The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
Open accessAbstract
Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of the pathogenic actinomycetes Mycobacterium tuberculosis and Corynebacterium diphtheriae, but unlike the linear chromosomes of the model actinomycete Streptomyces coelicolor A3(2) and the closely related Streptomyces avermitilis. The S. erythraea genome contains at least 25 gene clusters for production of known or predicted secondary metabolites, at least 72 genes predicted to confer resistance to a range of common antibiotic classes and many sets of duplicated genes to support its saprophytic lifestyle. The availability of the genome sequence of S. erythraea will improve insight into its biology and facilitate rational development of strains to generate high-titer producers of clinically important antibiotics.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Cited by
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Genomic basis for natural product biosynthetic diversity in the actinomycetes
Nett, M., Ikeda, H., & Moore, B. S. (2009) · Natural Product Reports · doi:10.1039/b817069j · Cited by 757
Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation
Kingston, D. G. I. (2011) · Journal of Natural Products · doi:10.1021/np100550t · Cited by 516
Renaissance in antibacterial discovery from actinomycetes
BALTZ, R. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.04.008 · Cited by 498
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Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468
Metadata
- Authors
- Oliynyk, M., Samborskyy, M., Lester, J. B., Mironenko, T., Scott, N., Dickens, S., Haydock, S. F., & Leadlay, P. F.
- Venue
- Nature Biotechnology
- Published
- 2007-03-18
- Volume
- 25
- Issue
- 4
- Pages
- 447-453
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W1999670767
- Cited by
- 402
- References
- 1
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Oliynyk, M., Samborskyy, M., Lester, J. B., Mironenko, T., Scott, N., Dickens, S., Haydock, S. F., & Leadlay, P. F. (2007). Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nature Biotechnology. https://doi.org/10.1038/nbt1297
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