The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Abstract
Human IL-1 family proteins are key mediators of the host response to infections, injury, and immunologic challenges. The mechanism by which IL-1 activates proinflammatory responses in target cells, and the plasma membrane receptors involved, is fairly well known. This has led to the development of innovative drugs that block IL-1 downstream to its synthesis and secretion. On the contrary, the mechanism of IL-1 and other IL-1 family members (e.g., IL-18) maturation and release is incompletely understood. Accruing evidence points to a plasma membrane receptor for extracellular ATP, the P2X7 receptor, as a key player in both processes. A deeper understanding of the mechanism by which the P2X7 receptor triggers IL-1 maturation and exteriorization may suggest novel avenues for the treatment of inflammatory diseases and provide a deeper insight in the fundamental mechanism of protease activation and cellular export of proteins lacking a leader sequence.
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ATP is a danger signal released from stressed or injured cells to signal damage to innate immune cells.
“ATP is also considered to be a danger signal that is released from stressed or injured cells to signal damage to innate immune cells (Ferrari et al, 2006).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Ferrari et al, 2006
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- Authors
- Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F.
- Affiliations
- University of Ferrara (IT)
- University of Bologna (IT)
- University of Freiburg (DE)
- Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara , Ferrara ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-04-01
- Volume
- 176
- Issue
- 7
- Pages
- 3877-3883
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1824528611
- Cited by
- 1,025
- References
- 126
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 27 · 2023: 37 · 2022: 32 · 2021: 49 · 2020: 44 · 2019: 49 · 2018: 30 · 2017: 45 · 2016: 53 · 2015: 69 · 2014: 64 · 2013: 63 · 2012: 80
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- P2X7 receptor, interleukin-1, extracellular ATP, IL-18, protease activation, inflammatory diseases, plasma membrane receptors, inflammatory cytokines
- MeSH terms
- Adenosine Triphosphate, Animals, Humans, Interleukin-1, Ligands, Receptors, Interleukin-1, Receptors, Purinergic P2, Interleukin-18, Receptors, Purinergic P2X7
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