Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

Cited by (326)

Items 101–200 of 326

  1. Metabolic reprogramming: a bridge between aging and tumorigenesis
    Drapela, Stanislav, Ilter, Didem, Gomes, Ana P. · 2022 · Molecular Oncology
  2. Manipulating T-cell metabolism to enhance immunotherapy in solid tumor
    Chen Chen, Zehua Wang, Yi Ding, Yanru Qin · 2022 · Frontiers in Immunology
  3. Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
    Hemaasri-Neya Girithar, Ananda Staats Pires, Seong Beom Ahn, Gilles J. Guillemin, Laurence Gluch, Benjamin Heng · 2023 · British Journal of Cancer
  4. Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination
    Zhaokai Zhou, Yumiao Mai, Ge Zhang, Yingjie Wang, Pan Sun, Zhaohe Jing, Zhengrui Li, Yudi Xu, Bo Ram Han, Jian Liu · 2024 · Cancer Letters
  5. Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment
    Racheal Louise Johnson, Michele Cummings, Amudha Thangavelu, Georgios Theophilou, Diederick De Jong, Nicolas Michel Orsi · 2021 · Cancers
  6. Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolism
    Quanjun Yang, Juan Hao, Mengyi Chi, Yaxian Wang, Bo Xin, Jinglu Huang, Jin Lu, Jie Li, Xipeng Sun, Chunyan Li et al. · 2022 · OncoImmunology
  7. Metabolic advantages of regulatory T cells dictated by cancer cells
    Masaki Kondo, Shogo Kumagai, Hiroyoshi Nishikawa · 2023 · International Immunology
  8. Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy
    Zhiren Wang, Wenpan Li, Yanhao Jiang, Tuyen Ba Tran, Leyla Estrella Cordova, Jinha Chung, Minhyeok Kim, Georg T. Wondrak, Jennifer Erdrich, Jianqin Lu · 2023 · Nature Communications
  9. Charge convertible biomimetic micellar nanoparticles for enhanced melanoma-targeted therapy through tumor cells and tumor-associated macrophages dual chemotherapy with IDO immunotherapy
    Kaipei Luo, Yunfei Lian, Min Zhang, Hua Yu, Guangji Wang, Juan Li · 2021 · Chemical Engineering Journal
  10. Targeting allosteric regulation of cancer metabolism
    Daniel M. Kremer, Costas Andreas Lyssiotis · 2022 · Nature Chemical Biology
  11. Enzyme Mimicking Based on the Natural Melanin Particles from Human Hair
    Sheng Hong, Qiuling Zhang, Diwei Zheng, Cheng Zhang, Yu Zhang, Jing‐Jie Ye, Han Lei Cheng, Xian‐Zheng Zhang · 2019 · iScience
  12. The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer
    Ricardo A. Léon-Letelier, Rongzhang Dou, Jody V. Vykoukal, Ali Hussein Abdel Sater, Edwin Justin Ostrin, Samir Hanash, Johannes Francois Fahrmann · 2023 · Frontiers in Oncology
  13. The Aryl Hydrocarbon Receptor: Impact on the Tumor Immune Microenvironment and Modulation as a Potential Therapy
    Brian D. Griffith, Timothy L. Frankel · 2024 · Cancers
  14. Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment
    Pengfei Zhao, Yuqi Chen, Shuyu Zhou, Fei Li · 2025 · Pharmacological Research
  15. Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality
    Jeremy P. Gygi, Cole P. Maguire, Ravi K. Patel, Pramod S. Shinde, Anna Konstorum, Casey P. Shannon, Leqi Xu, Annmarie Hoch, Naresh Doni Jayavelu, Impacc Network et al. · 2024 · Journal of Clinical Investigation
  16. Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming
    Xuan Han, Yu Zhu, Juan Ke, Yufeng Zhai, Min Huang, Xin Zhang, Hongjie He, Xiao‐Jing Zhang, Xuehong Zhao, Kaikai Guo et al. · 2024 · Cell Death Discovery
  17. Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ
    Takumi Kudo, Mirja Tamara Prentzell, Soumya R. Mohapatra, Felix Sahm, Zhongliang Zhao, Ingrid Grummt, Wolfgang Wick, Christiane A. Opitz, Michael Platten, Edward W. Green · 2020 · Frontiers in Immunology
  18. Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies
    Huijie Han, Hélder A. Santos · 2024 · Advanced Materials
  19. Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
    Johannes Francois Fahrmann, Jody V. Vykoukal, Edwin Justin Ostrin · 2020 · Frontiers in Oncology
  20. The immunotherapeutic role of indoleamine 2,3‐dioxygenase in head and neck squamous cell carcinoma: A systematic review
    Daniel J. Lin, James Chean Khun Ng, Lei Huang, Max Robinson, James O’Hara, Janet Ann Wilson, Andrew L. Mellor · 2021 · Clinical Otolaryngology
  21. CAR-T therapy and targeted treatments: Emerging combination strategies in solid tumors
    Jiahao Liu, Xiaofei Jiao, Ding Ma, Yong Fang, Qinglei Gao · 2024 · Med
  22. Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity
    Huan Liu, Wenyong Yang, Jingwen Jiang · 2024 · Journal of Pharmaceutical Analysis
  23. IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment
    Zhaorong Wu, Hongye Wang, Zhigang Zheng, Yan Lin, Linke Bian, Haigang Geng, Xiaorong Huang, Jiufei Zhu, Hongshu Jing, Yi Zhang et al. · 2025 · Journal of Translational Medicine
  24. Reversing Immunosuppression in Hypoxic and Immune‐Cold Tumors with Ultrathin Oxygen Self‐Supplementing Polymer Nanosheets under Near Infrared Light Irradiation
    Wei Jiang, Lei Wang, Qin Wang, Han Zhou, Yinchu Ma, Wang Xu Dong, Hangxun Xu, Yucai Wang · 2021 · Advanced Functional Materials
  25. Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance
    Javier Traba, Michael N. Sack, Thomas A. Waldmann, Olga M. Antón · 2021 · Frontiers in Immunology
  26. Semiconducting Polymer Nanoparticles as Activatable Nanomedicines for Combinational Phototherapy
    Mengke Xu, Chi Zhang, Ziling Zeng, Kanyi Pu · 2021 · ACS Applied Polymer Materials
  27. Self‐Splittable Transcytosis Nanoraspberry for NIR‐II Photo‐Immunometabolic Cancer Therapy in Deep Tumor Tissue
    Li Wang, Wei Jiang, Yanhong Su, Meixiao Zhan, Shaojun Peng, Hang Liu, Ligong Lu · 2022 · Advanced Science
  28. Activating Nanomedicines with Electromagnetic Energy for Deep‐Tissue Induction of Immunogenic Cell Death in Cancer Immunotherapy
    Fengshuo Wang, Kanyi Pu, Jingchao Li · 2022 · Small Methods
  29. The relationship between tryptophan metabolism and gut microbiota: Interaction mechanism and potential effects in infection treatment
    Tongchao Pei, Wenweiran Li, Ziyang Zhou, Qinyu Zhang, Guohong Yu, Sokun Yin, Hui Chen, Jianguo Tang · 2025 · Microbiological Research
  30. Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors
    Quoc D. Mac, Anirudh Sivakumar, Hathaichanok Phuengkham, Congmin Xu, James R. Bowen, Fang‐Yi Su, Samuel Z. Stentz, Hyoungjun Sim, Adrian M. Harris, Tonia T. Li et al. · 2022 · Nature Biomedical Engineering
  31. Metabolic guidance and stress in tumors modulate antigen-presenting cells
    Jaeoh Park, Limei Wang, Ping‐Chih Ho · 2022 · Oncogenesis
  32. Indoleamine 2,3-dioxygenase 1 in circumventing checkpoint inhibitor responses: Updated
    Arian Charehjoo, Jamal Majidpoor, Keywan Mortezaee · 2023 · International Immunopharmacology
  33. Targeting amino acid-metabolizing enzymes for cancer immunotherapy
    Yvonne Grobben · 2024 · Frontiers in Immunology
  34. Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation
    Junya Ning, Yingnan Ye, Hongru Shen, Runjiao Zhang, Huikai Li, Tianqiang Song, Rui Zhang, Pengpeng Liu, Guidong Chen, Hailong Wang et al. · 2024 · Cell Reports Medicine
  35. Amino acid metabolism in breast cancer: pathogenic drivers and therapeutic opportunities
    Yawen Liu, Xiangyun Zong, Patricia Altea‐Manzano, Jie Fu · 2025 · Protein & Cell
  36. Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma
    Jingwen Shao, Lin Hou, Jinyan Liu, Yulin Liu, Jie Ning, Qitai Zhao, Yi Zhang · 2021 · Frontiers in Immunology
  37. Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols
    Oren Barboy, Akhiad Bercovich, Hanjie Li, Yaniv Eyal-Lubling, Adam Yalin, Yuval Shapir Itai, Kathleen Abadie, Mor Zada, Eyal David, Shir Shlomi-Loubaton et al. · 2024 · Nature Cancer
  38. Remodeling metabolic fitness: Strategies for improving the efficacy of chimeric antigen receptor T cell therapy
    Luyan Shen, Yefei Xiao, Jiahe Tian, Zheming Lu · 2022 · Cancer Letters
  39. Tumor Microenvironment‐Responsive Nanoparticles Enhance IDO1 Blockade Immunotherapy by Remodeling Metabolic Immunosuppression
    Mengna Wang, Yuhong Liu, Yanshi Li, Tao Lü, Min Wang, Zhaobo Cheng, Lin Chen, Tongling Wen, Min Pan, Guohua Hu · 2024 · Advanced Science
  40. Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy
    Małgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Klaudyna Fidyt, Agata Braniewska, Zuzanna Sas, Iwona Kotuła, Tomasz P. Rygiel, Louis Boon, Jakub Gołąb et al. · 2020 · Cancer Immunology Immunotherapy
  41. Electric Pulse Responsive Magnetic Nanoclusters Loaded with Indoleamine 2,3-Dioxygenase Inhibitor for Synergistic Immuno-Ablation Cancer Therapy
    Bo Yu, Wentao Zhang, Kijung Kwak, Hyunjun Choi, Dong‐Hyun Kim · 2020 · ACS Applied Materials & Interfaces
  42. Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker
    Skaidre Jankovskaja, Johan Engblom, Melinda Rezeli, György Marko‐Varga, Tautgirdas A Ruzgas, Sebastian Björklund · 2021 · Scientific Reports
  43. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase
    Jiangxin Liu, Jian Xing Ren, Kun Yang, Shuang Chen, Xinni Yang, Qin‐Shi Zhao · 2022 · European Journal of Medicinal Chemistry
  44. Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy
    Anna C. Beielstein, Christian Philipp Pallasch · 2019 · International Journal of Molecular Sciences
  45. Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma
    Ali Mehdi, Mikhaël Attias, Niaz Mahmood, Ani Arakelian, Catalin Liviu Dragos Mihalcioiu, Ciriaco A. Piccirillo, Moshe Szyf, Shafaat Ahmed Rabbani · 2020 · Frontiers in Oncology
  46. Gastric Cancer Cell-Derived Kynurenines Hyperactive Regulatory T Cells to Promote Chemoresistance via the IL-10/STAT3/BCL2 Signaling Pathway
    Dandan Wu, Zhongli Wang · 2022 · DNA and Cell Biology
  47. Cladosporium protease/doxorubicin decorated Fe3O4@SiO2 nanocomposite: An efficient nanoparticle for drug delivery and combating breast cancer
    Leila Vahabi, Parviz Rashidi Ranjbar, Fatemeh Davar · 2022 · Journal of Drug Delivery Science and Technology
  48. IDO1 and inflammatory neovascularization: bringing new blood to tumor-promoting inflammation
    Alexander J. Muller, Arpita Mondal, Souvik Dey, George C. Prendergast · 2023 · Frontiers in Oncology
  49. Data-driven engineering of protein therapeutics
    Matthew S. Faber, Timothy A. Whitehead · 2019 · Current Opinion in Biotechnology
  50. Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
    Joyce Yongxu Huang, Tricia L. Larose, Hung Nguyen Luu, Renwei Wang, Anouar Fanidi, Karine Alcala, Victoria L. Stevens, Stephanie J. Weinstein, Demetrius Albanes, Neil E. Caporaso et al. · 2019 · International Journal of Cancer
  51. Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy
    Qiongjie Hu, Yueli Shi, Huang Wang, Bing Li, Zhiyong Xu · 2025 · Experimental Hematology and Oncology
  52. From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
    Masaru Tanaka, László Vécsei · 2025 · Biomedicines
  53. Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
    Ricardo A. Léon-Letelier, Ali Hussein Abdel Sater, Yihui Chen, Soyoung Park, Ranran Wu, Ehsan Irajizad, Jennifer B. Dennison, Hiroyuki Katayama, Jody V. Vykoukal, Samir Hanash et al. · 2023 · Cancers
  54. Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy
    Rui M. L. Coelho, Reno Debets, Dora Hammerl · 2025 · Molecular Cancer
  55. Metabolic and Immunological Subtypes of Esophageal Cancer Reveal Potential Therapeutic Opportunities
    Ryan J. King, Fang Qiu, Fang Yu, Pankaj K. Singh · 2021 · Frontiers in Cell and Developmental Biology
  56. Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD
    Joshua Walker, Sean Richards, Stephen A. Whelan, Sung Bok Yoo, Teresa Lynn Russell, Nkiruka V. Arinze, Saran Lotfollahzadeh, Marc Arthur Napoleon, Mostafa Belghasem, Norman Lee et al. · 2021 · Journal of the American Society of Nephrology
  57. Self‐Delivering Nanodrugs Developed via Small‐Molecule‐Directed Assembly and Macrophage Cloaking for Sonodynamic‐Augmented Immunotherapy
    Fang Xie, Zongjunlin Liu, Peiyuan Wang, Meimei Cai, Yang Li, Jianghua Yan, Qin Lin, Fanghong Luo · 2022 · Advanced Healthcare Materials
  58. Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
    Saeko Yoshioka, Tomonori Ikeda, Sogo Fukuchi, Yurika Kawai, Katsumi Ohta, Hisashi Murakami, Naohisa Ogo, Daisuke Muraoka, Osamu Takikawa, Akira Asai · 2022 · International Journal of Tryptophan Research
  59. Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system
    Junfei Xia, Ang‐Chen Tsai, Wenhao Cheng, Xuegang Yuan, Teng Ma, Jingjiao Guan · 2019 · Biomaterials Science
  60. Targeting metabolism to improve CAR-T cells therapeutic efficacy
    Shasha Liu, Yuyu Zhao, Yaoxin Gao, Feng Li, Yi Zhang · 2024 · Chinese Medical Journal
  61. Nanocarriers for Delivery of Anticancer Drugs: Current Developments, Challenges, and Perspectives
    Umme Hani, Vikram T. Choudhary, Mohammed Ghazwani, Yahia Alghazwani, Riyaz Ali M. Osmani, Gururaj S Kulkarni, Hosakote Gurumallappa Shivakumar, Shahid Ud Din Wani, Sathishbabu Paranthaman · 2024 · Pharmaceutics
  62. A Highlight of the Mechanisms of Immune Checkpoint Blocker Resistance
    Qian Huang, Yanna Lei, Xiaoying Li, Fukun Guo, Ming Liu · 2020 · Frontiers in Cell and Developmental Biology
  63. EGFR Inhibition Strongly Modulates the Tumour Immune Microenvironment in EGFR-Driven Non-Small-Cell Lung Cancer
    Carolin Selenz, Anik Compes, Marieke Nill, Sven Borchmann, Margarete Odenthal, Alexandra Florin, Johannes Brägelmann, Reinhard Büttner, Lydia Meder, Roland Tillmann Ullrich · 2022 · Cancers
  64. ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway
    Mingyuan Wang, Taoli Wang, Jinjin Wang, Yuexin Yang, Xi Li, Huan Chen, Jingnan Liao · 2024 · Cell Death and Disease
  65. Non-invasive monitoring of low molecular weight biomarkers relevant to skin inflammation and cancer
    Skaidre Jankovskaja · 2021
  66. Inhibiting CXCR4 reduces immunosuppressive effects of myeloid cells in breast cancer immunotherapy
    Nicholas G. Ciavattone, Avinash S. Bevoor, Alex P. Farfel, Aasia O. Rehman, Kenneth K. Y. Ho, Edwin C. Rock, Yu‐Chih Chen, Kathryn E. Luker, Brock A. Humphries, Gary D. Luker · 2025 · Scientific Reports
  67. Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer
    Y. Liu, Zhengyu Liu, Yating Hu, Yunyan Ling, Shunjie Qing, Yang Liu, Yizhi Zhan, Zhiyong Shen, Yuan Fang, Haijun Deng · 2025 · Nature Communications
  68. Advanced Strategies of Enzyme Activity Regulation for Biomedical Applications
    Zihan Chen, Yu Zhao, Yang Liu · 2022 · ChemBioChem
  69. Amino Acid Metabolism-Regulated Nanomedicine for Enhanced Tumor Immunotherapy through Synergistic Regulation of Immune Microenvironment
    Xiuying Duan, Yilei Zhao, Houyang Hu, Xuechun Wang, Jie Yan, Songyan Li, Yueying Zhang, Jianwei Jiao, Guiqiang Zhang · 2024 · Biomaterials Research
  70. Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation
    Christoph Steeneck, Olaf D. Kinzel, Simon J. Anderhub, Martin Hornberger, Sheena Pinto, Barbara Morschhaeuser, Floriane C. M. Braun, Gerald Kleymann, Thomas Karl Hoffmann · 2020 · ACS Medicinal Chemistry Letters
  71. Advances in immune therapies for the treatment of microsatellite instability‑high/deficient mismatch repair metastatic colorectal cancer (Review)
    Khalil Choucair, Maluki Radford, Ajay Kr Bansal, Robin Park, Anwaar Saeed · 2021 · International Journal of Oncology
  72. Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment
    Parviz Azimnasab-sorkhabi, Maryam Soltani-asl, Túlio Teruo Yoshinaga, M.L. Dagli, Cristina de Oliveira Massoco, José Roberto Kfoury · 2023 · Molecular Biology Reports
  73. Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells
    Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam V. Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Matthew J. Dorman, Subhash C. Sinha, Kent F. Hoskins, Gregory R. J. Thatcher et al. · 2020 · Journal for ImmunoTherapy of Cancer
  74. Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme
    John Blazeck, Christos S. Karamitros, Kyle M. Ford, Catrina M. Somody, Ahlam N. Qerqez, Kyle Murray, Nathaniel T. Burkholder, Nicholas Marshall, Anirudh Sivakumar, Weicheng Lu et al. · 2022 · Nature Catalysis
  75. Effect of metabolism on the immune microenvironment of breast cancer
    Yingming Zhou, Hu Wang, Yi Luo, Biguang Tuo, Xuemei Liu, Taolang Li · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  76. Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
    Julien Champagne, Morten Milek Nielsen, Xiaodong Feng, Jasmine Montenegro Navarro, Abhijeet Pataskar, Rhianne Voogd, Lisanne Giebel, Remco Nagel, Nadine Berenst, Amos Fumagalli et al. · 2025 · Immunity
  77. Liquid metal-based nanocomposite with triple-amplified Fenton-like reaction for tumor chemodynamic/photothermal/immunotherapy
    Shuai Wang, Yang Zou, Li Zhang, Yonggang Lv · 2025 · Chemical Engineering Journal
  78. IDO family: the metabolic crossroads connecting immunity, nerves and tumors
    Xijie Wang, Zhe Chen, Linxi Chen, Chengfeng Qiu · 2026 · Journal of Translational Medicine
  79. Metabolic rewiring directs melanoma immunology
    Ningyue Sun, Yangzi Tian, Yuhan Chen, Weinan Guo, Chunying Li · 2022 · Frontiers in Immunology
  80. Unveiling tumor immune evasion mechanisms: abnormal expression of transporters on immune cells in the tumor microenvironment
    Lu Chen, Yuchen Wang, Qingqing Hu, Yuxi Liu, Xuchen Qi, Zhihua Tang, Haihong Hu, Nengming Lin, Su Zeng, Lushan Yu · 2023 · Frontiers in Immunology
  81. Immunometabolism: a new dimension in immunotherapy resistance
    Chaoyue Xiao, Wei Xiong, Yiting Xu, Jian Peng Zou, Yue Zeng, Junqi Liu, Yurong Peng, Chunhong Hu, Fang Wu · 2023 · Frontiers of Medicine
  82. Drug resistance mechanism and reversal strategy in lung cancer immunotherapy
    Yishi Xu, Yaqing Liu, Yi Ge, Haozhe Li, Yi Zhang, Liping Wang · 2023 · Frontiers in Pharmacology
  83. Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy
    Chen Chen, Peng Han, Yanping Qing · 2024 · Autoimmunity Reviews
  84. The role of metabolic reprogramming in immune escape of triple-negative breast cancer
    Ruochen Bao, Hongtao Qu, Baifeng Li, Kai Cheng, Yandong Miao, Jiangtao Wang · 2024 · Frontiers in Immunology
  85. Single enzyme nanoparticle, an effective tool for enzyme replacement therapy
    Dong Hyun Kim, Han Sol Lee, Tae-Wan Kwon, Young-Min Han, Nae-Won Kang, Mee Yeon Lee, Dae‐Duk Kim, Myeong Gyu Kim, Jae‐Young Lee · 2020 · Archives of Pharmacal Research
  86. Genomic and Immunologic Correlates of Indoleamine 2,3-Dioxygenase Pathway Expression in Cancer
    Anshuman Panda, Shridar Ganesan · 2021 · Frontiers in Genetics
  87. Epacadostat Overcomes Cetuximab Resistance in Colorectal Cancer by Targeting IDO ‐Mediated Tryptophan Metabolism
    Yimin Zhou, Qian Tao, Chu‐Bin Luo, Jinsong Chen, Genwen Chen, Jianyong Sun · 2025 · Cancer Science
  88. The Emerging Landscape for Combating Resistance Associated with Energy‐Based Therapies via Nanomedicine
    Qitao Hu, Huali Zuo, Jessica C. Hsu, Cheng Zeng, Zhou Tian, Zhouyi Sun, Weibo Cai, Zhe Tang, Weiyu Chen · 2023 · Advanced Materials
  89. Zinc dampens antitumor immunity by promoting Foxp3+ regulatory T cells
    Narayan Sugandha, Sugandha Narayan, Rajdeep Dalal, Zaigham Abbas Rizvi · 2024 · Frontiers in Immunology
  90. Profiling Nascent Tumor Extracellular Vesicles via Metabolic Timestamping and Aptamer-Driven Specific Click Chemistry
    Qiuyue Wu, Yinyan Zeng, Wencheng Wang, Sinong Liu, Yihao Huang, Yuqian Zhang, Ximing Chen, Zhenlong You, Chi Zhang, Tonghao Wang et al. · 2025 · Journal of the American Chemical Society
  91. Combination of PD-1 Checkpoint Blockade and Botulinum Toxin Type A1 Improves Antitumor Responses in Mouse Tumor Models of Melanoma and Colon Carcinoma
    Seongsung Kwak, Ji‐Young Lee, Min Ju Kim, Hyo Jin Lee, Dong‐Kyu Lee, Jiyeon Kang, Won-Ho Kang, Woo‐Chan Son, Deu John M. Cruz · 2023 · Immunological Investigations
  92. Dual-enzyme decorated semiconducting polymer nanoagents for second near-infrared photoactivatable ferroptosis-immunotherapy
    Yue Liu, Renjie Lu, Meng Li, Danling Cheng, Fengshuo Wang, Xumei Ouyang, Yitian Zhang, Qin Zhang, Jingchao Li, Shaojun Peng · 2024 · Materials Horizons
  93. Metabolic Modulation of Kynurenine Based on Kynureninase-Loaded Nanoparticle Depot Overcomes Tumor Immune Evasion in Cancer Immunotherapy
    Se-Youl Chae, Hojeong Shin, J.I. Woo, Seounghun Kang, Soo Min Lee, Dal‐Hee Min · 2024 · ACS Applied Materials & Interfaces
  94. Interfering tumor metabolism by bimetallic nanoagent for amplifying nanocatalytic-mediated glioblastoma immunotherapy
    Qian‐Xiao Huang, Jun‐Long Liang, Mei‐Ting Niu, Xiao‐Kang Jin, Chengyuan Dong, Si‐Xue Cheng, Xian‐Zheng Zhang · 2024 · Nano Today
  95. Intelligent nanovesicle for remodeling tumor microenvironment and circulating tumor chemoimmunotherapy amplification
    Manxiu Huai, Yingjie Wang, Junhao Li, Jiaxing Pan, Fang Zhen Sun, Feiyu Zhang, Yi Zhang, Leiming Xu · 2024 · Journal of Nanobiotechnology
  96. Functional nanoplatform for modulating cellular forces to enhance antitumor immunity via mechanotransduction
    Wanheng Zhang, Shuqin Liu, Yan Hou, Shihui Xu, Jiayan An, Kyubae Lee, Qi Miao, Nana Wang, Yongtao Wang, Mengze Ma · 2025 · Journal of Controlled Release
  97. LAMP1 targeting of the large T antigen of Merkel cell polyomavirus results in potent CD4 T cell responses and tumor inhibition
    Claire Buchta Rosean, Erica C. Leyder, Jeneice Hamilton, Joseph J. Carter, Denise A. Galloway, David M. Koelle, Paul Nghiem, Teri Heiland · 2023 · Frontiers in Immunology
  98. Near-Infrared Photoactivatable Immunomodulatory Nanoparticles for Combinational Immunotherapy of Cancer
    Ningyue Yu, Mengbin Ding, Jingchao Li · 2021 · Frontiers in Chemistry
  99. Advances in Antibody-Based Immune-Stimulating Drugs: Driving Innovation in Cancer Therapy
    R R Zhao, Xingxing Fan · 2025 · International Journal of Molecular Sciences
  100. Overcoming current challenges to T-cell receptor therapy via metabolic targeting to increase antitumor efficacy, durability, and tolerability
    Wendy Mao · 2022 · Frontiers in Immunology