Chait, Brian T.

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

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Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers.

Hillenkamp, F., Karas, M., Beavis, R. C., & Chait, B. T. (1991) · Analytical Chemistry

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N., & Yue, Z. (2009) · Nature Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

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Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyHereditary Neurological Disorders

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

Ye, J. Z.-S., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., & de Lange, T. (2004) · Genes & Development

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

Cited by 459

The N-CoR-HDAC3 Nuclear Receptor Corepressor Complex Inhibits the JNK Pathway through the Integral Subunit GPS2

Zhang, J., Kalkum, M., Chait, B. T., & Roeder, R. G. (2002) · Molecular Cell

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 414

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Bosch, B., DeJesus, M. A., Poulton, N. C., Zhang, W., Engelhart, C. A., Zaveri, A., Lavalette, S., Ruecker, N., Trujillo, C., Wallach, J. B., et al. (2021) · Cell

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 316

Induction of Autophagy in Axonal Dystrophy and Degeneration

Wang, Q. J., Ding, Y., Kohtz, S., Mizushima, N., Cristea, I. M., Rout, M. P., Chait, B. T., Zhong, Y., Heintz, N., & Yue, Z. (2006) · The Journal of Neuroscience

Autophagy in Disease and TherapyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 308

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites.

Vinkemeier, U., Cohen, S. L., Moarefi, I., Chait, B. T., Kuriyan, J., & Darnell, J. E. (1996) · The EMBO Journal

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 308

Fluorescent Proteins as Proteomic Probes

Cristea, I. M., Williams, R., Chait, B. T., & Rout, M. P. (2005) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsAdvanced Fluorescence Microscopy Techniques

Cited by 251

Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex

Moorman, N. J., Cristea, I. M., Terhune, S. S., Rout, M. P., Chait, B. T., & Shenk, T. (2008) · Cell Host & Microbe

Cytomegalovirus and herpesvirus researchViral-associated cancers and disorders

Cited by 194

Tracking and Elucidating Alphavirus-Host Protein Interactions

Cristea, I. M., Carroll, J.-W. N., Rout, M. P., Rice, C. M., Chait, B. T., & MacDonald, M. R. (2006) · Journal of Biological Chemistry

Mosquito-borne diseases and controlVirology and Viral Diseases

Cited by 192

Comprehensive structure and functional adaptations of the yeast nuclear pore complex

Akey, C. W., Singh, D., Ouch, C., Echeverria, I., Nudelman, I., Varberg, J. M., Yu, Z., Fang, F., Shi, Y., Wang, J., et al. (2022) · Cell

Nuclear Structure and FunctionProtein Structure and Dynamics

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Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

Cristea, I. M., Moorman, N. J., Terhune, S. S., Cuevas, C. D., O'Keefe, E. S., Rout, M. P., Chait, B. T., & Shenk, T. (2010) · Journal of Virology

Cytomegalovirus and herpesvirus researchinterferon and immune responses

Cited by 155

Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex

Wieczorek, M., Urnavicius, L., Ti, S.-C., Molloy, K. R., Chait, B. T., & Kapoor, T. M. (2020) · Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

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Asymmetric molecular architecture of the human γ -tubulin ring complex

Wieczorek, M., Urnavicius, L., Ti, S.-C., Molloy, K. R., Chait, B. T., & Kapoor, T. M. (2019) · Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

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I-DIRT, A General Method for Distinguishing between Specific and Nonspecific Protein Interactions

Tackett, A. J., DeGrasse, J. A., Sekedat, M. D., Oeffinger, M., Rout, M. P., & Chait, B. T. (2005) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsBiotin and Related Studies

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The Molecular Architecture of the Nuclear Basket

Singh, D., Soni, N., Hutchings, J., Echeverria, I., Shaikh, F., Duquette, M., Suslov, S., Li, Z., van Eeuwen, T., Molloy, K., et al. (2024) · Cell

Nuclear Structure and FunctionProtein Structure and Dynamics

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A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells

Kleiner, R. E., Hang, L. E., Molloy, K. R., Chait, B. T., & Kapoor, T. M. (2018) · Cell Chemical Biology

Advanced Proteomics Techniques and ApplicationsClick Chemistry and Applications

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Human Cytomegalovirus UL29/28 Protein Interacts with Components of the NuRD Complex Which Promote Accumulation of Immediate-Early RNA

Terhune, S. S., Moorman, N. J., Cristea, I. M., Savaryn, J. P., Cuevas-Bennett, C., Rout, M. P., Chait, B. T., & Shenk, T. (2010) · PLoS Pathogens

Cytomegalovirus and herpesvirus researchGenomics and Chromatin Dynamics

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Shelterin is a dimeric complex with extensive structural heterogeneity

Zinder, J. C., Olinares, P. D. B., Svetlov, V., Bush, M. W., Nudler, E., Chait, B. T., Walz, T., & de Lange, T. (2022) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

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Embryonic and fetal human hemoglobins: structures, oxygen binding, and physiological roles

Manning, J. M., Manning, L. R., Dumoulin, A., Padovan, J. C., & Chait, B. (2020) · Subcellular Biochemistry

Hemoglobin structure and functionHemoglobinopathies and Related Disorders

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Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

Ketaren, N. E., Mast, F. D., Fridy, P. C., Olivier, J. P., Sanyal, T., Sali, A., Chait, B. T., Rout, M. P., & Aitchison, J. D. (2024) · eLife

SARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies Research

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Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader

Shatarupa, A., Brown, D., Olinares, P. D. B., Chase, J., Isiorho, E., Chait, B. T., & Jeruzalmi, D. (2025) · Nucleic Acids Research

Bacterial Genetics and BiotechnologyEnzyme Structure and Function

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