The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Discovery and characterization of chromatin states for systematic annotation of the human genome
Open accessAbstract
A plethora of epigenetic modifications have been described in the human genome and shown to play diverse roles in gene regulation, cellular differentiation and the onset of disease. Although individual modifications have been linked to the activity levels of various genetic functional elements, their combinatorial patterns are still unresolved and their potential for systematic de novo genome annotation remains untapped. Here, we use a multivariate Hidden Markov Model to reveal 'chromatin states' in human T cells, based on recurrent and spatially coherent combinations of chromatin marks. We define 51 distinct chromatin states, including promoter-associated, transcription-associated, active intergenic, large-scale repressed and repeat-associated states. Each chromatin state shows specific enrichments in functional annotations, sequence motifs and specific experimentally observed characteristics, suggesting distinct biological roles. This approach provides a complementary functional annotation of the human genome that reveals the genome-wide locations of diverse classes of epigenetic function.
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Cites
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Self-citationEvolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
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Integrative analysis of 111 reference human epigenomes
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Self-citationMaster Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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Annotation of functional variation in personal genomes using RegulomeDB
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Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898
Self-citationChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
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Metadata
- Authors
- Ernst, J., & Kellis, M.
- Venue
- Nature Biotechnology
- Published
- 2010-07-25
- Volume
- 28
- Issue
- 8
- Pages
- 817-825
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2044826047
- Cited by
- 1,056
- References
- 19
- FWCI
- 32.49
- Type
- journal article
- Language
- en
- Open access
- green
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