Cited by 245Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Quiescent tissue stem cells evade immune surveillance

Open access
Agudo, Judith, Park, Eun Sook, Rose, Samuel A., Alibo, Eziwoma, Sweeney, Robert, Dhainaut, Maxime, Kobayashi, Koichi S., Sachidanandam, Ravi +3 more·2018·Immunity

Abstract

Stem cells are critical for the maintenance of many tissues, but whether their integrity is maintained in the face of immunity is unclear. Here we found that cycling epithelial stem cells, including Lgr5+ intestinal stem cells, as well as ovary and mammary stem cells, were eliminated by activated T cells, but quiescent stem cells in the hair follicle and muscle were resistant to T cell killing. Immune evasion was an intrinsic property of the quiescent stem cells resulting from systemic downregulation of the antigen presentation machinery, including MHC class I and TAP proteins, and is mediated by the transactivator NLRC5. This process was reversed upon stem cell entry into the cell cycle. These studies identify a link between stem cell quiescence, antigen presentation, and immune evasion. As cancer-initiating cells can derive from stem cells, these findings may help explain how the earliest cancer cells evade immune surveillance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2018.02.001

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Agudo, J., Park, E. S., Rose, S. A., Alibo, E., Sweeney, R., Dhainaut, M., Kobayashi, K. S., Sachidanandam, R., Baccarini, A., Merad, M., & Brown, B. D.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Hokkaido University (JP)
  • Tisch Cancer Institute (US)
Corresponding author
Brown, Brian D.
Venue
Immunity
Publisher
Elsevier BV
Published
2018-02
Volume
48
Issue
2
Pages
271-285.e5
ISSN
1074-7613 (ISSN-L)
OpenAlex
W2788425782
Cited by
244
References
59
Citations by year
2026: 18 · 2025: 35 · 2024: 32 · 2023: 30 · 2022: 31 · 2021: 30 · 2020: 30 · 2019: 26 · 2018: 12
FWCI
10.53
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (R01AI104848, R01AI113221, R21OD020185, R01DK106593)
  • Robin Chemers Neustein Award
  • Juvenile Diabetes Research Foundation (JDRF) (3-2013-92)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
quiescent stem cells, immune evasion, antigen presentation, MHC class I, TAP, NLRC5, T cell-mediated killing, epithelial stem cells, intestinal stem cells, Lgr5, hair follicle stem cells, muscle stem cells, mammary stem cells, stem cell quiescence, tumor surveillance, cancer stem cells
MeSH terms
Animals, Immunologic Surveillance, Killer Cells, Natural, Mice, Inbred C57BL, Muscles, Stem Cells, Antigen Presentation, Hair Follicle, Tumor Escape, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Mice, Immune Evasion

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review