Cited by 1,025Adenosine and Purinergic SignalingInflammasome and immune disordersImmune Response and Inflammation

The P2X7 Receptor: A Key Player in IL-1 Processing and Release

Ferrari, Davide, Pizzirani, Cinzia, Adinolfi, Elena, Lemoli, Roberto M, Curti, Antonio, Idzko, Marco, Panther, Elisabeth, Di Virgilio, Francesco·2006·The Journal of Immunology

Abstract

Human IL-1 family proteins are key mediators of the host response to infections, injury, and immunologic challenges. The mechanism by which IL-1 activates proinflammatory responses in target cells, and the plasma membrane receptors involved, is fairly well known. This has led to the development of innovative drugs that block IL-1 downstream to its synthesis and secretion. On the contrary, the mechanism of IL-1 and other IL-1 family members (e.g., IL-18) maturation and release is incompletely understood. Accruing evidence points to a plasma membrane receptor for extracellular ATP, the P2X7 receptor, as a key player in both processes. A deeper understanding of the mechanism by which the P2X7 receptor triggers IL-1 maturation and exteriorization may suggest novel avenues for the treatment of inflammatory diseases and provide a deeper insight in the fundamental mechanism of protease activation and cellular export of proteins lacking a leader sequence.

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Crossref · 10.4049/jimmunol.176.7.3877

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126 of 126 references verified0 citation errors · 0 not checkable

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Authors
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F.
Affiliations
  • University of Ferrara (IT)
  • University of Bologna (IT)
  • University of Freiburg (DE)
  • Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara , Ferrara ,
Venue
The Journal of Immunology
Published
2006-04-01
Volume
176
Issue
7
Pages
3877-3883
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W1824528611
Cited by
1,025
References
126
Citations by year
2026: 18 · 2025: 21 · 2024: 27 · 2023: 37 · 2022: 32 · 2021: 49 · 2020: 44 · 2019: 49 · 2018: 30 · 2017: 45 · 2016: 53 · 2015: 69 · 2014: 64 · 2013: 63 · 2012: 80
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
P2X7 receptor, interleukin-1, extracellular ATP, IL-18, protease activation, inflammatory diseases, plasma membrane receptors, inflammatory cytokines
MeSH terms
Adenosine Triphosphate, Animals, Humans, Interleukin-1, Ligands, Receptors, Interleukin-1, Receptors, Purinergic P2, Interleukin-18, Receptors, Purinergic P2X7

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