Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

Di Micco, Raffaella, Sulli, Gabriele, Dobreva, Miryana, Liontos, Michalis, Botrugno, Oronza A., Gargiulo, Gaetano, dal Zuffo, Roberto, Matti, Valentina +7 more·2011·Nature Cell Biology

DOI 10.1038/ncb2170

Cited by (391)

Items 101–200 of 391

A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence
Mariana Acevedo, Mathieu Vernier, Lian Mignacca, Frédéric Lessard, Geneviève Huot, Olga V. Moiseeva, Véronique Bourdeau, Gerardo Ferbeyre · 2016 · Cancer Research
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Lauren M. Herr, Ethan D. Schaffer, Kathleen F. Fuchs, Arindam Datta, Robert M. Brosh · 2024 · Communications Biology
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Wei-Feng Zhang, Gaocai Li, Xingyu Zhou, Huaizhen Liang, Bide Tong, Di Wu, Kevin Yang, Yu Song, Bingjin Wang, Zhiwei Liao et al. · 2024 · Journal of Clinical Investigation
Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile
Sandra Buratta, Lorena Urbanelli, Krizia Sagini, Stefano Giovagnoli, Silvia Caponi, D. Fioretto, Nico Mitro, Donatella Caruso, Carla Emiliani · 2017 · PLoS ONE
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Tejal Shreeya, Mohd. Saifullah Ansari, Prabhat Kumar, Muskan Saifi, Ali Abdullah Shati, Mohammad Yahya Alfaifi, Serag Eldin I. Elbehairi · 2024 · Frontiers in Aging
Therapy-Induced Cellular Senescence: Potentiating Tumor Elimination or Driving Cancer Resistance and Recurrence?
Yue Liu, Isabelle Lomeli, Stephen J. Kron · 2024 · Cells
Assembly of telomeric chromatin to create ALTernative endings
Roderick J. O’Sullivan, Geneviève Almouzni · 2014 · Trends in Cell Biology
Epigenetic Basis of Cellular Senescence and Its Implications in Aging
Timothy Nacarelli, Pingyu Liu, Rugang Zhang · 2017 · Genes
Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
Kim, Jeongkyu, Sturgill, David, Tran, Andy D., Sinclair, David A., Oberdoerffer, Philipp · 2016 · Nucleic Acids Research
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Yu Chen, Anke Geng, Weina Zhang, Zhen Yu Qian, Xiaoping Wan, Ying Jiang, Zhiyong Mao · 2020 · Ageing Research Reviews
Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence
Graziano, S, Johnston, R, Deng, O, Zhang, J, Gonzalo, S · 2016 · Oncogene
Cellular Senescence in Liver Disease and Regeneration
Sofía Ferreira-González, Daniel Rodrigo‐Torres, Victoria L. Gadd, Stuart John Forbes · 2021 · Seminars in Liver Disease
Linking replication stress with heterochromatin formation
Ivaylo Nikolov, Angela Taddei · 2015 · Chromosoma
Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi
Sieu L. Tran, Sebastian Haferkamp, Lyndee L. Scurr, Kavitha Gowrishankar, Therese M. Becker, Chitra Desilva, John F. Thompson, Richard A. Scolyer, Richard F. Kefford, Helen Rizos · 2012 · Journal of Investigative Dermatology
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity
Özge Gürsoy-Yüzügüllü, Chelsea L. Carman, Rodolfo Bortolozo Serafim, Marios E. Myronakis, Valéria Valente, Brendan D. Price · 2017 · Oncotarget
YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor–Induced Activation of the PI3K Pathway
Chao Wang, Chao Gu, Kang Jin Jeong, Dong Zhang, Wei Guo, Yiling Lu, Zhenlin Ju, Nattapon Panupinthu, Ji Yeon Yang, Mihai Gagea et al. · 2017 · Cancer Research
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Eros Di Giorgio, Enrico Gagliostro, Claudio Brancolini · 2014 · Cellular and Molecular Life Sciences
Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells
Armelle Corpet, Manuel Stucki · 2014 · Chromosoma
KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization
Biao Huang, Bin Wang, Wayne Lee, Kin Pong U, Kam Tong Leung, Xican Li, Zhenqing Liu, Rui Chen, Jiacheng Lin, Lai Ling Tsang et al. · 2019 · iScience
Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria
Alexandre Chojnowski, Peh Fern Ong, Mattheus Xing Rong Foo, David Liebl, Louis‐Peter Hor, Colin L. Stewart, Oliver Dreesen · 2020 · Aging Cell
WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation
Jung Jin Kim, Seung Baek Lee, Sang Yeop Yi, Sang-Ah Han, Sun‐Hyun Kim, Jong‐Min Lee, Seo‐Yun Tong, Ping Yin, Bowen Gao, Jun Zhang et al. · 2016 · Cell Research
Old cells, new tricks: chromatin structure in senescence
Parry, Aled John, Narita, Masashi · 2016 · Mammalian Genome
Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome
Agnieszka Gadecka, Anna Bielak-Żmijewska · 2019 · Nutrients
The complex interplay between aging and cancer
Lucrezia A. Trastus, Fabrizio d’Adda di Fagagna · 2025 · Nature Aging
Cancer cell senescence: a new frontier in drug development
Cairney, Claire J., Bilsland, Alan E., Evans, T.R. Jeffry, Roffey, Jon, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol · 2012 · Drug Discovery Today
Deacetylation of H4-K16Ac and heterochromatin assembly in senescence
Kévin Contrepois, Jean‐Yves Thuret, Régis Courbeyrette, François Fenaille, Carl Mann · 2012 · Epigenetics & Chromatin
Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects
Valentina Gambacorta, Daniela Gnani, Luca Vago, Raffaella Di Micco · 2019 · Frontiers in Cell and Developmental Biology
Aging, Senescence, and Dementia
Qumars Behfar, A. Ramirez Zuniga, Pamela V. Martino Adami · 2022 · The Journal of Prevention of Alzheimer s Disease
The paradox of senescent-marker positive cancer cells: challenges and opportunities
Emily A. O’Sullivan, Ryan Wallis, Federica Mossa, Cleo L. Bishop · 2024 · npj Aging
BRG1 Is Required for Formation of Senescence-Associated Heterochromatin Foci Induced by Oncogenic RAS or BRCA1 Loss
Zhigang Tu, Xinying Zhuang, Yong‐Gang Yao, Rugang Zhang · 2013 · Molecular and Cellular Biology
Carbon-Ion Beam Irradiation Kills X-Ray-Resistant p53-Null Cancer Cells by Inducing Mitotic Catastrophe
Napapat Amornwichet, Takahiro Oike, Atsushi Shibata, Hideaki Ogiwara, Naoto Tsuchiya, Motohiro Yamauchi, Yuka Saitoh, Ryota Sekine, Mayu Isono, Yukari Yoshida et al. · 2014 · PLoS ONE
Senescence at a glance
Jeff S. Pawlikowski, Peter D. Adams, David M. Nelson · 2013 · Journal of Cell Science
DNA double strand break responses and chromatin alterations within the aging cell
Karolin Klement, Aaron A. Goodarzi · 2014 · Experimental Cell Research
Senescence regulation by mTOR
Dulic, Vjekoslav · 2013 · Methods in Molecular Biology
Alterations of Nuclear Architecture and Epigenetic Signatures during African Swine Fever Virus Infection
Margarida Simões, José Rino, Inês Pinheiro, Carlos L. V. Martins, Fernando Ferreira · 2015 · Viruses
Mitogen-Induced B-Cell Proliferation Activates Chk2-Dependent G1/S Cell Cycle Arrest
Pavel A. Nikitin, Alexander M. Price, Karyn McFadden, Christopher M. Yan, Micah A. Luftig · 2014 · PLoS ONE
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
Benítez, Sandra, Cordero, Alex, Santamaría, Patricia G., Redondo-Pedraza, Jaime, Rocha, Ana S., Collado-Solé, Alejandro, Jimenez, Maria, Sanz-Moreno, Adrian, Yoldi, Guillermo, Santos, Juliana C. et al. · 2021 · Developmental Cell
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
Oriol de Barrios, Balázs Győrffy, María Jesús Fernández‐Aceñero, Ester Sànchez‐Tilló, Lidia Sánchez-Moral, Laura Siles, Anna Esteve‐Arenys, Gaël Roué, José Ignacio Casal, Douglas S. Darling et al. · 2016 · Gut
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases
Wanvisa Udomsinprasert, Abhasnee Sobhonslidsuk, Jiraphun Jittikoon, Sittisak Honsawek, Usa Chaikledkaew · 2021 · Expert Opinion on Therapeutic Targets
Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations
Shaohua Peng, Banibrata Sen, Tuhina Mazumdar, Lauren A. Byers, Lixia Diao, Jing Wang, Pan Tong, Uma P. Giri, John Victor Heymach, Humam N. Kadara et al. · 2015 · Oncotarget
Tuberatolide B Suppresses Cancer Progression by Promoting ROS-Mediated Inhibition of STAT3 Signaling
Youn‐Hee Choi, Junseong Kim, Kang Lee, Yu‐Jeong Choi, Bo‐Ram Ye, Min Sun Kim, Seong‐Gyu Ko, Seung‐Hong Lee, Do-Hyung Kang, Soo‐Jin Heo · 2017 · Marine Drugs
Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability
Maddalena Mognato, Susanne Burdak‐Rothkamm, Kai Rothkamm · 2020 · Mutation Research/Reviews in Mutation Research
Recent Advancements in DNA Damage–Transcription Crosstalk and High-Resolution Mapping of DNA Breaks
Valerio Vitelli, Alessandro Galbiati, Fabio Iannelli, Fabio Pessina, Sheetal Sharma, Fabrizio d’Adda di Fagagna · 2017 · Annual Review of Genomics and Human Genetics
Metabolic alterations accompanying oncogene-induced senescence
Aird, Katherine M, Zhang, Rugang · 2014 · Molecular & Cellular Oncology
ZNF224, Krüppel like zinc finger protein, induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a
Jin Gu Cho, Seho Park, Chae Hyun Lim, Hong Sook Kim, Seung Yong Song, Tae‐Young Roh, Jong-Hyuk Sung, Wonhee Suh, Seokjin Ham, Key‐Hwan Lim et al. · 2016 · Oncotarget
DNA damage, tumor mutational load and their impact on immune responses against cancer
Michalis Liontos, Ioannis P. Anastasiou, Aristotelis Bamias, Meletios Athanasios Dimopoulos · 2016 · Annals of Translational Medicine
The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquid–liquid phase separation
Qianwen Liu, Peng Liu, Tuo Ji, Lihua Zheng, Chen Shen, Shasha Ran, Jinling Liu, Yafei Zhao, Yiding Niu, Tao Wang et al. · 2022 · Molecular Plant
Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression?
Di Giorgio, Eros, Xodo, Luigi E. · 2022 · Frontiers in Immunology
Vascular senescence in progeria: role of endothelial dysfunction
Qiu Xu, Anahita Mojiri, Luay Boulahouache, Elisa Morales, Brandon K. Walther, John P. Cooke · 2022 · European Heart Journal Open
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Beyond SAHF: An integrative view of chromatin compartmentalization during senescence
Ioana Olan, Tetsuya Handa, Masashi Narita · 2023 · Current Opinion in Cell Biology
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Giorgio Iotti, Elena Longobardi, Silvia Masella, Leila Dardaei, Francesca De Santis, Nicola Micali, Francesco Blasi · 2011 · Proceedings of the National Academy of Sciences
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Peter Lenárt, Lumír Krejčí · 2016 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells
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Expression of therapy-induced senescence markers in breast cancer samples upon incomplete response to neoadjuvant chemotherapy
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Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer?
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Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear Edge
Jérôme D. Robin, Frédérique Magdinier · 2016 · Frontiers in Genetics
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ATM activation in hypoxia - causes and consequences
Monica M. Olcina, Roger J.A. Grand, Ester M. Hammond · 2014 · Molecular & Cellular Oncology
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ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence
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Senescence Alterations in Pulmonary Hypertension
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PRL-3 promotes telomere deprotection and chromosomal instability
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Athanasios Siametis, George Niotis, George A. Garinis · 2021 · Journal of Investigative Dermatology
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