Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice
Open accessAbstract
To enable sophisticated optogenetic manipulation of neural circuits throughout the nervous system with limited disruption of animal behavior, light-delivery systems beyond fiber optic tethering and large, head-mounted wireless receivers are desirable. We report the development of an easy-to-construct, implantable wireless optogenetic device. Our smallest version (20 mg, 10 mm3) is two orders of magnitude smaller than previously reported wireless optogenetic systems, allowing the entire device to be implanted subcutaneously. With a radio-frequency (RF) power source and controller, this implant produces sufficient light power for optogenetic stimulation with minimal tissue heating (<1 °C). We show how three adaptations of the implant allow for untethered optogenetic control throughout the nervous system (brain, spinal cord and peripheral nerve endings) of behaving mice. This technology opens the door for optogenetic experiments in which animals are able to behave naturally with optogenetic manipulation of both central and peripheral targets.
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Optical stimulators for the spinal cord are generally flexible enough to be wraparound or wire-like.
“Thus, optical stimulators for spinal cord are generally flexible enough to be wraparound or wire-like.[556,569–571]”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [571]
The Online Methods (Implant construction; page unavailable) describe the spinal stimulator as an LED attached directly to the bottom of a circuit board; the wire extension belongs to the brain and peripheral implants. The Surgical procedures section says the spinal implant was cemented over a hole in the vertebra, rather than wrapped around the cord or implanted as a flexible wire. (LLM, conf=0.80)
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- Authors
- Montgomery, K. L., Yeh, A. J., Ho, J. S., Tsao, V., Mohan Iyer, S., Grosenick, L., Ferenczi, E. A., Tanabe, Y., Deisseroth, K., Delp, S. L., & Poon, A. S. Y.
- Affiliations
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Poon, Ada S Y
- ORCID
- Venue
- Nature Methods
- Published
- 2015-08-17
- Volume
- 12
- Issue
- 10
- Pages
- 969-974
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- PMC
- PMC5507210
- OpenAlex
- W2206596356
- Semantic Scholar
- bd7b6156eea51d9cf08366466843ad8bbfdde59e
- Cited by
- 565
- References
- 34
- Citations by year
- 2026: 31 · 2025: 34 · 2024: 29 · 2023: 52 · 2022: 51 · 2021: 58 · 2020: 60 · 2019: 74 · 2018: 54 · 2017: 65 · 2016: 52 · 2015: 4
- FWCI
- 24.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS080954)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Wireless Power Transfer Systems
- Keywords
- brain circuits, spinal cord circuits, peripheral nerve stimulation, subcutaneous implants, tissue heating, behaving mice
- MeSH terms
- Animals, Brain, Equipment Design, Female, Light, Mice, Inbred C57BL, Mice, Transgenic, Miniaturization, Motor Cortex, Nociceptors, Peripheral Nerves, Spinal Cord, Temperature, Implants, Experimental, Wireless Technology, Optogenetics
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