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Intracellular fluid flow in rapidly moving cells
Open accessAbstract
Cytosolic fluid dynamics have been implicated in cell motility because of the hydrodynamic forces they induce and because of their influence on transport of components of the actin machinery to the leading edge. To investigate the existence and the direction of fluid flow in rapidly moving cells, we introduced inert quantum dots into the lamellipodia of fish epithelial keratocytes and analysed their distribution and motion. Our results indicate that fluid flow is directed from the cell body towards the leading edge in the cell frame of reference, at about 40% of cell speed. We propose that this forward-directed flow is driven by increased hydrostatic pressure generated at the rear of the cell by myosin contraction, and show that inhibition of myosin II activity by blebbistatin reverses the direction of fluid flow and leads to a decrease in keratocyte speed. We present a physical model for fluid pressure and flow in moving cells that quantitatively accounts for our experimental data.
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Cites
Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions
Volkmann, N., Amann, K. J., Stoilova-McPhie, S., Egile, C., Winter, D. C., Hazelwood, L., Heuser, J. E., Li, R., Pollard, T. D., & Hanein, D. (2001) · Science · doi:10.1126/science.1063025 · Cited by 258
Cited by
Anomalous transport in the crowded world of biological cells
Höfling, F., & Franosch, T. (2013) · Reports on Progress in Physics · doi:10.1088/0034-4885/76/4/046602 · Cited by 1,247
The cytoplasm of living cells behaves as a poroelastic material
Moeendarbary, E., Valon, L., Fritzsche, M., Harris, A. R., Moulding, D. A., Thrasher, A. J., Stride, E., Mahadevan, L., & Charras, G. T. (2013) · Nature Materials · doi:10.1038/nmat3517 · Cited by 686
Phagocytosis: Receptors, signal integration, and the cytoskeleton
Freeman, S. A., & Grinstein, S. (2014) · Immunological Reviews · doi:10.1111/imr.12212 · Cited by 548
Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
Stroka, K. M., Jiang, H., Chen, S.-H., Tong, Z., Wirtz, D., Sun, S. X., & Konstantopoulos, K. (2014) · Cell · doi:10.1016/j.cell.2014.02.052 · Cited by 537
Trepat, X., Chen, Z., & Jacobson, K. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110012 · Cited by 406
Metadata
- Authors
- Keren, K., Yam, P. T., Kinkhabwala, A., Mogilner, A., & Theriot, J. A.
- Venue
- Nature Cell Biology
- Published
- 2009-09-20
- Volume
- 11
- Issue
- 10
- Pages
- 1219-1224
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2085542786
- Cited by
- 192
- References
- 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Keren, K., Yam, P. T., Kinkhabwala, A., Mogilner, A., & Theriot, J. A. (2009). Intracellular fluid flow in rapidly moving cells. Nature Cell Biology. https://doi.org/10.1038/ncb1965
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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