VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Open accessAbstract
Angiogenesis, the growth of new blood vessels, involves specification of endothelial cells to tip cells and stalk cells, which is controlled by Notch signalling, whereas vascular endothelial growth factor receptor (VEGFR)-2 and VEGFR-3 have been implicated in angiogenic sprouting. Surprisingly, we found that endothelial deletion of Vegfr3, but not VEGFR-3-blocking antibodies, postnatally led to excessive angiogenic sprouting and branching, and decreased the level of Notch signalling, indicating that VEGFR-3 possesses passive and active signalling modalities. Furthermore, macrophages expressing the VEGFR-3 and VEGFR-2 ligand VEGF-C localized to vessel branch points, and Vegfc heterozygous mice exhibited inefficient angiogenesis characterized by decreased vascular branching. FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2(+/-);Vegfr3(+/-) compound heterozygosity recapitulated homozygous loss of Vegfr3. These results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Microglia associate with endothelial tip cells during embryonic brain and postnatal retinal angiogenesis.
“microglia associate with endothelial tip cells, as demonstrated during embryonic brain and postnatal retinal angiogenesis”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Tammela et al., 2011
Microglia CNS endothelium interaction occurs during early stages of CNS vascularization.
“it thus constitute further in vivo evidence for microglia CNS endothelium interaction during early stages of CNS vascularization.”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Tammela et al., 2011
Resident microglia in the brain parenchyma interact with CNS microvessels.
“recent in vivo studies present evidence that resident microglia in the brain parenchyma also interact with CNS microvessels”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Tammela et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works
Self-citationAbnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931 · see citing works
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894 · see citing works
Self-citationDll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature · doi:10.1038/nature05571 · Cited by 1,775 · see citing works
Self-citationLymphangiogenesis: Molecular Mechanisms and Future Promise
Tammela, T., & Alitalo, K. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.045 · Cited by 1,443 · see citing works
Self-citationKaipainen, A., Korhonen, J., Mustonen, T., van Hinsbergh, V. W. M., Fang, G. H., Dumont, D., Breitman, M. L., & Alitalo, K. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3566 · Cited by 1,420 · see citing works
Self-citationKarkkainen, M. J., Haiko, P., Sainio, K., Partanen, J. M., Taipale, J., Petrova, T. V., Jeltsch, M., Jackson, D. G., Talikka, M., Rauvala, H., et al. (2003) · Nature Immunology · doi:10.1038/ni1013 · Cited by 1,419 · see citing works
Self-citationCarmeliet, P., Lampugnani, M. G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81010-7 · Cited by 1,284 · see citing works
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
Wang, Y., Nakayama, M., Pitulescu, M. E., Schmidt, T., Bochenek, M. L., Sakakibara, A., Adams, S., Davy, A., Deutsch, U., Lüthi, U., et al. (2010) · Nature · doi:10.1038/nature09002 · Cited by 1,276 · see citing works
Self-citationEndothelial Extracellular Matrix
Davis, G. E., & Senger, D. R. (2005) · Circulation Research · doi:10.1161/01.res.0000191547.64391.e3 · Cited by 1,225 · see citing works
Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153 · see citing works
The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis
Benedito, R., Roca, C., Sörensen, I., Adams, S., Gossler, A., Fruttiger, M., & Adams, R. H. (2009) · Cell · doi:10.1016/j.cell.2009.03.025 · Cited by 1,109 · see citing works
Self-citationEndothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson, L., Franco, C. A., Bentley, K., Collins, R., Ponsioen, B., Aspalter, I. M., Rosewell, I. R., Busse, M., Thurston, G., Medvinsky, A., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2103 · Cited by 974 · see citing works
Self-citationRuhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C., & Shima, D. T. (2002) · Genes & Development · doi:10.1101/gad.242002 · Cited by 918 · see citing works
Self-citationCardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
Dumont, D., Jussila, L., Taipale, J., Lymboussaki, A., Mustonen, T., Pajusola, K., Breitman, M. L., & Alitalo, K. K. (1998) · Science · doi:10.1126/science.282.5390.946 · Cited by 873 · see citing works
Self-citationMäkinen, T., Veikkola, T., Mustjoki, S. M., Kärpänen, T., Catimel, B., Nice, E. C., Wise, L. M., Mercer, A., Kowalski, H., Kerjaschki, D., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4762 · Cited by 845 · see citing works
Self-citationBlocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 814 · see citing works
Self-citationSuchting, S., Freitas, C., le Noble, F. A. C., Benedito, R., Bréant, C., Duarte, A., & Eichmann, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611177104 · Cited by 812 · see citing works
Self-citationDelta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
Lobov, I. B., Renard, R. A., Papadopoulos, N., Gale, N. W., Thurston, G., Yancopoulos, G. D., & Wiegand, S. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611206104 · Cited by 775 · see citing works
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
Siekmann, A. F., & Lawson, N. D. (2007) · Nature · doi:10.1038/nature05577 · Cited by 689 · see citing works
Prewett, M. C., Huber, J., Li, Y., Santiago, A., O'Connor, W., King, K. D., Overholser, J. C., Hooper, A. T., Pytowski, B., Witte, L., et al. (1999) · PubMed · Cited by 660 · see citing works
Analysis of Biological Effects and Signaling Properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2)
Gille, H., Kowalski, J., Li, B., LeCouter, J. E., Moffat, B., Zioncheck, T. F., Pelletier, N., & Ferrara, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m002016200 · Cited by 620 · see citing works
A model for gene therapy of human hereditary lymphedema
Karkkainen, M. J., Saaristo, A. M., Jussila, L., Karila, K. A., Lawrence, E., Pajusola, K., Büeler, H., Eichmann, A., Kauppinen, R. A., Kettunen, M. I., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221449198 · Cited by 606 · see citing works
Self-citationPathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Bałuk, P., Tammela, T., Ator, E., Lyubynska, N., Achen, M. G., Hicklin, D. J., Jeltsch, M., Petrova, T. V., Pytowski, B., Stacker, S. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22037 · Cited by 597 · see citing works
Self-citationPetrova, T. V., Kärpänen, T., Norrmén, C., Mellor, R. H., Tamakoshi, T., Finegold, D. N., Ferrell, R. E., Kerjaschki, D., Mortimer, P. S., Ylä‐Herttuala, S., et al. (2004) · Nature Medicine · doi:10.1038/nm1094 · Cited by 587 · see citing works
Self-citationPalma, M. D., Venneri, M. A., Roca, C., & Naldini, L. (2003) · Nature Medicine · doi:10.1038/nm871 · Cited by 549 · see citing works
VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer
Valtola, R., Salvén, P., Heikkilä, P., Taipale, J., Joensuu, H., Rehn, M., Pihlajaniemi, T. A., Weich, H. A., deWaal, R. M., & Alitalo, K. K. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65392-8 · Cited by 536 · see citing works
Self-citationEphrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
Sawamiphak, S., Seidel, S., Essmann, C. L., Wilkinson, G. A., Pitulescu, M. E., Acker, T., & Acker‐Palmer, A. (2010) · Nature · doi:10.1038/nature08995 · Cited by 532 · see citing works
Endothelial tubes assemble from intracellular vacuoles in vivo
Kamei, M., Saunders, W. B., Bayless, K. J., Dye, L., Davis, G. E., & Weinstein, B. M. (2006) · Nature · doi:10.1038/nature04923 · Cited by 521 · see citing works
Regulation of vascular morphogenesis by Notch signalingPreprint
Roca, C., & Adams, R. H. (2007) · Genes & Development · doi:10.1101/gad.1589207 · Cited by 440 · see citing works
Vascular Endothelial Growth Factor Receptor-3 in Lymphangiogenesis in Wound Healing
Paavonen, K., Puolakkainen, P. A., Jussila, L., Jahkola, T., & Alitalo, K. K. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65021-3 · Cited by 395 · see citing works
Self-citationSkobe, M., Hamberg, L. M., Hawighorst, T., Schirner, M., Wolf, G. L., Alitalo, K. K., & Detmar, M. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61765-8 · Cited by 388 · see citing works
Self-citationM-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
Kubota, Y., Takubo, K., Shimizu, T., Ohno, H., Kishi, K., Shibuya, M., Saya, H., & Suda, T. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081605 · Cited by 388 · see citing works
The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta
Strilić, B., Kučera, T., Eglinger, J., Hughes, M. R., McNagny, K. M., Tsukita, S., Dejana, E., Ferrara, N., & Lammert, E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.011 · Cited by 374 · see citing works
Norrmén, C., Ivanov, K. I., Cheng, J., Zangger, N., Delorenzi, M., Jaquet, M., Miura, N., Puolakkainen, P., Horsley, V., Hu, J., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200901104 · Cited by 340 · see citing works
Self-citationEfficient, inducible Cre‐recombinase activation in vascular endothelium
Claxton, S., Kostourou, V., Jadeja, S., Chambon, P., Hodivala‐Dilke, K., & Fruttiger, M. (2008) · genesis · doi:10.1002/dvg.20367 · Cited by 327 · see citing works
Self-citationJussila, L., Valtola, R., Partanen, T. A., et al. (1998) · PubMed · Cited by 313 · see citing works
Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors
Kärpänen, T., Heckman, C. A., Keskitalo, S., Jeltsch, M., Ollila, H. M., Neufeld, G., Tamagnone, L., & Alitalo, K. K. (2006) · The FASEB Journal · doi:10.1096/fj.05-5646com · Cited by 299 · see citing works
Self-citationWhitaker, G. B., Limberg, B. J., & Rosenbaum, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102315200 · Cited by 295 · see citing works
Wiktor-Jędrzejczak, W., Ahmed, A. A., Szczylik, C. A., & Skelly, R. R. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.5.1516 · Cited by 293 · see citing works
Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System
Baldwin, M. E., Halford, M. M., Roufail, S., Williams, R. A., Hibbs, M. L., Grail, D., Kubo, H., Stacker, S. A., & Achen, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2441-2449.2005 · Cited by 289 · see citing works
Dixelius, J., Mäkinen, T., Wirzenius, M., Karkkainen, M. J., Wernstedt, C., Alitalo, K. K., & Claesson, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304499200 · Cited by 285 · see citing works
Self-citationHeparan Sulfate in trans Potentiates VEGFR-Mediated Angiogenesis
Jakobsson, L., Kreuger, J., Holmborn, K., Lundin, L., Eriksson, I., Kjellén, L., & Claesson, L. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.009 · Cited by 275 · see citing works
Self-citationCovassin, L., Villefranc, J. A., Kacergis, M. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506886103 · Cited by 263 · see citing works
Iida, K., Koseki, H., Kakinuma, H., Kato, N., Mizutani-Koseki, Y., Ohuchi, H., Yoshioka, H., Noji, S., Kawamura, K., Kataoka, Y., et al. (1997) · Development · doi:10.1242/dev.124.22.4627 · Cited by 258 · see citing works
Self-citationPytowski, B., Goldman, J., Persaud, K., Wu, Y. L., Witte, L., Hicklin, D. J., Skobe, M., Boardman, K. C., & Swartz, M. A. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji003 · Cited by 250 · see citing works
Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
Laakkonen, P. M., Waltari, M., Holopainen, T., Takahashi, T., Pytowski, B., Steiner, P., Hicklin, D. J., Persaud, K., Tonra, J. R., Witte, L., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3567 · Cited by 242 · see citing works
Self-citationAngiopoietin-1 promotes lymphatic sprouting and hyperplasia
Tammela, T., Saaristo, A. M., Lohela, M. K., Morisada, T., Tornberg, J., Norrmén, C., Oike, Y., Pajusola, K., Thurston, G., Suda, T., et al. (2005) · Blood · doi:10.1182/blood-2004-08-3327 · Cited by 236 · see citing works
Self-citationCritical role of endothelial Notch1 signaling in postnatal angiogenesis
Takeshita, K., Satoh, M., Ii, M., Silver, M., Limbourg, F. P., Mukai, Y., Rikitake, Y., Radtke, F., Gridley, T., Losordo, D. W., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000254788.47304.6e · Cited by 232 · see citing works
Haiko, P., Mäkinen, T., Keskitalo, S., Taipale, J., Karkkainen, M. J., Baldwin, M. E., Stacker, S. A., Achen, M. G., & Alitalo, K. K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02214-07 · Cited by 199 · see citing works
Self-citationA brief introduction to FOXOlogy
Burgering, B. M. T. (2008) · Oncogene · doi:10.1038/onc.2008.29 · Cited by 195 · see citing works
VEGF receptor 2/‐3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
Nilsson, I., Bahram, F., Li, X., Gualandi, L., Koch, S., Jarvius, M., Söderberg, O., Anisimov, A., Kholová, I., Pytowski, B., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.30 · Cited by 185 · see citing works
Self-citationVEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Bras, B. L., Barallobre, M. J., Homman‐Ludiye, J., Ny, A., Wyns, S., Tammela, T., Haiko, P., Karkkainen, M. J., Yuan, L., Muriel, M., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1646 · Cited by 177 · see citing works
Self-citationHayashi, H., & Kume, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002401 · Cited by 168 · see citing works
Shawber, C. J., Funahashi, Y., Francisco, E., Vorontchikhina, M., Kitamura, Y., Stowell, S. A., Borisenko, V., Feirt, N. M., Podgrabinska, S., Shiraishi, K., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci24311 · Cited by 166 · see citing works
Zhang, L., Zhou, F., Han, W., Shen, B., Luo, J., Shibuya, M., & He, Y. (2010) · Cell Research · doi:10.1038/cr.2010.116 · Cited by 145 · see citing works
Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors
Yamamizu, K., Matsunaga, T., Uosaki, H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200904114 · Cited by 145 · see citing works
Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation
Kärpänen, T., Wirzenius, M., Mäkinen, T., Veikkola, T., Haisma, H. J., Achen, M. G., Stacker, S. A., Pytowski, B., Ylä‐Herttuala, S., & Alitalo, K. K. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051200 · Cited by 142 · see citing works
Self-citationTvorogov, D., Anisimov, A., Zheng, W., Leppänen, V., Tammela, T., Laurinavičius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.001 · Cited by 135 · see citing works
Self-citationNotch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Zheng, W., Tammela, T., Yamamoto, M., Anisimov, A., Holopainen, T., Kaijalainen, S., Karpanen, T., Lehti, K., Ylä-Herttuala, S., & Alitalo, K. (2011) · Blood · doi:10.1182/blood-2010-11-317800 · Cited by 132 · see citing works
Self-citationVegfc is required for vascular development and endoderm morphogenesis in zebrafish
Ober, E. A., Olofsson, B., Mäkinen, T., et al. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400047 · Cited by 114 · see citing works
Self-citationThe Notch Ligand Jagged-1 Is Able to Induce Maturation of Monocyte-Derived Human Dendritic Cells
Weijzen, S., Velders, M. P., Elmishad, A. G., Bacon, P. E., Panella, J. R., Nickoloff, B. J., Miele, L., & Kast, W. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4273 · Cited by 93 · see citing works
Galvagni, F., Pennacchini, S., Salameh, A., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.206326 · Cited by 86 · see citing works
Persaud, K., Tille, J., Liu, M., Zhu, Z., Jimenez, X., Pereira, D. S., Miao, H., Brennan, L. A., Witte, L., Pepper, M. S., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01138 · Cited by 79 · see citing works
Lohela, M., Heloterä, H., Haiko, P., Dumont, D. J., & Alitalo, K. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080378 · Cited by 73 · see citing works
Recessive primary congenital lymphoedema caused by a VEGFR3 mutation
Ghalamkarpour, A., Holnthoner, W., Saharinen, P., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.064469 · Cited by 70 · see citing works
Saharinen, P., Heloterä, H., Miettinen, J. J., et al. (2010) · Genes & Development · doi:10.1101/gad.565010 · Cited by 38 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [45]Nilsson I VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts EMBO J 29 1377 1388 2010 20224550 PMC2868571
Cited by
Sorted by citations
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498 · see citing works
The impact of microglial activation on blood-brain barrier in brain diseases
da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works
Leukotriene B <sub>4</sub> antagonism ameliorates experimental lymphedema
Tian, W., Rockson, S. G., Jiang, X., Kim, J., Begaye, A., Shuffle, E. M., Tu, A. B., Cribb, M., Nepiyushchikh, Z., Feroze, A. H., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3920 · Cited by 173 · see citing works
Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules
Hsu, C.-W., Poché, R. A., Saik, J. E., Ali, S., Wang, S., Yosef, N., Calderon, G. A., Scott, L., Vadakkan, T. J., Larina, I. V., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0131643 · Cited by 56 · see citing works
Jackson, T. L., Slakter, J., Buyse, M., Wang, K., Dugel, P. U., Wykoff, C. C., Boyer, D. S., Gerometta, M., Baldwin, M. E., Price, C. F., et al. (2023) · Ophthalmology · doi:10.1016/j.ophtha.2023.02.001 · Cited by 55 · see citing works
- Authors
- Tammela, T., Zarkada, G., Nurmi, H., Jakobsson, L., Heinolainen, K., Tvorogov, D., Zheng, W., Franco, C. A., Murtomäki, A., Aranda, E., Miura, N., Ylä-Herttuala, S., Fruttiger, M., Mäkinen, T., Eichmann, A., Pollard, J. W., Gerhardt, H., & Alitalo, K.
- Affiliations
- University of Helsinki (FI)
- Cancer Research UK (GB)
- Albert Einstein College of Medicine (US)
- Hamamatsu University (JP)
- University College London (GB)
- Inserm (FR)
- Corresponding author
- Alitalo, Kari
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2011-09-11
- Volume
- 13
- Issue
- 10
- Pages
- 1202-1213
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC3261765
- OpenAlex
- W2068104262
- Cited by
- 321
- References
- 70
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 12 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 15 · 2019: 14 · 2018: 29 · 2017: 20 · 2016: 23 · 2015: 33 · 2014: 30 · 2013: 41 · 2012: 33
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- Ida Montinin Säätiö
- Helsingin Yliopisto
- Suomen Lääketieteen Säätiö
- Maud Kuistilan Muistosäätiö
- Cancer Research UK
- Lister Institute of Preventive Medicine
- Louis-Jeantet Foundation
- Eidgenössische Technische Hochschule Zürich
- Peter MacCallum Cancer Centre
- Emil Aaltosen Säätiö
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Orionin Tutkimussäätiö
- K. Albin Johanssons Stiftelse
- National Cancer Institute (R01CA131270)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- VEGFR-3, Notch signaling, angiogenic sprouting, vascular branching, macrophages, VEGF-C, VEGFR2, FOXC2
- MeSH terms
- Animals, Antibodies, Gene Expression Regulation, Humans, Macrophages, Neovascularization, Pathologic, Retinal Vessels, Rhombencephalon, Time Factors, Transduction, Genetic, Transfection, Signal Transduction, Mice, Knockout, Neovascularization, Physiologic, RNA Interference, Vascular Endothelial Growth Factor Receptor-3, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor B, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Endothelial Cells, Cell Line, Tumor, Protein Kinase Inhibitors, Mice, Forkhead Transcription Factors, Receptors, Notch, Phosphatidylinositol 3-Kinase, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
