Cited by 812CRISPR and Genetic EngineeringRNA regulation and diseasePlant Genetic and Mutation Studies

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Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

Shimatani, Zenpei, Kashojiya, Sachiko, Takayama, Mariko, Terada, Rie, Arazoe, Takayuki, Ishii, Hisaki, Teramura, Hiroshi, Yamamoto, Tsuyoshi, Komatsu, Hiroki, Miura, Kenji, Ezura, Hiroshi, Nishida, Keiji, Ariizumi, Tohru, Kondo, Akihiko·2017·Nature Biotechnology

DOI 10.1038/nbt.3833

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Abstract

We applied a fusion of CRISPR-Cas9 and activation-induced cytidine deaminase (Target-AID) for point mutagenesis at genomic regions specified by single guide RNAs (sgRNAs) in two crop plants. In rice, we induced multiple herbicide-resistance point mutations by multiplexed editing using herbicide selection, while in tomato we generated marker-free plants with homozygous heritable DNA substitutions, demonstrating the feasibility of base editing for crop improvement.

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Authors: Shimatani, Z., Kashojiya, S., Takayama, M., Terada, R., Arazoe, T., Ishii, H., Teramura, H., Yamamoto, T., Komatsu, H., Miura, K., Ezura, H., Nishida, K., Ariizumi, T., & Kondo, A.
Affiliations: Kobe University (JP)
University of Tsukuba (JP)
Meijo University (JP)
Corresponding author: Ezura, Hiroshi
Nishida, Keiji
Ariizumi, Tohru
ORCID: Shimatani, Zenpei
Takayama, Mariko
Arazoe, Takayuki
Yamamoto, Tsuyoshi
Miura, Kenji
Ezura, Hiroshi
Nishida, Keiji
Ariizumi, Tohru
Kondo, Akihiko
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2017-03-27
Volume: 35
Issue: 5
Pages: 441-443
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt.3833
OpenAlex: W2598674316
Cited by: 812
References: 17
Citations by year: 2026: 43 · 2025: 71 · 2024: 82 · 2023: 83 · 2022: 117 · 2021: 113 · 2020: 107 · 2019: 97 · 2018: 62 · 2017: 37
FWCI: 33.83
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (15K18647, 16K14654, 16K07560)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
Keywords: base editing, CRISPR/Cas9, rice, tomato, point mutagenesis, herbicide resistance, single guide RNA, crop improvement
MeSH terms: Gene Editing, Cytidine Deaminase, Recombinant Fusion Proteins, Oryza, Mutagenesis, Site-Directed, Genes, Plant, Point Mutation, Solanum lycopersicum, DNA, Plant, Base Pairing, Plants, Genetically Modified, Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-Associated Proteins

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Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

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