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Genomic basis for natural product biosynthetic diversity in the actinomycetes
Open accessAbstract
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G + C, Gram-positive bacteria that have evolved a complex chemical language of natural product chemistry to help navigate their fascinatingly varied lifestyles. To date, 71 Actinobacteria genomes have been completed and annotated, with the vast majority representing the Actinomycetales, which are the source of numerous antibiotics and other drugs from genera such as Streptomyces, Saccharopolyspora and Salinispora. These genomic analyses have illuminated the secondary metabolic proficiency of these microbes – underappreciated for years based on conventional isolation programs – and have helped set the foundation for a new natural product discovery paradigm based on genome mining. Trends in the secondary metabolomes of natural product-rich actinomycetes are highlighted in this review article, which contains 199 references.
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Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Bioactive Microbial Metabolites: A Personal View
Bérdy, J. (2005) · The Journal of Antibiotics · doi:10.1038/ja.2005.1 · Cited by 3,170
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Actinomycetes: Still a source of novel antibiotics
Genilloud, O. (2017) · Natural Product Reports · doi:10.1039/c7np00026j · Cited by 465
PRISM 3: expanded prediction of natural product chemical structures from microbial genomes
Skinnider, M. A., Merwin, N. J., Johnston, C. W., & Magarvey, N. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx320 · Cited by 341
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora
Ziemert, N., Lechner, A., Wietz, M., Millán-Aguiñaga, N., Chavarria, K. L., & Jensen, P. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324161111 · Cited by 278
Metadata
- Authors
- Nett, M., Ikeda, H., & Moore, B. S.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 26
- Issue
- 11
- Pages
- 1362
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2169942471
- Cited by
- 757
- References
- 2
- FWCI
- 17.93
- Type
- journal article
- Language
- en
- Open access
- green
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