The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice
Open accessAbstract
Primary nociceptors are the first neurons involved in the complex processing system that regulates normal and pathological pain. Because of constraints on pharmacological and electrical stimulation, noninvasive excitation and inhibition of these neurons in freely moving nontransgenic animals has not been possible. Here we use an optogenetic strategy to bidirectionally control nociceptors of nontransgenic mice. Intrasciatic nerve injection of adeno-associated viruses encoding an excitatory opsin enabled light-inducible stimulation of acute pain, place aversion and optogenetically mediated reductions in withdrawal thresholds to mechanical and thermal stimuli. In contrast, viral delivery of an inhibitory opsin enabled light-inducible inhibition of acute pain perception, and reversed mechanical allodynia and thermal hyperalgesia in a model of neuropathic pain. Light was delivered transdermally, allowing these behaviors to be induced in freely moving animals. This approach may have utility in basic and translational pain research, and enable rapid drug screening and testing of newly engineered opsins.
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Cites
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Self-citationThe development and application of optogenetics
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Self-citationOptical control of mammalian endogenous transcription and epigenetic states
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Self-citationRemote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice
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Optogenetic Control of Targeted Peripheral Axons in Freely Moving Animals
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Cited by
Chan, K. Y., Jang, M. J., Yoo, B. B., Greenbaum, A., Ravi, N., Wu, W.-L., Sánchez-Guardado, L., Lois, C., Mazmanian, S. K., Deverman, B. E., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4593 · Cited by 1,578
Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics
Park, S. I., Brenner, D. S., Shin, G., Morgan, C. D., Copits, B. A., Chung, H. U., Pullen, M. Y., Noh, K. N., Davidson, S., Oh, S. J., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3415 · Cited by 794
Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility
Spencer, N. J., & Hu, H. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0271-2 · Cited by 593
Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice
Montgomery, K. L., Yeh, A. J., Ho, J. S., Tsao, V., Mohan Iyer, S., Grosenick, L., Ferenczi, E. A., Tanabe, Y., Deisseroth, K., Delp, S. L., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3536 · Cited by 565
Self-citationA wireless closed-loop system for optogenetic peripheral neuromodulation
Mickle, A. D., Won, S. M., Noh, K. N., Yoon, J., Meacham, K. W., Xue, Y., McIlvried, L. A., Copits, B. A., Samineni, V. K., Crawford, K. E., et al. (2019) · Nature · doi:10.1038/s41586-018-0823-6 · Cited by 514
Metadata
- Authors
- Iyer, S. M., Montgomery, K. L., Towne, C., Lee, S. Y., Ramakrishnan, C., Deisseroth, K., & Delp, S. L.
- Venue
- Nature Biotechnology
- Published
- 2014-02-16
- Volume
- 32
- Issue
- 3
- Pages
- 274-278
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2025645467
- Cited by
- 218
- References
- 10
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- green
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