Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
Zhong, Yun, Wang, Qing Jun, Li, Xianting, Yan, Ying, Backer, Jonathan M., Chait, Brian T., Heintz, Nathaniel, Yue, Zhenyu·2009·Nature Cell Biology
DOI 10.1038/ncb1854
Cited by (1,001)
Items 901–1,000 of 1,001
- Inhibiting protein clearance to induce cell death in tuberous sclerosis and pancreatic cancerJeremiah William Hendricks · 2014 · IUScholarWorks (Indiana University)
- Exosomes in the Preservation of Cellular HomeostasisFrancesc Baixauli, Marı́a Mittelbrunn · 2016 · Oxidative stress in applied basic research and clinical practice
- The role of phosphatidylinositol 3-kinases in autophagy regulationKelly A. Devereaux · 2014
- Second Messenger-mediated Regulation of AutophagyShahab Shahnazari · 2012 · TSpace (University of Toronto)
- The Role of the Small Rab24 GTPase in Autolysosome ClearanceR. Honkanen · 2016 · Työväentutkimus Vuosikirja
- Autophagy in Cardiac DevelopmentHongxin Zhu, Lin He · 2017 · Medical Research Archives
- Estudio de la ruta de la autofagia en carcinoma de endometrio esporádicoMarta Fernández Prieto · 2016
- Unselective Disposal of Cellular AggregatesPierfausto Seneci · 2015 · Elsevier eBooks
- Experimental Models and Measurement of AutophagyWei Zhu, Yong Sun, Yaoliang Tang, Chen Wang, Chang-Chen Xiao, Jing-Hai Chen, Hong Yu, Xin-yang Hu, Jianan Wang · 2018 · Elsevier eBooks
- The cellular functions of mammalian type II phosphatidylinositol 4-kinasesGaniyu O. Alli‐Balogun · 2017 · UCL Discovery (University College London)
- Nuevas aproximaciones en el estudio de la ruta autofágica en cáncer colorrectalVanessa Carolina Rivero Perdomo · 2018 · Gredos (University of Salamanca)
- Role of Apoptosis in Liver DiseasesHayato Hikita, Tetsuo Takehara · 2019 · Springer eBooks
- Anti-cancer effect of RKIP via modulating autophagy during metastasisMahmoud Ahmed, Deok Ryong Kim · 2020 · Elsevier eBooks
- Autophagic Dysfunction in NeurodegenerationMeenakshi Kaira, Abhilasha Ahlawat, Vaibhav Walia, Munish Garg · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- Structural and Post-Transcriptional Regulation of Autophagy in Saccharomyces cerevisiaeDamián Gatica · 2019 · Deep Blue (University of Michigan)
- Über die potenziell kardioprotektive Rolle des Hitzeschockproteins A4Svante S. Gersch · 2020
- Group AStreptococcus-Mediated Host Cell SignalingVijay Pancholi · 2019 · ASM Press eBooks
- Mitochondrial-localized Phosphatidylethanolamine in Mitochondrial Dynamics and AutophagyEliana Y.L. Chan · 2014 · TSpace (University of Toronto)
- Analysis of the Molecular Mechanism and Physiological Roles of the GRASP Proteins in the Golgi Apparatus and AutophagyLeibin Wang · 2018 · Deep Blue (University of Michigan)
- Study of the effects of macroautophagy deficiency on mitochondrial function, energy metabolism and cell fateLucia Sedlackova · 2020
- The role of autophagy in Alzheimer diseasePhilipp A. Jaeger · 2011 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
- Defect of autophagy signaling in sarcopenic muscleKunihiro Sakuma, Akihiko Yamaguchi, Haruyo Matsuo · 2021 · Elsevier eBooks
- Cross-Talk between STYK1 and EGFR in Autophagy Regulation and EGFR-TKIs Sensitivity in Non-Small Cell Lung CancerCefan Zhou, Xuehong Qian, Ming Wang, Xueying Dong, Miao Hu, Kai Liang, Yanyan Liang, Rui Zhang, Yuan Huang, Yongfei Tang et al. · 2021 · SSRN Electronic Journal
- Autophagy Regulation by Lipid Factors with Implications for Parkinson's DiseaseAlejandro Soto-Avellaneda · 2021 · ScholarWorks (Boise State University)
- The Role of Phosphatidylinositol-3 Kinases and Phosphatidylinositol Phosphatases in T Cell Intracellular Homeostasis and AutophagyIan Alexander McLeod · 2013 · DukeSpace (Duke University)
- Treatment With Glycogen Synthase Kinase 3β Inhibitor Decreases Apoptotic and Autophagic Reactions in Rat Rotator Cuff TearsYang‐Soo Kim, Yun-Gyoung Lee, Min‐Tae Kim, Hyo-Jin Lee · 2021 · Orthopaedic Journal of Sports Medicine
- SWCNH (Single walled carbon nanohorn) supervises ER (Endoplasmic reticulum) stress through triggering autophagy process of hepatocytes, especially in hepatoma cell line HepG2Jinling Dong, Ying Zhang, Zhihong Xie, Jie He, Tiantian Wu · 2021 · Materials Research Express
- Insulin-Like Growth Factor 2 (IGF2) and Autophagy Gene Expression Alteration in Parkinson’s Disease: Potential Predictor Markers.Denisse Sepúlveda, Alvaro Vidal, Felipe Grünenwald, Paulina Troncoso-Escudero, Marisol Cisternas-Olmedo, Roque Villagra, Pedro Vergara, Carlos Aguilera, Melissa Nassif, René L. Vidal · 2021 · Research Square
- Mst1-Nrf2 regulates myocardial injury in type 2 diabetic mice through autophagyJun Wang, Guangwei Li, Na Wang, Lulu Wang, Jin Li, Wei Xiao · 2022 · Research Square
- Faculty Opinions recommendation of Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.David Chaim Rubinsztein · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients on Antiviral TreatmentAtefeh Sadidoost, Kamran Bagheri Lankarani · 2022 · Research Square
- Is There any Role for Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients on Antiviral Treatment?Kamran Bagheri Lankarani, Atefeh Sadidoost, Mohammad Reza Fattahi, Saeid Amiri Zadeh Fard, Pooneh Mokarram · 2022 · Research Square
- AR12 increases BAG3 expression via ER stress signaling which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagyPaul Dent, Laurence A. Booth, Jane L. Roberts, Andrew Stewart Poklepovic, Jennifer Martinez, Derek Cridebring, Eric M. Reiman · 2022 · Research Square
- Oxidative Stress-Induced AutophagyJyoti Sethi, Utkarsh Sethi · 2022 · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
- Faculty Opinions recommendation of Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle.Matthew D. Welch, Rebecca L. Lamason · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis.Tamotsu Yoshimori · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Beclin 1María Inés Molejon · 2012
- Faculty Opinions recommendation of Network organization of the human autophagy system.Amy A. Kiger, Sofia Aligianni · 2010 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Understanding, Targeting, and Hijacking AutophagyHongguang Xia, Xiaoyan Xu, Mengxin Zhou, Manke Zhang, Lingzhi Ye · 2022 · Wiley eBooks
- Control of EGFR signaling by endocytosis and endosomal traffickingChinmoy Ghosh, Yanli Xing, Yue Sun · 2023 · Elsevier eBooks
- Does autophagy have a role in the pathogenesis of pediatric hepatic steatosis?Nermine Ahmed Ehsan, Mona Abd El-Halim Kandil, Nanis Shawky Holah, Gihan Ahmed Sobhy, Mohamed Mohamady, Shaymaa S El-Gammal, Marwa Gadallah · 2023 · Research Square
- Role of cyclooxygenase-2 in ischemia-reperfusion injury in the liverMarina Fuertes‐Agudo · 2023 · RiuNet (Universitat Politècnica de València)
- The Rubicon-WIPI axis regulates exosome biogenesis during agingKyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Fc immunoreceptors promote autophagy to regulate monocyte functionsMathilde Nugue, Marie D’Allemagne, Despoina Koumantou, Mathias Vétillard, Mark Steven Cragg, Pierre Bourdely, Sophie Lotersztajn, Loredana Saveanu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- ATG14 expression and its role in autophagy-mediated response to nervous necrosis virus in sevenband grouper (Hyporthodus septemfasciatus)Yong Jun Park, Jeong Gyu Kim, Seung Hyun Yoo, Ha Eun Lee, Gun‐Do Kim, Myung‐Joo Oh, Jong‐Oh Kim · 2025 · Fish & Shellfish Immunology
- Identification of co-segregating RUBCN and KANK1 mutations in a UK amyotrophic lateral sclerosis kindredMidhat Salman, Intan Barul Akma Bakhtiar, Alex G. Morris, Alexandra Rother, Simon D. Topp, Christopher E. Shaw, Bradley N. Smith, Jacqueline de Belleroche · 2025 · medRxiv
- The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in DrosophilaChia-Heng Hsu, Yi‐Jhan Li, Ting-Ni Guo, Fei‐Yang Tzou, Cheng-Li Hong, Chin‐Hsien Lin, Shu‐Yi Huang, Chih‐Chiang Chan · 2025 · Autophagy
- Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathwaysHyeong-Geug Kim, Menghao Huang, Shen Wang, Yang Zhang, Kailing Li, Sheng Liu, Chuanpeng Dong, Xiuxiu Yang, Jung-Hyo Cho, Kushan Chowdhury et al. · 2025 · eGastroenterology
- In the diffuse large B-cell lymphoma microenvironment, autophagy genes are upregulated in pro-inflammatory macrophages and linked to BCL2 overexpressionMiguel Resanoa, Alba Delgado, Claudia Rodiño, Marina Villar, Ana Aiastui, Mounia Sabrina Braza · 2025 · Frontiers in Immunology
- Additional file 2 of CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicityLiu, Baocai, Yinliang Lu, Zhang, Tingting, Yu, Xinyue, Wang, Qian, Yunbo Chi, Jin, Shunzi, Cheng, Guanghui · 2021 · Figshare
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and MacroautophagyMaria K. Traver · 2013 · DukeSpace (Duke University)
- Additional file 1 of Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagyZhao, Wanli, Taiyu Shen, Bichen Zhao, Li, Moli, Zhaoju Deng, Yihui Huo, Ben Aernouts, Juan J. Loor, Androniki Psifidi, Xu, Chuang · 2024 · Figshare
- The monkeypox virus suppresses autophagy by modulating Rubicon expressionGiulia Refolo, Cosmina Mija, Fabiola Ciccosanti, Giuseppe Sberna, Valentina Mazzotta, Fabrizio Maggi, Mauro Piacentini, Tiziana Vescovo, Licia Bordi · 2025 · Cell Death Discovery
- TAX1BP1 recruitment reactivates autophagy of Tau aggregates through ULK1 and TBK1Bernd Bauer, Martina Schuschnig, Sascha Martens · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Platelet Rubicon drives thrombosis independent of autophagyNirav Dhanesha · 2026 · Blood Advances
- A novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validationYi Yu, Zhennan Wang, Chentong Pan, Keyao Zhu, Liying Xu · 2026 · Journal of Natural Medicines
- Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic PathwaysShoaib Ahmad Malik · 2012 · theses.fr (ABES)
- Caractérisation cellulaire et fonctionnelle de l’autophagie : interactions avec la voie de maturation endosomale chez Caenorhabditis elegansAbderazak Djeddi · 2011 · theses.fr (ABES)
- Etude de l’interaction entre la protéine Vif du VIH-1 et la protéine LC3 impliquée dans le processus autophagiqueSophie Borel · 2012 · theses.fr (ABES)
- Study of lymphocyte autophagy in normal and autoimmune responsesDiane Murera · 2016 · theses.fr (ABES)
- Interactions VIH/autophagie dans les cellules dendritiques : de la réplication à la présentation des antigènesPierre-Gregoire A. Coulon · 2014 · theses.fr (ABES)
- Analyse du mécanisme et du rôle de l'inhibition de l'autophagie par deux protéines complémentaires du cytomégalovirus humainLina Mouna · 2015 · theses.fr (ABES)
- Autophagy in antigen presenting cellsFlorent Arbogast · 2018 · theses.fr (ABES)
- Rôles de la PI3 kinase de classe II alpha et de la PI3K de classe III, vps34, dans la production et les fonctions plaquettairesColin Valet · 2017 · theses.fr (ABES)
- Impact of Targeting the Autophagy Related Gene Beclin 1 on the Immune Landscape of MelanomaTsolère Arakelian · 2018 · theses.fr (ABES)
- Reconditionnement musculaire dans un modèle murin de myopathie centronucléaire autosomique dominante par inactivation du gène myostatineDavid Arnould · 2018 · theses.fr (ABES)
- Étude de l'autophagie lors d'une co-infection par le virus de la rougeole et Salmonella typhimuriumMathieu Clavière · 2018 · theses.fr (ABES)
- Mécanismes moléculaires de la production et des fonctions plaquettaires : rôle de Vps34 et impact des inhibiteurs ciblés de kinasesM Levade · 2017
- Role of autophagy in liver sinusoidal endothelial cells on nonalcoholic steatohepatitisAdel Hammoutène · 2018 · theses.fr (ABES)
- Rôle de l'autophagie dans l'émergence des cellules souches cancéreuses : implication du métabolismeMouradi El-Hout · 2019 · theses.fr (ABES)
- Vps15, the regulatory subunit of class 3 PI3K, maintains metabolic rhythmicity by acting as a transcriptional co-activator of Bmal1Chantal Alkhoury · 2020 · theses.fr (ABES)
- Interaction de la Cytogaligine avec l’α-Synucléine et les protéines d’autophagie. Perturbation de l’expression des gènes d’autophagie dans le sang périphérique de patients atteints de la maladie de ParkinsonSaïd El Haddad · 2017 · theses.fr (ABES)
- Modulation de l'autophagie des macrophages : rôle des lipides de l'enveloppeAïcha Bah · 2017 · theses.fr (ABES)
- Rôle de la rupture membranaire dans l'activation de la réponse antivirale lors d'infection par l’AdénovirusNoémie Pied · 2018 · theses.fr (ABES)
- Modulation de l'autophagie neuronale par la sérine protéase tPA en conditions ischémiquesAudrey M. Thiebaut · 2019 · theses.fr (ABES)
- Mécanismes de régulation de l’ecto-F1-ATPase par la mitophagieSteven Fried · 2018 · theses.fr (ABES)
- Etude du continuum mécanistique et physiopathologique entre la Sclérose Latérale Amyotrophique et la Démence FrontoTemporaleRobin Waegaert · 2019 · theses.fr (ABES)
- Etudes des facteurs cellulaires et lipidiques déterminant la localisation du site d'assemblage et de bourgeonnement du VIH-1Baptiste Gonzales · 2019 · theses.fr (ABES)
- Role of p27/Kip1 in auphagy under metabolic stress conditionsAda Nowosad · 2018 · theses.fr (ABES)
- Phosphoinositides in blood platelet : mapping of molecular species and evidence for a new localization and role of PI3PAbdulrahman Mujalli · 2018 · theses.fr (ABES)
- The potential role of Beclin 1 and Bcl-2 expression in renal cell carcinomaRania Abdallah Abdallah, Amal Farid Mostafa · 2018 · Egyptian Journal of Pathology
- Unravelling the contribution of lipids in plant autophagy : Identification and functional characterization of lipids implicated in the autophagic process in ArabidopsisRodrigo Enrique Gomez · 2021 · theses.fr (ABES)
- Autophagy mediates the hormonal regulation of neuronal homeostasis and brain agingManon Rivagorda · 2021 · theses.fr (ABES)
- Exploration of autophagy modulation in cancer and infectious diseasesEloïne Bestion · 2021 · theses.fr (ABES)
- Biochemical, biophysical and structural study of proteins associated to human diseases : tcDAC2 and ADAT complexElizabeth Ramos‐Morales · 2021 · theses.fr (ABES)
- Caractérisation du flux autophagique de cellules dendritiques humaines au cours de leur maturation : de l'individu sain au patient atteint de la maladie de CrohnGaëlle Quiniou · 2021 · theses.fr (ABES)
- Etude de la protéine IRUFY3 sur le trafic endolysosomal des phagocytes professionnelsRémy Char · 2022 · theses.fr (ABES)
- Étude du rôle des calpaïnes dans les complications microvasculaires du diabèteYann Salemkour · 2023 · theses.fr (ABES)
- Rôle de l'autophagie dans le tissu osseux en situation pathologiqueMarie-Charlotte Trojani · 2024 · theses.fr (ABES)
- Étude de la fonction de la protéine CIN85 dans la régulation de l'autophagie et dans la maintenance du réticulum endoplasmique au cours de la formation des fibres musculaires striées squelettiquesMarine Daura · 2025 · theses.fr (ABES)
- LC3-linked Golgi-bypass exocytosis fortifies epithelial barrier defenseJiabin Wang, Junkai Wang, Xinyu Xiao, Lingling Zheng, Xi Lu, Li Wang, Xin Bian, Long Lin · 2026 · Autophagy
- A review of autophagy in the pancreas: normal physiology and pathophysiologyMiles Piper, Conan Grant Kinsey · 2026 · Autophagy Reports
- TRP53/p53 protects adult hippocampal neural stem cells from psychological stress by preventing autophagic cell deathSeonghee Jung, Hyeonjeong Jeong, Seongwon Choe, Jieun Choi, Kyung Min Chung, Joo Yeon Kim, Eunsoo Lee, Han-Woong Lee, Youngtae Jeong, Eun‐Kyoung Kim et al. · 2026 · Autophagy
- Myeloid-specific Becn1 deficiency elicits spontaneous pulmonary injury and exacerbates acute lung injuryJingwen Liu, Meiling Tan, Shuiwen Huang, Jun Zhang, Lejiao Mao, Chengzhi Chen, Yu Fu, Xuejun Jiang, Zhen Zou · 2026 · Respiratory Research
- C19orf12 Deficiency Triggers Coordinated Alterations in Lipid Homeostasis, Autophagy, and FerroptosisEnrica Zanuttigh, Karolina Wiśniewska, Jan B. Stöckl, Thomas Alexandre Brunet, Barbara Gnutti, Lucia Berti, Karolina Pierzynowska, Sebastian G. Doll, Chiara Cavestro, Maria Nicol Colombo et al. · 2026 · Research Square
- Systemic loss of Rubicon aggravates pathological features in the SOD1G93A mouse modelLeonardo Rodriguez, Patricia Ojeda, Sebastián Beltrán, Ernesto Muñoz-Palma, Diego Rojas‐Rivera, Cristian A Bergmann, Fernanda Hernandez, Danilo B. Medinas, Patrício Manque, Ute Woehlbier · 2026 · Scientific Reports
- Facilitation of Autophagosome-Lysosome Fusion by LAPTM4A: A Novel Strategy for Attenuating Myocardial Ischemia-Reperfusion InjurySiyi Zhou, Jiayi Liu, Manli Hu, Song Tian, Junjie Zhou, Wei Li, Hailian Chen, Maoji Yin, Shiyi Wang, Lei Luo et al. · 2026 · Circulation
- Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagyMinghao Chen, Aniketh Bishnu, Yongjia Duan, Julia F. Riley, Qingyang Ni, Aaron M.N. Joiner, Isaac J. Allen, Erika L.F. Holzbaur, Ian G. Ganley, James H. Hurley · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulation and roles of mammalian mitophagySascha Martens, Ian G. Ganley · 2026 · Nature Reviews Molecular Cell Biology
- The malaria parasite Plasmodium falciparum Vps15 is a Phosphatidylinositol 3-kinase interactor important for host-cell cytosol delivery to the food vacuole and apicoplast and mitochondrion dynamicsAlexandra Bourgeois, Louis-David Martin, Harpreet Kaur, Dominic Gagnon, Joel B. Dacks, Dave Richard · 2026 · PLoS Pathogens