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Cited by 3,910Cancer-related molecular mechanisms researchMicroRNA in disease regulationRNA Research and Splicing

The multilayered complexity of ceRNA crosstalk and competition

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Tay, Yvonne, Rinn, John, Pandolfi, Pier Paolo·2014·Nature
DOI 10.1038/nature12986PMC PMC4113481
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Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

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Authors
Tay, Y., Rinn, J., & Pandolfi, P. P.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • Broad Institute (US)
Corresponding author
Pandolfi, Pier Paolo
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2014-01
Volume
505
Issue
7483
Pages
344-352
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature12986
PMC
PMC4113481
OpenAlex
W2130687298
Cited by
3,910
References
4
Citations by year
2026: 117 · 2025: 234 · 2024: 312 · 2023: 336 · 2022: 536 · 2021: 652 · 2020: 524 · 2019: 384 · 2018: 278 · 2017: 192 · 2016: 150 · 2015: 123 · 2014: 64 · 2013: 1
FWCI
17.51
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
National Cancer Institute (R01-CA-82328, R01CA170158, R01CA082328)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
competing endogenous RNA, microRNA sponge, long non-coding RNA, pseudogenes, circular RNA, microRNA competition, post-transcriptional regulation, gene regulatory networks, RNA-RNA interactions
MeSH terms
RNA, Circular, Animals, Binding, Competitive, Humans, Pseudogenes, RNA, RNA, Messenger, RNA-Binding Proteins, RNA Editing, MicroRNAs, Argonaute Proteins, RNA, Long Noncoding

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