Cited by 821Immunotherapy and Immune ResponsesRadiopharmaceutical Chemistry and ApplicationsCharacterization and Applications of Magnetic Nanoparticles

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Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy

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de Vries, I Jolanda M, Lesterhuis, W Joost, Barentsz, Jelle O, Verdijk, Pauline, van Krieken, J Han, Boerman, Otto C, Oyen, Wim J G, Bonenkamp, Johannes J, Boezeman, Jan B, Adema, Gosse J, Bulte, Jeff W M, Scheenen, Tom W J, Punt, Cornelis J A, Heerschap, Arend, Figdor, Carl G·2005·Nature Biotechnology

DOI 10.1038/nbt1154

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Abstract

The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. We show here that in vivo magnetic resonance tracking of magnetically labeled cells is feasible in humans for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information. Autologous dendritic cells were labeled with a clinical superparamagnetic iron oxide formulation or (111)In-oxine and were co-injected intranodally in melanoma patients under ultrasound guidance. In contrast to scintigraphic imaging, magnetic resonance imaging (MRI) allowed assessment of the accuracy of dendritic cell delivery and of inter- and intra-nodal cell migration patterns. MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans.

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Authors: de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., Bulte, J. W. M., Scheenen, T. W. J., Punt, C. J. A., Heerschap, A., & Figdor, C. G.
Affiliations: Radboud University Nijmegen (NL)
Johns Hopkins University (US)
Corresponding author: Bulte, Jeff W M
Figdor, Carl G
ORCID: Lesterhuis, W Joost
Barentsz, Jelle O
Verdijk, Pauline
Boerman, Otto C
Oyen, Wim J G
Adema, Gosse J
Bulte, Jeff W M
Scheenen, Tom W J
Punt, Cornelis J A
Heerschap, Arend
Figdor, Carl G
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2005-10-30
Volume: 23
Issue: 11
Pages: 1407-1413
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1154
OpenAlex: W2162666572
Cited by: 821
References: 29
Citations by year: 2026: 5 · 2025: 15 · 2024: 14 · 2023: 21 · 2022: 22 · 2021: 25 · 2020: 24 · 2019: 29 · 2018: 27 · 2017: 25 · 2016: 37 · 2015: 36 · 2014: 55 · 2013: 50 · 2012: 71
FWCI: 15.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders: National Institutes of Health (5r01ns045062-10, NS 045062, RO1 NS045062)
National Institute of Neurological Disorders and Stroke (R01-NS045062)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords: dendritic cell immunotherapy, melanoma, superparamagnetic iron oxide nanoparticles, indium-111 oxine, autologous dendritic cells
MeSH terms: Cell Movement, Cell Separation, Dendritic Cells, Ferric Compounds, Flow Cytometry, Humans, Immunohistochemistry, Immunotherapy, Indium Radioisotopes, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Melanoma, Monocytes, Phenotype, Radionuclide Imaging, Models, Statistical, Cell Transplantation

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Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy

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