The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Systematic identification of abundant A-to-I editing sites in the human transcriptome
Open accessAbstract
RNA editing by members of the ADAR (adenosine deaminases acting on RNA) family leads to site-specific conversion of adenosine to inosine (A-to-I) in precursor messenger RNAs. Editing by ADARs is believed to occur in all metazoa, and is essential for mammalian development. Currently, only a limited number of human ADAR substrates are known, whereas indirect evidence suggests a substantial fraction of all pre-mRNAs being affected. Here we describe a computational search for ADAR editing sites in the human transcriptome, using millions of available expressed sequences. We mapped 12,723 A-to-I editing sites in 1,637 different genes, with an estimated accuracy of 95%, raising the number of known editing sites by two orders of magnitude. We experimentally validated our method by verifying the occurrence of editing in 26 novel substrates. A-to-I editing in humans primarily occurs in noncoding regions of the RNA, typically in Alu repeats. Analysis of the large set of editing sites indicates the role of editing in controlling dsRNA stability.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
dbEST — database for “expressed sequence tags”
Boguski, M. S., Lowe, T. M. J., & Tolstoshev, C. M. (1993) · Nature Genetics · doi:10.1038/ng0893-332 · Cited by 1,338
RNA Editing by Adenosine Deaminases That Act on RNA
Bass, B. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135501 · Cited by 1,268
Higuchi, M., Maas, S., Single, F. N., Hartner, J., Rozov, A., Burnashev, N., Feldmeyer, D., Sprengel, R., & Seeburg, P. H. (2000) · Nature · doi:10.1038/35017558 · Cited by 967
Higuchi, M., Single, F. N., Köhler, M., Sommer, B., Sprengel, R., & Seeburg, P. H. (1993) · Cell · doi:10.1016/0092-8674(93)90622-w · Cited by 662
Brusa, R., Zimmermann, F., Koh, D.-S., Feldmeyer, D., Gass, P., Seeburg, P. H., & Sprengel, R. (1995) · Science · doi:10.1126/science.270.5242.1677 · Cited by 592
Patterson, J. B., & Samuel, C. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5376 · Cited by 576
RNA editing and death of motor neurons
Kawahara, Y., Ito, K., Sun, H., Aizawa, H., Kanazawa, I., & Kwak, S. (2004) · Nature · doi:10.1038/427801a · Cited by 536
Alu -Containing Exons are Alternatively Spliced
Sorek, R., Ast, G., & Graur, D. (2002) · Genome Research · doi:10.1101/gr.229302 · Cited by 505
Generation and analysis of 280,000 human expressed sequence tags.
Hillier, L. D., Lennon, G., Becker, M., Bonaldo, M. F., Chiapelli, B., Chissoe, S., Dietrich, N., DuBuque, T., Favello, A., Gish, W., et al. (1996) · Genome Research · doi:10.1101/gr.6.9.807 · Cited by 463
Kim, U., Wang, Y., Sanford, T., Zeng, Y., & Nishikura, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11457 · Cited by 442
Cited by
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
Self-citationThe multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910
Functions and Regulation of RNA Editing by ADAR Deaminases
Nishikura, K. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-105251 · Cited by 1,242
A-to-I editing of coding and non-coding RNAs by ADARs
Nishikura, K. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.4 · Cited by 1,041
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
Rice, G. I., Kasher, P. R., Forte, G. M. A., Mannion, N. M., Greenwood, S. M., Szynkiewicz, M., Dickerson, J. E., Bhaskar, S. S., Zampini, M., Briggs, T. A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2414 · Cited by 923
Metadata
- Authors
- Levanon, E. Y., Eisenberg, E., Yelin, R., Nemzer, S., Hallegger, M., Shemesh, R., Fligelman, Z. Y., Shoshan, A., Pollock, S. R., Sztybel, D., Olshansky, M., Rechavi, G., & Jantsch, M. F.
- Venue
- Nature Biotechnology
- Published
- 2004-07-18
- Volume
- 22
- Issue
- 8
- Pages
- 1001-1005
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2072016877
- Cited by
- 760
- References
- 30
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Systematic identification of abundant A-to-I editing sites in the human transcriptome. https://app.cochat.ai/papers/10.1038/nbt996
- The paper
- Levanon, E. Y., Eisenberg, E., Yelin, R., Nemzer, S., Hallegger, M., Shemesh, R., Fligelman, Z. Y., Shoshan, A., Pollock, S. R., Sztybel, D., Olshansky, M., Rechavi, G., & Jantsch, M. F. (2004). Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nature Biotechnology. https://doi.org/10.1038/nbt996
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
