Heterogeneity: Novel Insights and New Challenges from Multiple Fields

Beyes, S., Bediaga, N. G., & Zippo, A. (2021) · Cancers · doi:10.3390/cancers13194969 · Cited by 44

EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2

Cui, S., Wu, Q., Liu, M., Su, M., Liu, S., Shao, L., Han, X., & He, H. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03538-6 · Cited by 42

Mapping the evolving landscape of super-enhancers during cell differentiation

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Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia

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MYC’s Fine Line Between B Cell Development and Malignancy

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Therapy resistance mechanisms in hematological malignancies

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