Labeling of mesenchymal stromal cells with iron oxide–poly (L-lactide) nanoparticles for magnetic resonance imaging: uptake, persistence, effects on cellular function and magnetic resonance imaging properties
Open accessAbstract
Background aims Mesenchymal stromal cells (MSC) are the focus of research in regenerative medicine aiming at the regulatory approval of these cells for specific indications. To cope with the regulatory requirements for somatic cell therapy, novel approaches that do not interfere with the natural behavior of the cells are necessary. In this context in vivo magnetic resonance imaging (MRI) of labeled MSC could be an appropriate tool. Cell labeling for MRI with a variety of different iron oxide preparations is frequently published. However, most publications lack a comprehensive assessment of the non-interference of the contrast agent with the functionality of the labeled MSC, which is a prerequisite for the validity of cell-tracking via MRI.Methods We studied the effects of iron oxide-poly(l-lactide) nanoparticles in MSC with flow cytometry, transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), Prussian blue staining, CyQuant® proliferation testing, colony-forming unit-fibroblast (CFU-F) assays, flow chamber adhesion testing, immunologic tests and differentiation tests. Furthermore iron-labeled MSC were studied by MRI in agarose phantoms and Wistar rats.Results It could be demonstrated that MSC show rapid uptake of nanoparticles and long-lasting intracellular persistence in the endosomal compartment. Labeling of the MSC with these particles has no influence on viability, differentiation, clonogenicity, proliferation, adhesion, phenotype and immunosuppressive properties. They show excellent MRI properties in agarose phantoms and after subcutaneous implantation in rats over several weeks.Conclusions These particles qualify for studying MSC homing and trafficking via MRI.
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Studies investigating the biological effects of typically sugar-coated SPION on dendritic cells, mesenchymal stem cells, endothelial cells and tumor cells have reported no impact on phenotype and cellular function.
“Studies investigating the biological effects of (typically sugar-coated) SPION on dendritic cells [126], mesenchymal stem cells [127, 128], endothelial cells [129, 130] and tumor cells [131] have reported no impact on phenotype and cellular function.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [128]
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- Authors
- Schmidtke-Schrezenmeier, G., Urban, M., Musyanovych, A., Mailänder, V., Rojewski, M., Fekete, N., Menard, C., Deak, E., Tarte, K., Rasche, V., Landfester, K., & Schrezenmeier, H.
- Affiliations
- Universität Ulm (DE)
- Max Planck Institute for Polymer Research (DE)
- German Red Cross (DE)
- Inserm (FR)
- Corresponding author
- Schrezenmeier, Hubert
- ORCID
- Venue
- Cytotherapy
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 13
- Issue
- 8
- Pages
- 962-975
- ISSN
- 1465-3249 (ISSN-L)
- PMC
- PMC3172145
- OpenAlex
- W2047945111
- Cited by
- 34
- References
- 59
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cytotherapy (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Commission (223236, 241879)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- mesenchymal stem cells, iron oxide nanoparticles, poly(L-lactic acid), cell labeling, cell tracking, MRI contrast agents, nanoparticle uptake, cell viability, cell differentiation, cell adhesion, immunosuppressive properties, somatic cell therapy
- MeSH terms
- Animals, Dioxanes, Endocytosis, Feasibility Studies, Ferric Compounds, Humans, Injections, Subcutaneous, Magnetic Resonance Imaging, Radiography, Endosomes, Staining and Labeling, Rats, Wistar, Stem Cell Transplantation, Mesenchymal Stem Cell Transplantation, Rats, Nanoparticles, Mesenchymal Stem Cells
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