Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

Kortlever, Roderik M., Higgins, Paul J., Bernards, René·2006·Nature Cell Biology

DOI 10.1038/ncb1448

Cited by (635)

Items 401–500 of 635

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Maria Patrizia Stoppelli, Lisbeth M. Andersen, Giuseppina Votta, Peter A. Andreasen · 2008 · Springer eBooks
[P53 and its role in the ovarian surface epithelium. A review].
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Ashaq Hussain, Marc Tatar, Rujun Gong · 2026 · Cell & Bioscience
Replication-compromised cells require the mitotic checkpoint to prevent tetraploidization
Zilai Zhang, Sumit Arora, Yanjiao Zhou, Athena M. Cherry, Teresa S.‐F. Wang · 2010 · Chromosoma
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Franziska Weiner, Jan Torben Schille, Dirk Koczan, Xiao‐Feng Wu, Matthias Beller, Christian Junghanß, Marion Hewicker‐Trautwein, Hugo Murua Escobar, Ingo J. A. Nolte · 2021 · BMC Cancer
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Janice Wong, Anam Qudrat, Abdullah Al Mosabbir, Kevin Truong · 2018 · Springer eBooks
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Banumathy Gowrishankar, Peter D. Adams · 2009 · Springer eBooks
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Paul J. Higgins · 2014 · Cell & Developmental Biology
Hypoxia and Senescence
Yashi Gupta, Scott M. Welford · 2016 · WORLD SCIENTIFIC eBooks
The Role of Senescence in Hepatic Diseases
Ruth Pacheco-Rivera, Jaime Arellanes‐Robledo, M.C. García de León, Mineko Shibayama, Jesús Serrano‐Luna · 2017 · Elsevier eBooks