A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

A simplified system for generating recombinant adenoviruses

He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941

Creation of human tumour cells with defined genetic elements

Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,411

MYC oncogenes and human neoplastic disease

Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163

Teratocarcinomas and Embryonic Stem Cells: A Practical Approach

Robertson, E. J., & Beddington, R. (1988) · Development · doi:10.1242/dev.102.1.3 · Cited by 1,034

Teratocarcinomas and embryonic stem cells: A practical approach

Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

Cole, M. D. (1986) · Annual Review of Genetics · doi:10.1146/annurev.ge.20.120186.002045 · Cited by 699

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

Lu, P., Zhou, X. Z., Shen, M., & Lu, K. P. (1999) · Science · doi:10.1126/science.283.5406.1325 · Cited by 688

Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc

Sumi, T., Tsuneyoshi, N., Nakatsuji, N., & Suemori, H. (2007) · Oncogene · doi:10.1038/sj.onc.1210353 · Cited by 84

Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1

Liu, T., Liu, Y., Kao, H., & Pei, D. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901778v · Cited by 84

Altered Subcellular Localization of c-Myc Protein Identifies Aggressive B-cell Lymphomas Harboring a c-MYC Translocation

Ruzinova, M. B., Caron, T. J., & Rodig, S. J. (2010) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181db83af · Cited by 83

Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer

Stellas, D., Szabolcs, M. J., Koul, S., Li, Z., Polyzos, A., Anagnostopoulos, C., Cournia, Z., Tamvakopoulos, C., Klinakis, A., & Efstratiadis, A. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju320 · Cited by 87

O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis

Zeng, Q., Zhao, R., Chen, J., Li, Y., Li, X.-D., Liu, X.-L., Zhang, W.-M., Quan, C., Wang, Y.-S., Zhai, Y.-X., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606801113 · Cited by 83

Balance of Yin and Yang: Ubiquitylation-Mediated Regulation of p53 and c-Myc

Dai, M., Jin, Y., Gallegos, J. R., & Lu, H. (2006) · Neoplasia · doi:10.1593/neo.06334 · Cited by 85

ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc

Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y., & Liu, S. (2013) · Oncogene · doi:10.1038/onc.2013.505 · Cited by 82

Fuzziness enables context dependence of protein interactions

Miskei, M., Gregus, A., Sharma, R., Duro, N., Zsolyomi, F., & Fuxreiter, M. (2017) · FEBS Letters · doi:10.1002/1873-3468.12762 · Cited by 81

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

Zhang, X., Farrell, A. S., Daniel, C. J., Arnold, H., Scanlan, C., Laraway, B. J., Janghorban, M., Lum, L., Chen, D., Troxell, M. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100764108 · Cited by 81

The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy

Sheridan, M., & Öğretmen, B. (2021) · Cancers · doi:10.3390/cancers13102475 · Cited by 82

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

Li, Y., Yue, P., Deng, X., Ueda, T., Fukunaga, R., Khuri, F. R., & Sun, S. (2010) · Neoplasia · doi:10.1593/neo.10704 · Cited by 78

Myc degradation: Dancing with ubiquitin ligases

Amati, B. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403046101 · Cited by 79

The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia

Thomas, R. M., Kim, J., Revelo-Penafiel, M. P., Angel, R., Dawson, D. W., & Lowy, A. M. (2008) · Gut · doi:10.1136/gut.2007.143941 · Cited by 79

Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer

Xing, Z., Zhang, Y., Liang, K., Liang, Y., Xiang, Y., Li, C., Hu, Q., Jin, F., Putluri, V., Putluri, N., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-0385 · Cited by 79

G protein–coupled receptor kinase 2 (GRK2) modulation and cell cycle progression

Penela, P., Rivas, V., Salcedo, A., & Mayor, F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905778107 · Cited by 78

Peptidyl‐prolyl isomerase inhibitors

Wang, X. J., & Etzkorn, F. A. (2005) · Biopolymers · doi:10.1002/bip.20240 · Cited by 78

MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

Casacuberta‐Serra, S., González-Larreategui, Í., Capitán-Leo, D., & Soucek, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01907-z · Cited by 84

SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

Quan, Y., Wang, N., Chen, Q., Xu, J., Cheng, W., Di, M., Xia, W., & Gao, W. (2015) · Oncotarget · doi:10.18632/oncotarget.4764 · Cited by 76

Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo

Yang, H., Xiong, F., Wei, X., Yang, Y., McNutt, M. A., & Zhou, R. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.02.006 · Cited by 77

Negative regulation of Pim-1 protein kinase levels by the B56β subunit of PP2A

Ma, J., Arnold, H., Lilly, M. B., Sears, R. C., & Kraft, A. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210323 · Cited by 77

Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells

Lu, J., Meng, L.-H., Shankavaram, U. T., Zhu, C.-H., Tong, L.-J., Chen, G., Lin, L.-P., Weinstein, J. N., & Ding, J. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.02.016 · Cited by 75

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

Lam, P. B., Burga, L. N., Wu, B. P., Hofstatter, E. W., Lu, K. P., & Wulf, G. M. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-91 · Cited by 73

Substrate Recognition Reduces Side-Chain Flexibility for Conserved Hydrophobic Residues in Human Pin1

Namanja, A. T., Tao, P., Zintsmaster, J. S., Elson, A. C., Shakour, M. G., & Peng, J. W. (2007) · Structure · doi:10.1016/j.str.2007.01.014 · Cited by 74

MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7Preprint

Chappell, J., Sun, Y., Singh, A. M., & Dalton, S. (2013) · Genes & Development · doi:10.1101/gad.211300.112 · Cited by 72

Myc Function in DrosophilaPreprint

Gallant, P. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014324 · Cited by 74

CSN6 drives carcinogenesis by positively regulating Myc stability

Chen, J., Shin, J., Zhao, R., Phan, L. M., Wang, H., Xue, Y., Post, S. M., Choi, H. H., Chen, J., Wang, E., et al. (2014) · Nature Communications · doi:10.1038/ncomms6384 · Cited by 71

Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis

Crawford, H. C., di Magliano, M. P., & Banerjee, S. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.042 · Cited by 73

Molecular Requirements for Transformation of Fallopian Tube Epithelial Cells into Serous Carcinoma

Jazaeri, A. A., Bryant, J. L., Park, H., Li, H., Dahiya, N., Stoler, M. H., Ferriss, J. S., & Dutta, A. (2011) · Neoplasia · doi:10.1593/neo.11138 · Cited by 71

c-MYC Drives Breast Cancer Metastasis to the Brain, but Promotes Synthetic Lethality with TRAIL

Lee, H. Y., Cha, J., Kim, S., Park, J., Song, K. H., Kim, P., & Kim, M. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0630 · Cited by 69

Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase

Okamoto, K., & Sagata, N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607357104 · Cited by 70

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

Georgy, S. R., Cangkrama, M., Srivastava, S., Partridge, D. D., Auden, A., Dworkin, S., McLean, C., Jane, S. M., & Darido, C. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv152 · Cited by 69

Peptidyl‐prolyl cis/trans isomerases and transcription: is there a twist in the tail?

Shaw, P. E. (2007) · EMBO Reports · doi:10.1038/sj.embor.7400873 · Cited by 69

Molecular mechanisms of the phospho‐dependent prolyl cis/trans isomerase Pin1

Lippens, G. M., Landrieu, I., & Smet‐Nocca, C. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06057.x · Cited by 68

Control of cell metabolism by the epidermal growth factor receptor

Orofiamma, L. A., Vural, D., & Antonescu, C. N. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119359 · Cited by 73

PP2A-Mediated Regulation of Ras Signaling in G2 Is Essential for Stable Quiescence and Normal G1 Length

Naetar, N., Soundarapandian, V., Litovchick, L., Goguen, K. L., Sablina, A. A., Bowman-Colin, C., Siciński, P., Hahn, W. C., DeCaprio, J. A., & Livingston, D. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.023 · Cited by 67

Phosphatases: The New Brakes for Cancer Development?

Zhang, Q. C., & Claret, F. X. (2011) · Enzyme Research · doi:10.1155/2012/659649 · Cited by 65

Functional genetics and experimental models of human cancer

Zhao, J. J., Roberts, T. M., & Hahn, W. C. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.05.005 · Cited by 65

Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signalsPreprint

Su, Y., Pelz, C., Huang, T., Torkenczy, K. A., Wang, X., Cherry, A. E., Daniel, C. J., Liang, J. B., Nan, X., Dai, M., et al. (2018) · Genes & Development · doi:10.1101/gad.314377.118 · Cited by 64

MYC deregulation in lymphoid tumors: molecular mechanisms, clinical consequences and therapeutic implications

Sewastianik, T., Prochorec‐Sobieszek, M., Chapuy, B., & Juszczyński, P. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.08.006 · Cited by 65

Hyperphosphorylation regulates the activity of SREBP1 during mitosis

Bengoechea-Alonso, M. T., Punga, T., & Ericsson, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501494102 · Cited by 64

Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth Arrest

Yaari, S., Jacob‐Hirsch, J., Amariglio, N., Haklai, R., Rechavi, G., & Kloog, Y. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2071 · Cited by 65

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

Myant, K., Qiao, X., Halonen, T., Come, C., Laine, A., Janghorban, M., Partanen, J. I., Cassidy, J., Ogg, E.-L., Cammareri, P., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.003 · Cited by 59

Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis

Shachaf, C. M., Perez, O. D., Youssef, S., Fan, A. C., Elchuri, S. V., Goldstein, M. J., Shirer, A. E., Sharpe, O., Chen, J., Mitchell, D. J., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048033 · Cited by 63

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Dingar, D. D., Tu, W. B., Resetca, D., Lourenco, C., Tamachi, A., Melo, J. D., Houlahan, K. E., Kalkat, M., Chan, P.-K., Boutros, P. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05660-0 · Cited by 62

Molecular Mechanisms of MYCN Dysregulation in Cancers

Liu, R., Shi, P., Wang, Z., Yuan, C., & Cui, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.625332 · Cited by 67

Pin1 promotes production of Alzheimer’s amyloid β from β-cleaved amyloid precursor protein

Akiyama, H., Shin, R., Uchida, C., Kitamoto, T., & Uchida, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.130 · Cited by 63

Notch1 regulates chemotaxis and proliferation by controlling the CC‐chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia

Mirandola, L., Chiriva‐Internati, M., Montagna, D., Locatelli, F., Zecca, M., Ranzani, M., Basile, A., Locati, M., Cobos, E., Kast, W. M., et al. (2011) · The Journal of Pathology · doi:10.1002/path.3015 · Cited by 62

Protein phosphatase 2A as therapeutic targets in various disease models

Baskaran, R., & Velmurugan, B. K. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.063 · Cited by 63

Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription

Li, Z., & Hann, S. (2012) · Oncogene · doi:10.1038/onc.2012.227 · Cited by 61

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

Vaughan, L. S., Clarke, P. A., Barker, K. T., Chanthery, Y. H., Gustafson, C., Tucker, E. R., Renshaw, J., Raynaud, F. I., Li, X., Burke, R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10544 · Cited by 65

Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer

Beglyarova, N., Banina, E., Zhou, Y., Mukhamadeeva, R., Andrianov, G. V., Bobrov, E., Lysenko, E., Skobeleva, N., Gabitova, L., Restifo, D., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0149 · Cited by 62

Writing and erasing MYC ubiquitination and SUMOylation

Chen, Y., Sun, X., Sears, R. C., & Dai, M. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.05.006 · Cited by 64

Survival Signals Generated by Estrogen and Phospholipase D in MCF-7 Breast Cancer Cells Are Dependent on Myc

Rodrik-Outmezguine, V. S., Yang, Z., Harrow, F. J., Chen, Y., & Foster, D. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7917-7925.2005 · Cited by 61

Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells

Sun, J., & Jin, T. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.010 · Cited by 61

Genetic induction of tumorigenesis in Swine

Adam, S. J., Rund, L. A., Kuzmuk, K. N., Zachary, J. F., Schook, L. B., & Counter, C. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209892 · Cited by 60

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

Wirth, M., Stojanovic, N., Christian, J. G., Paul, M. C., Stauber, R. H., Schmid, R. M., Häcker, G. A., Krämer, O. H., Saur, D., & Schneider, G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku763 · Cited by 62

BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis

Parang, B., Kaz, A. M., Barrett, C. W., Short, S. P., Wei, N., Keating, C. E., Mittal, M. K., Naik, R. D., Washington, M. K., Revetta, F. L., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310255 · Cited by 60

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

Stanya, K. J., Liu, Y., Means, A. R., & Kao, H. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806172 · Cited by 59

Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis

Fila, C., Metz, C. H. G., & van der Sluijs, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710264200 · Cited by 62

Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

Welcker, M., Wang, B., Rusnac, D.-V., Hussaini, Y., Swanger, J., Zheng, N., & Clurman, B. E. (2022) · Science Advances · doi:10.1126/sciadv.abl7872 · Cited by 57

Integrating Opposing Signals Toward Forkhead Box O

van den Berg, M. C. W., & Burgering, B. M. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3415 · Cited by 58

Spatial control of protein phosphatase 2A (de)methylation

Longin, S., Zwaenepoel, K., Martens, E., Louis, J. V., Rondelez, E., Goris, J., & Janssens, V. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.07.030 · Cited by 59

Challenges and Strategies in Ascribing Functions to Long Noncoding RNAs

Zhao, Y., Teng, H., Yao, F., Yap, S., Sun, Y., & Ma, L. (2020) · Cancers · doi:10.3390/cancers12061458 · Cited by 60

Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer

Signore, M., Alfonsi, R., Federici, G., Nanni, S., Addario, A., Bertuccini, L., Aiello, A., Pace, A. L. D., Sperduti, I., Muto, G., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03909-z · Cited by 59

Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation

Sontag, J. M., & Sontag, E. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6300-7 · Cited by 61

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

Helander, S., Montecchio, M., Pilstål, R., Su, Y., Kuruvilla, J., Elvén, M., Ziauddin, J. M. E., Anandapadamanaban, M., Cristóbal, S., Lundström, P., et al. (2015) · Structure · doi:10.1016/j.str.2015.10.010 · Cited by 57

Essential role of O-GlcNAcylation in stabilization of oncogenic factors

Makwana, V., Ryan, P., Patel, B., Anoopkumar‐Dukie, S., & Rudrawar, S. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.04.002 · Cited by 60

UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Qiao, X., Liu, Y., Prada, M. L., Mohan, A. K., Gupta, A., Jaiswal, A., Sharma, M., Merisaari, J., Haikala, H. M., Talvinen, K., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1647 · Cited by 56

Burkitt’s lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis

Cowling, V. H., Turner, S. A., & Cole, M. D. (2013) · Oncogene · doi:10.1038/onc.2013.338 · Cited by 55

Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56γ Knockdown

Moreno, C. S., Ramachandran, S., Ashby, D. G., Laycock, N., Plattner, C. A., Chen, W., Hahn, W. C., & Pallas, D. C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1150 · Cited by 56

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function

Sultan, I. Y., Senkal, C. E., Ponnusamy, S., Bielawski, J., Szulc, Z. M., Bielawska, A. E., Hannun, Y. A., & Öğretmen, B. (2005) · Biochemical Journal · doi:10.1042/bj20051083 · Cited by 55

Increase in CIP2A expression is associated with doxorubicin resistance

Choi, Y. A., Park, J. S., Park, M. Y., Oh, K. S., Lee, M. S., Lim, J.-S., Kim, K. I., Kim, K.-Y., Kwon, J., Yoon, D. Y., et al. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.01.018 · Cited by 54

A Genetically Defined Normal Human Somatic Cell System to Study Ras Oncogenesis In Vivo and In Vitro

O’Hayer, K., & Counter, C. M. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07050-3 · Cited by 55

ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ–PP2A

Shouse, G., Nobumori, Y., Panowicz, M. J., & Liu, X. (2011) · Oncogene · doi:10.1038/onc.2011.95 · Cited by 53

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia

Perrotti, D., & Neviani, P. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603317 · Cited by 53

Transcription factors, chromatin and cancer

Thorne, J. L., Campbell, M. J., & Turner, B. M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.029 · Cited by 54

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes

Loganathan, J., Jiang, J., Smith, A. M., Jedinak, A., Thyagarajan‐Sahu, A., Sandusky, G. E., Nakshatri, H., & Slíva, D. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2375 · Cited by 52

Pin1 Catalyzes Conformational Changes of Thr-187 in p27Kip1 and Mediates Its Stability through a Polyubiquitination Process

Zhou, W., Yang, Q., Low, C. B., Chandrababu, K. B., Wang, Y., Ryo, A., Yao, S. Q., Yang, D., & Liou, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022814 · Cited by 52

Targeting carcinogenesis: A role for the prolyl isomerase Pin1?

Lu, K. P., Suizu, F., Zhou, X. Z., Finn, G., Lam, P. B., & Wulf, G. M. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20216 · Cited by 52

N-myc functions in transcription and development

Hurlin, P. J. (2005) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20059 · Cited by 52

MYC in Germinal Center‐derived lymphomas: Mechanisms and therapeutic opportunities

Bisso, A., Sabò, A., & Amati, B. B. (2019) · Immunological Reviews · doi:10.1111/imr.12734 · Cited by 51

PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma

Ganci, F., Pulito, C., Valsoni, S., Sacconi, A., Turco, C., Vahabi, M., Manciocco, V., Mazza, E. M. C., Meens, J., Karamboulas, C., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2485 · Cited by 51

The Circadian Clock and Tumor Suppression by Mammalian Period Genes

Lee, C. C. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93045-0 · Cited by 51

Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo

Lambrecht, C., Libbrecht, L., Sagaert, X., Pauwels, P., Hoorne, Y., Crowther, J., Louis, J. V., Sents, W., Sablina, A., & Janssens, V (2018) · Oncogene · doi:10.1038/onc.2017.350 · Cited by 50

Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell Function

Esnault, S. J., Shen, Z.-J., & Malter, J. S. (2008) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v28.i1.30 · Cited by 50

CD40: A Growing Cytoplasmic Tale

Harnett, M. M. (2004) · Science s STKE · doi:10.1126/stke.2372004pe25 · Cited by 50

Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity

Risom, T., Wang, X., Liang, J. B., Zhang, X., Pelz, C., Campbell, L. G., Eng, J., Chin, K., Farrington, C. C., Narla, G., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126390 · Cited by 48

Turning Up the Heat on MYC: Progress in Small-Molecule Inhibitors

Truica, M. I., Burns, M. C., Han, H., & Abdulkadir, S. A. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2959 · Cited by 51

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells

Bharadwaj, S., Singh, M. V., Kirtipal, N., & Kang, S. G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.627842 · Cited by 50

Creating oral squamous cancer cells: A cellular model of oral–esophageal carcinogenesis

Goessel, G., Quante, M., Hahn, W. C., Harada, H., Heeg, S., Suliman, Y., Doebele, M., von Werder, A., Fulda, C., Nakagawa, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409730102 · Cited by 51

Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc

Peng, Y., Liu, J., Wang, Z., Cui, C., Zhang, S., Zhang, S., Gao, P., Hou, Z., Liu, H., Guo, J., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00960-x · Cited by 50

Regulation of Bruton Tyrosine Kinase by the Peptidylprolyl Isomerase Pin1

Yu, L., Mohamed, A. J., Vargas, L., Berglöf, A., Finn, G., Lu, K. P., & Smith, C. I. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603090200 · Cited by 49

PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: A mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment

Guénin, S., Schwartz, L. H., Morvan, D., Steyaert, J., Poignet, A., Madelmont, J., & Demidem, A. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.1.49 · Cited by 49

MIR7–3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1

Capizzi, M., Strappazzon, F., Cianfanelli, V., Papaleo, E., & Cecconi, F. (2017) · Autophagy · doi:10.1080/15548627.2016.1269989 · Cited by 48

Loss of FOXP3 and TSC1 Accelerates Prostate Cancer Progression through Synergistic Transcriptional and Posttranslational Regulation of c-MYC

Wu, L., Yi, B., Wei, S., Rao, D., He, Y., Naik, G., Bae, S., Liu, M., Yang, W., Sonpavde, G., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2049 · Cited by 49

Phosphoinositide 3-Kinase Activation in Late G 1 Is Required for c-Myc Stabilization and S Phase Entry

Kumar, A., Marqués, M., & Carrera, A. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00783-06 · Cited by 49

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway

Wheler, J. J., Moulder, S., Naing, A., Jankú, F., Piha-Paul, S. A., Falchook, G. S., Zinner, R., Tsimberidou, A. M., Fu, S., Hong, D. S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1799 · Cited by 49

Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease

Magraoui, F. E., Reidick, C., Meyer, H. E., & Platta, H. W. (2015) · Cells · doi:10.3390/cells4040596 · Cited by 48

Mechanisms of c-Myc Degradation by Nickel Compounds and Hypoxia

Li, Q., Kluz, T., Sun, H., & Costa, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008531 · Cited by 48

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression

Thomas, W. D., Chen, J., Gao, Y. R., Cheung, B. B., Koach, J., Sekyere, E. O., Norris, M. D., Haber, M., Ellis, T., Wainwright, B. J., et al. (2009) · Oncogene · doi:10.1038/onc.2009.3 · Cited by 48

PINning down the c-Myc oncoprotein

Dominguez-Sola, D., & Dalla‐Favera, R. (2004) · Nature Cell Biology · doi:10.1038/ncb0404-288 · Cited by 30

Abstract IA10: Post-translational regulation of MYC's oncogenic activity

Sears, R. C., Farrell, A., Wang, X., Liang, J. B., Janghorban, M., Su, Y., Allen-Petersen, B. L., Ohlemeyer, M., & Narla, G. (2015) · Molecular Cancer Research · doi:10.1158/1557-3125.myc15-ia10

Abstract A89: Targeting the MYC activation and degradation pathway for the treatment of pancreatic cancer

Farrell, A. S., Allen-Petersen, B. L., Daniel, C. J., Wang, X., Wang, Z., Christensen, D. J., Sheppard, B. C., & Sears, R. C. (2015) · Cancer Research · doi:10.1158/1538-7445.panca2014-a89

Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels

Ando, S., Ikeda, S., Tanaka, K., Tomabechi, Y., Yamagata, A., Shirouzu, M., Tsunedomi, R., Nagano, H., Tsuji, S., Sato, K., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509374123

SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62

Wang, W., Liao, P., Shen, M., Chen, T., Chen, Y., Li, Y. C. A. B. W. H., Lin, X., Ge, X., & Wang, P. (2015) · Oncogene · doi:10.1038/onc.2015.106 · Cited by 37