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Cited by 347FOXO transcription factor regulationT-cell and B-cell ImmunologyRedox biology and oxidative stress

FOXO transcription factors throughout T cell biology

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Hedrick, Stephen M., Michelini, Rodrigo Hess, Doedens, Andrew L., Goldrath, Ananda W., Stone, Erica L.·2012·Nature Reviews Immunology
DOI 10.1038/nri3278PMC PMC3875397
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Abstract

The outcome of an infection with any given pathogen varies according to the dosage and route of infection, but, in addition, the physiological state of the host can determine the efficacy of clearance, the severity of infection and the extent of immunopathology. Here we propose that the forkhead box O (FOXO) transcription factor family--which is central to the integration of growth factor signalling, oxidative stress and inflammation--provides connections between physical well-being and the form and magnitude of an immune response. We present a case that FOXO transcription factors guide T cell differentiation and function in a context-driven manner, and might provide a link between metabolism and immunity.

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Cited by

Sorted by citations

Authors
Hedrick, S. M., Michelini, R. H., Doedens, A. L., Goldrath, A. W., & Stone, E. L.
Affiliations
University of California San Diego (US)
ORCID
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2012-08-24
Volume
12
Issue
9
Pages
649-661
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri3278
PMC
PMC3875397
OpenAlex
W2065187811
Cited by
347
References
4
Citations by year
2026: 18 · 2025: 26 · 2024: 18 · 2023: 17 · 2022: 26 · 2021: 37 · 2020: 35 · 2019: 21 · 2018: 37 · 2017: 26 · 2016: 20 · 2015: 29 · 2014: 17 · 2013: 19 · 2012: 1
FWCI
1.92
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI103440, R37AI067545)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
FOXO transcription factors, T cell differentiation, T cell function, metabolism, oxidative stress, inflammation, growth factor signaling, infection, immunopathology
MeSH terms
Animals, Gene Expression Regulation, Humans, Protein Processing, Post-Translational, T-Lymphocytes, Signal Transduction, Forkhead Transcription Factors

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