Lukas, Claudia

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,688

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 1,362

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,064

ATR prohibits replication catastrophe by preventing global exhaustion of RPA

Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 911

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 787

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 758

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 735

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Lukas, J., Lukas, C., & Bartek, J. (2011) · Nature Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 645

Deep Visual Proteomics defines single-cell identity and heterogeneity

Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A.-D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., et al. (2022) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsSingle-cell and spatial transcriptomics

Cited by 562

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.

Lukas, C., Falck, J., Bartkova, J., Bartek, J., & Lukas, J. (2003) · Nature Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 474

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

Lukas, J., Lukas, C., & Bartek, J. (2004) · DNA Repair

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 381

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.

Poulsen, M., Lukas, C., Lukas, J., Bekker-Jensen, S., & Mailand, N. (2012) · Journal of Cell Biology

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 146

Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation

Syljuåsen, R. G., Sørensen, C. S., Nylandsted, J., Lukas, C., Lukas, J., & Bartek, J. (2004) · Cancer Research

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 99

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., et al. (2018) · Genome Biology

DNA Repair MechanismsCancer Genomics and Diagnostics

Cited by 67