Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

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3. PAI-1 Regulation of TGF-β1–induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
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4. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species
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6. Exploring the multiple roles of guardian of the genome: P53
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7. Fibrin and Fibrinolysis in Cancer
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8. TGF-β1/p53 signaling in renal fibrogenesis
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9. The role of cellular senescence and SASP in tumour microenvironment
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10. Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
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11. Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
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12. Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
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13. Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2
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14. Microphthalmia-Associated Transcription Factor Controls the DNA Damage Response and a Lineage-Specific Senescence Program in Melanomas
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15. Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice
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16. Cellular senescence and cancer chemotherapy resistance
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17. Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N ω -Nitro- l -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence
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18. The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure
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19. Tumor suppressor p53 and its gain-of-function mutants in cancer
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20. The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation
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21. Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease
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22. New insights into p53 activation
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23. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas
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24. Stressing the cell cycle in senescence and aging
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25. Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
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26. JMJD2A Promotes Cellular Transformation by Blocking Cellular Senescence through Transcriptional Repression of the Tumor Suppressor CHD5
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27. Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
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28. Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
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29. The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation
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30. Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model
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31. Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging
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32. Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
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33. Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
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34. p53 downstream target genes and tumor suppression: a classical view in evolution
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35. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes
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36. Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective
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37. Senescent Cells and Their Secretory Phenotype as Targets for Cancer Therapy
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38. Cellular Senescence - its role in cancer and the response to ionizing radiation
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39. NF-κB in Cellular Senescence and Cancer Treatment
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40. Transmitting senescence to the cell neighbourhood
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41. Cellular senescence: hot or what?
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42. Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
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43. Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
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44. Adipose Tissue‐Derived Plasminogen Activator Inhibitor‐1 Function and Regulation
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45. Control of senescence by CXCR2 and its ligands
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46. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
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47. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype
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48. Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin
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49. Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
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50. Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
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51. WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway
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52. Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq
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53. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
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54. The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
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55. Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression
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56. Role of Plasminogen Activator Inhibitor-1 in Senescence and Aging
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57. Transcriptional regulation of cellular senescence
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58. Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseases
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59. Plasminogen Activation–Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis
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60. Endothelial cell senescence and thrombosis: Ageing clots
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61. DNA Damage: A Main Determinant of Vascular Aging
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62. Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells
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63. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence
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64. The RP-Mdm2-p53 Pathway and Tumorigenesis
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65. The role of senescence in cancer development
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66. Dissecting primary and secondary senescence to enable new senotherapeutic strategies
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67. The Deubiquitinating Enzyme USP26 Is a Regulator of Androgen Receptor Signaling
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68. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
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69. SIRT 1‐mediated epigenetic downregulation of plasminogen activator inhibitor‐1 prevents vascular endothelial replicative senescence
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70. A Role for CXCR2 in Senescence, but What about in Cancer?
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71. TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription
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75. Non-cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy.
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80. SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-“Activated” Keratinocytes
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81. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
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82. Cellular senescence and kidney aging
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83. Ras-Induced Senescence and its Physiological Relevance in Cancer
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85. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
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86. Identification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability
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88. Cellular senescence: a hitchhiker’s guide
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89. Microbiome and cancer
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92. PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
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95. Lessons from senescence: Chromatin maintenance in non-proliferating cells
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