Cited by 403Antimicrobial Peptides and ActivitiesImmune Response and InflammationSepsis Diagnosis and Treatment

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

An anti-infective peptide that selectively modulates the innate immune response

Scott, Monisha G, Dullaghan, Edie, Mookherjee, Neeloffer, Glavas, Natalie, Waldbrook, Matthew, Thompson, Annick, Wang, Aikun, Lee, Ken, Doria, Silvana, Hamill, Pam, Yu, Jie Jessie, Li, Yuexin, Donini, Oreola, Guarna, M Marta, Finlay, B Brett, North, John R, Hancock, Robert E W·2007·Nature Biotechnology

DOI 10.1038/nbt1288

Open this paper in CoChat — free account

Abstract

We show that an innate defense-regulator peptide (IDR-1) was protective in mouse models of infection with important Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Salmonella enterica serovar Typhimurium. When given from 48 h before to 6 h after infection, the peptide was effective by both local and systemic administration. Because protection by IDR-1 was prevented by in vivo depletion of monocytes and macrophages, but not neutrophils or B- and T-lymphocytes, we conclude that monocytes and macrophages are key effector cells. IDR-1 was not directly antimicrobial: gene and protein expression analysis in human and mouse monocytes and macrophages indicated that IDR-1, acting through mitogen-activated protein kinase and other signaling pathways, enhanced the levels of monocyte chemokines while reducing pro-inflammatory cytokine responses. To our knowledge, an innate defense regulator that counters infection by selective modulation of innate immunity without obvious toxicities has not been reported previously.

Integrity signals

Registry

Crossref · 10.1038/nbt1288

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Trends in antimicrobial drug development: Implications for the future
Spellberg, B., Powers, J. H., Brass, E. P., Miller, L. G., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/420937 · Cited by 867
Alarmins: chemotactic activators of immune responses
Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780
NLRs join TLRs as innate sensors of pathogens
Martinon, F., & Tschopp, J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.004 · Cited by 673
Toll-Like Receptors: Linking Innate and Adaptive Immunity
Pasare, C., & Medzhitov, R. M. (2005) · Advances in experimental medicine and biology · doi:10.1007/0-387-24180-9_2 · Cited by 666
How Toll-like receptors signal: what we know and what we don’t know
O'Neill, L. A. J. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.012 · Cited by 614
Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37
Mookherjee, N., Brown, K. L., Bowdish, D. M. E., Doria, S., Falsafi, R., Hokamp, K., Roche, F. M., Mu, R., Doho, G., Pistolic, J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2455 · Cited by 562
Self-citation
Innate immune responses to infection
Tosi, M. F. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.05.036 · Cited by 387
Impact of LL-37 on anti-infective immunity
Bowdish, D. M. E., Davidson, D. J., Lau, Y. E., Lee, K. C. L., Scott, M. G., & Hancock, R. E. W. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704380 · Cited by 382
Self-citation
Cytokine Cascade in Sepsis
Cavaillon, J., Adib‐Conquy, M., Fitting, C., Adrie, C., & Payen, D. M. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540310015935 · Cited by 336

Flagged first, then by citations

Show all 31 references

1 of the 31 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

National Research Council Treating Infectious Diseases in a Microbial World: Report of Two Workshops. Washington, D.C.: The National Academies Press, (2005).

Sorted by citations

Items 301–400 of 401

Chicken CATH-2 Increases Antigen Presentation Markers on Chicken Monocytes and Macrophages
Kraaij, M. D., van Dijk, A. I. J. M., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2019) · Protein and Peptide Letters · doi:10.2174/0929866526666190730125525 · Cited by 9
Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002
Piyadasa, H., Hemshekhar, M., Osawa, N., Lloyd, D., Altieri, A., Basu, S., Krokhin, O. V., Halayko, A. J., & Mookherjee, N. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02065 · Cited by 9
Self-citation
Dusquetide modulates innate immune response through binding to p62
Zhang, Y., Towers, C. G., Singh, U. K., Liu, J., Håkansson, M., Logan, D. T., Donini, O., & Kutateladze, T. G. (2022) · Structure · doi:10.1016/j.str.2022.05.003 · Cited by 8
Self-citation
Immunopeptides: immunomodulatory strategies and prospects for ocular immunity applications
Tang, Y. P., Qu, S., Ning, Z., & Wu, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1406762 · Cited by 8
Biological properties of Schinus terebinthifolia Raddi essential oil
Vasconcelos, P. G. S., Alves, É. P., Maia, C. M. D. A., Brito, A. C. M., Silva, D. R., Freires, I. A., Cavalcanti, Y. W., Rehder, V. L. G., Ruiz, A. L. T. G., Duarte, M. C. T., et al. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902021000x2e20417 · Cited by 8
Xenobiotic Binding Domain of Glutathione S-Transferase Has Cryptic Antimicrobial Peptides
Horam, S., Raj, S., Tripathi, V. C., Pant, G., Mitra, K., Reddy, T. J., Arockiaraj, J., & Pasupuleti, M. (2018) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-018-9793-7 · Cited by 8
Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization
Skovbakke, S. L., & Franzyk, H. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6737-7_27 · Cited by 8
Immune-Based Anti-Staphylococcal Therapeutic Approaches
Park, B., & Liu, G. Y. (2021) · Microorganisms · doi:10.3390/microorganisms9020328 · Cited by 8
Antiviral Effect of Antimicrobial Peptoid TM9 and Murine Model of Respiratory Coronavirus Infection
Lebedev, M., Benjamin, A. B., Kumar, S., Molchanova, N., Lin, J. S., Koster, K. J., Leibowitz, J. L., Barron, A. E., & Cirillo, J. D. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040464 · Cited by 7
Overview of Host Defense Peptides and Their Applications for Plastic and Reconstructive Surgeons
DeLong, M. R., Tandon, V. J., Lio, A. L. D., Deming, T. J., & Cederna, P. S. (2020) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000006910 · Cited by 7
Peptides as Therapeutic Molecules to Neutralize Gram-negative Bacterial Lipopolysaccharides in Sepsis and Septic Shock
Luna-Reyes, I., Pérez-Hernández, E. G., Delgado‐Coello, B., & Mas‐Oliva, J. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.08.001 · Cited by 7
Dynamic Gene Clusters Mediating Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates
Selim, S., Faried, O. A., Almuhayawi, M. S., Mohammed, O. A., Saleh, F. M., & Warrad, M. (2022) · Antibiotics · doi:10.3390/antibiotics11020168 · Cited by 7
Antimicrobial Peptides, An Alternative Antimicrobial Agent Against Multi-drug-Resistant Microbes: Source, Application, and Potential
Ramzah, N. H. H. L., Yenn, T. W., Lee, W., Loo, C., Tan, W., & Ring, L. C. (2023) · Advanced structured materials · doi:10.1007/978-3-031-21959-7_17 · Cited by 7
Targeting collagen damage for sustained in situ antimicrobial activities
Mo, X., Zhao, S., Zhao, J., Huang, Y., Li, T., Zhu, Y., Li, G., Li, Y., & Shan, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.06.013 · Cited by 7
Self-citation
Outcome and Prevention of Pseudomonas aeruginosa-Staphylococcus aureus Interactions During Pulmonary Infections in Cystic Fibrosis
Mitchell, G., & Maloui, F. (2012) · InTech eBooks · doi:10.5772/31527 · Cited by 7
Antibacterial potential of hGlyrichin encoded by a human gene
Sha, J., Zhao, G., Chen, X., Guan, W., He, Y., & Wang, Z. (2011) · Journal of Peptide Science · doi:10.1002/psc.1421 · Cited by 7
Immunomodulation by zwitterionic polysaccharides
McLoughlin, R. M., & Kasper, D. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00049-3 · Cited by 7
Alternative Therapies to Antibiotics to Combat Drug-Resistant Bacterial Pathogens
Kaul, G., Shukla, M., Dasgupta, A., & Chopra, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-9871-1_9 · Cited by 7
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)
Noordin, M. A. M., Najm, A. A., Dyari, H. R. E., Law, D. S. N., Alwi, S. S. S., Lazim, А. M., Cheah, Y. H., Tee, T. T., & Fazry, S. (2025) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575362479241231054240 · Cited by 6
Mammalian antimicrobial peptides: defensins and cathelicidins
Cui, X., Huang, Y., Peng, Z., Li, Z., & Cen, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-818619-0.00103-9 · Cited by 6
A pathway-focused RT-qPCR array study on immune relevant genes in rainbow trout (Oncorhynchus mykiss) harboring cecropin P1 transgene
Han, Y.-C., & Chen, T. T. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.03.027 · Cited by 6
Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
Brown, K. L., Falsafi, R., Kum, W. W. S., Hamill, P., Gardy, J. L., Davidson, D. J., Turvey, S. E., Finlay, B. B., Speert, D. P., & Hancock, R. E. W. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-6 · Cited by 6
Self-citation
Biodistribution of Native and Nanoformulated Innate Defense Regulator Peptide 1002
Esposito, T., Blackadar, C., Wu, L., Rodríguez‐Rodríguez, C., Haney, E. F., Pletzer, D., Saatchi, K., Hancock, R. E. W., & Häfeli, U. O. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c01169 · Cited by 5
Self-citation
[Possibilities and limitations of Caridex System as an alternative to conventional caries removal].
Scheutzel, P. (1989) · PubMed · Cited by 5
Immunomodulatory Cationic Peptide Therapeutics: A New Paradigm in Infection and Immunity
Mookherjee, N., Chow, L. N. Y., & Hancock, R. E. W. (2012) · ACS symposium series · doi:10.1021/bk-2012-1095.ch001 · Cited by 5
Self-citation
The Roles of User/Producer Hybrids in the Production of Translational Science
Douglas, C. M. W., Lander, B., Fairley, C., & Atkinson‐Grosjean, J. (2014) · Social Epistemology · doi:10.1080/02691728.2013.848951 · Cited by 5
Antimicrobial, Host Defence Peptides and Proteins
Brown, K. L., Mookherjee, N., & Hancock, R. E. W. (2007) · Wiley eBooks · doi:10.1002/9780470015902.a0001212.pub2 · Cited by 6
Self-citation
Interactions of SARS-CoV-2 spike protein and transient receptor potential (TRP) cation channels could explain smell, taste, and/or chemesthesis disordersPreprint
Maaroufi, H. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2101.06294 · Cited by 5
Non-covalent interactions drive the self-assembly to enhanced stability of peptide-based nanomaterials
Ding, Y., Yang, S., Chen, J., Xing, M., Ma, D., Wang, J., Gu, S., Khan, M. A., & Hao, H. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173242 · Cited by 4
Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo
Afacan, N. J., Janot, L., & Hancock, R. E. W. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0541-4_13 · Cited by 4
Self-citation
The synthetic antimicrobial peptide LTX 21 induces inflammatory responses in a human whole blood model and a murine peritoneum model
Granslo, H. N., Fredheim, E. G. A., Esaiassen, E., Christophersen, L., Jensen, P. Ø., Mollnes, T. E., Moser, C. E., Flægstad, T., Klingenberg, C., & Cavanagh, J. P. (2019) · Apmis · doi:10.1111/apm.12946 · Cited by 4
Immunomodulatory Responses of Two Synthetic Peptides against Salmonella Typhimurium Infection
Ibarra-Valencia, M. A., Espino-Solís, G. P., Estrada, B. E., & Corzo, G. A. (2021) · Molecules · doi:10.3390/molecules26185573 · Cited by 4
Peptides and Wound Healing: From Monomer to Combination
Liu, C., Yang, Q., & Zhou, Y. L. (2024) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-024-10627-5 · Cited by 3
Unveiling the Function of Antimicrobial Peptides in Relation to Source and Structure
Zhang, K., Teng, D., Mao, R., Yang, N., Hao, Y., & Wang, J. (2025) · Medicinal Research Reviews · doi:10.1002/med.70016 · Cited by 3
Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Flores‐Valdez, M. A., & Chopra, S. (2009) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0087 · Cited by 3
New peptide modulator of innate immunity
Flemming, A. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2319 · Cited by 3
Nature-Inspired Multifunctional Host Defense Peptides with Dual Antimicrobial-Immunomodulatory Activities
Khara, J. S., & Ee, P. L. R. (2015) · Springer eBooks · doi:10.1007/978-3-319-18045-8_6 · Cited by 3
Cathelicidin ΔPb-CATH4 derived from Python bivittatus accelerates the healing of Staphylococcus aureus-infected wounds in mice
Soundrarajan, N., Cho, H. S., Prathap, S., Kang, M., Choi, M., Lee, Y., Jeon, H., Song, H., Kim, J., & Park, C. (2021) · Amino Acids · doi:10.1007/s00726-021-02948-2 · Cited by 3
Deconstructing host quality offers insight into disease ecology
Mommer, L., Esser, H. J., van den Booren, S., Adelman, J. S., Bever, J. D., de Boer, W. F., Bron, G. M., Douma, J. C., Ezenwa, V. O., Halliday, F. W., et al. (2025) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2025.11.014 · Cited by 2
Antimicrobial peptides for bacterial infections and their biomedical applications
Gu, Z., Chen, X., Yin, C., Zhou, Y., Song, L., Wu, K., Wang, T., & Chang, J. (2026) · Discover Nano · doi:10.1186/s11671-026-04534-5 · Cited by 2
The History of Antibiotics Illumes the Future of Antimicrobial Peptides Administered Through Nanosystems
Nassar, N., Kasapis, S., Pyreddy, S., & Istivan, T. S. (2022) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-10220-2_1 · Cited by 2
C7 Anti-infective activity of immunomodulators
Masihi, K. N. (2011) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0136-8_22 · Cited by 2
Innate Response to Infection
Lipińska-Gediga, M. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s13-008 · Cited by 2
Leveraging Drosophila Models to Explore AI-generated Synthetic Peptide’s Potential in Boosting Honeybee Health and ResiliencePreprint
Sun, Y., Jia, W., Wei, Y., Zhou, X.-Y., Dong, R., Lee, J., Bang, J. K., Ning, F., & Kim, W. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.24.630224 · Cited by 2
Novel antimicrobial peptide ECCT from Chinese water snake is a potential candidate for the treatment of Helicobacter pylori infection and gastric cancer
Qiu, J., Shi, W., Qian, Z., Zhang, P., Li, S., Shen, G., Wang, Y., & Li, B. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107821 · Cited by 1
2025 ICM: Immune Status
Whitmarsh-Brown, M. A., Helton, A. G., Farli, H. A., Aronson, J., Barlow, F. E. G.-D., Cichos, K. H., Copello, J. F. R., Gililland, J. M., Jiranek, W. A., Langsfeld, J. M., et al. (2025) · The Journal of Arthroplasty · doi:10.1016/j.arth.2025.10.097 · Cited by 1
PEPTIDE IDR-1002 REGULATES THE ANTIOXIDANT AND ANTI-INFLAMMATORY RESPONSES BY ACTIVATING THE KEAP1-NRF2 SIGNALING PATHWAY
Romero-Durán, M. A., Maldonado-Pichardo, M. C., Perez‐Aguilar, J. M., & Aguirre, V. M. B. (2026) · F1000Research · doi:10.12688/f1000research.177148.3 · Cited by 1
Anti-virulence activity and immunomodulation of Oreoch-1 against enteroinvasive Escherichia coli infection
Palma, F., Giugliano, R., Chianese, A., Marca, R. D., Monti, A., Doti, N., Zannella, C., Galdiero, M., & Filippis, A. D. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108253 · Cited by 1
Bioinformatics: Novel Insights from Genomic Information
Hancock, R. E. W. (2016) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000436950 · Cited by 1
Self-citation
ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT
Méndez‐Samperio, P., & de‐la‐Rosa‐Arana, J. (2013) · Journal of the Egyptian Society of Parasitology · doi:10.12816/0006377 · Cited by 1
Polymer Brushes with Precise Architectures for Molecular Biorecognition
Perrino, M. P., Molina, S., & Navarro, R. (2015) · Springer eBooks · doi:10.1007/978-3-319-17061-9_10 · Cited by 1
Host Defense Peptides and Their Advancements in Translational Staphylococcus aureus Research
Mansour, S., Hancock, R. E. W., & Otto, M. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-32949-9_12 · Cited by 1
Self-citation
Antimicrobial Peptides: New Frontiers in the Therapy of Infections
Zucca, M., Scutera, S., & Savoi, D. (2011) · InTech eBooks · doi:10.5772/29323 · Cited by 1
Peptides and antibiotic resistance
Umnyakova, E. S., Orlov, D. S., & Валерьевна, Ш. О. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820141-1.00025-x · Cited by 1
Functional dualism of antimicrobial host defence peptides
Björstad, Å. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Recombinant Antimicrobial Peptides
Rodríguez‐Cabello, J. C., García‐Arévalo, C., Girotti, A., Martín, L., & Santos, M. (2011) · Wiley eBooks · doi:10.1002/9781118150887.ch9 · Cited by 1
Avaliação da atividade imunomoduladora da microplusina sobre macrófagos murinos in vitro.
Gerardi, L. A. (2010) · doi:10.11606/d.87.2010.tde-01122010-110647
Membrane‐Targeted Enzybiotics
Gasset, M. (2009) · Wiley eBooks · doi:10.1002/9780470570548.ch8
Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases
Brown, K. L. (2011) · Wiley eBooks · doi:10.1002/9780470571224.pse446
Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
Kalle, M. (2013) · Lund University Publications (Lund University)
Subcellular Proteomics for Understanding Host Defense Peptides Mechanism of Action
López‐Abarrategui, C., & Otero‐González, A. J. (2013) · Organelles Proteomics · doi:10.2478/orpr-2013-0003
Blocking bacterial division
Fulmer, T. (2008) · Science-Business eXchange · doi:10.1038/scibx.2008.866
Gene-specific control of inflammation by toll-like-receptor induced chromatin modifications
Foster, S. L. (2008) · ProQuest Demo Repository
Neutrophil granule proteins : Modulators of the immune response
Soehnlein, O. (2008) · Figshare
Host–Pathogen Interactions
Saleh, M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.032
Shedding light on antibacterial activities of cathelicidins
Schneider, V. A. F. (2016) · Utrecht University Repository (Utrecht University)
Composição proteica e caracterização funcional da secreção cutânea de Dendropsophus columbianus (Boettger, 1892)
Vidal, L. E. T. (2017) · doi:10.26512/2017.03.t.23393
Essential role of monocyte chemoattractant protein-1 in gram-negative bacterial pneumonia
Balamayooran, G. (2012) · doi:10.31390/gradschool_dissertations.3407
Novel Targets for Drug Development
Cross, A. S., & Opal, S. M. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch63
Molecular mechanisms and effector functions of the human cathelicidin host defence peptide LL-37: modulation of cytokine IL-32γ-induced responses and inflammatory arthritis
Choi, K.-Y. G. (2016) · Mspace (University of Manitoba)
The Emergence and Re-emergence of Infectious Diseases: A Challenge for Humanity and Health Systems in the 21st Century
Jorge, R.-E. (2018) · Cohesive Journal of Microbiology & Infectious Disease · doi:10.31031/cjmi.2018.01.000513
A Study on Transcriptomic Profiling of Differentially Expressed Genes Relevant to Innate and Adaptive Immune Pathways in Transgenic Rainbow Trout (Oncorhynchus mykiss) Harboring Cecropin P1 Transgene
Han, Y.-C. (2018) · OpenCommons at University of Connecticut (University of Connecticut)
Innate Defense Regulator IDR-1018 Activates Human Mast Cells Through G Protein-, Phospholipase C-, MAPK- and NF-κB-Sensitive Pathways
Yanashima, K., Chieosilapatham, P., Yoshimoto, E., Okumura, K., Ogawa, H., & Niyonsaba, F. (2019) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2019.65.jmj18-r12
An Antimicrobial Peptide with Angiogenic Properties, AG-30/5C, Activates Human Mast Cells Through the MAPK and NF-κB Pathways
Kanazawa, K., Okumura, K., Ogawa, H., & Niyonsaba, F. (2019) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2019.65.jmj19-r02
The development of novel antimicrobial peptides and various strategies to improve their activity and biocompatibility
Kumar, P. (2019) · cIRcle (University of British Columbia) · doi:10.14288/1.0369270
Chicken respiratory infections
Peng, L. (2020) · doi:10.33540/83
Comparing the Potency, Stability and Cell Stimulating Activity of Protegrin-1 with a Hybrid Antimicrobial Peptide
Maystrenko, A. (2020) · The Atrium (University of Guelph)
Potencial imunomodulador de peptídeos associados a altas concentrações de glicose
Cantuária, A. P. D. C. (2016) · doi:10.26512/2016.07.d.21368
[Research progress of antibacterial modification of orthopaedic implants surface].
Zhang, C., Wu, Y., & Xu, Y. (2022) · PubMed Central · doi:10.7507/1002-1892.202112109
New routes to commercialization
(2007) · Nature Biotechnology · doi:10.1038/nbt1107-1217b
ระดบของแลคโตเฟอรนในรอยโรคไลเคนแพลนสและรอยโรคไลเคนอยดชองปากทรบการรกษาดวยยาสเตยรอยดเฉพาะท
แสงประสิทธิโชค, ณ. (2017) · doi:10.58837/chula.the.2017.659
Antimicrobial Peptides: From Natural to Synthetic, Conjugated and Polypeptides
Pranantyo, D. (2025) · Wiley eBooks · doi:10.1002/9783527846979.ch06
Additional file 5 of Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Li, X., Su, N., Yu, H., Li, X., & Sun, S.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26743688
Additional file 2 of Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Li, X., Su, N., Yu, H., Li, X., & Sun, S.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26195846
Additional file 1 of Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Li, X., Su, N., Yu, H., Li, X., & Sun, S.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26195796
Additional file 3 of Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Li, X., Su, N., Yu, H., Li, X., & Sun, S.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26743682
Additional file 4 of Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
Li, X., Su, N., Yu, H., Li, X., & Sun, S.-L. (2024) · Figshare · doi:10.6084/m9.figshare.26743685
Functional characterization of Cr-CATHs: Novel antimicrobial peptides from the coastal bird Chroicocephalus ridibundus
Dou, H., Li, S., Zhang, P., Ye, Z., Li, L., Wang, Y., & Jiao, X. (2025) · Biochimie · doi:10.1016/j.biochi.2025.12.008
PEPTIDE IDR-1002 REGULATES THE ANTIOXIDANT AND ANTI-INFLAMMATORY RESPONSES BY ACTIVATING THE KEAP1-NRF2 SIGNALING PATHWAY
Romero-Durán, M. A., Maldonado-Pichardo, M. C., Perez‐Aguilar, J. M., & Aguirre, V. M. B. (2026) · F1000Research · doi:10.12688/f1000research.177148.1
Impact du peptide antimicrobien issu du venin de la fourmi Tetramorium bicarinatum P17 sur la polarisation et l'acquisition des fonctions antifongiques des macrophages humains vis-à-vis de Candida albicans
Benmoussa, K. (2017) · theses.fr (ABES) · doi:10.70675/d053725dz35f7z478az9483zad9166ee89c7
In Vivo Evaluation Of Antimicrobial And Immunomodulatory Effects Of Antimicrobial Peptide–Inspired Compounds In Cavia Porcellus
Garg, A., Kumar, A., Sharma, S., Kumar, M. S., Kumar, V., Pankaj, P., Garg, S., Siddiqui, S., & Ahmad, R. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.16s.83
The Multifunctional Peptide AP10W Enhances Skin Wound Healing Through Macrophage Reprogramming and Angiogenesis
Xuan, C., Liu, Z. C., Zhang, P., Liu, B., Gao, Z., & Wu, F. (2026) · Biomolecules · doi:10.3390/biom16050720
PAN4, an AI-designed host-directed immunomodulatory peptide, promotes PGRP-SC1a-associated intestinal immune homeostasis in Drosophila melanogaster
Sun, Y., Wei, Y., Jia, W., Zhou, X., Dong, R., Wu, Z., Miao, H., Li, Z. Y., Chen, Z., Liu, C., et al. (2026) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2026.104635
PEPTIDE IDR-1002 REGULATES THE ANTIOXIDANT AND ANTI-INFLAMMATORY RESPONSES BY ACTIVATING THE KEAP1-NRF2 SIGNALING PATHWAY
Romero-Durán, M. A., Maldonado-Pichardo, M. C., Perez‐Aguilar, J. M., & Aguirre, V. M. B. (2026) · F1000Research · doi:10.12688/f1000research.177148.4
Encrypted immunity mediated by peptides
Zhang, Z. J., Merbl, Y., & de la Fuente‐Núñez, C. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003914
The Silent Orchestrators: Redefining Invertebrate Host Defense Through the Lens of Innate Defense Regulator Peptides
Sun, Y., Wei, Y., Bang, J. K., & Kim, W. J. (2026) · Entomologia Experimentalis et Applicata · doi:10.1111/eea.70171
Antimicrobial Peptides Targeting Salmonella enterica serovar Typhi: Mechanism of Action, Structural Insights, and Translational Challenges – A Review
Drakhshaan, Chohan, T. A., Qayyum, A., Qayyum, N.-E.-E., sarfraz, H., Khurshid, U., Riaz, H., & Chohan, T. A. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11214-4
Antimicrobial Peptides Beyond the Petri Dish: Translational Barriers to Therapeutic Development
Torrent, M. (2026) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.6c00126
Effects of anthocyanin-rich dried fruits on sterol regulatory element-binding protein-1c expression and selected gut microbiota in patients with coronary artery disease: An exploratory analysis
Tavakoli, S., Ansarifard, F., Parsa, S. A., Eslami, V., Taherkhani, M., Safi, M., & Nasrollahzadeh, J. (2026) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2026.200389
Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway
Jiang, L., Yang, F., Wu, J., Li, Z., Zhu, X., Pan, H., Zhang, S., Pan, H., Wang, H., 姚静婷, et al. (2026) · Veterinary Research · doi:10.1186/s13567-026-01844-5

Authors: Scott, M. G., Dullaghan, E., Mookherjee, N., Glavas, N., Waldbrook, M., Thompson, A., Wang, A., Lee, K., Doria, S., Hamill, P., Yu, J. J., Li, Y., Donini, O., Guarna, M. M., Finlay, B. B., North, J. R., & Hancock, R. E. W.
Affiliations: City of Vancouver (CA)
University of British Columbia (CA)
Corresponding author: Hancock, Robert E W
ORCID: Mookherjee, Neeloffer
Wang, Aikun
Lee, Ken
Yu, Jie Jessie
Li, Yuexin
Donini, Oreola
Guarna, M Marta
Finlay, B Brett
Hancock, Robert E W
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2007-03-25
Volume: 25
Issue: 4
Pages: 465-472
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1288
OpenAlex: W2040733257
Cited by: 403
References: 31
Citations by year: 2026: 16 · 2025: 12 · 2024: 19 · 2023: 15 · 2022: 14 · 2021: 20 · 2020: 16 · 2019: 15 · 2018: 22 · 2017: 16 · 2016: 25 · 2015: 28 · 2014: 14 · 2013: 30 · 2012: 29
FWCI: 25.65
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords: monocytes, macrophages, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Salmonella typhimurium, Gram-positive pathogens, Gram-negative pathogens, inflammatory cytokines, MAPK signaling
MeSH terms: Animals, Anti-Infective Agents, Bacterial Infections, Disease Models, Animal, Gene Expression Regulation, Humans, Immunity, Innate, Inflammation, Lipopolysaccharides, Peptides, Treatment Outcome, Models, Immunological, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An anti-infective peptide that selectively modulates the innate immune response

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks