The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
Open accessAbstract
Pluripotency of embryonic stem cells (ESCs) is defined by their ability to differentiate into three germ layers and derivative cell types and is established by an interactive network of proteins including OCT4 (also known as POU5F1; ref. ), NANOG (refs , ), SOX2 (ref. ) and their binding partners. The forkhead box O (FoxO) transcription factors are evolutionarily conserved regulators of longevity and stress response whose function is inhibited by AKT protein kinase. FoxO proteins are required for the maintenance of somatic and cancer stem cells; however, their function in ESCs is unknown. We show that FOXO1 is essential for the maintenance of human ESC pluripotency, and that an orthologue of FOXO1 (Foxo1) exerts a similar function in mouse ESCs. This function is probably mediated through direct control by FOXO1 of OCT4 and SOX2 gene expression through occupation and activation of their respective promoters. Finally, AKT is not the predominant regulator of FOXO1 in human ESCs. Together these results indicate that FOXO1 is a component of the circuitry of human ESC pluripotency. These findings have critical implications for stem cell biology, development, longevity and reprogramming, with potentially important ramifications for therapy.
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00302-2 · Cited by 868
Self-citationFOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
Essers, M. A., Weijzen, S., de Vries‐Smits, A. M., Saarloos, I., de Ruiter, N. D., Bos, J. L., & Burgering, B. M. T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600476 · Cited by 798
FoxO3 Regulates Neural Stem Cell Homeostasis
Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.014 · Cited by 586
Yalcin, S., Zhang, X., Luciano, J. P., Mungamuri, S. K., Marinkovic, D., Vercherat, C., Sarkar, A., Grisotto, M., Taneja, R., & Ghaffari, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800517200 · Cited by 247
Self-citationRedox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
Dansen, T. B., Smits, L. M. M., van Triest, M. H., de Keizer, P. L. J., van Leenen, D., Koerkamp, M. G., Szypowska, A., Meppelink, A., Brenkman, A. B., Yodoi, J., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.194 · Cited by 201
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Powell, A. E., Wang, Y., Li, Y., Poulin, E. J., Means, A. L., Washington, M. K., Higginbotham, J. N., Juchheim, A., Prasad, N., Levy, S. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.042 · Cited by 694
Stem cells and the impact of ROS signaling
Bigarella, C. L., Liang, R., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 632
Self-citationFOXO3: A Major Gene for Human Longevity - A Mini-Review
Morris, B. J., Willcox, D. C., Donlon, T. A., & Willcox, B. J. (2015) · Gerontology · doi:10.1159/000375235 · Cited by 353
FOXO transcription factors throughout T cell biology
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Metadata
- Authors
- Zhang, X., Yalcin, S., Lee, D.-F., Yeh, T.-Y. J., Lee, S.-M., Su, J., Mungamuri, S. K., Rimmelé, P., Kennedy, M., Sellers, R., Landthaler, M., Tuschl, T., Chi, N.-W., Lemischka, I., Keller, G., & Ghaffari, S.
- Venue
- Nature Cell Biology
- Published
- 2011-07-31
- Volume
- 13
- Issue
- 9
- Pages
- 1092-1099
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2148856565
- Cited by
- 265
- References
- 8
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, X., Yalcin, S., Lee, D.-F., Yeh, T.-Y. J., Lee, S.-M., Su, J., Mungamuri, S. K., Rimmelé, P., Kennedy, M., Sellers, R., Landthaler, M., Tuschl, T., Chi, N.-W., Lemischka, I., Keller, G., & Ghaffari, S. (2011). FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nature Cell Biology. https://doi.org/10.1038/ncb2293
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