The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
Open accessAbstract
Phosphatidylserine (PS) exposure is normally associated with apoptosis and the removal of dying cells. We observed that PS is exposed constitutively at high levels on T lymphocytes that express low levels of the transmembrane tyrosine phosphatase CD45RB. CD45 was shown to be a negative regulator of PS translocation in response to various signals, including activation of the ATP receptor P2X7. Changes in PS distribution were shown to modulate several membrane activities: Ca2+ and Na+ uptake through the P2X7 cation channel itself; P2X7-stimulated shedding of the homing receptor CD62L; and reversal of activity of the multidrug transporter P-glycoprotein. The data identify a role for PS distribution changes in signal transduction, rapidly modulating the activities of several membrane proteins. This seems to be an all-or-none effect, coordinating the activity of most or all the molecules of a target protein in each cell. The data also suggest a new approach to circumventing multidrug resistance.
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Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Reanalysis of P2X7Receptor Expression in Rodent Brain
Sim, J. A., Young, M. T., Sung, H.-Y., North, R. A., & Surprenant, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-04.2004 · Cited by 264
Marty, V., Médina, C., Combe, C., Parnet, P., & Amédée, T. (2005) · Glia · doi:10.1002/glia.20138 · Cited by 41
Cited by
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025
Phagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959
ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles
Muralidharan-Chari, V., Clancy, J., Plou, C., Romao, M., Chavrier, P., Raposo, G., & D'Souza-Schorey, C. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.059 · Cited by 912
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance, J. E., & Tasseva, G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.08.016 · Cited by 521
Eaten alive! Cell death by primary phagocytosis: ‘phagoptosis’
Brown, G. C., & Neher, J. J. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.05.002 · Cited by 323
Metadata
- Authors
- Elliott, J. I., Surprenant, A., Marelli-Berg, F. M., Cooper, J. C., Cassady-Cain, R. L., Wooding, C., Linton, K., Alexander, D. R., & Higgins, C. F.
- Venue
- Nature Cell Biology
- Published
- 2005-07-17
- Volume
- 7
- Issue
- 8
- Pages
- 808-816
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2155409515
- Cited by
- 227
- References
- 3
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Elliott, J. I., Surprenant, A., Marelli-Berg, F. M., Cooper, J. C., Cassady-Cain, R. L., Wooding, C., Linton, K., Alexander, D. R., & Higgins, C. F. (2005). Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nature Cell Biology. https://doi.org/10.1038/ncb1279
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