GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions
Open accessAbstract
There are numerous cell types with scarcely understood functions, whose interactions with the immune system are not well characterized. To facilitate their study, we generated a mouse bearing enhanced green fluorescent protein (EGFP)-specific CD8+ T cells. Transfer of the T cells into EGFP reporter animals can be used to kill EGFP-expressing cells, allowing selective depletion of desired cell types, or to interrogate T-cell interactions with specific populations. Using this system, we eliminate a rare EGFP-expressing cell type in the heart and demonstrate its role in cardiac function. We also show that naive T cells are recruited into the mouse brain by antigen-expressing microglia, providing evidence of an immune surveillance pathway in the central nervous system. The just EGFP death-inducing (Jedi) T cells enable visualization of a T-cell antigen. They also make it possible to utilize hundreds of existing EGFP-expressing mice, tumors, pathogens and other tools, to study T-cell interactions with many different cell types, to model disease states and to determine the functions of poorly characterized cell populations.
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Jedi T cells express a T cell receptor that recognizes the immunodominant epitope of GFP loaded in the H-2Kd allele of MHC-I.
“we took advantage of just eGFP death inducing (Jedi) T cells, which express a T cell receptor that recognizes the immunodominant epitope of GFP loaded in the H-2Kd allele of MHC-I (Agudo et al., 2015).”
From Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens (2018) · cites this paper as Agudo et al., 2015
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Atomistic TCR-ligand interactions instruct memory T-cell differentiation 2330211
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Atomistic TCR-pMHC interactions bias CD8 memory fate within a single antigen-specific repertoire
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Elevated Intraocular Pressure Facilitates T-Cell–Mediated Retinal Ganglion Cell Loss
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- Authors
- Agudo, J., Ruzo, A., Park, E. S., Sweeney, R., Kana, V., Wu, M., Zhao, Y., Egli, D., Merad, M., & Brown, B. D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- New York Stem Cell Foundation (US)
- Tisch Cancer Institute (US)
- Corresponding author
- Brown, Brian D
- Venue
- Nature Biotechnology
- Published
- 2015-11-02
- Volume
- 33
- Issue
- 12
- Pages
- 1287-1292
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- PMC
- PMC4675673
- OpenAlex
- W1963130477
- Cited by
- 64
- References
- 31
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K02HL103597, R01HL107376)
- National Cancer Institute (R01CA173861, R01CA190400, P30CA196521)
- National Institute of Allergy and Infectious Diseases (R01AI104848, R01AI113221)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK026687)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- T cell interactions, naive T cells, microglia, central nervous system, cardiac function, T cell transfer
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