Cited by 870Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionPhotosynthetic Processes and Mechanisms

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Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde

Atsumi, Shota, Higashide, Wendy, Liao, James C·2009·Nature Biotechnology

DOI 10.1038/nbt.1586

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Abstract

Global climate change has stimulated efforts to reduce CO(2) emissions. One approach to addressing this problem is to recycle CO(2) directly into fuels or chemicals using photosynthesis. Here we genetically engineered Synechococcus elongatus PCC7942 to produce isobutyraldehyde and isobutanol directly from CO(2) and increased productivity by overexpression of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco). Isobutyraldehyde is a precursor for the synthesis of other chemicals, and isobutanol can be used as a gasoline substitute. The high vapor pressure of isobutyraldehyde allows in situ product recovery and reduces product toxicity. The engineered strain remained active for 8 d and produced isobutyraldehyde at a higher rate than those reported for ethanol, hydrogen or lipid production by cyanobacteria or algae. These results underscore the promise of direct bioconversion of CO(2) into fuels and chemicals, which bypasses the need for deconstruction of biomass.

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Authors: Atsumi, S., Higashide, W., & Liao, J. C.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Liao, James C
ORCID: Atsumi, Shota
Liao, James C
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2009-11-15
Volume: 27
Issue: 12
Pages: 1177-1180
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt.1586
OpenAlex: W2117741404
Cited by: 870
References: 36
Citations by year: 2026: 18 · 2025: 34 · 2024: 29 · 2023: 38 · 2022: 51 · 2021: 61 · 2020: 49 · 2019: 42 · 2018: 46 · 2017: 55 · 2016: 82 · 2015: 74 · 2014: 75 · 2013: 65 · 2012: 72
FWCI: 20.11
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords: CO2 recycling, isobutyraldehyde, isobutanol, Anacystis nidulans, cyanobacteria, photosynthetic carbon fixation, in situ product recovery, biofuels, bio-based chemicals
MeSH terms: Aldehydes, Carbon Dioxide, Conservation of Natural Resources, Light, Photosynthesis, Synechococcus, Biofuels

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Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde

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