Cited by 653DNA Repair MechanismsGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Lukas, Jiri, Lukas, Claudia, Bartek, Jiri·2011·Nature Cell Biology

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Abstract

Following the discovery in 1998 of γ-H2AX, the first histone modification induced by DNA damage, interest in the changes to chromatin induced by DNA damage has exploded, and a vast amount of information has been generated. However, there has been a discrepancy between our rapidly advancing knowledge of how chromatin responds to DNA damage and the understanding of why cells mobilize large segments of chromatin to protect the genome against destabilizing effects posed by tiny DNA lesions. Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity.

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Authors: Lukas, J., Lukas, C., & Bartek, J.
Affiliations: Danish Cancer Society (DK)
Corresponding author: Lukas, Jiri
Lukas, Claudia
ORCID: Lukas, Claudia
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2011-10
Volume: 13
Issue: 10
Pages: 1161-1169
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2344
OpenAlex: W2008185037
Cited by: 645
References: 102
Citations by year: 2026: 11 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 33 · 2021: 36 · 2020: 36 · 2019: 35 · 2018: 45 · 2017: 45 · 2016: 60 · 2015: 56 · 2014: 71 · 2013: 82 · 2012: 64
FWCI: 6.50
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: genome stability, DNA damage response, γH2AX, histone modifications, nuclear foci, DNA lesions
MeSH terms: Animals, Cell Cycle, DNA Damage, DNA Repair, Histones, Humans, Protein Processing, Post-Translational, Chromatin Assembly and Disassembly, Genomic Instability

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

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