Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
Kortlever, Roderik M., Higgins, Paul J., Bernards, René·2006·Nature Cell Biology
DOI 10.1038/ncb1448
Cited by (637)
Items 201–300 of 637
- Porphyromonas gingivalis downregulates the immune response of fibroblastsE. C. Palm, Hazem Khalaf, Torbjörn Bengtsson · 2013 · BMC Microbiology
- Stress granules counteract senescence by sequestration of PAI‐1Amr Omer, Devang M. Patel, Xian Jin Lian, Jason Sadek, Sergio Di Marco, Arnim Pause, Myriam Gorospe, Imed‐Eddine Gallouzi · 2018 · EMBO Reports
- p53’s Extended Reach: The Mutant p53 SecretomeEvangelos Pavlakis, Thorsten Stiewe · 2020 · Biomolecules
- Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implicationsBinghao Zhao, Bo Chang Wu, Nan Feng, Xiang Zhang, Xin Zhang, Yiping Wei, Wenxiong Zhang · 2023 · Journal of Hematology & Oncology
- Paracrine Effects of Mesenchymal Stem Cells Induce Senescence and Differentiation of Glioblastoma Stem-Like CellsKatja Kološa, Helena Motaln, Christel C. Herold‐Mende, Marjan Koršič, Tamara T. Lah · 2015 · Cell Transplantation
- Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: An exploratory analysisRoy Sidi, Giulia Pasello, Isabelle Opitz, Alex Soltermann, Michaela Tutic, Hubert Rehrauer, Walter Weder, Rolf Arno Stahel, Emanuela Felley‐Bosco · 2010 · European Journal of Cancer
- Induction of genetic instability by gain-of-function p53 cancer mutantsYang Xu · 2008 · Oncogene
- Regulation of Plasminogen Activator Inhibitor-1 Expression by Tumor Suppressor Protein p53Sreerama Shetty, Praveenkumar K. Shetty, Steven Idell, Thirunavukkarasu Velusamy, Yashodhar P. Bhandary, Rashmi R Shetty · 2008 · Journal of Biological Chemistry
- Chemokine receptor CXCR 2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damageHaiyang Guo, Zhaojian Liu, Bing Xu, Huili Hu, Zhao Wei, Qiao Liu, Xiyu Zhang, Xuebin Ding, Yu Wang, Minnan Zhao et al. · 2013 · Aging Cell
- Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer CellsArun Azad, Susan Jackson, Carleen M. Cullinane, Anthony L. Natoli, Paul Matthew Neilsen, David Frederick Callen, Sauveur-Michel Maira, Wolfgang Hackl, Grant A. McArthur, Benjamin Solomon · 2011 · Molecular Cancer Research
- SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescenceFrédérick A. Mallette, Viviane Calabrese, Subburaj Ilangumaran, Gerardo Ferbeyre · 2010 · Aging
- Cellular senescence and protein degradationXavier Deschênes‐Simard, Frédéric Lessard, Marie‐France Gaumont‐Leclerc, Nabeel M. Bardeesy, Gerardo Ferbeyre · 2014 · Cell Cycle
- The Emerging Role of Senescence in Ocular DiseaseParameswaran Gangadharan Sreekumar, David R. Hinton, Ram Kannan · 2020 · Oxidative Medicine and Cellular Longevity
- IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cellsZuo, Shuguang, Liu, Chang, Wang, Jianguo, Wang, Fuqing, Xu, Wanling, Cui, Shao, Yuan, Lei, Chen, Xudong, Fan, Wenjuan, Cui, Mingchen et al. · 2012 · Journal of Cancer Research and Clinical Oncology
- Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cellsPaul R. Coleman, Christopher Norman Hahn, Matthew J. Grimshaw, Ying Lü, Xiaochun Li, Peter J Brautigan, Konstanze Beck, Roland Stocker, Mathew Alexander Vadas, Jennifer R. Gamble · 2010 · Blood
- Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionTimothy P. Cash, Joshua James Gruber, Tiffiney R. Hartman, Elizabeth P. Henske, Marie Celeste Simon · 2011 · Oncogene
- p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T CellsValérie Janelle, Mathieu Neault, Marie‐Ève Lebel, Dave Maurice De Sousa, Salix Boulet, Ludovic Durrieu, Cédric Carli, Chloé Muzac, Sébastien Lemieux, Nathalie Labrecque et al. · 2021 · Frontiers in Immunology
- Cancer Evo–Dev: A Theory of Inflammation-Induced OncogenesisWenbin Liu, Yang Deng, Zishuai Li, Yifan Chen, Xiaoqiong Zhu, Xiaojie Tan, Guangwen Cao · 2021 · Frontiers in Immunology
- Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortalitySeong-Jun Cho, Andrea Rossi, Yong-Sam Jung, Wensheng Yan, Gang Liu, Jin Zhang, Min Zhang, Xinbin Chen · 2013 · Proceedings of the National Academy of Sciences
- Effects of long-term culture on the biological characteristics and RNA profiles of human bone-marrow-derived mesenchymal stem cellsShan Wang, Ziming Wang, Hongjun Su, Fenglei Chen, Mengjun Ma, Wenhui Yu, Guiwen Ye, Shuizhong Cen, Rujia Mi, Xiaohua Wu et al. · 2021 · Molecular Therapy — Nucleic Acids
- Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescenceHouZao Chen, Yan-zhen Wan, Shuang Zhou, Yunbiao Lu, Zhu‐Qin Zhang, Ran Zhang, Feng Chen, De‐Long Hao, Xiang Zhao, Zhi-Chen Guo et al. · 2012 · Science China Life Sciences
- Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironmentMark Gramling, Frank Church · 2010 · Thrombosis Research
- A connection between magnesium deficiency and aging: new insights from cellular studies.David W. Killilea, Jeanette A.M. Maier · 2008 · PubMed
- Cellular senescence: a double‐edged sword in the fight against cancerOhtani, Naoko, Takahashi, Akiko, Mann, David J., Hara, Eiji · 2012 · Experimental Dermatology
- Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell deathLifeng Yuan, Linhui Zhai, Lili Qian, De Huang, Yi Ding, Handan Xiang, Xiaojing Liu, J. Will Thompson, Juan Liu, Yonghan He et al. · 2018 · Cell Research
- Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver InjuryChristopher R. Cox, Stephen Lynch, Christopher E. Goldring, Parveen Sharma · 2020 · Frontiers in Medical Technology
- Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic OpportunitiesXinghui Sun, Mark W. Feinberg · 2021 · Frontiers in Physiology
- A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescenceSadiya Bi Shaikh, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Yashodhar P. Bhandary, Hoshang Jehangir Unwalla, Thottethodi Subrahmanya Keshava Prasad, Irfan Rahman · 2024 · Cell Communication and Signaling
- Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal MuscleFasih Ahmad Rahman, Sarah A. Angus, Kyle Stokes, Phillip A. Karpowicz, Matthew Paul Krause · 2020 · International Journal of Molecular Sciences
- Crosstalk between YAP and TGFβ regulates SERPINE1 expression in mesenchymal lung cancer cellsHyeon‐Joon Kong, Eun‐Ji Kwon, Ok‐Seon Kwon, Haeseung Lee, Jeong‐Yun Choi, Yung‐Jeong Kim, Wankyu Kim, Hyuk‐Jin Cha · 2020 · International Journal of Oncology
- Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 DeficiencyTomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E. Bayliss, Christopher E. Carr, Jennifer Linda Johnson, Sujay Guha, Patrick Kobler, Sergio Daniel Catz, Matthew S. Gill et al. · 2014 · PLoS Genetics
- Transforming Growth Factor-β Requires Its Target Plasminogen Activator Inhibitor-1 for Cytostatic ActivityRoderik M. Kortlever, Jeroen H. Nijwening, René Bernards · 2008 · Journal of Biological Chemistry
- Cellular senescence and other age-related mechanisms in skeletal diseasesKe Li, Sihan Hu, Hao Chen · 2025 · Bone Research
- Serine/Threonine Kinase 17A Is a Novel p53 Target Gene and Modulator of Cisplatin Toxicity and Reactive Oxygen Species in Testicular Cancer CellsPingping Mao, Mary P. Hever-Jardine, Lynn Niemaszyk, Jessica M. Haghkerdar, Esty G. Yanco, Damayanti Desai, Maroun J. Beyrouthy, Joanna S. Kerley-Hamilton, Sarah J. Freemantle, Michael J. Spinella · 2011 · Journal of Biological Chemistry
- Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min miceMichihiro Mutoh, Naoko Niho, Masami Komiya, Mami Takahashi, Rina Ohtsubo, Kiyoshi Nakatogawa, Kentaro Ueda, Takashi Sügimura, Keiji Wakabayashi · 2008 · Carcinogenesis
- The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrixPaul Hiebert · 2021 · Matrix Biology Plus
- The Cancer Genome AtlasB. Minu Chandra Muddabhaktuni, Venkata Pradeep Babu Koyyala · 2021 · Indian Journal of Medical and Paediatric Oncology
- Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular agingNathan A. DeCarolis, Keith A. Wharton, Amelia J. Eisch · 2008 · BioEssays
- A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte RegenerationNuria Oliva‐Vilarnau, Sabine U. Vorrink, Magnus Ingelman‐Sundberg, Volker Martin Lauschke · 2020 · Advanced Science
- Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cellsBURTON, DOMINICK G. A., SHEERIN, ANGELA N., OSTLER, ELIZABETH L., SMITH, KAYE, GILES, PETER J., LOWE, JILL, RHYS‐WILLIAMS, WILLIAM, KIPLING, DAVID G., FARAGHER, RICHARD G. A. · 2007 · Annals of the New York Academy of Sciences
- Metabolic syndrome: A novel high-risk state for colorectal cancerKousuke Ishino, Michihiro Mutoh, Yukari Totsuka, Hitoshi Nakagama · 2012 · Cancer Letters
- Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cellsAlireza Delfarah, Sydney Parrish, Jason A. Junge, Jesse Yang, Frances Seo, Si Li, John Mac, Pin Wang, Scott E. Fraser, Nicholas Alexander Graham · 2019 · Journal of Biological Chemistry
- Plasminogen Activator Inhibitor-1 Suppresses Profibrotic Responses in Fibroblasts from Fibrotic LungsAmarnath Satheesh Marudamuthu, Shwetha Kumari Shetty, Yashodhar P. Bhandary, Sophia Karandashova, Michael Thompson, Venkatachalem Sathish, Galina Florova, Taryn B. Hogan, Christina M. Pabelick, Y.S. Prakash et al. · 2015 · Journal of Biological Chemistry
- Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423Tomoko Kashiyama, Katsutoshi Oda, Yuji Ikeda, Yoshinobu Shiose, Yasuhide Hirota, Kanako Inaba, Chinami Makii, Reiko Kurikawa, Aki Miyasaka, Takahiro Koso et al. · 2014 · PLoS ONE
- NF90 coordinately represses the senescence-associated secretory phenotypeTominaga-Yamanaka, Kumiko, Abdelmohsen, Kotb, Martindale, Jennifer L., Yang, Xiaoling, Taub, Dennis D., Gorospe, Myriam · 2012 · Aging
- Emerging role of tumor suppressor p53 in acute and chronic kidney diseasesJessica M. Overstreet, Cody C. Gifford, Jiaqi Tang, Paul J. Higgins, Rohan Samarakoon · 2022 · Cellular and Molecular Life Sciences
- The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence programStephan Schmidt, Larry X. Schneider, Frank Eßmann, Ion Cristian Cirstea, Fabian Kuck, Anja Kletke, Reiner U. Jänicke, Constanze Wiek, Helmut Hanenberg, Mohammad Reza Ahmadian et al. · 2010 · Oncogene
- Plasminogen Activator Inhibitor 1 Protects Fibrosarcoma Cells from Etoposide-Induced Apoptosis through Activation of the PI3K/Akt Cell Survival PathwayMaria Unni Rømer, Lise Larsen, Hanne Offenberg, Nils Brünner, Ulrik A. Lademann · 2008 · Neoplasia
- Regulation of Airway and Alveolar Epithelial Cell Apoptosis by p53-Induced Plasminogen Activator Inhibitor-1 during Cigarette Smoke Exposure InjuryShwetha Kumari Shetty, Yashodhar P. Bhandary, Amarnath Satheesh Marudamuthu, Daniel G. Abernathy, Thirunavukkarasu Velusamy, BARRY C. STARCHER, Sreerama Shetty · 2012 · American Journal of Respiratory Cell and Molecular Biology
- p53 and RAD9, the DNA Damage Response, and Regulation of Transcription NetworksHoward B. Lieberman, Sunil K. Panigrahi, Kevin M. Hopkins, Li Wang, Constantinos G. Broustas · 2017 · Radiation Research
- PAI-1 contributes to homocysteine-induced cellular senescenceTianjiao Sun, Asish K. Ghosh, Mesut Eren, Toshio Miyata, Douglas E. Vaughan · 2019 · Cellular Signalling
- Evidence of oncogene-induced senescence in thyroid carcinogenesisVizioli, Maria Grazia, Possik, Patricia A, Tarantino, Eva, Meissl, Katrin, Borrello, Maria Grazia, Miranda, Claudia, Anania, Maria Chiara, Pagliardini, Sonia, Seregni, Ettore, Pierotti, Marco A et al. · 2011 · Endocrine-Related Cancer
- Enhanced Endothelial Cell Senescence by Lithium-induced Matrix Metalloproteinase-1 ExpressionIan T. Struewing, Samuel N Durham, Corey D. Barnett, Catherine D. Mao · 2009 · Journal of Biological Chemistry
- Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescenceLucinda S. McRobb, Matthew J. McKay, Jennifer R. Gamble, Michael Grace, Vaughan Moutrie, Estevam D. Santos, Vivienne S. Lee, Zhenjun Zhao, Mark P. Molloy, Marcus Andrew Stoodley · 2017 · Aging
- Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesisSimone Marquard, Stefan Thomann, Sofia M.E. Weiler, Michaela Bissinger, Teresa Lutz, Carsten Sticht, Marcell Tóth, Carolina De La Torre, Norbert Gretz, Beate Katharina Straub et al. · 2020 · Cell Communication and Signaling
- MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver DiseaseJunior Junior, Yin‐Siew Lai, Huyen Thi Nguyen, Farrah Putri Salmanida, Ko‐Tung Chang · 2021 · International Journal of Molecular Sciences
- Role of the Urokinase-Fibrinolytic System in Epithelial–Mesenchymal Transition during Lung InjuryAmarnath Satheesh Marudamuthu, Yashodhar P. Bhandary, Shwetha Kumari Shetty, Jian Fu, Venkatachalem Sathish, Y. S. Prakash, Sreerama Shetty · 2014 · American Journal Of Pathology
- Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine ModelEun Joo Chung, Grace B. McKay-Corkum, Su I. Chung, Ayla O. White, Bradley T. Scroggins, James B. Mitchell, Mary Jo Mulligan‐Kehoe, Deborah E. Citrin · 2015 · International Journal of Radiation Oncology*Biology*Physics
- BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescenceKeith Wheaton, Jennifer Muir, Weili Ma, Samuel Benchimol · 2010 · Aging Cell
- Oncogene-induced senescence: An essential role for RunxAnne Terry, Ewan R. Cameron, James C. Neil, Anna Kilbey · 2008 · Cell Cycle
- Senescence of alveolar epithelial cells impacts initiation and chronic phases of murine fibrosing interstitial lung diseaseZento Yamada, Junko Nishio, Kaori Motomura, Satoshi Mizutani, Soichi Yamada, Tetuo Mikami, Toshihiro Nanki · 2022 · Frontiers in Immunology
- Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer MetastasisEvangelos Pavlakis, Michelle M. Neumann, Thorsten Stiewe · 2020 · International Journal of Molecular Sciences
- How to become immortal: let MEFs count the waysAdam F. Odell, Jon M. Askham, Catherine Whibley, Monica Hollstein · 2010 · Aging
- Cellular Senescence as a Target in Cancer ControlMar Vergel, Juan Marín, Purificación Estévez, Amancio Carnero · 2010 · Journal of Aging Research
- Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational ChallengesHubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz · 2025 · Cells
- Pyruvate promotes tumor angiogenesis through HIF-1-dependent PAI-1 expressionKim · 2010 · International Journal of Oncology
- Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest ResponsesSergio Liarte, Ángel Bernabé‐García, Francisco José Nicolás · 2020 · Cells
- Cellular senescence: from anti-cancer weapon to anti-aging targetLifeng Yuan, Peter B. Alexander, Xiao‐Fan Wang · 2020 · Science China Life Sciences
- Normal Aging and Its Role in Cancer MetastasisMitchell E. Fane, Ashani T. Weeraratna · 2019 · Cold Spring Harbor Perspectives in Medicine
- Signalling networks associated with urokinase‐type plasminogen activator (uPA) and its inhibitor PAI‐1 in breast cancer tissues: new insights from protein microarray analysisClaudia Wolff, Katharina Malinowsky, Daniela Berg, Kerstin Schragner, Tibor Schuster, Axel Karl Walch, Holger Bronger, Heinz Höfler, Karl‐Friedrich Becker · 2010 · The Journal of Pathology
- Adult Thymic Epithelium Contains Nonsenescent Label-Retaining CellsMaude Dumont-Lagacé, Sylvie Brochu, Charles St-Pierre, Claude Perreault · 2014 · The Journal of Immunology
- The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cellsHsi-Hsien Hsieh, Ying‐Chieh Chen, Jing-Ru Jhan, Jing‐Jer Lin · 2017 · Journal of Cell Science
- Chronic wounds – is cellular ‘reception’ at fault? Examining integrins and intracellular signallingAlan David Widgerow · 2012 · International Wound Journal
- Early Embryonic Lethality of Mice Lacking the Essential Protein SNEVKlaus Fortschegger, Bettina Wagner, Regina Voglauer, Hermann W. D. Katinger, Maria Chiara Sibilia, Johannes Grillari · 2007 · Molecular and Cellular Biology
- Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescenceXiuhua Xu, Qiao Liu, Chen Zhang, Shuai Ren, Limei Xu, Zixiao Zhao, Hao Dou, Peishan Li, Xiyu Zhang, Yaoqin Gong et al. · 2019 · Cell Death and Disease
- CXCL5‐CXCR2 signaling is a senescence‐associated secretory phenotype in preimplantation embryosYuta Kawagoe, Ikko Kawashima, Yorino Sato, Naoki Okamoto, Kazuei Matsubara, Kazuhiro Kawamura · 2020 · Aging Cell
- Are aging biomarkers clinically relevant in oncogeriatrics?Claire Falandry, Éric Gilson, K. Lenhard Rudolph · 2012 · Critical Reviews in Oncology/Hematology
- MDM2 and MDMX in Cancer and DevelopmentJean‐Christophe Marine · 2011 · Current topics in developmental biology/Current Topics in Developmental Biology
- AKT mediates actinomycin D-induced p53 expressionChen‐Li Cheng, Dong‐Ru Ho, Fei-Yun Chen, Chang-Rong Chen, Yu-De Ke, Jyan-Gwo Joseph Su · 2014 · Oncotarget
- Identification of a transcriptional signature for the wound healing continuumMatthew A. Peake, Mathew P. Caley, Peter J. Giles, Ivan B. Wall, Stuart Enoch, Lindsay C. Davies, David Kipling, David Wayne Thomas, Phil Stephens · 2014 · Wound Repair and Regeneration
- Senescence and pre-malignancy: How do tumors progress?Raya Hamad Saab · 2011 · Seminars in Cancer Biology
- Therapeutic Implications of Ferroptosis in Renal FibrosisYao Zhang, Yanhua Mou, Jianjian Zhang, Chuanjian Suo, Hai Zhou, Min Jeong Gu, Zengjun Wang, Ruoyun Tan · 2022 · Frontiers in Molecular Biosciences
- Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathwaysA. Yokoyama, F. Ficara, Mark J. Murphy, C. Meisel, Alpana Naresh, I. Kitabayashi, M. Cleary · 2011 · Journal of Cell Science
- Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic StrokeZhijun Pu, Xinyu Bao, Shengnan Xia, Pengfei Shao, Yun Xu · 2022 · Journal of Inflammation Research
- PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?Mohammad Badran, David Gozal · 2022 · International Journal of Molecular Sciences
- Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid FibroblastsTai‐Lan Tuan, Paul Hwu, Wendy Ho, Peter Yiu, Richard Chang, Annette B. Wysocki, Paul D. Benya · 2008 · American Journal Of Pathology
- At the stem of youth and healthAntonio Paolo Beltrami, Daniela Cesselli, Carlo Alberto Beltrami · 2010 · Pharmacology & Therapeutics
- Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathwayYun‐Ui Bae, Joon Hyuk Choi, András Nagy, Hoon‐Ki Sung, Jae‐Ryong Kim · 2015 · The FASEB Journal
- The IGF-1R/AKT pathway determines cell fate in response to p53Lei Duan, Carl G. Maki · 2016 · Translational Cancer Research
- WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansionJohannes Lehmann, Roberto Narcisi, Natasja Franceschini, Danai Chatzivasileiou, Cindy Germaine Boer, Wendy J. L. M. Koevoet, Diana A. Putavet, Dubravka Drabek, Rien van Haperen, Peter L.J. de Keizer et al. · 2022 · Cellular and Molecular Life Sciences
- Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescenceThomas M. Johnson, Kristin E. Meade, Navneeta Pathak, Michelle R. Marques, Laura Donatella Attardi · 2008 · Proceedings of the National Academy of Sciences
- Upstream stimulatory factor‐2 mediates quercetin‐induced suppression of PAI‐1 gene expression in human endothelial cellsNelida C. Olave, Maximiliano H. Grenett, Martín Cadeiras, Hernan E. Grenett, Paul J. Higgins · 2010 · Journal of Cellular Biochemistry
- Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathwaysJogitha Selvarajah, K Nathawat, Abdeladim Moumen, Margaret A. Ashcroft, Veronica A. Carroll · 2013 · Cell Death and Disease
- Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cellsElena E. Tzekaki, George D. Geromichalos, Sophia N. Lavrentiadou, Maria P. Tsantarliotou, Αnastasia A. Pantazaki, Angelos Papaspyropoulos · 2021 · Breast Cancer Research and Treatment
- PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell CarcinomaJennifer Freytag, Cynthia E. Wilkins-Port, Craig E. Higgins, J. Andrew Carlson, Agnès Noël, Jean‐Michel Foidart, Stephen P. Higgins, Rohan Samarakoon, Paul J. Higgins · 2009 · Journal of Oncology
- Targeting LINC00673 expression triggers cellular senescence in lung cancerAnna Roth, Karine Boulay, Matthias Groß, Maria Polycarpou‐Schwarz, Frédérick A. Mallette, Marine Regnier, Or Bida, Doron Ginsberg, Arne Warth, Philipp Albert Schnabel et al. · 2018 · RNA Biology
- TGF‐β1–p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implicationsCraig E. Higgins, Jiaqi Tang, Badar M. Mian, Stephen P. Higgins, Cody C. Gifford, David J. Conti, Kirstan K. Meldrum, Rohan Samarakoon, Paul J. Higgins · 2019 · The FASEB Journal
- Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancerSuisui Hao, Jingshan Tong, Anupma Jha, Denise Risnik, Darleny Y. Lizardo, Xinyan Y. Lu, Ajay Goel, Patricia Lynn Opresko, Jian Yu, Lin Zhang · 2022 · Proceedings of the National Academy of Sciences
- The Central Role of PAI-1 in COVID-19: Thrombosis and beyondSadiya S. Khan · 2021 · American Journal of Respiratory Cell and Molecular Biology
- PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2Nina Kozlova, Jan Kristian Jensen, Tabughang Franklin Chi, Anatoly Samoylenko, Thomas Kietzmann · 2015 · Thrombosis and Haemostasis